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The map label for this gene is prlC [H]

Identifier: 15602545

GI number: 15602545

Start: 788587

End: 790626

Strand: Direct

Name: prlC [H]

Synonym: PM0680

Alternate gene names: 15602545

Gene position: 788587-790626 (Clockwise)

Preceding gene: 15602542

Following gene: 15602551

Centisome position: 34.93

GC content: 40.15

Gene sequence:

>2040_bases
ATGTCCAATCCTTTACTTAGCTTTGAAGGGCTCCCCCCTTTTTCACAAATAAAACCAGAACATGTGCAACCTGCCGTCGA
AAATTTGATTCAAGCTTGCCGTGACAATATTGAACAATTACTCAAACAAGAGCAATTCACATGGGATAATTTTATTTTAC
CTTTAACTGAAATGGGTGACCGTTTCAGTAAAGCCTGGTCTCCTGTTTCCCATCTCAATGCCGTCAAAAACAGTCCTGAA
CTCCGTGCAGCATATCAAGCGTGTTTGCCTTTGTTGTCGGAATACAGTACTTGGGTAGGTCAACATAAAGGGTTATATCA
GGCTTATGAAAAACTTAAAAACAGTCCTGAGTTTGCACATTACGATTTAGCACAGCAAAAAACTATTGATAATGCCCTAC
GTGATTTCAAATTATCTGGTATTTCTTTATCGGCAGAGAAACAAAAACGTTATGGTGAAATCTCTGCACGCTTATCTGAA
TTAAGTGCGCAATTTAGTAATAATGTCCTTGATGCCACAATGGGCTGGGATAAAGTGATTGAAAATCTCGAGGAATTAAA
AGGATTACCCGAATCAGCTTTAGCAGCAGCCAAACAATCTGCTGAGAATAAAGGGCTAGAAGGCTATCGTTTCACATTAG
AAATCCCAAGTTATTTACCTGTCATGACCTATTGTGAAAATCGAGCATTGCGTGAAGAAATGTATCGTGCTTTTGTTACA
CGCGCTTCCGACCAAGGTCCAAATGCAGGAAAATGGGATAACAGCGCTATTATGCAAGAAATTCTCAACTTACGTGTAGA
GCTTGCCCACCTTCTTGATTTTAACTGTTATACCGAGCTTTCCCTTGCAACCAAAATGGCGGAAAAACCACAACAGGTGT
TAGATTTCTTAGACAGCCTGGCAAAACGTTCAAAAACACAAGGTGAGAAAGAATTAGCCGAGTTACTTGATTTCTGCCAA
ACACAATTTGGCGTAAATGAGCTTGAAGCTTGGGATATTGCTTTTTACAGCGAAAAGCAAAAACAATATCTTTATTCAAT
CAATGATGAAGAATTACGCCCTTACTTCCCTGAAAATCGTGTATTAGCCGGTTTATTTGAGTTAATTCAACGCATTTTTA
ATATTCGTACCGTTGAACGCTTTGGAATTGATACTTGGCATAACGATGTGCGTTTTTTTGATCTTATTGATGAAAACGAT
AACCTACGTGGCAGTTTCTACCTTGATTTATATGCACGTGAGAATAAACGTGGCGGTGCCTGGATGGATGATTGTATCGG
ACGTCGCAAAAAAGCAAATGGTGAAATCCAAAAACCGGTTGCCTATCTCACCTGTAATTTTAACGCCCCTGTAGGAGATA
AACCGGCTTTATTTACTCATGATGAAGTCACCACATTATTCCATGAGTTTGGTCATGGTATTCACCATATGCTGACTGAA
ATTGATGTTGCTGATGTTGCAGGAATCAGTGGCGTACCTTGGGATGCGGTGGAATTACCAAGCCAGTTTTTAGAAAATTG
GTGCTGGGAAGCCGACGCGCTCGACTTTATCTCTGGTCACTATGAAACCGGTGAACCGCTACCAAAAGAAAAATTAGCAC
AGCTCTTAAAAGCGAAAAATTTCCAAGCTGCGATGTTTGTCTTGCGTCAATTAGAATTTGGTTTATTTGATTTCCGTTTA
CACCATCATTTTGATCCAACCAAAGCAAATCAAATCCTTGATACCTTAAAAGCGGTTAAAGAGGAAGTGGCTGTGATTAA
AGGCGTAGAATGGGCAAGAGCCCCGCACAGTTTTAGCCATATTTTTGCAGGTGGGTATGCCGCAGGTTATTACAGTTATT
TATGGGCAGAAGTGCTTTCAGCTGATGCCTTTTCACGCTTTGAAGAAGAAGGTATTTTTAATCCAGAAACGGGGAAATCT
TTCTTAGCTGAAATCTTAAGCCGAGGAGGAAGTGAAGAGCCTATGACCTTATTTAAGCGTTTCCGTGGACGTGAACCACA
ATTAGATGCCCTTTTAAGACATAAAGGCATTGCGAATTAA

Upstream 100 bases:

>100_bases
CAATTCTCAATTATCTACAATTTTTTCGCTTTTTCAAGCTTGATATTATAAAATTTTGCCCAATGTAGTAAAAACTTATC
ATCGTTTAAGGAAATTATTT

Downstream 100 bases:

>100_bases
CATTTTTCCAATAAAAAATACCGCACCATCTAAAGTGCGGTATTTTTTTATCAAATTAGGTTAATTCAACCAGCCTGCTT
GTTGAGCAATAAACAGCAAC

Product: PrlC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MSNPLLSFEGLPPFSQIKPEHVQPAVENLIQACRDNIEQLLKQEQFTWDNFILPLTEMGDRFSKAWSPVSHLNAVKNSPE
LRAAYQACLPLLSEYSTWVGQHKGLYQAYEKLKNSPEFAHYDLAQQKTIDNALRDFKLSGISLSAEKQKRYGEISARLSE
LSAQFSNNVLDATMGWDKVIENLEELKGLPESALAAAKQSAENKGLEGYRFTLEIPSYLPVMTYCENRALREEMYRAFVT
RASDQGPNAGKWDNSAIMQEILNLRVELAHLLDFNCYTELSLATKMAEKPQQVLDFLDSLAKRSKTQGEKELAELLDFCQ
TQFGVNELEAWDIAFYSEKQKQYLYSINDEELRPYFPENRVLAGLFELIQRIFNIRTVERFGIDTWHNDVRFFDLIDEND
NLRGSFYLDLYARENKRGGAWMDDCIGRRKKANGEIQKPVAYLTCNFNAPVGDKPALFTHDEVTTLFHEFGHGIHHMLTE
IDVADVAGISGVPWDAVELPSQFLENWCWEADALDFISGHYETGEPLPKEKLAQLLKAKNFQAAMFVLRQLEFGLFDFRL
HHHFDPTKANQILDTLKAVKEEVAVIKGVEWARAPHSFSHIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNPETGKS
FLAEILSRGGSEEPMTLFKRFRGREPQLDALLRHKGIAN

Sequences:

>Translated_679_residues
MSNPLLSFEGLPPFSQIKPEHVQPAVENLIQACRDNIEQLLKQEQFTWDNFILPLTEMGDRFSKAWSPVSHLNAVKNSPE
LRAAYQACLPLLSEYSTWVGQHKGLYQAYEKLKNSPEFAHYDLAQQKTIDNALRDFKLSGISLSAEKQKRYGEISARLSE
LSAQFSNNVLDATMGWDKVIENLEELKGLPESALAAAKQSAENKGLEGYRFTLEIPSYLPVMTYCENRALREEMYRAFVT
RASDQGPNAGKWDNSAIMQEILNLRVELAHLLDFNCYTELSLATKMAEKPQQVLDFLDSLAKRSKTQGEKELAELLDFCQ
TQFGVNELEAWDIAFYSEKQKQYLYSINDEELRPYFPENRVLAGLFELIQRIFNIRTVERFGIDTWHNDVRFFDLIDEND
NLRGSFYLDLYARENKRGGAWMDDCIGRRKKANGEIQKPVAYLTCNFNAPVGDKPALFTHDEVTTLFHEFGHGIHHMLTE
IDVADVAGISGVPWDAVELPSQFLENWCWEADALDFISGHYETGEPLPKEKLAQLLKAKNFQAAMFVLRQLEFGLFDFRL
HHHFDPTKANQILDTLKAVKEEVAVIKGVEWARAPHSFSHIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNPETGKS
FLAEILSRGGSEEPMTLFKRFRGREPQLDALLRHKGIAN
>Mature_678_residues
SNPLLSFEGLPPFSQIKPEHVQPAVENLIQACRDNIEQLLKQEQFTWDNFILPLTEMGDRFSKAWSPVSHLNAVKNSPEL
RAAYQACLPLLSEYSTWVGQHKGLYQAYEKLKNSPEFAHYDLAQQKTIDNALRDFKLSGISLSAEKQKRYGEISARLSEL
SAQFSNNVLDATMGWDKVIENLEELKGLPESALAAAKQSAENKGLEGYRFTLEIPSYLPVMTYCENRALREEMYRAFVTR
ASDQGPNAGKWDNSAIMQEILNLRVELAHLLDFNCYTELSLATKMAEKPQQVLDFLDSLAKRSKTQGEKELAELLDFCQT
QFGVNELEAWDIAFYSEKQKQYLYSINDEELRPYFPENRVLAGLFELIQRIFNIRTVERFGIDTWHNDVRFFDLIDENDN
LRGSFYLDLYARENKRGGAWMDDCIGRRKKANGEIQKPVAYLTCNFNAPVGDKPALFTHDEVTTLFHEFGHGIHHMLTEI
DVADVAGISGVPWDAVELPSQFLENWCWEADALDFISGHYETGEPLPKEKLAQLLKAKNFQAAMFVLRQLEFGLFDFRLH
HHFDPTKANQILDTLKAVKEEVAVIKGVEWARAPHSFSHIFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNPETGKSF
LAEILSRGGSEEPMTLFKRFRGREPQLDALLRHKGIAN

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=682, Percent_Identity=30.6451612903226, Blast_Score=308, Evalue=1e-83,
Organism=Homo sapiens, GI14149738, Length=679, Percent_Identity=29.8969072164948, Blast_Score=278, Evalue=2e-74,
Organism=Homo sapiens, GI156105687, Length=623, Percent_Identity=25.3611556982343, Blast_Score=185, Evalue=1e-46,
Organism=Escherichia coli, GI1789913, Length=678, Percent_Identity=70.0589970501475, Blast_Score=986, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=684, Percent_Identity=29.9707602339181, Blast_Score=291, Evalue=7e-80,
Organism=Caenorhabditis elegans, GI71999758, Length=562, Percent_Identity=25.4448398576512, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI32565901, Length=648, Percent_Identity=23.9197530864198, Blast_Score=126, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6319793, Length=687, Percent_Identity=28.5298398835517, Blast_Score=287, Evalue=4e-78,
Organism=Saccharomyces cerevisiae, GI6322715, Length=707, Percent_Identity=23.7623762376238, Blast_Score=145, Evalue=2e-35,
Organism=Drosophila melanogaster, GI21356111, Length=584, Percent_Identity=29.6232876712329, Blast_Score=245, Evalue=6e-65,
Organism=Drosophila melanogaster, GI20129717, Length=648, Percent_Identity=24.6913580246914, Blast_Score=174, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 77546; Mature: 77415

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPLLSFEGLPPFSQIKPEHVQPAVENLIQACRDNIEQLLKQEQFTWDNFILPLTEMGD
CCCCCCCCCCCCCHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHH
RFSKAWSPVSHLNAVKNSPELRAAYQACLPLLSEYSTWVGQHKGLYQAYEKLKNSPEFAH
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHH
YDLAQQKTIDNALRDFKLSGISLSAEKQKRYGEISARLSELSAQFSNNVLDATMGWDKVI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHH
ENLEELKGLPESALAAAKQSAENKGLEGYRFTLEIPSYLPVMTYCENRALREEMYRAFVT
HHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
RASDQGPNAGKWDNSAIMQEILNLRVELAHLLDFNCYTELSLATKMAEKPQQVLDFLDSL
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHH
AKRSKTQGEKELAELLDFCQTQFGVNELEAWDIAFYSEKQKQYLYSINDEELRPYFPENR
HHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
VLAGLFELIQRIFNIRTVERFGIDTWHNDVRFFDLIDENDNLRGSFYLDLYARENKRGGA
HHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCCC
WMDDCIGRRKKANGEIQKPVAYLTCNFNAPVGDKPALFTHDEVTTLFHEFGHGIHHMLTE
CHHHHHCHHHCCCCCHHCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
IDVADVAGISGVPWDAVELPSQFLENWCWEADALDFISGHYETGEPLPKEKLAQLLKAKN
CCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
FQAAMFVLRQLEFGLFDFRLHHHFDPTKANQILDTLKAVKEEVAVIKGVEWARAPHSFSH
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHH
IFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNPETGKSFLAEILSRGGSEEPMTLFKR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHH
FRGREPQLDALLRHKGIAN
HCCCCCHHHHHHHHCCCCC
>Mature Secondary Structure 
SNPLLSFEGLPPFSQIKPEHVQPAVENLIQACRDNIEQLLKQEQFTWDNFILPLTEMGD
CCCCCCCCCCCCHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHH
RFSKAWSPVSHLNAVKNSPELRAAYQACLPLLSEYSTWVGQHKGLYQAYEKLKNSPEFAH
HHHHHCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCHH
YDLAQQKTIDNALRDFKLSGISLSAEKQKRYGEISARLSELSAQFSNNVLDATMGWDKVI
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCHHHHH
ENLEELKGLPESALAAAKQSAENKGLEGYRFTLEIPSYLPVMTYCENRALREEMYRAFVT
HHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
RASDQGPNAGKWDNSAIMQEILNLRVELAHLLDFNCYTELSLATKMAEKPQQVLDFLDSL
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCHHHHHHHHHHH
AKRSKTQGEKELAELLDFCQTQFGVNELEAWDIAFYSEKQKQYLYSINDEELRPYFPENR
HHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCH
VLAGLFELIQRIFNIRTVERFGIDTWHNDVRFFDLIDENDNLRGSFYLDLYARENKRGGA
HHHHHHHHHHHHHHHHHHHHHCCCHHCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCCC
WMDDCIGRRKKANGEIQKPVAYLTCNFNAPVGDKPALFTHDEVTTLFHEFGHGIHHMLTE
CHHHHHCHHHCCCCCHHCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHH
IDVADVAGISGVPWDAVELPSQFLENWCWEADALDFISGHYETGEPLPKEKLAQLLKAKN
CCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCC
FQAAMFVLRQLEFGLFDFRLHHHFDPTKANQILDTLKAVKEEVAVIKGVEWARAPHSFSH
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCHHHH
IFAGGYAAGYYSYLWAEVLSADAFSRFEEEGIFNPETGKSFLAEILSRGGSEEPMTLFKR
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHH
FRGREPQLDALLRHKGIAN
HCCCCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]