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The map label for this gene is yeaH

Identifier: 15672387

GI number: 15672387

Start: 409093

End: 410049

Strand: Direct

Name: yeaH

Synonym: L9089

Alternate gene names: NA

Gene position: 409093-410049 (Clockwise)

Preceding gene: 30023988

Following gene: 15672388

Centisome position: 17.29

GC content: 38.45

Gene sequence:

>957_bases
ATGAAAAATATTGTTACTGCAAGGGCGCATACAAATATCGCCTTGATTAAATATTGGGGAAAAGCGGATATCGCTCTAAA
TATTCCAACAACCTCTTCTTTGTCAATGACTCTGGAGCCATTTTATACAACAACCTCTGTTGAATTTACTGACAATGAGT
CTGATTCCTTGATTTTGAATTCTGAAGTGGCAGATAGCAGCCGTGTCAGTCAATTTTTGGAAATGATGCGTGGACAATAT
GGAAATTTCCCTAAAGTAATGATTCAATCAGAAAATCATGTGCCAACAGCTGCTGGTTTGGCTTCAAGTGCTTCAAGTTT
TGCTGCTCTGACAGCTGCTATGTTTGGACTTTTAGATTTAGAAAAAGATGATTCAGAAATGTCACGAATAGCTAGACGCG
GTTCAGGGTCGGCTTCTCGGTCAATTTTTGGAAATTTTTCAGTTTGGAATAAAGGAGAAGATCATCAATCTTCCTTTGCG
GAATCTTTTTACAACGAAGATATTGGTCTTTCAATGATTGTTGCTGAAATCTCTGCTGAAAAGAAAAAAATGTCGTCAAC
TAAGGGCATGCAATTGGCACAAACTGCACCAACTTACAGTGCTTGGGTTGAAAAATCGGCCATTCAACTGGAAGAAATGA
AGCAGGCCATTTTAAATGCTGATATTGAAAAAGTTGGTCTAGTTGCTCAGGATAATGCATTAGGTATGCATGAACAAAAT
CGTCTCTCTAATCAACCTTTTGATTATTTCACGCATGAAACAAGACACGTGATTGACTTTGTGAATCAGGCTTATCAATC
AGGATTGCTTGCTTTTGTGACTATTGATGCCGGTCCAAACGTCAAAATTATTACTGACCACGCGACTGAAAAAGTTCTCT
TAGCTAAATTACAAGCGGAATTTCCAGAATTAACATTTGATATCGCACGTGCTGGGGGCGCTTATGAATATCTCTGA

Upstream 100 bases:

>100_bases
TTCATCATTTAGTCTGAAAAAATGTATTTTTTAGTGTAAAAAATAACTTATTGAAATGATAGGAGAGAAGAAAGAATCAA
ATTTTTGATATAATAGTTTC

Downstream 100 bases:

>100_bases
GAAAAAAATGTCAATCAAAGTGCCAGGAAAACTTTTTTTTGCGGGAGAATATTCGGTCACAAAAGAAGGAAACCTCGCCC
TTATCACAACAATTGAAACA

Product: diphosphomevalonate decarboxylase

Products: ADP; phosphate; isopentenyl diphosphate; CO2

Alternate protein names: Mevalonate Diphosphate Decarboxylase; Mevalonate Pyrophosphate Decarboxylase; Phosphomevalonate Kinase

Number of amino acids: Translated: 318; Mature: 318

Protein sequence:

>318_residues
MKNIVTARAHTNIALIKYWGKADIALNIPTTSSLSMTLEPFYTTTSVEFTDNESDSLILNSEVADSSRVSQFLEMMRGQY
GNFPKVMIQSENHVPTAAGLASSASSFAALTAAMFGLLDLEKDDSEMSRIARRGSGSASRSIFGNFSVWNKGEDHQSSFA
ESFYNEDIGLSMIVAEISAEKKKMSSTKGMQLAQTAPTYSAWVEKSAIQLEEMKQAILNADIEKVGLVAQDNALGMHEQN
RLSNQPFDYFTHETRHVIDFVNQAYQSGLLAFVTIDAGPNVKIITDHATEKVLLAKLQAEFPELTFDIARAGGAYEYL

Sequences:

>Translated_318_residues
MKNIVTARAHTNIALIKYWGKADIALNIPTTSSLSMTLEPFYTTTSVEFTDNESDSLILNSEVADSSRVSQFLEMMRGQY
GNFPKVMIQSENHVPTAAGLASSASSFAALTAAMFGLLDLEKDDSEMSRIARRGSGSASRSIFGNFSVWNKGEDHQSSFA
ESFYNEDIGLSMIVAEISAEKKKMSSTKGMQLAQTAPTYSAWVEKSAIQLEEMKQAILNADIEKVGLVAQDNALGMHEQN
RLSNQPFDYFTHETRHVIDFVNQAYQSGLLAFVTIDAGPNVKIITDHATEKVLLAKLQAEFPELTFDIARAGGAYEYL
>Mature_318_residues
MKNIVTARAHTNIALIKYWGKADIALNIPTTSSLSMTLEPFYTTTSVEFTDNESDSLILNSEVADSSRVSQFLEMMRGQY
GNFPKVMIQSENHVPTAAGLASSASSFAALTAAMFGLLDLEKDDSEMSRIARRGSGSASRSIFGNFSVWNKGEDHQSSFA
ESFYNEDIGLSMIVAEISAEKKKMSSTKGMQLAQTAPTYSAWVEKSAIQLEEMKQAILNADIEKVGLVAQDNALGMHEQN
RLSNQPFDYFTHETRHVIDFVNQAYQSGLLAFVTIDAGPNVKIITDHATEKVLLAKLQAEFPELTFDIARAGGAYEYL

Specific function: Unknown

COG id: COG3407

COG function: function code I; Mevalonate pyrophosphate decarboxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4505289, Length=328, Percent_Identity=33.5365853658537, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17537201, Length=308, Percent_Identity=30.1948051948052, Blast_Score=90, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17537203, Length=172, Percent_Identity=29.0697674418605, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6324371, Length=304, Percent_Identity=37.171052631579, Blast_Score=128, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28571205, Length=336, Percent_Identity=32.1428571428571, Blast_Score=106, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.1.1.33

Molecular weight: Translated: 34971; Mature: 34971

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIVTARAHTNIALIKYWGKADIALNIPTTSSLSMTLEPFYTTTSVEFTDNESDSLILN
CCCEEEECCCCCEEEEEEECCCEEEEECCCCCCCEEEEECEEEEEEEEECCCCCCCEEEE
SEVADSSRVSQFLEMMRGQYGNFPKVMIQSENHVPTAAGLASSASSFAALTAAMFGLLDL
CCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
EKDDSEMSRIARRGSGSASRSIFGNFSVWNKGEDHQSSFAESFYNEDIGLSMIVAEISAE
CCCHHHHHHHHHCCCCCCCHHEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
KKKMSSTKGMQLAQTAPTYSAWVEKSAIQLEEMKQAILNADIEKVGLVAQDNALGMHEQN
HHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCEEECCCCCCCCHHH
RLSNQPFDYFTHETRHVIDFVNQAYQSGLLAFVTIDAGPNVKIITDHATEKVLLAKLQAE
HCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHH
FPELTFDIARAGGAYEYL
CCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKNIVTARAHTNIALIKYWGKADIALNIPTTSSLSMTLEPFYTTTSVEFTDNESDSLILN
CCCEEEECCCCCEEEEEEECCCEEEEECCCCCCCEEEEECEEEEEEEEECCCCCCCEEEE
SEVADSSRVSQFLEMMRGQYGNFPKVMIQSENHVPTAAGLASSASSFAALTAAMFGLLDL
CCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
EKDDSEMSRIARRGSGSASRSIFGNFSVWNKGEDHQSSFAESFYNEDIGLSMIVAEISAE
CCCHHHHHHHHHCCCCCCCHHEECCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
KKKMSSTKGMQLAQTAPTYSAWVEKSAIQLEEMKQAILNADIEKVGLVAQDNALGMHEQN
HHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCEEECCCCCCCCHHH
RLSNQPFDYFTHETRHVIDFVNQAYQSGLLAFVTIDAGPNVKIITDHATEKVLLAKLQAE
HCCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHH
FPELTFDIARAGGAYEYL
CCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; (R)-5-diphosphomevalonate

Specific reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA