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The map label for this gene is cysM

Identifier: 15672522

GI number: 15672522

Start: 526263

End: 527195

Strand: Reverse

Name: cysM

Synonym: L0088

Alternate gene names: 15672522

Gene position: 527195-526263 (Counterclockwise)

Preceding gene: 15672524

Following gene: 15672521

Centisome position: 22.29

GC content: 41.59

Gene sequence:

>933_bases
ATGACTAAAATTTATGATAACATTACTGAATTAATCGGACAAACTCCAATTGTTAAACTTCAACATGTTCCAGCAGAGAG
TGCTGATGTCTATGTCAAACTTGAAGCTTTCAATCCTGGTGGTTCTGTGAAAGATCGGATTGCCCTTGCAATGATTCGGG
CGGCTGAGGCCGATGGACATTTAAAACCTGGTGGAACAATCGTTGAACCGACTTCTGGAAATACAGGAATTGGACTCGCC
TTCGTTGGCTCTGCTTTGGGTTACAAAGTTGTCATTGTCATGCCAGAGTCATTCTCACTTGAACGTCGCAAATTGATTCA
AGCTTACGGGGCTCAATTAGTTTTAACACCCGCTAGTGGTGGAATGAAAGCAGCAATTGCTAAGGCAAAAGAACTCTCAG
AAACAGAAGGTTATTTTCTTGCCATGCAATTTGAAAATCCCGCAAATCCTGAAATTCATGAAAAAACAACAGGAGCTGAG
ATTATTGATGCTTTTGGGCCAACTGGACTTGATGCCTTTGTGGCAGGTGCAGGGACTGGTGGAACGATAACAGGAGTTTC
GCATGCCCTCAAAAAAGCAAATCCAACTATCAAAACTTATGTTGTCGAAGCTGATGAATCTGCTATTCTCTCGGGTGAGG
CTGCTGGCCCACATAAAATCCAAGGTATTTCTGCTGGTTTTATTCCTGGGAATCTTGACACTAAATCTTATGATGAAATC
ATTCGGGTCAAAGGAGATGATGCCATTTTAACGGCTCGTCATCTTGGAGGAAAAGAAGGATTTTTAGTTGGAATTTCTTC
GGGCGCAGCCATTTATGCTGCCCTTGAAGTAGCTAAAAAATTAGGTAAGGGTAAAAAAGTGTTAGCGATTGCTCCTGATA
ATGGAGAACGCTACTTATCAACGGCTCTTTATGATTTTGAGTCTGAAAAATAA

Upstream 100 bases:

>100_bases
TTTTAAATTTCACATCATAAATTTTTTTTAGAGCCATGATTATAATATTAGGAGGCAAATCTTTTTATTTGAGCTATAAT
AAAGTAAAAGGAGCGAAAAA

Downstream 100 bases:

>100_bases
ATAATTTTCACTGACAGAAAGTAAAAAAGTTACTGACAGAAATTTGAGAAGATAAATCAGCTAAAAAGGTTGACAAAATT
TTCTGATTTTCCTGTCAGTA

Product: cysteine synthase

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MTKIYDNITELIGQTPIVKLQHVPAESADVYVKLEAFNPGGSVKDRIALAMIRAAEADGHLKPGGTIVEPTSGNTGIGLA
FVGSALGYKVVIVMPESFSLERRKLIQAYGAQLVLTPASGGMKAAIAKAKELSETEGYFLAMQFENPANPEIHEKTTGAE
IIDAFGPTGLDAFVAGAGTGGTITGVSHALKKANPTIKTYVVEADESAILSGEAAGPHKIQGISAGFIPGNLDTKSYDEI
IRVKGDDAILTARHLGGKEGFLVGISSGAAIYAALEVAKKLGKGKKVLAIAPDNGERYLSTALYDFESEK

Sequences:

>Translated_310_residues
MTKIYDNITELIGQTPIVKLQHVPAESADVYVKLEAFNPGGSVKDRIALAMIRAAEADGHLKPGGTIVEPTSGNTGIGLA
FVGSALGYKVVIVMPESFSLERRKLIQAYGAQLVLTPASGGMKAAIAKAKELSETEGYFLAMQFENPANPEIHEKTTGAE
IIDAFGPTGLDAFVAGAGTGGTITGVSHALKKANPTIKTYVVEADESAILSGEAAGPHKIQGISAGFIPGNLDTKSYDEI
IRVKGDDAILTARHLGGKEGFLVGISSGAAIYAALEVAKKLGKGKKVLAIAPDNGERYLSTALYDFESEK
>Mature_309_residues
TKIYDNITELIGQTPIVKLQHVPAESADVYVKLEAFNPGGSVKDRIALAMIRAAEADGHLKPGGTIVEPTSGNTGIGLAF
VGSALGYKVVIVMPESFSLERRKLIQAYGAQLVLTPASGGMKAAIAKAKELSETEGYFLAMQFENPANPEIHEKTTGAEI
IDAFGPTGLDAFVAGAGTGGTITGVSHALKKANPTIKTYVVEADESAILSGEAAGPHKIQGISAGFIPGNLDTKSYDEII
RVKGDDAILTARHLGGKEGFLVGISSGAAIYAALEVAKKLGKGKKVLAIAPDNGERYLSTALYDFESEK

