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The map label for this gene is pntB [H]

Identifier: 15602617

GI number: 15602617

Start: 885081

End: 886505

Strand: Reverse

Name: pntB [H]

Synonym: PM0752

Alternate gene names: 15602617

Gene position: 886505-885081 (Counterclockwise)

Preceding gene: 15602618

Following gene: 15602616

Centisome position: 39.27

GC content: 44.84

Gene sequence:

>1425_bases
ATGTCTGAAGGTTTAGTACAAGCGGCTTATATTGTCGCAGCATTACTTTTCATTATGAGCTTAGCAGGTCTGTCTAAACA
TGAAACTGCAAAAGCGGGATGTTGGTATGGGATTGTCGGTATGGCAATCGCTTTGGTGGCAACCATTTTTGGTCCGCAAT
CAGCAGGTACATTTTGGATTCTGATCGCGATGGCGGTAGGTGCGGTGATTGGGATTAAACGTGCCTTAAAAGTGGAAATG
ACCGAAATGCCTGAGCTAGTAGCAATTTTGCACAGCTTTGTCGGTTTAGCTGCGGTATTAGTCGGCTTTAATAGTTACGG
TTTACACCATGAAGCCGTGATGCCAGCCAATCTTGATGCAGCAGCACAAGCGGCATTTATAGCTGAGCAACAGGTACTGA
GTAATATCCATAATGTAGAAGTGTTCTTGGGGATCTTTATTGGTGCCGTGACATTTACCGGCTCAGTAGTCGCCTTCGGT
AAATTACGTGGTATTATCGATTCCAAAGCACTCACTTTGCCACATCGTCATAAATTAAATTTAGCCGCTATCGTGGTTTC
AGCCTTGTTAATGGTGTCTTTCTTAAATAGCCCAGAAAATATTTTTCCTGTGCTATTGATGACAGCCATTGCGCTTGCTT
TTGGTTGGCATCTCGTCGCATCAATTGGTGGCGCGGATATGCCAGTGGTAGTGTCGATGCTGAACTCTTATTCAGGTTGG
GCAGCGGCAGCCGCAGGTTTTATGTTAAGTAATGACTTGTTGATCGTCACTGGTGCATTAGTGGGATCATCAGGTGCTAT
TCTGTCTTACATTATGTGTAAAGCCATGAACCGTTCATTTATTAGCGTGATTGCAGGTGGATTTGGTAACGATCCGGTGG
CAAGTAGCGATGAAGAACAAGGCGAACACCGTGAAACCACGGCAGAGGAAGTGGCAGAATTACTCAAAAACTCAAGCTCG
GTGATTATTACACCGGGATATGGTATGGCGGTGGCGCAAGCGCAGTACCCTGTAGCGGAAATTACGCAAAAATTACGTGA
ACGCGGTATCAATGTTCGTTTTGGTATTCACCCTGTGGCAGGGCGTTTACCGGGGCACATGAACGTGTTATTGGCAGAGG
CGAAAGTGCCTTATGATATCGTATTAGAAATGGACGAAATTAATGACGATTTCGCGGACACTGATACGGTTCTCGTCATT
GGTGCCAACGATACCGTTAACCCAGCAGCAATGGATGATCCAAACAGCCCGATCGCAGGTATGCCAGTATTAGAAGTGTG
GAAAGCACAAAATGTGATTGTGTTTAAACGCTCAATGAATACCGGTTATGCTGGGGTACAAAATCCATTGTTCTTTAAAG
ACAACACACAAATGCTATTTGGCGATGCGAAAGATCGCGTTGATGATATTTTGAAAGCGCTTTAA

Upstream 100 bases:

>100_bases
GCATTTATTGCAATTTTAGTCGCAAGTATCAATATCTTTGGGGGCTTTAAAGTGACCCAACGGATGCTTGCTATGTTTAG
AAAAGATTAAGGAGTAAGCC

Downstream 100 bases:

>100_bases
TTGCATGGAAAAGGGAATGGATCGGCATTCCCTTTCTTTATGTGAGTTTGTAAAACGTTCTAGAAATCGACCGCACTTTC
CTGAATAAAGGTGGAGTGTG

Product: pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Pyridine nucleotide transhydrogenase subunit beta [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MSEGLVQAAYIVAALLFIMSLAGLSKHETAKAGCWYGIVGMAIALVATIFGPQSAGTFWILIAMAVGAVIGIKRALKVEM
TEMPELVAILHSFVGLAAVLVGFNSYGLHHEAVMPANLDAAAQAAFIAEQQVLSNIHNVEVFLGIFIGAVTFTGSVVAFG
KLRGIIDSKALTLPHRHKLNLAAIVVSALLMVSFLNSPENIFPVLLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGW
AAAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGNDPVASSDEEQGEHRETTAEEVAELLKNSSS
VIITPGYGMAVAQAQYPVAEITQKLRERGINVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFADTDTVLVI
GANDTVNPAAMDDPNSPIAGMPVLEVWKAQNVIVFKRSMNTGYAGVQNPLFFKDNTQMLFGDAKDRVDDILKAL

Sequences:

>Translated_474_residues
MSEGLVQAAYIVAALLFIMSLAGLSKHETAKAGCWYGIVGMAIALVATIFGPQSAGTFWILIAMAVGAVIGIKRALKVEM
TEMPELVAILHSFVGLAAVLVGFNSYGLHHEAVMPANLDAAAQAAFIAEQQVLSNIHNVEVFLGIFIGAVTFTGSVVAFG
KLRGIIDSKALTLPHRHKLNLAAIVVSALLMVSFLNSPENIFPVLLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGW
AAAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGNDPVASSDEEQGEHRETTAEEVAELLKNSSS
VIITPGYGMAVAQAQYPVAEITQKLRERGINVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFADTDTVLVI
GANDTVNPAAMDDPNSPIAGMPVLEVWKAQNVIVFKRSMNTGYAGVQNPLFFKDNTQMLFGDAKDRVDDILKAL
>Mature_473_residues
SEGLVQAAYIVAALLFIMSLAGLSKHETAKAGCWYGIVGMAIALVATIFGPQSAGTFWILIAMAVGAVIGIKRALKVEMT
EMPELVAILHSFVGLAAVLVGFNSYGLHHEAVMPANLDAAAQAAFIAEQQVLSNIHNVEVFLGIFIGAVTFTGSVVAFGK
LRGIIDSKALTLPHRHKLNLAAIVVSALLMVSFLNSPENIFPVLLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGWA
AAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGNDPVASSDEEQGEHRETTAEEVAELLKNSSSV
IITPGYGMAVAQAQYPVAEITQKLRERGINVRFGIHPVAGRLPGHMNVLLAEAKVPYDIVLEMDEINDDFADTDTVLVIG
ANDTVNPAAMDDPNSPIAGMPVLEVWKAQNVIVFKRSMNTGYAGVQNPLFFKDNTQMLFGDAKDRVDDILKAL

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=469, Percent_Identity=49.680170575693, Blast_Score=440, Evalue=1e-123,
Organism=Homo sapiens, GI122939153, Length=469, Percent_Identity=49.680170575693, Blast_Score=440, Evalue=1e-123,
Organism=Escherichia coli, GI1787886, Length=478, Percent_Identity=79.2887029288703, Blast_Score=738, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17550456, Length=473, Percent_Identity=47.7801268498943, Blast_Score=406, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 50231; Mature: 50100

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEGLVQAAYIVAALLFIMSLAGLSKHETAKAGCWYGIVGMAIALVATIFGPQSAGTFWI
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
LIAMAVGAVIGIKRALKVEMTEMPELVAILHSFVGLAAVLVGFNSYGLHHEAVMPANLDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
AAQAAFIAEQQVLSNIHNVEVFLGIFIGAVTFTGSVVAFGKLRGIIDSKALTLPHRHKLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCH
LAAIVVSALLMVSFLNSPENIFPVLLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGW
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCH
AAAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGNDPVASSDEEQ
HHHHHHHHHCCCEEEEEEHHHCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCHHC
GEHRETTAEEVAELLKNSSSVIITPGYGMAVAQAQYPVAEITQKLRERGINVRFGIHPVA
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHCCCCHHHHHHHHHHCCCEEEECCCHHC
GRLPGHMNVLLAEAKVPYDIVLEMDEINDDFADTDTVLVIGANDTVNPAAMDDPNSPIAG
CCCCCCCEEEEECCCCCEEEEEEEHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
MPVLEVWKAQNVIVFKRSMNTGYAGVQNPLFFKDNTQMLFGDAKDRVDDILKAL
CCHHHHHCCCCEEEEEECCCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
SEGLVQAAYIVAALLFIMSLAGLSKHETAKAGCWYGIVGMAIALVATIFGPQSAGTFWI
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHH
LIAMAVGAVIGIKRALKVEMTEMPELVAILHSFVGLAAVLVGFNSYGLHHEAVMPANLDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
AAQAAFIAEQQVLSNIHNVEVFLGIFIGAVTFTGSVVAFGKLRGIIDSKALTLPHRHKLN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCH
LAAIVVSALLMVSFLNSPENIFPVLLMTAIALAFGWHLVASIGGADMPVVVSMLNSYSGW
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCH
AAAAAGFMLSNDLLIVTGALVGSSGAILSYIMCKAMNRSFISVIAGGFGNDPVASSDEEQ
HHHHHHHHHCCCEEEEEEHHHCCCCHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCCCHHC
GEHRETTAEEVAELLKNSSSVIITPGYGMAVAQAQYPVAEITQKLRERGINVRFGIHPVA
CHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHCCCCHHHHHHHHHHCCCEEEECCCHHC
GRLPGHMNVLLAEAKVPYDIVLEMDEINDDFADTDTVLVIGANDTVNPAAMDDPNSPIAG
CCCCCCCEEEEECCCCCEEEEEEEHHCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCC
MPVLEVWKAQNVIVFKRSMNTGYAGVQNPLFFKDNTQMLFGDAKDRVDDILKAL
CCHHHHHCCCCEEEEEECCCCCCCCCCCCEEEECCCEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 8635745 [H]