Click here to switch to the map view.

The map label for this gene is fhuB

Identifier: 15672310

GI number: 15672310

Start: 327472

End: 328422

Strand: Direct

Name: fhuB

Synonym: L127476

Alternate gene names: 15672310

Gene position: 327472-328422 (Clockwise)

Preceding gene: 15672309

Following gene: 15672311

Centisome position: 13.84

GC content: 36.28

Gene sequence:

>951_bases
ATGCCTAAAAAACATTTTCTGACAATCTTTTTTGCCCTAGTTTTTTCTTTACTTTTTTTGTCAGTAATATACCTGATGCT
TGGAAATAAAAATGTTCCTCTGACAGAAATTTTAGTAAATAAAATGGTCTTACAATTAAGATTTCCAAGATTAATAAGTC
TTTATCTCACAGGATTTCTCTTATCCGTCAGTGGATTTATTGTTCAAATTATGACTAGAAACCCAATTGCCGAAATGGCA
ACTTTAGGGATTTCTGGCGGTTCGAGCTTGGCTTTATCACTCATTTTAACTTTGGGTTGGTCAACAAATGATGGGATTTC
AGTTCTAGTTTCATCACTAGGAGCATTTATTGCTTTAGCCGTCGTCATGCTTTTGACTGCCAGAACGCATTTTCAGCCAT
TAAAAGTTGTACTAGTTGGAACGTCAGTTGGACTTTTTGCAACTAGTTTAGCCAGCTCCTTAACTTTTGCCAGCCACGAT
ACACAGGCCTATTTTCGCTGGATTGTGGGTTCTTTTTCAGGGATAACTAATACTAAAGTTCTTTTGATGGCAGTAGTAAG
TCTTATTTTTCTTATCCTCTTGCTTTTATTTTCAAAACAAATTTATTTATTGAATTTTGGTGATGAGCTTGCTCAATCTT
TTGGGATTTCTGTCAATTTTGTTCGTTTAGTCATTATGTTTTTAGTTGCGCTGGCTTCTGGTGTAACTGTTGCCTCAGTT
GGGGTGGTCAGCTTTGTCGGTTTGATTGCTCCACATATTGCCAAGAAGCTTGTCAGAGCTAATTTTTGGCAAAATGTAAT
TCTGTCAGTACTGACAGGAATGTTATTGCTTGTTTTAGCTGATTTGATAGCCAGAAATTTATTTAAACCTTACGAATTTC
CAGCAGGAAGTCTAACCATGCTTCTAGGTGCTCCCTTCTTTCTTTGGGTTATTACAAAGGAGGCAAAATAG

Upstream 100 bases:

>100_bases
GAGTTATTTACTCAAAAAACGTTGAAAGAATGCTTTGGATTAGATGTCACTTTAGGATGTGATACCTTTACCAAAAAATT
AATGATTACTGGGGTGAAAG

Downstream 100 bases:

>100_bases
AATGAAAAGAAAATTCACTTTACTTTTTGTCCTGCTTTTGGTTTTGATAGTGGTTGATTTGACGCAATTTTCAACAAATC
CTCAAATTCTATCAATCCTA

Product: ferrichrome ABC transporter permease protein

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 316; Mature: 315

Protein sequence:

>316_residues
MPKKHFLTIFFALVFSLLFLSVIYLMLGNKNVPLTEILVNKMVLQLRFPRLISLYLTGFLLSVSGFIVQIMTRNPIAEMA
TLGISGGSSLALSLILTLGWSTNDGISVLVSSLGAFIALAVVMLLTARTHFQPLKVVLVGTSVGLFATSLASSLTFASHD
TQAYFRWIVGSFSGITNTKVLLMAVVSLIFLILLLLFSKQIYLLNFGDELAQSFGISVNFVRLVIMFLVALASGVTVASV
GVVSFVGLIAPHIAKKLVRANFWQNVILSVLTGMLLLVLADLIARNLFKPYEFPAGSLTMLLGAPFFLWVITKEAK