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=315, Percent_Identity=37.4603174603175, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI295821200, Length=315, Percent_Identity=37.4603174603175, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI4557415, Length=315, Percent_Identity=37.4603174603175, Blast_Score=199, Evalue=3e-51,
Organism=Escherichia coli, GI1788754, Length=323, Percent_Identity=51.0835913312694, Blast_Score=257, Evalue=8e-70,
Organism=Escherichia coli, GI2367138, Length=299, Percent_Identity=40.4682274247492, Blast_Score=204, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI115535073, Length=305, Percent_Identity=50.8196721311475, Blast_Score=256, Evalue=8e-69,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=47.1571906354515, Blast_Score=254, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17562970, Length=299, Percent_Identity=45.1505016722408, Blast_Score=238, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI32566674, Length=294, Percent_Identity=45.2380952380952, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17561720, Length=299, Percent_Identity=43.4782608695652, Blast_Score=203, Evalue=7e-53,
Organism=Caenorhabditis elegans, GI17534315, Length=320, Percent_Identity=40.625, Blast_Score=182, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25147552, Length=317, Percent_Identity=38.801261829653, Blast_Score=174, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=43.6619718309859, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17561716, Length=116, Percent_Identity=45.6896551724138, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=329, Percent_Identity=24.9240121580547, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6321594, Length=323, Percent_Identity=37.7708978328173, Blast_Score=188, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6321449, Length=329, Percent_Identity=39.209726443769, Blast_Score=147, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24643623, Length=319, Percent_Identity=38.2445141065831, Blast_Score=188, Evalue=5e-48,
Organism=Drosophila melanogaster, GI20129101, Length=319, Percent_Identity=38.2445141065831, Blast_Score=188, Evalue=5e-48,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 32358; Mature: 32227

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIYDNITELIGQTPIVKLQHVPAESADVYVKLEAFNPGGSVKDRIALAMIRAAEADGH
CCCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCC
LKPGGTIVEPTSGNTGIGLAFVGSALGYKVVIVMPESFSLERRKLIQAYGAQLVLTPASG
CCCCCEEEECCCCCCCEEHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCC
GMKAAIAKAKELSETEGYFLAMQFENPANPEIHEKTTGAEIIDAFGPTGLDAFVAGAGTG
CHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCHHEEECCCCC
GTITGVSHALKKANPTIKTYVVEADESAILSGEAAGPHKIQGISAGFIPGNLDTKSYDEI
CCHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCEECEEEECCCCCCCCCCCCCCE
IRVKGDDAILTARHLGGKEGFLVGISSGAAIYAALEVAKKLGKGKKVLAIAPDNGERYLS
EEECCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
TALYDFESEK
HHHHHCCCCC
>Mature Secondary Structure 
TKIYDNITELIGQTPIVKLQHVPAESADVYVKLEAFNPGGSVKDRIALAMIRAAEADGH
CCHHHHHHHHHCCCCEEEEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCC
LKPGGTIVEPTSGNTGIGLAFVGSALGYKVVIVMPESFSLERRKLIQAYGAQLVLTPASG
CCCCCEEEECCCCCCCEEHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCEEEEEECCC
GMKAAIAKAKELSETEGYFLAMQFENPANPEIHEKTTGAEIIDAFGPTGLDAFVAGAGTG
CHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHCCCCCCHHEEECCCCC
GTITGVSHALKKANPTIKTYVVEADESAILSGEAAGPHKIQGISAGFIPGNLDTKSYDEI
CCHHHHHHHHHHCCCCEEEEEEECCCCEEEECCCCCCCEECEEEECCCCCCCCCCCCCCE
IRVKGDDAILTARHLGGKEGFLVGISSGAAIYAALEVAKKLGKGKKVLAIAPDNGERYLS
EEECCCCEEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCCHHHH
TALYDFESEK
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA