Click here to switch to the map view.

The map label for this gene is trpS

Identifier: 15672048

GI number: 15672048

Start: 67264

End: 68289

Strand: Reverse

Name: trpS

Synonym: L0358

Alternate gene names: 15672048

Gene position: 68289-67264 (Counterclockwise)

Preceding gene: 15672052

Following gene: 15672047

Centisome position: 2.89

GC content: 38.79

Gene sequence:

>1026_bases
ATGACAAAACCAACTATTTTAACTGGAGACCGTCCAACAGGAAAACTTCACATCGGCCACTATGTAGGCTCTTTGCAAAA
TCGTGTCAAAATGCAAAATGAAGATAAATACAATATGTTTGTCTTTTTAGCTGACCAACAAGCTTTAACTGACCATGCAA
AAGAACCTGAACTCATTCGTCAATCTGTCGGTGATGTTGCCCTTGACTACTTAGCAGCAGGACTTGACCCTGAAAAATCA
ACCATTTTCATTCAAAGTCAAATTCCTGAACTGGCTGAACTTTCAATGTATTATATGAATTTAGTTTCACTTGCCCGCCT
TGAACGCAATCCTACTGTAAAAACAGAGATTGCACAAAAAGCTTTTGGTGAATCAATCCCTGCCGGCTTTTTAGTGTATC
CAGTTTCTCAAGCTGCTGATATTACTGCTTTTAAAGCCACTCATGTTCCAGTCGGAAATGATCAAAAACCAATGATTGAA
CAAACACGAGAAATTGTTCGCTCATTTAATAATGCTTATCACACAGATGTTTTAGTTGAACCAGAAGGAATTTACCCTGA
AAATGAAGCTGCTGGTCGTTTACCTGGACTTGACGGAAATGCCAAAATGTCTAAATCTCTTGGAAACGGAATTTTCCTTG
CTGATGACATGGACACACTCAAGAAAAAAGTGATGTCAATGTATACTGACCCTGACCATATCAAAGTTGAAGATCCTGGT
AAAATTGAAGGAAACATGGTTTTCCATTATCTTGACGTTTTTGGTAAAGCTGAAGATGCAGAGCAAATTTCTGAAATGAA
AGCCCAATATCAAGCGGGTGGTCTTGGTGATGTGAAAACAAAACGTTTCCTTCTTGATGTTCTTGACCGCGAACTTTCAC
CAATCCGTGAACGTCGTATTGAGTTTGCACAAAATATGGACTACGTTTACGATATGCTTAAAGCAGGCTCACTTAAGGCC
CAAGCTGTAGCCAGTCAAACTCTTGATGAAGTCAAGTCTGCTATGGGAATTAACTATTTCAAATAA

Upstream 100 bases:

>100_bases
TTTATAGTTCTATGGGTGCTTTTTTTATTTTTTATTTAGTGTAAACCAGTTTACACTCTTCAATAATCAATCTAATCCAA
ACACACATAAGGAGAACAAA

Downstream 100 bases:

>100_bases
TTCATTTTCAAATTTTACTTCCTTAGCCTTACTAATCTTGAGGATTTACCAGTTTACACTATTTGGTTTTAGTTGACACT
GGTGTAAACTCAAGTTATTT

Product: tryptophanyl-tRNA synthetase II

Products: NA

Alternate protein names: Tryptophan--tRNA ligase; TrpRS

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTKPTILTGDRPTGKLHIGHYVGSLQNRVKMQNEDKYNMFVFLADQQALTDHAKEPELIRQSVGDVALDYLAAGLDPEKS
TIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQKAFGESIPAGFLVYPVSQAADITAFKATHVPVGNDQKPMIE
QTREIVRSFNNAYHTDVLVEPEGIYPENEAAGRLPGLDGNAKMSKSLGNGIFLADDMDTLKKKVMSMYTDPDHIKVEDPG
KIEGNMVFHYLDVFGKAEDAEQISEMKAQYQAGGLGDVKTKRFLLDVLDRELSPIRERRIEFAQNMDYVYDMLKAGSLKA
QAVASQTLDEVKSAMGINYFK

Sequences:

>Translated_341_residues
MTKPTILTGDRPTGKLHIGHYVGSLQNRVKMQNEDKYNMFVFLADQQALTDHAKEPELIRQSVGDVALDYLAAGLDPEKS
TIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQKAFGESIPAGFLVYPVSQAADITAFKATHVPVGNDQKPMIE
QTREIVRSFNNAYHTDVLVEPEGIYPENEAAGRLPGLDGNAKMSKSLGNGIFLADDMDTLKKKVMSMYTDPDHIKVEDPG
KIEGNMVFHYLDVFGKAEDAEQISEMKAQYQAGGLGDVKTKRFLLDVLDRELSPIRERRIEFAQNMDYVYDMLKAGSLKA
QAVASQTLDEVKSAMGINYFK
>Mature_340_residues
TKPTILTGDRPTGKLHIGHYVGSLQNRVKMQNEDKYNMFVFLADQQALTDHAKEPELIRQSVGDVALDYLAAGLDPEKST
IFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQKAFGESIPAGFLVYPVSQAADITAFKATHVPVGNDQKPMIEQ
TREIVRSFNNAYHTDVLVEPEGIYPENEAAGRLPGLDGNAKMSKSLGNGIFLADDMDTLKKKVMSMYTDPDHIKVEDPGK
IEGNMVFHYLDVFGKAEDAEQISEMKAQYQAGGLGDVKTKRFLLDVLDRELSPIRERRIEFAQNMDYVYDMLKAGSLKAQ
AVASQTLDEVKSAMGINYFK

Specific function: Unknown

COG id: COG0180

COG function: function code J; Tryptophanyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI7710154, Length=341, Percent_Identity=29.9120234604106, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI41352700, Length=173, Percent_Identity=36.4161849710983, Blast_Score=119, Evalue=4e-27,
Organism=Escherichia coli, GI1789786, Length=340, Percent_Identity=34.4117647058824, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71982800, Length=347, Percent_Identity=30.835734870317, Blast_Score=137, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71982793, Length=348, Percent_Identity=30.7471264367816, Blast_Score=137, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6320474, Length=356, Percent_Identity=26.9662921348315, Blast_Score=112, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24666151, Length=337, Percent_Identity=31.7507418397626, Blast_Score=149, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYW_LACLA (Q9CJD1)

Other databases:

- EMBL:   AE005176
- PIR:   B86633
- RefSeq:   NP_266222.1
- ProteinModelPortal:   Q9CJD1
- SMR:   Q9CJD1
- GeneID:   1113669
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0358
- NMPDR:   fig|272623.1.peg.71
- HOGENOM:   HBG293263
- OMA:   TYLDAFH
- ProtClustDB:   PRK12282
- BioCyc:   LLAC272623:L0358-MONOMER
- BRENDA:   6.1.1.2
- GO:   GO:0005737
- HAMAP:   MF_00140_B
- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002306
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10055
- PRINTS:   PR01039
- TIGRFAMs:   TIGR00233

Pfam domain/function: PF00579 tRNA-synt_1b

EC number: =6.1.1.2

Molecular weight: Translated: 38052; Mature: 37921

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 205-205

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPTILTGDRPTGKLHIGHYVGSLQNRVKMQNEDKYNMFVFLADQQALTDHAKEPELIR
CCCCCEEECCCCCCEEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHCCCCHHHHH
QSVGDVALDYLAAGLDPEKSTIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQK
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AFGESIPAGFLVYPVSQAADITAFKATHVPVGNDQKPMIEQTREIVRSFNNAYHTDVLVE
HHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEC
PEGIYPENEAAGRLPGLDGNAKMSKSLGNGIFLADDMDTLKKKVMSMYTDPDHIKVEDPG
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHCCCCCCEEECCCC
KIEGNMVFHYLDVFGKAEDAEQISEMKAQYQAGGLGDVKTKRFLLDVLDRELSPIRERRI
CCCCCCCEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EFAQNMDYVYDMLKAGSLKAQAVASQTLDEVKSAMGINYFK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TKPTILTGDRPTGKLHIGHYVGSLQNRVKMQNEDKYNMFVFLADQQALTDHAKEPELIR
CCCCEEECCCCCCEEEHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHCCCCHHHHH
QSVGDVALDYLAAGLDPEKSTIFIQSQIPELAELSMYYMNLVSLARLERNPTVKTEIAQK
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AFGESIPAGFLVYPVSQAADITAFKATHVPVGNDQKPMIEQTREIVRSFNNAYHTDVLVE
HHCCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEC
PEGIYPENEAAGRLPGLDGNAKMSKSLGNGIFLADDMDTLKKKVMSMYTDPDHIKVEDPG
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEECCHHHHHHHHHHHCCCCCCEEECCCC
KIEGNMVFHYLDVFGKAEDAEQISEMKAQYQAGGLGDVKTKRFLLDVLDRELSPIRERRI
CCCCCCCEEEHHHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
EFAQNMDYVYDMLKAGSLKAQAVASQTLDEVKSAMGINYFK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11337471