Sequences:

>Translated_316_residues
MPKKHFLTIFFALVFSLLFLSVIYLMLGNKNVPLTEILVNKMVLQLRFPRLISLYLTGFLLSVSGFIVQIMTRNPIAEMA
TLGISGGSSLALSLILTLGWSTNDGISVLVSSLGAFIALAVVMLLTARTHFQPLKVVLVGTSVGLFATSLASSLTFASHD
TQAYFRWIVGSFSGITNTKVLLMAVVSLIFLILLLLFSKQIYLLNFGDELAQSFGISVNFVRLVIMFLVALASGVTVASV
GVVSFVGLIAPHIAKKLVRANFWQNVILSVLTGMLLLVLADLIARNLFKPYEFPAGSLTMLLGAPFFLWVITKEAK
>Mature_315_residues
PKKHFLTIFFALVFSLLFLSVIYLMLGNKNVPLTEILVNKMVLQLRFPRLISLYLTGFLLSVSGFIVQIMTRNPIAEMAT
LGISGGSSLALSLILTLGWSTNDGISVLVSSLGAFIALAVVMLLTARTHFQPLKVVLVGTSVGLFATSLASSLTFASHDT
QAYFRWIVGSFSGITNTKVLLMAVVSLIFLILLLLFSKQIYLLNFGDELAQSFGISVNFVRLVIMFLVALASGVTVASVG
VVSFVGLIAPHIAKKLVRANFWQNVILSVLTGMLLLVLADLIARNLFKPYEFPAGSLTMLLGAPFFLWVITKEAK

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=272, Percent_Identity=31.9852941176471, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1790740, Length=274, Percent_Identity=33.2116788321168, Blast_Score=118, Evalue=6e-28,
Organism=Escherichia coli, GI1790741, Length=292, Percent_Identity=31.8493150684932, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788004, Length=294, Percent_Identity=28.5714285714286, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1786804, Length=287, Percent_Identity=29.2682926829268, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786805, Length=308, Percent_Identity=27.2727272727273, Blast_Score=82, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 34370; Mature: 34239

Theoretical pI: Translated: 10.76; Mature: 10.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKKHFLTIFFALVFSLLFLSVIYLMLGNKNVPLTEILVNKMVLQLRFPRLISLYLTGFL
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSVSGFIVQIMTRNPIAEMATLGISGGSSLALSLILTLGWSTNDGISVLVSSLGAFIALA
HHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VVMLLTARTHFQPLKVVLVGTSVGLFATSLASSLTFASHDTQAYFRWIVGSFSGITNTKV
HHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHH
LLMAVVSLIFLILLLLFSKQIYLLNFGDELAQSFGISVNFVRLVIMFLVALASGVTVASV
HHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHH
GVVSFVGLIAPHIAKKLVRANFWQNVILSVLTGMLLLVLADLIARNLFKPYEFPAGSLTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LLGAPFFLWVITKEAK
HHCCHHHEEEEECCCC
>Mature Secondary Structure 
PKKHFLTIFFALVFSLLFLSVIYLMLGNKNVPLTEILVNKMVLQLRFPRLISLYLTGFL
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSVSGFIVQIMTRNPIAEMATLGISGGSSLALSLILTLGWSTNDGISVLVSSLGAFIALA
HHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
VVMLLTARTHFQPLKVVLVGTSVGLFATSLASSLTFASHDTQAYFRWIVGSFSGITNTKV
HHHHHHHHCCCCCEEEEEEECHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHH
LLMAVVSLIFLILLLLFSKQIYLLNFGDELAQSFGISVNFVRLVIMFLVALASGVTVASV
HHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHH
GVVSFVGLIAPHIAKKLVRANFWQNVILSVLTGMLLLVLADLIARNLFKPYEFPAGSLTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LLGAPFFLWVITKEAK
HHCCHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]