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The map label for this gene is tyrA [C]

Identifier: 15668793

GI number: 15668793

Start: 542300

End: 543640

Strand: Direct

Name: tyrA [C]

Synonym: MJ0612

Alternate gene names: 15668793

Gene position: 542300-543640 (Clockwise)

Preceding gene: 15668792

Following gene: 15668798

Centisome position: 32.57

GC content: 31.25

Gene sequence:

>1341_bases
ATGAAAAATACGAACTTAACAATCTCAATTATTGGAGGAACTGATGGTTTAGGGAAGTGGTTTGCAAGATATTTAAAAAA
TAAAGGGTTTAACGTTATAGTTACTGGGAGAGATATTGAGAAAGGAAAAAATGTTGAGAAAGAGTTAGGGGTTGAATTTA
CTAACAACAACATTGAAGCTGCTAAAAAAGGAGATATTGTTATTGTAGCAGTTCCAATAAATGTTACAGAAAGGGTTATA
AAAGAGGTAGCTCCTCATGTTAGGGAAGGATGTTTATTAATGGACATAACCTCAATTAAAGAGATTCCTTCAAAAGCTAT
GGAAGAGCATGTTAAAGAGGGAGTTACAGTTATTCCAACCCACCCAATGTTCGGCCCATCAACACCTTCTTTGTTAAGAC
AAGTGGTTATCTTAACCCCTTCTGAAAAGCATAAAAATACTGAGTGGTTTAACAAGGTTTATAATTTTTTAAAGAAAGAA
GGGGCTAAGGTTATAGTCATCCCTCCAGAAAAACATGATAGAATTATGGGGATTGTTCAGGGTTTGACTCACTTCGCCTT
TATATCTTTAGGAGCAACGTTAAAAGAACTCAACGTTGATATAAAAGAGTCAAGAAAGTTTGCCTCCCCAATATACGAGT
TGATGATTTCTATCATTGGGAGGATTATAGGACAGAATCCCTATTTATATGCTGACATCCAAATGTTTAATCCAAGGATA
AAGGAGATTCATGAAACCTTTATAAATCAGTGTAAGGAAATCAGTGAAATTGTTAAAAATAAAGATAGAGAAGGTTTTGT
TAAGATAATGAAAGAAGCTGCAAAGCATTTTGGTAGTGAGGCAAAGAGAGGGGCTTATTATTCAGATAAGGCCGTGTTTG
CATTAACATCTGAAATTGAAAAGCTAAATAAACTCATTGGTAAAGATGTGGCTGTAAAAAATATAAATTCAAATGTTGTT
CATTTTGGAGTTTTAAAAGACATTGAAGATGATTACTTAATATTAAATAAAAATGGCAAAGAGCAGAAGTTTAATATTTT
AAGGGTTGAGGTATTTGCTGGAGATGAGTTGAGTAAACTAAAAAAGAAGCACTTAGAAAAAAAATATATAGATGTGTCTG
TTTTATTTAAAAAGGATGTTGATGAGGAAGTTATTTTAAATTTATTAAAGAAAATGTTCGATATTGAGATAATTGATGTT
TATGAGGGAGAAAAAATAGAAGAAGGGTATAAAAGTATAACATTTAGAATTTATGGATACAATAAGGATGAGTTAAAAAA
TATAGAAAAGGAATTTTTGAAGATAATTAAAAATATTGGTGGAAAGGAGAGATTTAAGTAA

Upstream 100 bases:

>100_bases
ATTTAGGTGAAATTCATGGAAAATAAAAACCTAACAATGAAACTTTTAGAAAAAGTTTCATCAAAATATATATACTACAA
TCCTATAAAGGGGGAATATT

Downstream 100 bases:

>100_bases
ATTATGGTTTTAAATAGAAGAGATGACTCTTACAGCATAGGAGGAGACCTCCTATTGCTATGAAACTTTTAGAAAAAGTT
AAATGAAAATCAAAGATTTT

Product: prephenate dehydrogenase

Products: 4-hydroxyphenylpyruvate; CO2; NADH

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MKNTNLTISIIGGTDGLGKWFARYLKNKGFNVIVTGRDIEKGKNVEKELGVEFTNNNIEAAKKGDIVIVAVPINVTERVI
KEVAPHVREGCLLMDITSIKEIPSKAMEEHVKEGVTVIPTHPMFGPSTPSLLRQVVILTPSEKHKNTEWFNKVYNFLKKE
GAKVIVIPPEKHDRIMGIVQGLTHFAFISLGATLKELNVDIKESRKFASPIYELMISIIGRIIGQNPYLYADIQMFNPRI
KEIHETFINQCKEISEIVKNKDREGFVKIMKEAAKHFGSEAKRGAYYSDKAVFALTSEIEKLNKLIGKDVAVKNINSNVV
HFGVLKDIEDDYLILNKNGKEQKFNILRVEVFAGDELSKLKKKHLEKKYIDVSVLFKKDVDEEVILNLLKKMFDIEIIDV
YEGEKIEEGYKSITFRIYGYNKDELKNIEKEFLKIIKNIGGKERFK

Sequences:

>Translated_446_residues
MKNTNLTISIIGGTDGLGKWFARYLKNKGFNVIVTGRDIEKGKNVEKELGVEFTNNNIEAAKKGDIVIVAVPINVTERVI
KEVAPHVREGCLLMDITSIKEIPSKAMEEHVKEGVTVIPTHPMFGPSTPSLLRQVVILTPSEKHKNTEWFNKVYNFLKKE
GAKVIVIPPEKHDRIMGIVQGLTHFAFISLGATLKELNVDIKESRKFASPIYELMISIIGRIIGQNPYLYADIQMFNPRI
KEIHETFINQCKEISEIVKNKDREGFVKIMKEAAKHFGSEAKRGAYYSDKAVFALTSEIEKLNKLIGKDVAVKNINSNVV
HFGVLKDIEDDYLILNKNGKEQKFNILRVEVFAGDELSKLKKKHLEKKYIDVSVLFKKDVDEEVILNLLKKMFDIEIIDV
YEGEKIEEGYKSITFRIYGYNKDELKNIEKEFLKIIKNIGGKERFK
>Mature_446_residues
MKNTNLTISIIGGTDGLGKWFARYLKNKGFNVIVTGRDIEKGKNVEKELGVEFTNNNIEAAKKGDIVIVAVPINVTERVI
KEVAPHVREGCLLMDITSIKEIPSKAMEEHVKEGVTVIPTHPMFGPSTPSLLRQVVILTPSEKHKNTEWFNKVYNFLKKE
GAKVIVIPPEKHDRIMGIVQGLTHFAFISLGATLKELNVDIKESRKFASPIYELMISIIGRIIGQNPYLYADIQMFNPRI
KEIHETFINQCKEISEIVKNKDREGFVKIMKEAAKHFGSEAKRGAYYSDKAVFALTSEIEKLNKLIGKDVAVKNINSNVV
HFGVLKDIEDDYLILNKNGKEQKFNILRVEVFAGDELSKLKKKHLEKKYIDVSVLFKKDVDEEVILNLLKKMFDIEIIDV
YEGEKIEEGYKSITFRIYGYNKDELKNIEKEFLKIIKNIGGKERFK

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain

Homologues:

Organism=Escherichia coli, GI1788952, Length=277, Percent_Identity=31.4079422382672, Blast_Score=147, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6319643, Length=277, Percent_Identity=23.1046931407942, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): Y612_METJA (Q58029)

Other databases:

- EMBL:   L77117
- PIR:   D64376
- RefSeq:   NP_247596.1
- ProteinModelPortal:   Q58029
- SMR:   Q58029
- GeneID:   1451478
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0612
- NMPDR:   fig|243232.1.peg.633
- TIGR:   MJ0612
- HOGENOM:   HBG538602
- OMA:   QNPYLYA
- ProtClustDB:   PRK08655
- BioCyc:   MJAN243232:MJ_0612-MONOMER
- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR005121
- InterPro:   IPR008299
- InterPro:   IPR003099
- Gene3D:   G3DSA:3.30.70.380
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR21363
- PIRSF:   PIRSF006549

Pfam domain/function: PF03147 FDX-ACB; PF02153 PDH; SSF48179 6DGDH_C_like; SSF54991 Fdx_AntiC_bd

EC number: 1.3.1.12

Molecular weight: Translated: 50889; Mature: 50889

Theoretical pI: Translated: 9.57; Mature: 9.57

Prosite motif: PS51176 PDH_ADH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNTNLTISIIGGTDGLGKWFARYLKNKGFNVIVTGRDIEKGKNVEKELGVEFTNNNIEA
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHCCCEEECCCCCC
AKKGDIVIVAVPINVTERVIKEVAPHVREGCLLMDITSIKEIPSKAMEEHVKEGVTVIPT
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEC
HPMFGPSTPSLLRQVVILTPSEKHKNTEWFNKVYNFLKKEGAKVIVIPPEKHDRIMGIVQ
CCCCCCCCHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
GLTHFAFISLGATLKELNVDIKESRKFASPIYELMISIIGRIIGQNPYLYADIQMFNPRI
HHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHH
KEIHETFINQCKEISEIVKNKDREGFVKIMKEAAKHFGSEAKRGAYYSDKAVFALTSEIE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHH
KLNKLIGKDVAVKNINSNVVHFGVLKDIEDDYLILNKNGKEQKFNILRVEVFAGDELSKL
HHHHHHCCCCEEECCCCCEEEEEEHHCCCCCEEEECCCCCCCEEEEEEEEEECCCHHHHH
KKKHLEKKYIDVSVLFKKDVDEEVILNLLKKMFDIEIIDVYEGEKIEEGYKSITFRIYGY
HHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHEEEEEEEEC
NKDELKNIEKEFLKIIKNIGGKERFK
CHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKNTNLTISIIGGTDGLGKWFARYLKNKGFNVIVTGRDIEKGKNVEKELGVEFTNNNIEA
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHCCCEEECCCCCC
AKKGDIVIVAVPINVTERVIKEVAPHVREGCLLMDITSIKEIPSKAMEEHVKEGVTVIPT
CCCCCEEEEEECCCHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEC
HPMFGPSTPSLLRQVVILTPSEKHKNTEWFNKVYNFLKKEGAKVIVIPPEKHDRIMGIVQ
CCCCCCCCHHHHHEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHH
GLTHFAFISLGATLKELNVDIKESRKFASPIYELMISIIGRIIGQNPYLYADIQMFNPRI
HHHHHHHHHHCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHH
KEIHETFINQCKEISEIVKNKDREGFVKIMKEAAKHFGSEAKRGAYYSDKAVFALTSEIE
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHCCCCCCCCHHHHHHHHHH
KLNKLIGKDVAVKNINSNVVHFGVLKDIEDDYLILNKNGKEQKFNILRVEVFAGDELSKL
HHHHHHCCCCEEECCCCCEEEEEEHHCCCCCEEEECCCCCCCEEEEEEEEEECCCHHHHH
KKKHLEKKYIDVSVLFKKDVDEEVILNLLKKMFDIEIIDVYEGEKIEEGYKSITFRIYGY
HHHHHHHHHCEEEEEEECCCCHHHHHHHHHHHHCEEEEEECCCCHHHHHHHEEEEEEEEC
NKDELKNIEKEFLKIIKNIGGKERFK
CHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: prephenate; NAD+

Specific reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087