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The map label for this gene is apt

Identifier: 15672615

GI number: 15672615

Start: 622784

End: 623341

Strand: Direct

Name: apt

Synonym: L22735

Alternate gene names: 15672615

Gene position: 622784-623341 (Clockwise)

Preceding gene: 15672614

Following gene: 15672616

Centisome position: 26.33

GC content: 38.71

Gene sequence:

>558_bases
ATGTTAGAAAAAAGGAGCACTGACAATTCTGTCAGTAACAAAAACATGGAATTAAAAGACTATATTGCAACAATTGAAAA
CTATCCTAAAGAAGGCGTAGTTTTTCGCGACATCAGCCCTTTGATGGCAGACGGAAATGCCTATAACTATGCTGCTACCG
AAATTGTTCAGTATGCAAGAGATAAAGAAATAGATATGGTTGTAGGTCCAGAAGCACGTGGTTTCATCATTGGATGTCCA
GTTGCTTTTGCACTTGGTGTAGGATTTGCCCCAGTTCGTAAGCCTGGTAAATTACCTCGTGAAGTCATTGAAGCAACTTA
CGAAAAAGAATACGGAACAGACACACTCACAATGCATTCAGATAGCATCAAACCAGGACAACGTGTCTTGATTGTTGATG
ATTTGCTTGCAACTGGTGGAACAATTGCCGCTACAATTGAACTTGTTGAAAAAATGGGTGGAATTGTTGTTGGATGTGCA
TTCCTTATCGAACTTGATGAACTTAAAGGTCGCGAAAAAATCGGAGATTACGATTATAAAGTTCTAATGCACTATTAA

Upstream 100 bases:

>100_bases
ATCAAAATTTATTAGAAAAATAATTTCGTTTTTATAAAAAGATAGTGACGAAATCAGCTATACTCATAATAATAAAGCTG
TCAGTAAAAATAACGGACTT

Downstream 100 bases:

>100_bases
TTTCTTTACTGTCAGTAGCCAATAAATGTTATTAGTATTCTTTTGATAAAAACAAGAGAGTATAGTTAAGCTAAAAGCAA
GTAAACAGAGGTTTTTTGGC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MLEKRSTDNSVSNKNMELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYARDKEIDMVVGPEARGFIIGCP
VAFALGVGFAPVRKPGKLPREVIEATYEKEYGTDTLTMHSDSIKPGQRVLIVDDLLATGGTIAATIELVEKMGGIVVGCA
FLIELDELKGREKIGDYDYKVLMHY

Sequences:

>Translated_185_residues
MLEKRSTDNSVSNKNMELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYARDKEIDMVVGPEARGFIIGCP
VAFALGVGFAPVRKPGKLPREVIEATYEKEYGTDTLTMHSDSIKPGQRVLIVDDLLATGGTIAATIELVEKMGGIVVGCA
FLIELDELKGREKIGDYDYKVLMHY
>Mature_185_residues
MLEKRSTDNSVSNKNMELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYARDKEIDMVVGPEARGFIIGCP
VAFALGVGFAPVRKPGKLPREVIEATYEKEYGTDTLTMHSDSIKPGQRVLIVDDLLATGGTIAATIELVEKMGGIVVGCA
FLIELDELKGREKIGDYDYKVLMHY

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=40.7185628742515, Blast_Score=133, Evalue=8e-32,
Organism=Homo sapiens, GI71773201, Length=133, Percent_Identity=38.3458646616541, Blast_Score=99, Evalue=2e-21,
Organism=Escherichia coli, GI1786675, Length=157, Percent_Identity=54.140127388535, Blast_Score=178, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=171, Percent_Identity=43.859649122807, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6323619, Length=170, Percent_Identity=41.7647058823529, Blast_Score=123, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320649, Length=170, Percent_Identity=32.9411764705882, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17136334, Length=171, Percent_Identity=42.1052631578947, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20418; Mature: 20418

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKRSTDNSVSNKNMELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYAR
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHCCCCCCCHHHHHHHHHHC
DKEIDMVVGPEARGFIIGCPVAFALGVGFAPVRKPGKLPREVIEATYEKEYGTDTLTMHS
CCCCEEEECCCCCCEEEECHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEC
DSIKPGQRVLIVDDLLATGGTIAATIELVEKMGGIVVGCAFLIELDELKGREKIGDYDYK
CCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCCHHEEHHHHHHHHHHCCCCCCCCCCEE
VLMHY
EEEEC
>Mature Secondary Structure
MLEKRSTDNSVSNKNMELKDYIATIENYPKEGVVFRDISPLMADGNAYNYAATEIVQYAR
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEECCCHHHCCCCCCCHHHHHHHHHHC
DKEIDMVVGPEARGFIIGCPVAFALGVGFAPVRKPGKLPREVIEATYEKEYGTDTLTMHS
CCCCEEEECCCCCCEEEECHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEC
DSIKPGQRVLIVDDLLATGGTIAATIELVEKMGGIVVGCAFLIELDELKGREKIGDYDYK
CCCCCCCEEEEEEHHHHCCCHHHHHHHHHHHHCCHHEEHHHHHHHHHHCCCCCCCCCCEE
VLMHY
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]