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The map label for this gene is era

Identifier: 15672333

GI number: 15672333

Start: 355047

End: 355958

Strand: Direct

Name: era

Synonym: L0155

Alternate gene names: 15672333

Gene position: 355047-355958 (Clockwise)

Preceding gene: 15672332

Following gene: 15672334

Centisome position: 15.01

GC content: 36.4

Gene sequence:

>912_bases
ATGACAAATAACAAATTTAAATCAGGATTTGTGGCGATTTTAGGTCGTCCAAATGTTGGAAAATCAACATTTATGAACCA
CGTGATGGGACAAAAAATTGCCATCATGTCAGATAAACCTCAAACAACAAGAAATAAAATTCAAGGAATTTATACTACAG
AAAATGAACAAATTGTTTTCATTGATACGCCAGGTATTCACAAACCACACAATGCTTTAGGCGATTTCATGGTTCAATCT
GCTTATTCGACTTTACGTGAATGTGATGTCGTTTTGTTCATGGTTGCGGCTGATGAACCACGTTCAACCGGTGAAAATAT
GATTATTGAGCGCTTGAAAAAGGCAGAAGTTCCTGTCATTTTGGTCGTCAATAAAATTGATAAAATTCATCCTGACCGTC
TTTTTGAAATTGTAGCCGATTATACTTCACAAATGGAGTTTTCTGAAGTGGTTCCAATCTCAGCTAAACAAGGGAATAAT
ACAGAAAGATTAATTGATACGCTCTCTGAAAAATTGGACGAGGGTCCTCAATATTTCCCAGAAGATCAAATCACTGACCA
TCCTGAGCGTTTTCTTGTTTCAGAAATGATTCGTGAAAAAATCTTATTATTAACTCGGGAAGAAGTTCCACATTCAATCG
CAGTCACTACTGACCAAATGACTCGAGATGAAGAAACTGGAAAGATTCATATCATGGCAACAATTATTGTTGAACGCAAG
AGCCAAAAAGGGATTATTCTTGGTAAAGGCGGCGATATGATTCGTAAAATCGGAAAAATGGCTCGTCGAGATATTGAAAT
TATGCTTGGGGATAAAGTTTATCTTGAAACTTGGGTCAAAATCAAAAATGACTGGCGCGACCGAAAAATGGATTTAGCTG
ACTTTGGCTACAATCGTGATGATTATATGTAA

Upstream 100 bases:

>100_bases
AAAGAATTTGTCAGCTTTACTGATGATTCTGTCAGTAATTTTCACAATCATTTTTTAGAATTTTACTTAAAAAGGACTGA
TTTTATGCTATAATAGCGCT

Downstream 100 bases:

>100_bases
TGAAAATAGCGAATTATCGCTATTTTTGTTTTATTATGAAATTTCCAGACAATTGTGATATAATATTGAAAATTATAATT
ATTATTGGGGGAAATTATGT

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTNNKFKSGFVAILGRPNVGKSTFMNHVMGQKIAIMSDKPQTTRNKIQGIYTTENEQIVFIDTPGIHKPHNALGDFMVQS
AYSTLRECDVVLFMVAADEPRSTGENMIIERLKKAEVPVILVVNKIDKIHPDRLFEIVADYTSQMEFSEVVPISAKQGNN
TERLIDTLSEKLDEGPQYFPEDQITDHPERFLVSEMIREKILLLTREEVPHSIAVTTDQMTRDEETGKIHIMATIIVERK
SQKGIILGKGGDMIRKIGKMARRDIEIMLGDKVYLETWVKIKNDWRDRKMDLADFGYNRDDYM

Sequences:

