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The map label for this gene is coxA1 [H]

Identifier: 15607122

GI number: 15607122

Start: 1540270

End: 1541727

Strand: Direct

Name: coxA1 [H]

Synonym: aq_2191

Alternate gene names: 15607122

Gene position: 1540270-1541727 (Clockwise)

Preceding gene: 15607121

Following gene: 15607123

Centisome position: 99.29

GC content: 47.53

Gene sequence:

>1458_bases
GTGCCCGGGATGCAGGTCGTTGACTTCAAGACCTATAACTACTTACTTACCGGGCACGGAGTAGGAATGCTCTTCTGGTG
GGCTATAGCAGCTCACATAGGAGGATTCGGTAACTTCCTACTCCCCTTAATGATTGGAGCAAAAGACGTCGCATTTCCCA
GACTGAACGCGCTCAGCTGGTGGGCATTCTTTGCAGCAAACGTACTCTTCCTTATGACTCTTATCCCGGGAAACCACATA
ATGACTATGTGGACCGGATACCCACCCTTCTCCCTTAACAACGATGCGGGAGTAACAGCTCTCTACGTATTCGTAATGCA
CTTACTCGGAGCATCTTCTATAGCAACCGCTGTTAACTTCCTTGTTACTTACATTACGATGAGAGCTCCCGGATACACCT
TCTTCAAGACGAACCTCTTCGTACATACTCTCATAGCTGCTAACGTAATTCAGCTTGTAGGTGTTCCTTCTCTTGCAGGC
GCAGTTACGATGCTCTTCCTTGACAAGTACCTCGGAACTAACTTCTTTAACCCCGCTAAGGGTGGAGACCCCCTCATATA
CCAGAACATTTTCTGGTTCTACTCTCACCCTGTTGTTTACGTTCAAGTTCTACCGGTATTCGGTTTCTACTCCGAAATAA
TTCCCGTATTCGCAAGGAGACCTCTCTTCGGATACACCTCTATGGTATTTGCAGTTTGGGCAATAACGGCGGTAAGCTTC
TTCCTATGGATACACCACATGTTCGTTTCCGGAGTACCCAACTGGACAAGAGTACTTTTCTCCTACACCACACTCCTGAT
AGCAGTTCCCACAGGAATTAAAATCTTCAACTGGATGTTAACTCTATACAGAGGGGCAATTCACTTCAGATCACAAATGC
TCTACGCACTCGGTGGAGTGTTCATGTTCCTCATAGGTGGTCTCACAGGGTTACCTCTTGGAATGGTCGCTATAGACCTG
GGTGTATCCGATTCTTTATTCGTAGTAGGACACTTCCACTACGTTCTCGGGATGGCTATTACCCTCGGAATTCTCGGAGC
TGTAATACACTGGTTCCCCCTTGCAACAGGAAAGTACTACCCTGAAAACCTCGGAAAACTCAGCTTCTGGCTCATATTCG
CAGGAGCAAACATCTTCTACTTCCTCCAAATGGTCGCAGGTATGCTTGGTAATCCCAGAAGGTATCCTGACTATCCTCCC
ATACCCGAATGGACAACCCTCCACGTAATACAGACTATCGGAGCTCTCATACTCGGTGTAGGTGTAGTAATCTTCACATA
CGGAATAATTAAGGGACTCAAAAGCGGTGAAAAGGCTTCAGACAATCCCTGGAAGTCTCCTTCTCTTGAATGGAAGGTCG
GAGTTCCCGCAAGGGCACACGGTCACGGAGACCATCCTCCCAGGGTAGAACCCGACTGGCACCCATACAGATACGACAAA
GAAGAAATACTCAAGTGA

Upstream 100 bases:

>100_bases
TACCGATCACAAAAAGATCGGAATACTTTACTTTACGACCAGCTTCCTCGTTTTCCTTATAGCGGGTGTATTTGGTCTGC
TCGTAAGGCTGGAGCAGTCT

Downstream 100 bases:

>100_bases
TTTCTCCTCTTTCCTTCCTCTATATTTTTTTATTTGAAAAAATTAATTACTTTTTGATCACAAAATCACTTTTATCTTAA
ATTTGAGCTAAAACATAAAA

Product: cytochrome C oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I; Oxidase aa(3) subunit 1 [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MPGMQVVDFKTYNYLLTGHGVGMLFWWAIAAHIGGFGNFLLPLMIGAKDVAFPRLNALSWWAFFAANVLFLMTLIPGNHI
MTMWTGYPPFSLNNDAGVTALYVFVMHLLGASSIATAVNFLVTYITMRAPGYTFFKTNLFVHTLIAANVIQLVGVPSLAG
AVTMLFLDKYLGTNFFNPAKGGDPLIYQNIFWFYSHPVVYVQVLPVFGFYSEIIPVFARRPLFGYTSMVFAVWAITAVSF
FLWIHHMFVSGVPNWTRVLFSYTTLLIAVPTGIKIFNWMLTLYRGAIHFRSQMLYALGGVFMFLIGGLTGLPLGMVAIDL
GVSDSLFVVGHFHYVLGMAITLGILGAVIHWFPLATGKYYPENLGKLSFWLIFAGANIFYFLQMVAGMLGNPRRYPDYPP
IPEWTTLHVIQTIGALILGVGVVIFTYGIIKGLKSGEKASDNPWKSPSLEWKVGVPARAHGHGDHPPRVEPDWHPYRYDK
EEILK

