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The map label for this gene is pi120

Identifier: 15672437

GI number: 15672437

Start: 458873

End: 459292

Strand: Direct

Name: pi120

Synonym: L58858

Alternate gene names: 15672437

Gene position: 458873-459292 (Clockwise)

Preceding gene: 15672436

Following gene: 15672438

Centisome position: 19.4

GC content: 39.05

Gene sequence:

>420_bases
ATGACAAGAGGATTTAAAAAACTAGACGAAAATGCGACTATTCCAGAACGAGCGACAGAACATAGCGCAGGATATGACAT
TTCCGCAAGTGAAACAGTTACGATTCAACCTGATGAAATTAAAATGGTAAGCACAGGGCTAGCTGTTCAACTTGGAGATG
ATGAAGTATTGAAATTATACGACCGTTCAAGTAATCCAGTTAAGCGTGGCATTGCATTGATTAATTCAGTAGGAATTATC
GATTCAGATTACTATCCGCAAGAATTTAAAGGCTTATTTATGAACATCTCAAAAGAGCCTGTAACCATTTCTAAAGGTCA
AAGAATAATGCAAGGGGTATTTGTCAAATACCTTACAACAGACGATGACAACGCAAACGGAAAGCGAACAGGCGGTTTTG
GTAGCACTGGGGAGTTGTGA

Upstream 100 bases:

>100_bases
CGCATTCTATTGGCACTGCATGGAAGTTAACCTTCACCCAGCAAGAAATCGACAGCATGCAAACTGGGAGCTATGAGCTT
GTGCCTGTGGAGGACGGAGA

Downstream 100 bases:

>100_bases
TGGACAATAAAAGAATTTCTGAAATCGTTGAAGAAGAAATGATAAAGCAAGATGCAAACAGATATCGTGATATGAGGAAA
ATTCTCACGATTCCGAAAAG

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 139; Mature: 138

Protein sequence:

>139_residues
MTRGFKKLDENATIPERATEHSAGYDISASETVTIQPDEIKMVSTGLAVQLGDDEVLKLYDRSSNPVKRGIALINSVGII
DSDYYPQEFKGLFMNISKEPVTISKGQRIMQGVFVKYLTTDDDNANGKRTGGFGSTGEL

Sequences:

>Translated_139_residues
MTRGFKKLDENATIPERATEHSAGYDISASETVTIQPDEIKMVSTGLAVQLGDDEVLKLYDRSSNPVKRGIALINSVGII
DSDYYPQEFKGLFMNISKEPVTISKGQRIMQGVFVKYLTTDDDNANGKRTGGFGSTGEL
>Mature_138_residues
TRGFKKLDENATIPERATEHSAGYDISASETVTIQPDEIKMVSTGLAVQLGDDEVLKLYDRSSNPVKRGIALINSVGIID
SDYYPQEFKGLFMNISKEPVTISKGQRIMQGVFVKYLTTDDDNANGKRTGGFGSTGEL

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Escherichia coli, GI1790071, Length=133, Percent_Identity=35.3383458646617, Blast_Score=69, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 15211; Mature: 15080

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRGFKKLDENATIPERATEHSAGYDISASETVTIQPDEIKMVSTGLAVQLGDDEVLKLY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCEEEEECCCCEEEEE
DRSSNPVKRGIALINSVGIIDSDYYPQEFKGLFMNISKEPVTISKGQRIMQGVFVKYLTT
CCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHEECCCCCEECCCCHHHHHHHHEEEEEC
DDDNANGKRTGGFGSTGEL
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TRGFKKLDENATIPERATEHSAGYDISASETVTIQPDEIKMVSTGLAVQLGDDEVLKLY
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCEEEEECCEEEEECCCCEEEEE
DRSSNPVKRGIALINSVGIIDSDYYPQEFKGLFMNISKEPVTISKGQRIMQGVFVKYLTT
CCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHEECCCCCEECCCCHHHHHHHHEEEEEC
DDDNANGKRTGGFGSTGEL
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]