Click here to switch to the map view.

The map label for this gene is uvrB

Identifier: 15672544

GI number: 15672544

Start: 556127

End: 558205

Strand: Direct

Name: uvrB

Synonym: L0257

Alternate gene names: 15672544

Gene position: 556127-558205 (Clockwise)

Preceding gene: 15672543

Following gene: 15672545

Centisome position: 23.51

GC content: 39.01

Gene sequence:

>2079_bases
ATGGCTATAGAAAGAATAACAGATAATAAATTTGAACTTGTTTCAAAATATGAGCCAGCCGGTGACCAAGGTGAGGCGAT
TGCTGAGTTAGTAGATAATATTGAGAATGGGGAAAAAGCTCAAATTTTACGTGGAGCAACAGGAACAGGGAAAACTTACA
CCATGAGTCAAGTGATTGCACGGACAGGTAAACCTACTCTTGTTATGGCTCATAATAAAACACTGGCTGGTCAATTATAC
AGTGAATTTAAAGAGTTTTTTCCAAATAATGCAGTCGAGTATTTCGTATCCTACTATGATTATTATCAACCCGAAGCCTA
TGTTCCAAGTTCTGACACCTATATTGAAAAAGACAGTTCGGTCAATGATGAAATTGATAAATTGCGTCATAGTGCGACCT
CAAGCTTATTGGAACGTAATGATGTGATTGTTGTGGCCTCAGTTTCTTGTATTTATGGATTGGGTTCACCCAAAGAGTAT
CAAGATTCGGTGGTTTCATTGCGCCCAGGTCAAGAAATTTCTCGTGACCAACTTTTAAATGATTTGGTAGGAATTCAATT
TGAGCGAAATGATATTGACTTTCAACGGGGCTGTTTCCGAGTTCGCGGGGATGTTGTAGAAGTTTTTCCAGCCTCTCGTG
ATGAACATGCCTTTCGTGTTGAATTTTTCGGTGATGAAATTGACCGTATCCGTGAAATTGAAGTTTTGACCGGACAAGTT
TTAGGTGAAGTAGACCATTTGGCAATTTTCCCAGCGACACATTTCATGACAAATGATGACCGTATGGAAGAATCAATTGC
CAAGATAGAAGCAGAATTAGAAGAACAATTAAAAGTTTTCCGCTCAGAAGGAAAACTTCTTGAGGCTCAACGTTTAGAAC
AAAGAACCAACTACGATATCGAAATGCTCCGTGAAATGGGTTATTGTAATGGGGTCGAAAACTATTCACGTCATATGGAT
GGGCGCGAGGAAGGCGAACCTCCGTATACTTTACTTGATTTCTTTCCTGATGATTTCATGATTATGATTGATGAATCACA
CATGACAATGGGGCAAGTAAAAGGAATGTATAACGGTGACAGAGCCCGTAAAGAAATGCTTTGTAATTATGGATTCCGCC
TGCCTTCAGCCCTCGATAACCGTCCTTTAAAAAGAGAAGAATTTGAAAGTCATGTGCATCAAATTGTTTATGTTTCAGCA
ACCCCTGGGGATTATGAGATGGAGCAGACCGATACCATTGTTGAACAAATTATTCGTCCAACAGGTCTATTAGATCCTGT
CGTAGAAGTTCGACCAATGATGGGACAAATCGATGATTTAGTTGGTGAAATTCATAAACGAGCTGAGAAAAACGAACGAG
TATTCGTCACGACTTTGACTAAAAAGATGTCAGAAGATTTAACTGCCTATTTCAAGGAAATGGGGATAAAAGTTAAATAT
ATGCACTCGGATATCAAAACATTAGAACGAACCGAAATTATTCGGGATTTGCGTTTAGGAGTCTTTGATGTTCTGGTGGG
AATAAATCTGCTTCGCGAAGGGATTGACGTGCCAGAAGTTTCTTTAGTCGCGATTTTGGATGCTGATAAAGAAGGATTTT
TACGTAATGAGCGTGGCTTGATTCAGACCATTGGTCGTGCAGCACGTAATAGTGAAGGTCATGTTATTCTTTATTCTGAT
ATGGCTAAAGCCCTTGATGAAAATGATCCTGTGGATAAAGAAATCTTAGATAGTGGTTATTATACAGAATACGAGGGTCA
AAAGTATAAAATAACGCGTTCAATGAAACATGCGATGGATGAAACAGCCCGTCGGCGTGAAATTCAAATGGCTTATAATG
AAGAACATGGAATCACACCTCAAACGATCAAAAAAGAAATTCGTGATTTGATTGCCATTACTAAGAAAACTGATTCTGGT
GAGATTGAAGAAGTTGATGCAAGTGCGATGACTAAGAAAGAACGTAAAGCATTAGTCAAAAAACTTGAAAAAGAAATGCA
ACAAGCGGCTAGCGCCCTCGACTTTGAAGGAGCTGCTCAGTTACGTGATATGGTATTAGAATTACGTGCAATGGATTGA

