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The map label for this gene is preA

Identifier: 15672163

GI number: 15672163

Start: 186285

End: 187265

Strand: Direct

Name: preA

Synonym: L186258

Alternate gene names: 15672163

Gene position: 186285-187265 (Clockwise)

Preceding gene: 15672162

Following gene: 15672164

Centisome position: 7.87

GC content: 36.49

Gene sequence:

>981_bases
TTGCTCACATTTTGGCAGGATTATCCCGAAATTCAGAATAAATTAAAGGATGTTCAAGCGCTCATGATTGAGCGTTTAAA
AATTAATAATCAAGAGATAGAAGCAGCACTAGAGAAATTTGCATCACGTGGCGGGAAAATGGTTCGTCCTGCGCTTTTTT
TGCTGTTCGCTGGGATTGTCCCTAATGGCTCTAAAGATGAAGAGAAGATCATTAAAATCGCCGCATCATTAGAGATGCTT
CATTCAGCAACATTGATTCACGATGATATTATCGACGACTCTCCTTTAAGACGTGGTTTACCGTCAATAGAGTCACAATT
TGGCAAAGATGTAGCTGTTTATGCTGGAGATTTTGTTTATACTGTTTATTTTGAATTATTGATTGAAACCATGAATGGGA
CAAGTTTTGTCGCTAAAAATGCTCAATCAATGAAAAAAATTCTTCAGGGTGAATTGACTCAAATGCAATCTGCTTTTGAC
AAAAATAATACAGCGAGACGCTATATGAAAGCAATTAGTGGAAAAACAGCTGAATTACTGAGTCTTAGCTGTTTAGAAGG
TGTTTATTTTGCTGGTGGGGATAAAAAATTACAACATTCTGCCCGTAAAATTGGTCGAGCAATTGGTCTTGCTTTTCAAG
TTTATGATGACATTTTAAATTTTACAGTAGGACTTGATGAAGCTGATAAACCTATTTTGACAGATTTCCGTCAAGGGATT
TATACATTACCTTTACTCTTGGCTCGTGAAGTAAATGATGAAGCGATTGCTCCTTATTTAGAAGCGCCAGAAAATTTGTC
AAGACAAGAATGTTTAGATTTAGCAGAATTAGTGACAGAATCAGGTGGGATAGCAGGAGCGCTCCTTGTTGCTGGAAGAT
TAACAGAACTGGCTTTGAATGAAATTCGGAAATTACCAGAGTCGACAAATCGGCAGATTTTAGAAGAAGCAACACAAATT
TTATTGGAAAGAAATTATTGA

Upstream 100 bases:

>100_bases
GTTCGCAACATTGGGTCTATTTTGCTAAAATGGAGTAAGATATTTGATAAGTTATTATCAAAAGAAATGAATGAATTATC
GAGAGGAAAGAGAAAAAACA

Downstream 100 bases:

>100_bases
AAACCTGTCACTGACAGGCTTTTTCATAGAAAATTTTACTGACAGCTATTAGAAAAGTTTTCTGTCAGTAACTTTTGAGA
TAAAGCTTTTAAAGCTAGTA

Product: prenyl transferase

Products: NA

Alternate protein names: HEPPP synthase subunit 2; Spore germination protein C3 [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MLTFWQDYPEIQNKLKDVQALMIERLKINNQEIEAALEKFASRGGKMVRPALFLLFAGIVPNGSKDEEKIIKIAASLEML
HSATLIHDDIIDDSPLRRGLPSIESQFGKDVAVYAGDFVYTVYFELLIETMNGTSFVAKNAQSMKKILQGELTQMQSAFD
KNNTARRYMKAISGKTAELLSLSCLEGVYFAGGDKKLQHSARKIGRAIGLAFQVYDDILNFTVGLDEADKPILTDFRQGI
YTLPLLLAREVNDEAIAPYLEAPENLSRQECLDLAELVTESGGIAGALLVAGRLTELALNEIRKLPESTNRQILEEATQI
LLERNY