>Translated_303_residues
MTNNKFKSGFVAILGRPNVGKSTFMNHVMGQKIAIMSDKPQTTRNKIQGIYTTENEQIVFIDTPGIHKPHNALGDFMVQS
AYSTLRECDVVLFMVAADEPRSTGENMIIERLKKAEVPVILVVNKIDKIHPDRLFEIVADYTSQMEFSEVVPISAKQGNN
TERLIDTLSEKLDEGPQYFPEDQITDHPERFLVSEMIREKILLLTREEVPHSIAVTTDQMTRDEETGKIHIMATIIVERK
SQKGIILGKGGDMIRKIGKMARRDIEIMLGDKVYLETWVKIKNDWRDRKMDLADFGYNRDDYM
>Mature_302_residues
TNNKFKSGFVAILGRPNVGKSTFMNHVMGQKIAIMSDKPQTTRNKIQGIYTTENEQIVFIDTPGIHKPHNALGDFMVQSA
YSTLRECDVVLFMVAADEPRSTGENMIIERLKKAEVPVILVVNKIDKIHPDRLFEIVADYTSQMEFSEVVPISAKQGNNT
ERLIDTLSEKLDEGPQYFPEDQITDHPERFLVSEMIREKILLLTREEVPHSIAVTTDQMTRDEETGKIHIMATIIVERKS
QKGIILGKGGDMIRKIGKMARRDIEIMLGDKVYLETWVKIKNDWRDRKMDLADFGYNRDDYM

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain

Homologues:

Organism=Homo sapiens, GI24307899, Length=312, Percent_Identity=23.7179487179487, Blast_Score=77, Evalue=3e-14,
Organism=Escherichia coli, GI1788919, Length=302, Percent_Identity=39.0728476821192, Blast_Score=222, Evalue=2e-59,
Organism=Escherichia coli, GI87082120, Length=181, Percent_Identity=32.0441988950276, Blast_Score=94, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6323665, Length=197, Percent_Identity=25.8883248730964, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24646434, Length=305, Percent_Identity=25.9016393442623, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI28572034, Length=168, Percent_Identity=29.7619047619048, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ERA_LACLA (P0A3C1)

Other databases:

- EMBL:   AE005176
- PIR:   G86668
- RefSeq:   NP_266507.1
- ProteinModelPortal:   P0A3C1
- SMR:   P0A3C1
- GeneID:   1113962
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0155
- NMPDR:   fig|272623.1.peg.359
- HOGENOM:   HBG561652
- OMA:   AKDWQRD
- ProtClustDB:   PRK00089
- BioCyc:   LLAC272623:L0155-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00367
- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- TIGRFAMs:   TIGR00436
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1; SSF54814 KH_prok

EC number: NA

Molecular weight: Translated: 34738; Mature: 34606

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNNKFKSGFVAILGRPNVGKSTFMNHVMGQKIAIMSDKPQTTRNKIQGIYTTENEQIVF
CCCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCHHHHHCCEEEECCCCEEEE
IDTPGIHKPHNALGDFMVQSAYSTLRECDVVLFMVAADEPRSTGENMIIERLKKAEVPVI
EECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEE
LVVNKIDKIHPDRLFEIVADYTSQMEFSEVVPISAKQGNNTERLIDTLSEKLDEGPQYFP
EEECCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
EDQITDHPERFLVSEMIREKILLLTREEVPHSIAVTTDQMTRDEETGKIHIMATIIVERK
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCCCCCEEEEEEEEEEECC
SQKGIILGKGGDMIRKIGKMARRDIEIMLGDKVYLETWVKIKNDWRDRKMDLADFGYNRD
CCCCEEEECCHHHHHHHHHHHHCCEEEEECCCEEEHHHHHHHCCHHHHCCCHHHCCCCCC
DYM
CCC
>Mature Secondary Structure 
TNNKFKSGFVAILGRPNVGKSTFMNHVMGQKIAIMSDKPQTTRNKIQGIYTTENEQIVF
CCCCCCCCEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCHHHHHCCEEEECCCCEEEE
IDTPGIHKPHNALGDFMVQSAYSTLRECDVVLFMVAADEPRSTGENMIIERLKKAEVPVI
EECCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHCCCCEE
LVVNKIDKIHPDRLFEIVADYTSQMEFSEVVPISAKQGNNTERLIDTLSEKLDEGPQYFP
EEECCCCCCCHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCC
EDQITDHPERFLVSEMIREKILLLTREEVPHSIAVTTDQMTRDEETGKIHIMATIIVERK
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECHHHCCCCCCCEEEEEEEEEEECC
SQKGIILGKGGDMIRKIGKMARRDIEIMLGDKVYLETWVKIKNDWRDRKMDLADFGYNRD
CCCCEEEECCHHHHHHHHHHHHCCEEEEECCCEEEHHHHHHHCCHHHHCCCHHHCCCCCC
DYM
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11337471