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The map label for this gene is murA2

Identifier: 15672531

GI number: 15672531

Start: 534233

End: 535516

Strand: Direct

Name: murA2

Synonym: L134243

Alternate gene names: 15672531

Gene position: 534233-535516 (Clockwise)

Preceding gene: 30024001

Following gene: 15672532

Centisome position: 22.58

GC content: 39.41

Gene sequence:

>1284_bases
ATGATGGATAAAATAATTGTAAAAGGTGGGCAAACAAAACTTCAAGGTGAAGTTGAAATTGAAGGAGCAAAGAACGCCGT
TCTTCCTCTTCTTGCAGCAACATTACTCGCTAGTGAGGGTGAAGTTGTACTTACTAATGTCCCTATTTTAAGCGACGTTT
TTATGATGAATAATTTGGTAAATCATCTTGGAACTGCGATTAGCTTTGACCAAGAAGCAAAGAAAATTATTGCTAAATCA
AATTCAGAAATAAAAACAACTGCACCATATGAGTATGTCAGCAAAATGCGTGCCTCAATCGTTGTTATGGGACCAATCTT
AGCCCGCAACGGACAAGCACGTGTATCAATGCCAGGTGGATGTTCCATTGGATCTCGACCAATTGATTTACATTTACGCG
GTTTTGAACAAATGGGAGCAACAATCACTCAAAATGCTGGTTATATTGAAGCTAAGGCTGATAAATTAAAAGGAGCTCAT
ATTTATCTTGACTTTCCATCAGTAGGAGCTACTCAAAATCTTATTCTTGCTGCGACACTAGCTGACGGGACAACGACACT
TGAAAATGCAGCACGTGAACCAGAAATTGTTGACTTAGCAAACCTCCTAAATAAAATGGGAGCAAATGTTAAGGGGGCCG
GAACAGATACAATTATTATTAAAGGTGTTGAAAAAATGCATGGGGCAAACCATTCAGTTGTTCAAGACCGAATTGAAGCA
GGAACTTTCATGGTTGCGGCCGCAATGACACAAGGTGATGTTTTAATCAAAGATGCGATTGCTGAACATAACCGTCCATT
GATTTCAAAACTTAGCGAAATGGGTGTTAATTTTATCCAAGAAGAATCTGGACTTCGAGTTGTTGGGCCTGAAAAACTAA
AAGCAACAAGCGTTAAGACTTTACCACACCCAGGATTTCCTACAGATATGCAATCACAAATGACAGCTGCTCAGGCCGTT
GCCGTGGGAGAATCAGTGATGGTAGAGACAGTATTTGAAAATCGTTTCCAACATTTGAAAGAAATGCGTCGTATAGGATT
GGAAGTTGACATTACTAGAAATACAGCGCTTATTCAAGGAAATTCAAATTTACAAGGCGCTGCGGTAAAATCAACAGATT
TACGGGCAAGTGCCGCATTGATTCTTTTGGGATTGGTTGCCAAAGGGCAAACAACTGTTAGAAGATTAAGTCATTTAGAC
CGAGGTTACTATAAATTCCATGAAAAATTAAAAGCTCTGGGAGCTGATATTATTCGTGTAGAAGACGAAGACGGAGAAGG
CTAA

Upstream 100 bases:

>100_bases
CAAAAAATAAACAGAGTGAAATATTTCAGAAAAATGGAAGGTACTTTTGTGTTATAATCTAAAAATATAAAATAAAATTT
AGAGGAAAAATAGGATTTAA

Downstream 100 bases:

>100_bases
TGTTTAAGAAAACCATAAAATTTTTAGGACTAAGACTCTCTATTATTATTATTTTTGTTATAGTTCTACTAGTTCTTGCC
GCCGTTTTAGGACTTATGGT

Product: UDP-N-acetylglucosamine 1-carboxyvinyltransferase

Products: NA

Alternate protein names: Enoylpyruvate transferase 1; UDP-N-acetylglucosamine enolpyruvyl transferase 1; EPT 1

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MMDKIIVKGGQTKLQGEVEIEGAKNAVLPLLAATLLASEGEVVLTNVPILSDVFMMNNLVNHLGTAISFDQEAKKIIAKS
NSEIKTTAPYEYVSKMRASIVVMGPILARNGQARVSMPGGCSIGSRPIDLHLRGFEQMGATITQNAGYIEAKADKLKGAH
IYLDFPSVGATQNLILAATLADGTTTLENAAREPEIVDLANLLNKMGANVKGAGTDTIIIKGVEKMHGANHSVVQDRIEA
GTFMVAAAMTQGDVLIKDAIAEHNRPLISKLSEMGVNFIQEESGLRVVGPEKLKATSVKTLPHPGFPTDMQSQMTAAQAV
AVGESVMVETVFENRFQHLKEMRRIGLEVDITRNTALIQGNSNLQGAAVKSTDLRASAALILLGLVAKGQTTVRRLSHLD
RGYYKFHEKLKALGADIIRVEDEDGEG

Sequences:

>Translated_427_residues
MMDKIIVKGGQTKLQGEVEIEGAKNAVLPLLAATLLASEGEVVLTNVPILSDVFMMNNLVNHLGTAISFDQEAKKIIAKS
NSEIKTTAPYEYVSKMRASIVVMGPILARNGQARVSMPGGCSIGSRPIDLHLRGFEQMGATITQNAGYIEAKADKLKGAH
IYLDFPSVGATQNLILAATLADGTTTLENAAREPEIVDLANLLNKMGANVKGAGTDTIIIKGVEKMHGANHSVVQDRIEA
GTFMVAAAMTQGDVLIKDAIAEHNRPLISKLSEMGVNFIQEESGLRVVGPEKLKATSVKTLPHPGFPTDMQSQMTAAQAV
AVGESVMVETVFENRFQHLKEMRRIGLEVDITRNTALIQGNSNLQGAAVKSTDLRASAALILLGLVAKGQTTVRRLSHLD
RGYYKFHEKLKALGADIIRVEDEDGEG
>Mature_427_residues
MMDKIIVKGGQTKLQGEVEIEGAKNAVLPLLAATLLASEGEVVLTNVPILSDVFMMNNLVNHLGTAISFDQEAKKIIAKS
NSEIKTTAPYEYVSKMRASIVVMGPILARNGQARVSMPGGCSIGSRPIDLHLRGFEQMGATITQNAGYIEAKADKLKGAH
IYLDFPSVGATQNLILAATLADGTTTLENAAREPEIVDLANLLNKMGANVKGAGTDTIIIKGVEKMHGANHSVVQDRIEA
GTFMVAAAMTQGDVLIKDAIAEHNRPLISKLSEMGVNFIQEESGLRVVGPEKLKATSVKTLPHPGFPTDMQSQMTAAQAV
AVGESVMVETVFENRFQHLKEMRRIGLEVDITRNTALIQGNSNLQGAAVKSTDLRASAALILLGLVAKGQTTVRRLSHLD
RGYYKFHEKLKALGADIIRVEDEDGEG

Specific function: Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine

COG id: COG0766

COG function: function code M; UDP-N-acetylglucosamine enolpyruvyl transferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family. MurA subfamily

Homologues:

Organism=Escherichia coli, GI1789580, Length=424, Percent_Identity=49.2924528301887, Blast_Score=389, Evalue=1e-109,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURA1_LACLA (Q9CI17)

Other databases:

- EMBL:   AE005176
- PIR:   E86693
- RefSeq:   NP_266705.1
- ProteinModelPortal:   Q9CI17
- GeneID:   1114168
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L134243
- NMPDR:   fig|272623.1.peg.564
- HOGENOM:   HBG482701
- OMA:   ETEILNA
- ProtClustDB:   PRK09369
- BioCyc:   LLAC272623:L134243-MONOMER
- BRENDA:   2.5.1.7
- GO:   GO:0005737
- HAMAP:   MF_00111
- InterPro:   IPR001986
- InterPro:   IPR013792
- InterPro:   IPR005750
- Gene3D:   G3DSA:3.65.10.10
- PANTHER:   PTHR21090:SF4
- TIGRFAMs:   TIGR01072

Pfam domain/function: PF00275 EPSP_synthase; SSF55205 RNA3'_cycl/enolpyr_transf_A/B

EC number: =2.5.1.7

Molecular weight: Translated: 45773; Mature: 45773

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: ACT_SITE 121-121

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDKIIVKGGQTKLQGEVEIEGAKNAVLPLLAATLLASEGEVVLTNVPILSDVFMMNNLV
CCCCEEEECCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
NHLGTAISFDQEAKKIIAKSNSEIKTTAPYEYVSKMRASIVVMGPILARNGQARVSMPGG
HHHCCCCCCCHHHHHHHHCCCCCCEECCCHHHHHHHHHCEEEECHHEECCCCEEEECCCC
CSIGSRPIDLHLRGFEQMGATITQNAGYIEAKADKLKGAHIYLDFPSVGATQNLILAATL
CCCCCCCEEEEECCHHHHCCEEECCCCEEEEEHHHCCCCEEEEECCCCCCCCCEEEEEEE
ADGTTTLENAAREPEIVDLANLLNKMGANVKGAGTDTIIIKGVEKMHGANHSVVQDRIEA
CCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCCHHHHHHHHHC
GTFMVAAAMTQGDVLIKDAIAEHNRPLISKLSEMGVNFIQEESGLRVVGPEKLKATSVKT
CCEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCHHHHCCCCCEEECCCHHHHCCEEC
LPHPGFPTDMQSQMTAAQAVAVGESVMVETVFENRFQHLKEMRRIGLEVDITRNTALIQG
CCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEC
NSNLQGAAVKSTDLRASAALILLGLVAKGQTTVRRLSHLDRGYYKFHEKLKALGADIIRV
CCCCCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
EDEDGEG
ECCCCCC
>Mature Secondary Structure
MMDKIIVKGGQTKLQGEVEIEGAKNAVLPLLAATLLASEGEVVLTNVPILSDVFMMNNLV
CCCCEEEECCCEEEEEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHH
NHLGTAISFDQEAKKIIAKSNSEIKTTAPYEYVSKMRASIVVMGPILARNGQARVSMPGG
HHHCCCCCCCHHHHHHHHCCCCCCEECCCHHHHHHHHHCEEEECHHEECCCCEEEECCCC
CSIGSRPIDLHLRGFEQMGATITQNAGYIEAKADKLKGAHIYLDFPSVGATQNLILAATL
CCCCCCCEEEEECCHHHHCCEEECCCCEEEEEHHHCCCCEEEEECCCCCCCCCEEEEEEE
ADGTTTLENAAREPEIVDLANLLNKMGANVKGAGTDTIIIKGVEKMHGANHSVVQDRIEA
CCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECHHHHCCCCHHHHHHHHHC
GTFMVAAAMTQGDVLIKDAIAEHNRPLISKLSEMGVNFIQEESGLRVVGPEKLKATSVKT
CCEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHCCHHHHCCCCCEEECCCHHHHCCEEC
LPHPGFPTDMQSQMTAAQAVAVGESVMVETVFENRFQHLKEMRRIGLEVDITRNTALIQG
CCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCEEEEEC
NSNLQGAAVKSTDLRASAALILLGLVAKGQTTVRRLSHLDRGYYKFHEKLKALGADIIRV
CCCCCCCEEECCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
EDEDGEG
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471