Upstream 100 bases:

>100_bases
TCTGAAATTCGTAAAATGGATTTTGGCTTTAAAAATGATGTTTATCATCAAGCATTAGATTATTTTTCAAAGATAATAGA
AAAGAATTAAAGGAAAAAGA

Downstream 100 bases:

>100_bases
TTAATAATTAATAAAAATTCACTCATTGAGTGAATTTTTATTTTGAATCAAGTATAAAAGTACAGTTTTTATCTAAAAAT
CTTTGTTTATTAAATAATTA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MAIERITDNKFELVSKYEPAGDQGEAIAELVDNIENGEKAQILRGATGTGKTYTMSQVIARTGKPTLVMAHNKTLAGQLY
SEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEY
QDSVVSLRPGQEISRDQLLNDLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQV
LGEVDHLAIFPATHFMTNDDRMEESIAKIEAELEEQLKVFRSEGKLLEAQRLEQRTNYDIEMLREMGYCNGVENYSRHMD
GREEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGDRARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSA
TPGDYEMEQTDTIVEQIIRPTGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKY
MHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVILYSD
MAKALDENDPVDKEILDSGYYTEYEGQKYKITRSMKHAMDETARRREIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSG
EIEEVDASAMTKKERKALVKKLEKEMQQAASALDFEGAAQLRDMVLELRAMD

Sequences:

>Translated_692_residues
MAIERITDNKFELVSKYEPAGDQGEAIAELVDNIENGEKAQILRGATGTGKTYTMSQVIARTGKPTLVMAHNKTLAGQLY
SEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEY
QDSVVSLRPGQEISRDQLLNDLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQV
LGEVDHLAIFPATHFMTNDDRMEESIAKIEAELEEQLKVFRSEGKLLEAQRLEQRTNYDIEMLREMGYCNGVENYSRHMD
GREEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGDRARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSA
TPGDYEMEQTDTIVEQIIRPTGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKY
MHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVILYSD
MAKALDENDPVDKEILDSGYYTEYEGQKYKITRSMKHAMDETARRREIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSG
EIEEVDASAMTKKERKALVKKLEKEMQQAASALDFEGAAQLRDMVLELRAMD
>Mature_691_residues
AIERITDNKFELVSKYEPAGDQGEAIAELVDNIENGEKAQILRGATGTGKTYTMSQVIARTGKPTLVMAHNKTLAGQLYS
EFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSSVNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYQ
DSVVSLRPGQEISRDQLLNDLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQVL
GEVDHLAIFPATHFMTNDDRMEESIAKIEAELEEQLKVFRSEGKLLEAQRLEQRTNYDIEMLREMGYCNGVENYSRHMDG
REEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGDRARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSAT
PGDYEMEQTDTIVEQIIRPTGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKYM
HSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGLIQTIGRAARNSEGHVILYSDM
AKALDENDPVDKEILDSGYYTEYEGQKYKITRSMKHAMDETARRREIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSGE
IEEVDASAMTKKERKALVKKLEKEMQQAASALDFEGAAQLRDMVLELRAMD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=693, Percent_Identity=54.8340548340548, Blast_Score=731, Evalue=0.0,
Organism=Escherichia coli, GI1787357, Length=234, Percent_Identity=23.0769230769231, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_LACLA (Q9CI06)

Other databases:

- EMBL:   AE005176
- PIR:   B86695
- RefSeq:   NP_266718.1
- ProteinModelPortal:   Q9CI06
- SMR:   Q9CI06
- GeneID:   1114181
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0257
- NMPDR:   fig|272623.1.peg.577
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   LLAC272623:L0257-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 79133; Mature: 79001

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERITDNKFELVSKYEPAGDQGEAIAELVDNIENGEKAQILRGATGTGKTYTMSQVIA
CCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHEEECCCCCCCCHHHHHHHH
RTGKPTLVMAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSS
HCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCC
VNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYQDSVVSLRPGQEISRDQLLN
CCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCCEECCCCCCCCHHHHHH
DLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQV
HHHCCEEECCCCCHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
LGEVDHLAIFPATHFMTNDDRMEESIAKIEAELEEQLKVFRSEGKLLEAQRLEQRTNYDI
HCCCHHEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
EMLREMGYCNGVENYSRHMDGREEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGD
HHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHCCCCCCH
RARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSATPGDYEMEQTDTIVEQIIRP
HHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHCC
TGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEE
MHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGL
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCHH
IQTIGRAARNSEGHVILYSDMAKALDENDPVDKEILDSGYYTEYEGQKYKITRSMKHAMD
HHHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCHHHHCCCCEECCCCCEEEHHHHHHHHHH
ETARRREIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSGEIEEVDASAMTKKERKALVK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHH
KLEKEMQQAASALDFEGAAQLRDMVLELRAMD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AIERITDNKFELVSKYEPAGDQGEAIAELVDNIENGEKAQILRGATGTGKTYTMSQVIA
CCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHEEECCCCCCCCHHHHHHHH
RTGKPTLVMAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVPSSDTYIEKDSS
HCCCCEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCC
VNDEIDKLRHSATSSLLERNDVIVVASVSCIYGLGSPKEYQDSVVSLRPGQEISRDQLLN
CCHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHCCCCCHHHHCCCEECCCCCCCCHHHHHH
DLVGIQFERNDIDFQRGCFRVRGDVVEVFPASRDEHAFRVEFFGDEIDRIREIEVLTGQV
HHHCCEEECCCCCHHHHHHHHCCCEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH
LGEVDHLAIFPATHFMTNDDRMEESIAKIEAELEEQLKVFRSEGKLLEAQRLEQRTNYDI
HCCCHHEEEECHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCH
EMLREMGYCNGVENYSRHMDGREEGEPPYTLLDFFPDDFMIMIDESHMTMGQVKGMYNGD
HHHHHCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCHHHHHCCCCCCH
RARKEMLCNYGFRLPSALDNRPLKREEFESHVHQIVYVSATPGDYEMEQTDTIVEQIIRP
HHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHHHCC
TGLLDPVVEVRPMMGQIDDLVGEIHKRAEKNERVFVTTLTKKMSEDLTAYFKEMGIKVKY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCEEEE
MHSDIKTLERTEIIRDLRLGVFDVLVGINLLREGIDVPEVSLVAILDADKEGFLRNERGL
EHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCHH
IQTIGRAARNSEGHVILYSDMAKALDENDPVDKEILDSGYYTEYEGQKYKITRSMKHAMD
HHHHHHHHCCCCCCEEEEHHHHHHCCCCCCCCHHHHCCCCEECCCCCEEEHHHHHHHHHH
ETARRREIQMAYNEEHGITPQTIKKEIRDLIAITKKTDSGEIEEVDASAMTKKERKALVK
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCHHHHHHHHHHHHHH
KLEKEMQQAASALDFEGAAQLRDMVLELRAMD
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471