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The map label for this gene is nadC

Identifier: 15668670

GI number: 15668670

Start: 435518

End: 436369

Strand: Reverse

Name: nadC

Synonym: MJ0493

Alternate gene names: 15668670

Gene position: 436369-435518 (Counterclockwise)

Preceding gene: 15668674

Following gene: 15668669

Centisome position: 26.21

GC content: 31.69

Gene sequence:

>852_bases
ATGCTCAAAGATTATGCTCTTAAAATACTAAAAAAATCTTTGGAATACGATGTTGGATTTGGAGATATAACAACAAACTC
CATCATTCCAGAAGGTGTAAAGGCTAAGGGTGTTATTAAAGCTAAAGAAAAATGTATAGTTTGTGGGATTGATTTTATCG
TTGCATTTTTTGAAGAATACGGTATAAAATGTAAAAAATTATTTAATGATGGAGAAGAAGCTTATGGAAACATATTAGAG
TTTGAAGGGGATGCAAGAACCATTTTAATGCTTGAAAGAACCGCCTTAAATCTACTTATGCACCTCTCCGGAATAGCCAC
TATGACAAACAGAATAGTTAAAAAAGCTAAATCAGTAAATAAAAACGTCAGGGTGGCCTGCACAAGAAAAACTCTTCCTT
TATTATCTCCACTACAAAAATATGCAGTATATATTGGTGGTGGAGACACACATAGATTTAGGTTAGATGACTGTGTTTTA
ATTAAAGATAATCATATAGCAATTGTTGGTGTGAAAGAAGCTATAAGAAGGGCTAAGGAAAATGTTAGCTTTACAAAAAA
GATTGAAGTTGAGGTTAGTAACTTGAAAGAGTTGAGAGAAGCTTTAGAGGAGAGGGCAGATATAATAATGCTTGACAACT
TCAAACCAGAAGAGATAGAGGAAGCTTTAAAGATAATTGATGAATTTGAAAGAAAAACCAATTTTAAGCCAATAATTGAA
GTTAGCGGTGGAATAAAAGAAGATAATATTTTAGAATATGCAAAATACAATGTTGATGTTATATCAATGGGAGCTTTAAC
TCATTCTGTAAAGAGTGTTGATATGAGTTTGGATATAGTTAGGTATCAATAA

Upstream 100 bases:

>100_bases
ATTTAGAAATTTTTATACTACACATATTTTTTAACAAAAGTTTTTATTATTTAAGTTTTATTAAATTAAAAAATTAAAAA
CTTAATAATGGGGGATATTC

Downstream 100 bases:

>100_bases
AATTAAAATTTAATAGAAAGAATAATAAAATAAAAATACTAATATCACAAATAATAAACTTTATAATTCTGTGATTTATT
TGGGGTATATCACAATTTTT

Product: nicotinate-nucleotide pyrophosphorylase NadC

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MLKDYALKILKKSLEYDVGFGDITTNSIIPEGVKAKGVIKAKEKCIVCGIDFIVAFFEEYGIKCKKLFNDGEEAYGNILE
FEGDARTILMLERTALNLLMHLSGIATMTNRIVKKAKSVNKNVRVACTRKTLPLLSPLQKYAVYIGGGDTHRFRLDDCVL
IKDNHIAIVGVKEAIRRAKENVSFTKKIEVEVSNLKELREALEERADIIMLDNFKPEEIEEALKIIDEFERKTNFKPIIE
VSGGIKEDNILEYAKYNVDVISMGALTHSVKSVDMSLDIVRYQ

Sequences:

>Translated_283_residues
MLKDYALKILKKSLEYDVGFGDITTNSIIPEGVKAKGVIKAKEKCIVCGIDFIVAFFEEYGIKCKKLFNDGEEAYGNILE
FEGDARTILMLERTALNLLMHLSGIATMTNRIVKKAKSVNKNVRVACTRKTLPLLSPLQKYAVYIGGGDTHRFRLDDCVL
IKDNHIAIVGVKEAIRRAKENVSFTKKIEVEVSNLKELREALEERADIIMLDNFKPEEIEEALKIIDEFERKTNFKPIIE
VSGGIKEDNILEYAKYNVDVISMGALTHSVKSVDMSLDIVRYQ
>Mature_283_residues
MLKDYALKILKKSLEYDVGFGDITTNSIIPEGVKAKGVIKAKEKCIVCGIDFIVAFFEEYGIKCKKLFNDGEEAYGNILE
FEGDARTILMLERTALNLLMHLSGIATMTNRIVKKAKSVNKNVRVACTRKTLPLLSPLQKYAVYIGGGDTHRFRLDDCVL
IKDNHIAIVGVKEAIRRAKENVSFTKKIEVEVSNLKELREALEERADIIMLDNFKPEEIEEALKIIDEFERKTNFKPIIE
VSGGIKEDNILEYAKYNVDVISMGALTHSVKSVDMSLDIVRYQ

Specific function: Involved in the catabolism of quinolinic acid (QA)

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family

Homologues:

Organism=Homo sapiens, GI45269149, Length=250, Percent_Identity=35.2, Blast_Score=157, Evalue=1e-38,
Organism=Escherichia coli, GI1786299, Length=278, Percent_Identity=37.410071942446, Blast_Score=144, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6321162, Length=251, Percent_Identity=35.8565737051793, Blast_Score=152, Evalue=4e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NADC_METJA (Q57916)

Other databases:

- EMBL:   L77117
- PIR:   E64361
- RefSeq:   NP_247469.1
- ProteinModelPortal:   Q57916
- SMR:   Q57916
- GeneID:   1451355
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0493
- NMPDR:   fig|243232.1.peg.506
- TIGR:   MJ0493
- HOGENOM:   HBG751540
- OMA:   NHRIGLY
- ProtClustDB:   CLSK876206
- BioCyc:   MJAN243232:MJ_0493-MONOMER
- BRENDA:   2.4.2.19
- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00078

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N; SSF51690 Q_phspho_trans

EC number: =2.4.2.19

Molecular weight: Translated: 31971; Mature: 31971

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: BINDING 93-93 BINDING 152-152 BINDING 162-162 BINDING 191-191 BINDING 212-212

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKDYALKILKKSLEYDVGFGDITTNSIIPEGVKAKGVIKAKEKCIVCGIDFIVAFFEEY
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEECHHHHHHHHHHH
GIKCKKLFNDGEEAYGNILEFEGDARTILMLERTALNLLMHLSGIATMTNRIVKKAKSVN
CCCHHHHHCCCHHHCCCEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KNVRVACTRKTLPLLSPLQKYAVYIGGGDTHRFRLDDCVLIKDNHIAIVGVKEAIRRAKE
CCEEEEEECCCCHHHHHHHHHEEEECCCCCEEEEECCEEEEECCCEEEEEHHHHHHHHHH
NVSFTKKIEVEVSNLKELREALEERADIIMLDNFKPEEIEEALKIIDEFERKTNFKPIIE
CCCEEEEEEEEHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEE
VSGGIKEDNILEYAKYNVDVISMGALTHSVKSVDMSLDIVRYQ
ECCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHCCEEEEEEEC
>Mature Secondary Structure
MLKDYALKILKKSLEYDVGFGDITTNSIIPEGVKAKGVIKAKEKCIVCGIDFIVAFFEEY
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEECCCEEEECHHHHHHHHHHH
GIKCKKLFNDGEEAYGNILEFEGDARTILMLERTALNLLMHLSGIATMTNRIVKKAKSVN
CCCHHHHHCCCHHHCCCEEEECCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
KNVRVACTRKTLPLLSPLQKYAVYIGGGDTHRFRLDDCVLIKDNHIAIVGVKEAIRRAKE
CCEEEEEECCCCHHHHHHHHHEEEECCCCCEEEEECCEEEEECCCEEEEEHHHHHHHHHH
NVSFTKKIEVEVSNLKELREALEERADIIMLDNFKPEEIEEALKIIDEFERKTNFKPIIE
CCCEEEEEEEEHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEE
VSGGIKEDNILEYAKYNVDVISMGALTHSVKSVDMSLDIVRYQ
ECCCCCCCCHHHHHHCCCEEEEECHHHHHHHHHCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087