Click here to switch to the map view.

The map label for this gene is lysA

Identifier: 15673266

GI number: 15673266

Start: 1313706

End: 1314965

Strand: Reverse

Name: lysA

Synonym: L0121

Alternate gene names: 15673266

Gene position: 1314965-1313706 (Counterclockwise)

Preceding gene: 15673267

Following gene: 15673265

Centisome position: 55.59

GC content: 35.32

Gene sequence:

>1260_bases
ATGAAGACACCATTTGTAACAAAAGAACAATTAGAACAAATCACGAAGGAATTTCCAACACCATTTCATCTTTATGATGA
AAAAGGAATTCGTCAAAAAGCGCGTGACCTTCACAAAGCCTTTGCTTGGAATAAAGGATTTAAAGAATTTTTTGCTGTGA
AAGCGACACCCACACCAGCTATTTTAAAAATTCTTCATGAAGAGGGGTGTGGAGTTGATTGCGCCTCTTATGTCGAATTG
TTACTTTCCGAAAAATGTGGGTTTGACGGCTCTGAGATGATGTTTTCATCAAACGATACTCCAGCTGAAGAATTTCAATT
TGCTAATCAATTGGGTGCGACAATCAATCTTGATGCCTATGAAGATATTGAATTTTTGAAAAATCTGACAGATTTTATTT
TTCCGGAAACAATGAGTTTGAGATACAATCCCGGTGGAGTTTTTGCTATGGGAACAAAAATTATGGATAATCCAGAAGAA
TCTAAATTCGGAATGACAAAAGCCCAACTCATCCAAGGAATTAAAGATTTGCAAAAATTAGGCGTGAAAAAATTTGGAAT
GCATAGTTTTTTGGCTTCAAATACAGTGACAAATGATTATTACCCAGAACTTGCCAACAAGCTCTTTAAGCTTGCTTTAG
AAATTAGAGAAGAAACTGGAATTACCCTTGATTTCATTAACTTATCAGGCGGAATTGGTGTGAACTATCGTCCTGATGAG
GAGGCAAATGATATTGCAAAAATCGGACAAGGTGTTCACGAAGCTTATGATGAAGTTTTGAGGGCTAACGGAATAGAAAA
TCTAAAAATTTATACCGAATTGGGACGTTTTATGCTTGCTCCACACGGTCATTTGATTACAAAAGTTTTGCATATTAAAG
AAACTTATCGAAAATATGTTGGCGTTGATGCATCAGCAGTTAACTTGATGCGTCCAGCCTTTTATGATGCTTATCACCAC
ATCACAGTTGCTGGAAAAGAAAAAGATGAAGCGACTGAAATTTATGATATTACAGGTTCTTTATGTGAGAATAATGATAA
ATTTGCAAAAGAAAGAGCCTTTCCTAAAATAGAAATAGGAGATTTATTAGTGATTCATGATACTGGTGCGCATGGATTCT
CAATGGGTTATCAATATAATGCTAAATTAAGAAGTTCCGAAGTTTTGCTTCAAGAAGATGGAAAGACTCGTTTAATTCGT
CGAGCAGAGAAGCCAGCTGATTATTTTGCAACATTAGATGGTTTTGATTTTACAATTTGA

Upstream 100 bases:

>100_bases
TAAAAAAAAGTTTCTGTCAGTAAAAATGGCAGGAACTTTTTTGTGTCCAAGCTTTTGATGATATGCTATACTTATAAATA
ATCTAAAAATGAGGTGAGAG

Downstream 100 bases:

>100_bases
GAAATAAAAAGTTACTGACAGCTCCGTCAGTAACTTTTGCCTCATTTATCCTTTCTGTCAGTAATATAAAGTGCTGACAA
AAGGACTAAAATTTGATATA

Product: diaminopimelate decarboxylase

Products: L-lysine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKTPFVTKEQLEQITKEFPTPFHLYDEKGIRQKARDLHKAFAWNKGFKEFFAVKATPTPAILKILHEEGCGVDCASYVEL
LLSEKCGFDGSEMMFSSNDTPAEEFQFANQLGATINLDAYEDIEFLKNLTDFIFPETMSLRYNPGGVFAMGTKIMDNPEE
SKFGMTKAQLIQGIKDLQKLGVKKFGMHSFLASNTVTNDYYPELANKLFKLALEIREETGITLDFINLSGGIGVNYRPDE
EANDIAKIGQGVHEAYDEVLRANGIENLKIYTELGRFMLAPHGHLITKVLHIKETYRKYVGVDASAVNLMRPAFYDAYHH
ITVAGKEKDEATEIYDITGSLCENNDKFAKERAFPKIEIGDLLVIHDTGAHGFSMGYQYNAKLRSSEVLLQEDGKTRLIR
RAEKPADYFATLDGFDFTI

Sequences:

>Translated_419_residues
MKTPFVTKEQLEQITKEFPTPFHLYDEKGIRQKARDLHKAFAWNKGFKEFFAVKATPTPAILKILHEEGCGVDCASYVEL
LLSEKCGFDGSEMMFSSNDTPAEEFQFANQLGATINLDAYEDIEFLKNLTDFIFPETMSLRYNPGGVFAMGTKIMDNPEE
SKFGMTKAQLIQGIKDLQKLGVKKFGMHSFLASNTVTNDYYPELANKLFKLALEIREETGITLDFINLSGGIGVNYRPDE
EANDIAKIGQGVHEAYDEVLRANGIENLKIYTELGRFMLAPHGHLITKVLHIKETYRKYVGVDASAVNLMRPAFYDAYHH
ITVAGKEKDEATEIYDITGSLCENNDKFAKERAFPKIEIGDLLVIHDTGAHGFSMGYQYNAKLRSSEVLLQEDGKTRLIR
RAEKPADYFATLDGFDFTI
>Mature_419_residues
MKTPFVTKEQLEQITKEFPTPFHLYDEKGIRQKARDLHKAFAWNKGFKEFFAVKATPTPAILKILHEEGCGVDCASYVEL
LLSEKCGFDGSEMMFSSNDTPAEEFQFANQLGATINLDAYEDIEFLKNLTDFIFPETMSLRYNPGGVFAMGTKIMDNPEE
SKFGMTKAQLIQGIKDLQKLGVKKFGMHSFLASNTVTNDYYPELANKLFKLALEIREETGITLDFINLSGGIGVNYRPDE
EANDIAKIGQGVHEAYDEVLRANGIENLKIYTELGRFMLAPHGHLITKVLHIKETYRKYVGVDASAVNLMRPAFYDAYHH
ITVAGKEKDEATEIYDITGSLCENNDKFAKERAFPKIEIGDLLVIHDTGAHGFSMGYQYNAKLRSSEVLLQEDGKTRLIR
RAEKPADYFATLDGFDFTI

Specific function: Involved in tabtoxin production and pathogenicity [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=418, Percent_Identity=29.4258373205742, Blast_Score=155, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: 4.1.1.20

Molecular weight: Translated: 47280; Mature: 47280

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTPFVTKEQLEQITKEFPTPFHLYDEKGIRQKARDLHKAFAWNKGFKEFFAVKATPTPA
CCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCHH
ILKILHEEGCGVDCASYVELLLSEKCGFDGSEMMFSSNDTPAEEFQFANQLGATINLDAY
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHCCCEEECCCH
EDIEFLKNLTDFIFPETMSLRYNPGGVFAMGTKIMDNPEESKFGMTKAQLIQGIKDLQKL
HHHHHHHHHHHHHCCCCCEEEECCCCEEEECCHHHCCCCHHHCCCCHHHHHHHHHHHHHH
GVKKFGMHSFLASNTVTNDYYPELANKLFKLALEIREETGITLDFINLSGGIGVNYRPDE
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
EANDIAKIGQGVHEAYDEVLRANGIENLKIYTELGRFMLAPHGHLITKVLHIKETYRKYV
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GVDASAVNLMRPAFYDAYHHITVAGKEKDEATEIYDITGSLCENNDKFAKERAFPKIEIG
CCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHCCHHHHCCCHHHHHHHCCCCEEEC
DLLVIHDTGAHGFSMGYQYNAKLRSSEVLLQEDGKTRLIRRAEKPADYFATLDGFDFTI
CEEEEECCCCCCEECCEEECCCCCCCEEEEECCCHHHHHHHHCCCHHHHEEECCCCCCC
>Mature Secondary Structure
MKTPFVTKEQLEQITKEFPTPFHLYDEKGIRQKARDLHKAFAWNKGFKEFFAVKATPTPA
CCCCCCCHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHCCCCHHHEEECCCCCHH
ILKILHEEGCGVDCASYVELLLSEKCGFDGSEMMFSSNDTPAEEFQFANQLGATINLDAY
HHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHCCCEEECCCH
EDIEFLKNLTDFIFPETMSLRYNPGGVFAMGTKIMDNPEESKFGMTKAQLIQGIKDLQKL
HHHHHHHHHHHHHCCCCCEEEECCCCEEEECCHHHCCCCHHHCCCCHHHHHHHHHHHHHH
GVKKFGMHSFLASNTVTNDYYPELANKLFKLALEIREETGITLDFINLSGGIGVNYRPDE
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCC
EANDIAKIGQGVHEAYDEVLRANGIENLKIYTELGRFMLAPHGHLITKVLHIKETYRKYV
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
GVDASAVNLMRPAFYDAYHHITVAGKEKDEATEIYDITGSLCENNDKFAKERAFPKIEIG
CCCHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHCCHHHHCCCHHHHHHHCCCCEEEC
DLLVIHDTGAHGFSMGYQYNAKLRSSEVLLQEDGKTRLIRRAEKPADYFATLDGFDFTI
CEEEEECCCCCCEECCEEECCCCCCCEEEEECCCHHHHHHHHCCCHHHHEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: D-Lysine; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1.7 {meso-2,6-diamininoheptanedioate}} [C]

Substrates: meso-2,6-diaminoheptanedioate

Specific reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2

General reaction: Decarboxylation [C]

Inhibitor: 2, 3-Diaminopropionic acid; Glutamic acid; L-Cystine; L-Lysine; Penicillamine [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1515668 [H]