Click here to switch to the map view.

The map label for this gene is dxsA

Identifier: 15673463

GI number: 15673463

Start: 1509163

End: 1510962

Strand: Reverse

Name: dxsA

Synonym: L108911

Alternate gene names: 15673463

Gene position: 1510962-1509163 (Counterclockwise)

Preceding gene: 15673464

Following gene: 15673461

Centisome position: 63.87

GC content: 37.17

Gene sequence:

>1800_bases
ATGACAGTATTAGACAAAGTAAATGACCCCACAGACATCAAGGCTCTTACACCGCTAGAACTAGAAGAGCTCGCTACAAA
TGTACGCGATGCAATTCTTAATCGTGTCAGTCAATATCCAGGGGGCCATCTCGGACCAAATCTTGGTGTTGTAGAAATGA
CTATTGCTTTACATAAAGTCTTTAACTCACCTGTTGATAAATTAATTTGGGACGTTAGTCATCAAAGCTATCCGCATAAA
GTTTTAACGGGACGTAAAGAATTTTTTACTGACAAAGACAAATTTTCTGGAACAACAGGCTATACAGACCCTGAAGAAAA
TGAACATGACTTTATACGAGTCGGTCATACATCTACATCTATTGCAACAGCTATGGGATACGCCTTGGCTCGAGATGTGC
AAGGAAAAAAAGAAAATATTGTAGCCATCATTGGTGATGGCGCGCTCTCAGGAGGACTTGCATTTGAGGGACTTGATGGC
GCAGGTACACTTAACGGGAATCTTATTATTATTGTAAATGATAATGAAATGGCCATCACCGAAAATCATGGAGGAATCTA
TCAACATCTTGCAGATCTGCGAGCAAGTAAAGGAACCTCAGCAAATAATCTTTTTAAATCATTTGGGCTTGATTACCGTT
ACCTTGAGGAGGGAAATGATATCCAAAGTTTGATTGTCCTTTTTGAATCAGTAAAAGATATCAATCGGCCAATTGTTCTT
CATATCCACATAGAGAAAGGACATGGCTATAAACCAGCAGTTGAAAATAAAGAAGGAATGCACCAAGTCTTTGCACCCTT
TGATATTGCTACAGGTCAACCAGTCAATAGCTCAACCAATATCGTTCGTAGCTATAATAATGTATTTCTTGACTTTATGG
AAGAAAAGTTAGCCAAAGGTGACAATCTTATCGCCATTAATGCCGCAATTCCAATGTTCTTTGGCCTGTCACAATTTGCT
AAGAATCATCCAAAAAATTATGTTGATGGAGGAATTGCTGAACAATATACAGTGACACTTGGTGGAGCAATCGCAGCAGC
AGGAACTCGAGCTATTATTTTCCAAAATGCAACTTTCTTACAACGTGCTTATGACCAACTTAACCATGATTTGGCACTGA
ATAAAGAACCAGCAATTGTTATTATCAGTAATAGTCAAATTGGCGGAACAAACGATACTCATCAAGGAAGTTTTGTTTAT
AGTCAAACATCAAATATTCCCAATGTAATTGACCTTGCAGCAACAAGTGAAGAAGACCTTTTTGCAATGCTTAATTGGGC
ATATAATCAACATGAACATCCAGTATTTATACACTTGCCAGAGCATACTTTGGAAAATCGCCCAACAAAAATTACTGATT
TTAGTAAACCTCAGTATGAAGTTGTTAAGTCTGGCGAAAAAGTTGCAATCTTAGGACTTGGTGCAATGCTTGAGAAAGCT
GAAAATGTCGCAGAAGAACTTGAAAAATCAGGATTTAATCCAACGGTTGTAAATCCATTCTTTGCAAATCTTTTGGATGT
AGCTGCTTTAGACAAATTATCTGAAACTCATGGACTCTTTGTTACGATTGAAGATGGCACTAAAGATGGGGGATTTGGTC
AAAAAGTGGCGACCTATTTGGCAAGTAAAGGGATAAAAACACTTGTATATGGTGCAGATACTGAGTTTATTGATGCTGTT
CCAAAAGAAGAACTTTACAATCGTTATCACATAAGACCAGAACTTATGGCAACTGATATTATTGAAGCAACCAAAGAATC
TAAAGGACCTAATTTTTTTAAGAAAATATTTTCTAAATAA

Upstream 100 bases:

>100_bases
ACAAACGTAAACGTCAATGATATATTAGCTTATTAAACTTAAATAATATTAAATTTTACTCGCAGCTTTATAATCTAAAT
AGAACTAGGAAGAAAAAATT

Downstream 100 bases:

>100_bases
TAATTTTTGAAGACAGAGCTTATTTGCTAGATAAAATATGAAATAAATAGCTAAAAAAGATACTAGCGATTAACTAGTAT
CTTTTTTTATCTAAAATATT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MTVLDKVNDPTDIKALTPLELEELATNVRDAILNRVSQYPGGHLGPNLGVVEMTIALHKVFNSPVDKLIWDVSHQSYPHK
VLTGRKEFFTDKDKFSGTTGYTDPEENEHDFIRVGHTSTSIATAMGYALARDVQGKKENIVAIIGDGALSGGLAFEGLDG
AGTLNGNLIIIVNDNEMAITENHGGIYQHLADLRASKGTSANNLFKSFGLDYRYLEEGNDIQSLIVLFESVKDINRPIVL
HIHIEKGHGYKPAVENKEGMHQVFAPFDIATGQPVNSSTNIVRSYNNVFLDFMEEKLAKGDNLIAINAAIPMFFGLSQFA
KNHPKNYVDGGIAEQYTVTLGGAIAAAGTRAIIFQNATFLQRAYDQLNHDLALNKEPAIVIISNSQIGGTNDTHQGSFVY
SQTSNIPNVIDLAATSEEDLFAMLNWAYNQHEHPVFIHLPEHTLENRPTKITDFSKPQYEVVKSGEKVAILGLGAMLEKA
ENVAEELEKSGFNPTVVNPFFANLLDVAALDKLSETHGLFVTIEDGTKDGGFGQKVATYLASKGIKTLVYGADTEFIDAV
PKEELYNRYHIRPELMATDIIEATKESKGPNFFKKIFSK

Sequences:

>Translated_599_residues
MTVLDKVNDPTDIKALTPLELEELATNVRDAILNRVSQYPGGHLGPNLGVVEMTIALHKVFNSPVDKLIWDVSHQSYPHK
VLTGRKEFFTDKDKFSGTTGYTDPEENEHDFIRVGHTSTSIATAMGYALARDVQGKKENIVAIIGDGALSGGLAFEGLDG
AGTLNGNLIIIVNDNEMAITENHGGIYQHLADLRASKGTSANNLFKSFGLDYRYLEEGNDIQSLIVLFESVKDINRPIVL
HIHIEKGHGYKPAVENKEGMHQVFAPFDIATGQPVNSSTNIVRSYNNVFLDFMEEKLAKGDNLIAINAAIPMFFGLSQFA
KNHPKNYVDGGIAEQYTVTLGGAIAAAGTRAIIFQNATFLQRAYDQLNHDLALNKEPAIVIISNSQIGGTNDTHQGSFVY
SQTSNIPNVIDLAATSEEDLFAMLNWAYNQHEHPVFIHLPEHTLENRPTKITDFSKPQYEVVKSGEKVAILGLGAMLEKA
ENVAEELEKSGFNPTVVNPFFANLLDVAALDKLSETHGLFVTIEDGTKDGGFGQKVATYLASKGIKTLVYGADTEFIDAV
PKEELYNRYHIRPELMATDIIEATKESKGPNFFKKIFSK
>Mature_598_residues
TVLDKVNDPTDIKALTPLELEELATNVRDAILNRVSQYPGGHLGPNLGVVEMTIALHKVFNSPVDKLIWDVSHQSYPHKV
LTGRKEFFTDKDKFSGTTGYTDPEENEHDFIRVGHTSTSIATAMGYALARDVQGKKENIVAIIGDGALSGGLAFEGLDGA
GTLNGNLIIIVNDNEMAITENHGGIYQHLADLRASKGTSANNLFKSFGLDYRYLEEGNDIQSLIVLFESVKDINRPIVLH
IHIEKGHGYKPAVENKEGMHQVFAPFDIATGQPVNSSTNIVRSYNNVFLDFMEEKLAKGDNLIAINAAIPMFFGLSQFAK
NHPKNYVDGGIAEQYTVTLGGAIAAAGTRAIIFQNATFLQRAYDQLNHDLALNKEPAIVIISNSQIGGTNDTHQGSFVYS
QTSNIPNVIDLAATSEEDLFAMLNWAYNQHEHPVFIHLPEHTLENRPTKITDFSKPQYEVVKSGEKVAILGLGAMLEKAE
NVAEELEKSGFNPTVVNPFFANLLDVAALDKLSETHGLFVTIEDGTKDGGFGQKVATYLASKGIKTLVYGADTEFIDAVP
KEELYNRYHIRPELMATDIIEATKESKGPNFFKKIFSK