Sequences:

>Translated_326_residues
MLTFWQDYPEIQNKLKDVQALMIERLKINNQEIEAALEKFASRGGKMVRPALFLLFAGIVPNGSKDEEKIIKIAASLEML
HSATLIHDDIIDDSPLRRGLPSIESQFGKDVAVYAGDFVYTVYFELLIETMNGTSFVAKNAQSMKKILQGELTQMQSAFD
KNNTARRYMKAISGKTAELLSLSCLEGVYFAGGDKKLQHSARKIGRAIGLAFQVYDDILNFTVGLDEADKPILTDFRQGI
YTLPLLLAREVNDEAIAPYLEAPENLSRQECLDLAELVTESGGIAGALLVAGRLTELALNEIRKLPESTNRQILEEATQI
LLERNY
>Mature_326_residues
MLTFWQDYPEIQNKLKDVQALMIERLKINNQEIEAALEKFASRGGKMVRPALFLLFAGIVPNGSKDEEKIIKIAASLEML
HSATLIHDDIIDDSPLRRGLPSIESQFGKDVAVYAGDFVYTVYFELLIETMNGTSFVAKNAQSMKKILQGELTQMQSAFD
KNNTARRYMKAISGKTAELLSLSCLEGVYFAGGDKKLQHSARKIGRAIGLAFQVYDDILNFTVGLDEADKPILTDFRQGI
YTLPLLLAREVNDEAIAPYLEAPENLSRQECLDLAELVTESGGIAGALLVAGRLTELALNEIRKLPESTNRQILEEATQI
LLERNY

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=328, Percent_Identity=28.3536585365854, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI1789578, Length=234, Percent_Identity=31.1965811965812, Blast_Score=121, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI17505681, Length=238, Percent_Identity=31.9327731092437, Blast_Score=114, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6319475, Length=299, Percent_Identity=28.0936454849498, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24651612, Length=288, Percent_Identity=28.4722222222222, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 36322; Mature: 36322

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTFWQDYPEIQNKLKDVQALMIERLKINNQEIEAALEKFASRGGKMVRPALFLLFAGIV
CCCCHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
PNGSKDEEKIIKIAASLEMLHSATLIHDDIIDDSPLRRGLPSIESQFGKDVAVYAGDFVY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCEEHHHHHHHH
TVYFELLIETMNGTSFVAKNAQSMKKILQGELTQMQSAFDKNNTARRYMKAISGKTAELL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHH
SLSCLEGVYFAGGDKKLQHSARKIGRAIGLAFQVYDDILNFTVGLDEADKPILTDFRQGI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
YTLPLLLAREVNDEAIAPYLEAPENLSRQECLDLAELVTESGGIAGALLVAGRLTELALN
HHHHHHHHHHCCCHHHCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EIRKLPESTNRQILEEATQILLERNY
HHHHCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLTFWQDYPEIQNKLKDVQALMIERLKINNQEIEAALEKFASRGGKMVRPALFLLFAGIV
CCCCHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCC
PNGSKDEEKIIKIAASLEMLHSATLIHDDIIDDSPLRRGLPSIESQFGKDVAVYAGDFVY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCEEHHHHHHHH
TVYFELLIETMNGTSFVAKNAQSMKKILQGELTQMQSAFDKNNTARRYMKAISGKTAELL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHH
SLSCLEGVYFAGGDKKLQHSARKIGRAIGLAFQVYDDILNFTVGLDEADKPILTDFRQGI
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
YTLPLLLAREVNDEAIAPYLEAPENLSRQECLDLAELVTESGGIAGALLVAGRLTELALN
HHHHHHHHHHCCCHHHCHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
EIRKLPESTNRQILEEATQILLERNY
HHHHCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 2121900; 9720033 [H]