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The map label for this gene is menA [H]

Identifier: 15603034

GI number: 15603034

Start: 1364738

End: 1365649

Strand: Reverse

Name: menA [H]

Synonym: PM1169

Alternate gene names: 15603034

Gene position: 1365649-1364738 (Counterclockwise)

Preceding gene: 15603036

Following gene: 15603033

Centisome position: 60.49

GC content: 39.69

Gene sequence:

>912_bases
ATGTTTATGACAAATAATGTATTAAAAAAGTGGGTGGAAACAGCAAGACCAAAAACCTTGCCATTGGCAATCGCATCTAT
TATCACTGGTGCTTCATTGGCTTTTTGGTCTGGCAAATTCAGTTGGACAATTACGGTATGGTGTTTAATCACGACGGTGT
TGCTACAAATTCTCTCGAATTTTGCCAACGATTATGGTGATCACCAAAAAGGCTCGGATACGGCAGATCGAATTGGTCCC
TTACGCGCAATTCAACAGGGTGAGATCAGCGCGAGTCAACTGAAAAAAGGGTTAATTGTTGTCGCCTTGGCGAGTCTATG
TTCTGGTGCAATTTTAATTATTGTGGCATATCAATCCTTAGCGGATTTATTGGCGTTTAGTTTACTGGGGCTATTGGCAG
TAGTTGCTGCAATTACTTACACCGTAGGGGCGAAACCTTATGGCTATATGGGATTGGGCGATTTATCGGTCTTGCTATTT
TTTGGTTTACTTGGGGTTGGTGGAAGTTATTACCTACAAACCCAGCAGCTCAATTTAGCTATTTTATTACCGGCGTTTGC
TTCAGGCTTATTAGCCAGTGCAGTATTAAATATCAATAATTTACGAGATATTGAACAAGATAGTCAAGTCGGTAAAAATA
CCTTAGCGGTACGTTTAGGCAGTGAAAAAGGTCGGATTTATCATGCATGTTTATTATTGGTGGCTATCCTTTGTTATTTG
ATTTTTACTTTGTGTTATGTGCAAAAACTGACAGGCTTTATTTTTCTTTTCGCGCTCCCTTTGTTTGTCAAACATGCGTT
GTTTGTGTATCAAAATAAGTCACCACTCCAGTTACGCCCGATGTTGGCACAAATGTCCTTATTGGCGTTACTTATCAATC
TGTTATTTAGTTTAGGCTTGCTTATCAGCTAG

Upstream 100 bases:

>100_bases
GACATATTTTCCTTCGTATGAAGATTTCGTGTAGAATAAACTGATTTCAGTATTTTACGTAAAAGTACGTGAAAAATCGT
GCTTTTTCTTTTAACAAGTG

Downstream 100 bases:

>100_bases
CAATAGGCATATACTAACGAAATGAATTTTCTTCAAAATAAGGTAATGTTATGTACATTGATACTTCTGAGCTTTGTGAT
ATTTATCTTGATCAAGTGGA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MFMTNNVLKKWVETARPKTLPLAIASIITGASLAFWSGKFSWTITVWCLITTVLLQILSNFANDYGDHQKGSDTADRIGP
LRAIQQGEISASQLKKGLIVVALASLCSGAILIIVAYQSLADLLAFSLLGLLAVVAAITYTVGAKPYGYMGLGDLSVLLF
FGLLGVGGSYYLQTQQLNLAILLPAFASGLLASAVLNINNLRDIEQDSQVGKNTLAVRLGSEKGRIYHACLLLVAILCYL
IFTLCYVQKLTGFIFLFALPLFVKHALFVYQNKSPLQLRPMLAQMSLLALLINLLFSLGLLIS

Sequences:

>Translated_303_residues
MFMTNNVLKKWVETARPKTLPLAIASIITGASLAFWSGKFSWTITVWCLITTVLLQILSNFANDYGDHQKGSDTADRIGP
LRAIQQGEISASQLKKGLIVVALASLCSGAILIIVAYQSLADLLAFSLLGLLAVVAAITYTVGAKPYGYMGLGDLSVLLF
FGLLGVGGSYYLQTQQLNLAILLPAFASGLLASAVLNINNLRDIEQDSQVGKNTLAVRLGSEKGRIYHACLLLVAILCYL
IFTLCYVQKLTGFIFLFALPLFVKHALFVYQNKSPLQLRPMLAQMSLLALLINLLFSLGLLIS
>Mature_303_residues
MFMTNNVLKKWVETARPKTLPLAIASIITGASLAFWSGKFSWTITVWCLITTVLLQILSNFANDYGDHQKGSDTADRIGP
LRAIQQGEISASQLKKGLIVVALASLCSGAILIIVAYQSLADLLAFSLLGLLAVVAAITYTVGAKPYGYMGLGDLSVLLF
FGLLGVGGSYYLQTQQLNLAILLPAFASGLLASAVLNINNLRDIEQDSQVGKNTLAVRLGSEKGRIYHACLLLVAILCYL
IFTLCYVQKLTGFIFLFALPLFVKHALFVYQNKSPLQLRPMLAQMSLLALLINLLFSLGLLIS

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=299, Percent_Identity=26.7558528428094, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1790365, Length=295, Percent_Identity=54.2372881355932, Blast_Score=313, Evalue=9e-87,
Organism=Drosophila melanogaster, GI17737429, Length=245, Percent_Identity=27.7551020408163, Blast_Score=75, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 32837; Mature: 32837

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFMTNNVLKKWVETARPKTLPLAIASIITGASLAFWSGKFSWTITVWCLITTVLLQILSN
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
FANDYGDHQKGSDTADRIGPLRAIQQGEISASQLKKGLIVVALASLCSGAILIIVAYQSL
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ADLLAFSLLGLLAVVAAITYTVGAKPYGYMGLGDLSVLLFFGLLGVGGSYYLQTQQLNLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCE
ILLPAFASGLLASAVLNINNLRDIEQDSQVGKNTLAVRLGSEKGRIYHACLLLVAILCYL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
IFTLCYVQKLTGFIFLFALPLFVKHALFVYQNKSPLQLRPMLAQMSLLALLINLLFSLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LIS
HCC
>Mature Secondary Structure
MFMTNNVLKKWVETARPKTLPLAIASIITGASLAFWSGKFSWTITVWCLITTVLLQILSN
CCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
FANDYGDHQKGSDTADRIGPLRAIQQGEISASQLKKGLIVVALASLCSGAILIIVAYQSL
HHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
ADLLAFSLLGLLAVVAAITYTVGAKPYGYMGLGDLSVLLFFGLLGVGGSYYLQTQQLNLA
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCE
ILLPAFASGLLASAVLNINNLRDIEQDSQVGKNTLAVRLGSEKGRIYHACLLLVAILCYL
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
IFTLCYVQKLTGFIFLFALPLFVKHALFVYQNKSPLQLRPMLAQMSLLALLINLLFSLGL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LIS
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]