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The map label for this gene is rmlA

Identifier: 15672176

GI number: 15672176

Start: 197074

End: 197943

Strand: Direct

Name: rmlA

Synonym: L197041

Alternate gene names: 15672176

Gene position: 197074-197943 (Clockwise)

Preceding gene: 15672175

Following gene: 15672177

Centisome position: 8.33

GC content: 37.47

Gene sequence:

>870_bases
ATGAAAGGGATTATTTTAGCAGGAGGGTCTGGAACACGACTTTACCCACTGACACGTGCTGCGTCAAAACAATTGATGCC
TATTTACGATAAACCAATGATTTATTACCCATTGTCAACTTTGATGTTGGCTGGGATTAAAGACATTTTAATTATCTCGA
CACCAACAGATACTCCACGTTTTAAAGAGTTACTTCAAGATGGTTCTGAGTTTGGGATTAATCTGCAATATGCGGTACAA
CCATCACCAGATGGATTGGCTCAAGCCTTTATTATTGGTGAAGAATTTATTGGCGATGATTCAGTTGCGCTTATTTTGGG
TGATAATATTTATCACGGACCTGGAATGTCTAAAATGCTCCAAAATGCAGCTGCAAAAGAAAAAGGAGCCACTGTTTTTG
GTTATCATGTTCCTGATCCAGAACGTTTTGGTGTCGTTGAATTTGATGAAAACATGAATGCTGTTTCTATTGAAGAAAAA
CCAGAAGAACCTAAATCAAATTATGCAGTAACTGGTTTATACTTCTACGATAATGATGTTATTGAAATTGCCAAAAACAT
TGAACCTTCACCTCGTGGAGAGCTTGAAATTACTGACGTAAATAAAGCTTATCTTGAACGTGGTGATTTGTCAGTTGAAT
TAATGGGCCGTGGCTTTGCTTGGTTAGATACTGGAACACATGAATCTCTCCTTGAAGCTGCACAATATATTGAAACAGTT
CAACGGATGCAAAATATGCAAGTGGCAAACTTGGAAGAAATTGCTTATCGTATGGGTTATATTACAGCTGACGATGTTCT
TAAATTGGCCCAACCACTTAAGAAAAATGAGTATGGTCAGTACTTGCTTCGTTTGATTGGAAAAGACTAA

Upstream 100 bases:

>100_bases
ATCAACCTTTTATCCCCAAAATGACCACAGAGGGTTGTGTATTGAGAAACATTTTGTGTTATAATGTATATTGATTAATT
ATGATTATGGAGGTCCTTTG

Downstream 100 bases:

>100_bases
AAAGTCATTATTAAAGTAAAGTTGTCAAAGTACAAGAAGGACAATCAATGCTAAAAAATATTTGGGAATGGTTTTTATGG
TTTACTGGTGTGACTGACGC

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPTDTPRFKELLQDGSEFGINLQYAVQ
PSPDGLAQAFIIGEEFIGDDSVALILGDNIYHGPGMSKMLQNAAAKEKGATVFGYHVPDPERFGVVEFDENMNAVSIEEK
PEEPKSNYAVTGLYFYDNDVIEIAKNIEPSPRGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
QRMQNMQVANLEEIAYRMGYITADDVLKLAQPLKKNEYGQYLLRLIGKD

Sequences:

>Translated_289_residues
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPTDTPRFKELLQDGSEFGINLQYAVQ
PSPDGLAQAFIIGEEFIGDDSVALILGDNIYHGPGMSKMLQNAAAKEKGATVFGYHVPDPERFGVVEFDENMNAVSIEEK
PEEPKSNYAVTGLYFYDNDVIEIAKNIEPSPRGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
QRMQNMQVANLEEIAYRMGYITADDVLKLAQPLKKNEYGQYLLRLIGKD
>Mature_289_residues
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPTDTPRFKELLQDGSEFGINLQYAVQ
PSPDGLAQAFIIGEEFIGDDSVALILGDNIYHGPGMSKMLQNAAAKEKGATVFGYHVPDPERFGVVEFDENMNAVSIEEK
PEEPKSNYAVTGLYFYDNDVIEIAKNIEPSPRGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
QRMQNMQVANLEEIAYRMGYITADDVLKLAQPLKKNEYGQYLLRLIGKD

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=253, Percent_Identity=23.7154150197628, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1788351, Length=284, Percent_Identity=70.7746478873239, Blast_Score=429, Evalue=1e-121,
Organism=Escherichia coli, GI1790224, Length=286, Percent_Identity=65.3846153846154, Blast_Score=398, Evalue=1e-112,
Organism=Escherichia coli, GI1787488, Length=244, Percent_Identity=25.4098360655738, Blast_Score=68, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=237, Percent_Identity=24.4725738396624, Blast_Score=76, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320148, Length=253, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21355443, Length=249, Percent_Identity=25.3012048192771, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24644084, Length=249, Percent_Identity=25.3012048192771, Blast_Score=82, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 32131; Mature: 32131

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPTDTPR
CCCEEEECCCCCEEEEEHHHCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHH
FKELLQDGSEFGINLQYAVQPSPDGLAQAFIIGEEFIGDDSVALILGDNIYHGPGMSKML
HHHHHHCCHHHCEEEEEEECCCCCHHHEEEEEHHHHCCCCCEEEEECCCEECCCCHHHHH
QNAAAKEKGATVFGYHVPDPERFGVVEFDENMNAVSIEEKPEEPKSNYAVTGLYFYDNDV
HHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCCH
IEIAKNIEPSPRGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
HHHHHCCCCCCCCCEEEEECCHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHH
QRMQNMQVANLEEIAYRMGYITADDVLKLAQPLKKNEYGQYLLRLIGKD
HHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPLTRAASKQLMPIYDKPMIYYPLSTLMLAGIKDILIISTPTDTPR
CCCEEEECCCCCEEEEEHHHCCCCCCCCCCCCEEEECHHHHHHHCCCEEEEEECCCCCHH
FKELLQDGSEFGINLQYAVQPSPDGLAQAFIIGEEFIGDDSVALILGDNIYHGPGMSKML
HHHHHHCCHHHCEEEEEEECCCCCHHHEEEEEHHHHCCCCCEEEEECCCEECCCCHHHHH
QNAAAKEKGATVFGYHVPDPERFGVVEFDENMNAVSIEEKPEEPKSNYAVTGLYFYDNDV
HHHHHHHCCCEEEEEECCCCCCEEEEEECCCCCEEEECCCCCCCCCCEEEEEEEEECCCH
IEIAKNIEPSPRGELEITDVNKAYLERGDLSVELMGRGFAWLDTGTHESLLEAAQYIETV
HHHHHCCCCCCCCCEEEEECCHHHHHCCCCEEEEECCCEEEEECCCHHHHHHHHHHHHHH
QRMQNMQVANLEEIAYRMGYITADDVLKLAQPLKKNEYGQYLLRLIGKD
HHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12397186 [H]