Sequences:

>Translated_485_residues
MPGMQVVDFKTYNYLLTGHGVGMLFWWAIAAHIGGFGNFLLPLMIGAKDVAFPRLNALSWWAFFAANVLFLMTLIPGNHI
MTMWTGYPPFSLNNDAGVTALYVFVMHLLGASSIATAVNFLVTYITMRAPGYTFFKTNLFVHTLIAANVIQLVGVPSLAG
AVTMLFLDKYLGTNFFNPAKGGDPLIYQNIFWFYSHPVVYVQVLPVFGFYSEIIPVFARRPLFGYTSMVFAVWAITAVSF
FLWIHHMFVSGVPNWTRVLFSYTTLLIAVPTGIKIFNWMLTLYRGAIHFRSQMLYALGGVFMFLIGGLTGLPLGMVAIDL
GVSDSLFVVGHFHYVLGMAITLGILGAVIHWFPLATGKYYPENLGKLSFWLIFAGANIFYFLQMVAGMLGNPRRYPDYPP
IPEWTTLHVIQTIGALILGVGVVIFTYGIIKGLKSGEKASDNPWKSPSLEWKVGVPARAHGHGDHPPRVEPDWHPYRYDK
EEILK
>Mature_484_residues
PGMQVVDFKTYNYLLTGHGVGMLFWWAIAAHIGGFGNFLLPLMIGAKDVAFPRLNALSWWAFFAANVLFLMTLIPGNHIM
TMWTGYPPFSLNNDAGVTALYVFVMHLLGASSIATAVNFLVTYITMRAPGYTFFKTNLFVHTLIAANVIQLVGVPSLAGA
VTMLFLDKYLGTNFFNPAKGGDPLIYQNIFWFYSHPVVYVQVLPVFGFYSEIIPVFARRPLFGYTSMVFAVWAITAVSFF
LWIHHMFVSGVPNWTRVLFSYTTLLIAVPTGIKIFNWMLTLYRGAIHFRSQMLYALGGVFMFLIGGLTGLPLGMVAIDLG
VSDSLFVVGHFHYVLGMAITLGILGAVIHWFPLATGKYYPENLGKLSFWLIFAGANIFYFLQMVAGMLGNPRRYPDYPPI
PEWTTLHVIQTIGALILGVGVVIFTYGIIKGLKSGEKASDNPWKSPSLEWKVGVPARAHGHGDHPPRVEPDWHPYRYDKE
EILK

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=462, Percent_Identity=39.6103896103896, Blast_Score=320, Evalue=2e-87,
Organism=Escherichia coli, GI1786634, Length=479, Percent_Identity=37.160751565762, Blast_Score=296, Evalue=2e-81,
Organism=Saccharomyces cerevisiae, GI6226519, Length=486, Percent_Identity=37.6543209876543, Blast_Score=320, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6226524, Length=284, Percent_Identity=40.4929577464789, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6226523, Length=193, Percent_Identity=38.860103626943, Blast_Score=121, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 54171; Mature: 54039

Theoretical pI: Translated: 9.55; Mature: 9.55

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGMQVVDFKTYNYLLTGHGVGMLFWWAIAAHIGGFGNFLLPLMIGAKDVAFPRLNALSW
CCCCEEEEEEEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHCCCCHHHHHH
WAFFAANVLFLMTLIPGNHIMTMWTGYPPFSLNNDAGVTALYVFVMHLLGASSIATAVNF
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHH
LVTYITMRAPGYTFFKTNLFVHTLIAANVIQLVGVPSLAGAVTMLFLDKYLGTNFFNPAK
HHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCC
GGDPLIYQNIFWFYSHPVVYVQVLPVFGFYSEIIPVFARRPLFGYTSMVFAVWAITAVSF
CCCCEEHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FLWIHHMFVSGVPNWTRVLFSYTTLLIAVPTGIKIFNWMLTLYRGAIHFRSQMLYALGGV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMFLIGGLTGLPLGMVAIDLGVSDSLFVVGHFHYVLGMAITLGILGAVIHWFPLATGKYY
HHHHHHCCCCCCHHHHEEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PENLGKLSFWLIFAGANIFYFLQMVAGMLGNPRRYPDYPPIPEWTTLHVIQTIGALILGV
CHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GVVIFTYGIIKGLKSGEKASDNPWKSPSLEWKVGVPARAHGHGDHPPRVEPDWHPYRYDK
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCH
EEILK
HHHCC
>Mature Secondary Structure 
PGMQVVDFKTYNYLLTGHGVGMLFWWAIAAHIGGFGNFLLPLMIGAKDVAFPRLNALSW
CCCEEEEEEEEEEEEECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCHHCCCCHHHHHH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HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8399373 [H]