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786622, Length=598, Percent_Identity=33.6120401337793, Blast_Score=323, Evalue=3e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 65787; Mature: 65656

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVLDKVNDPTDIKALTPLELEELATNVRDAILNRVSQYPGGHLGPNLGVVEMTIALHKV
CCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
FNSPVDKLIWDVSHQSYPHKVLTGRKEFFTDKDKFSGTTGYTDPEENEHDFIRVGHTSTS
HCCCHHHHHHHCCCCCCCHHHHCCCHHHCCCCHHCCCCCCCCCCCCCCCCEEEECCCCHH
IATAMGYALARDVQGKKENIVAIIGDGALSGGLAFEGLDGAGTLNGNLIIIVNDNEMAIT
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCCCEECCCEEEEECCCEEEEE
ENHGGIYQHLADLRASKGTSANNLFKSFGLDYRYLEEGNDIQSLIVLFESVKDINRPIVL
ECCCHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEE
HIHIEKGHGYKPAVENKEGMHQVFAPFDIATGQPVNSSTNIVRSYNNVFLDFMEEKLAKG
EEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
DNLIAINAAIPMFFGLSQFAKNHPKNYVDGGIAEQYTVTLGGAIAAAGTRAIIFQNATFL
CCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHCCCEEEEEECHHHH
QRAYDQLNHDLALNKEPAIVIISNSQIGGTNDTHQGSFVYSQTSNIPNVIDLAATSEEDL
HHHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCHHH
FAMLNWAYNQHEHPVFIHLPEHTLENRPTKITDFSKPQYEVVKSGEKVAILGLGAMLEKA
HHHHHHHHCCCCCCEEEECCCHHHCCCCCCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHH
ENVAEELEKSGFNPTVVNPFFANLLDVAALDKLSETHGLFVTIEDGTKDGGFGQKVATYL
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHH
ASKGIKTLVYGADTEFIDAVPKEELYNRYHIRPELMATDIIEATKESKGPNFFKKIFSK
HHCCCEEEEECCCCHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHCC
>Mature Secondary Structure 
TVLDKVNDPTDIKALTPLELEELATNVRDAILNRVSQYPGGHLGPNLGVVEMTIALHKV
CCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHH
FNSPVDKLIWDVSHQSYPHKVLTGRKEFFTDKDKFSGTTGYTDPEENEHDFIRVGHTSTS
HCCCHHHHHHHCCCCCCCHHHHCCCHHHCCCCHHCCCCCCCCCCCCCCCCEEEECCCCHH
IATAMGYALARDVQGKKENIVAIIGDGALSGGLAFEGLDGAGTLNGNLIIIVNDNEMAIT
HHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCEEEECCCCCCEECCCEEEEECCCEEEEE
ENHGGIYQHLADLRASKGTSANNLFKSFGLDYRYLEEGNDIQSLIVLFESVKDINRPIVL
ECCCHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHCCCCEEE
HIHIEKGHGYKPAVENKEGMHQVFAPFDIATGQPVNSSTNIVRSYNNVFLDFMEEKLAKG
EEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
DNLIAINAAIPMFFGLSQFAKNHPKNYVDGGIAEQYTVTLGGAIAAAGTRAIIFQNATFL
CCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCHHHHCCCEEEEEECHHHH
QRAYDQLNHDLALNKEPAIVIISNSQIGGTNDTHQGSFVYSQTSNIPNVIDLAATSEEDL
HHHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCCCCEEEECCCCCCCEEEEECCCCHHH
FAMLNWAYNQHEHPVFIHLPEHTLENRPTKITDFSKPQYEVVKSGEKVAILGLGAMLEKA
HHHHHHHHCCCCCCEEEECCCHHHCCCCCCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHH
ENVAEELEKSGFNPTVVNPFFANLLDVAALDKLSETHGLFVTIEDGTKDGGFGQKVATYL
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHH
ASKGIKTLVYGADTEFIDAVPKEELYNRYHIRPELMATDIIEATKESKGPNFFKKIFSK
HHCCCEEEEECCCCHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA