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The map label for this gene is murC [H]

Identifier: 15595162

GI number: 15595162

Start: 863636

End: 865042

Strand: Direct

Name: murC [H]

Synonym: BB0817

Alternate gene names: 15595162

Gene position: 863636-865042 (Clockwise)

Preceding gene: 15595161

Following gene: 15595163

Centisome position: 94.83

GC content: 26.72

Gene sequence:

>1407_bases
ATGAAGGTTGATTTTGACGATTTGAATAATATTTTTTTTGTAGGAATAAAGGGAAGTGGGGCTTGTTCTCTGGCTTGTTT
TTTAAATTCAAAAGGGTATTGTGTAGAAGGGGTAGATGTTTCTGATAAATTTTATACCGATGAAATTTTAAGTAATAATA
AAATATCTTATTATGATAATATTTATGAGTTTTCATTAAAACAGCTTGATAGGTCTTTTGATTTAATAGTATATTCTTCA
GCCTATAATAAGGATGGTTTGCAAGTTTTACTTGAGGCAAAAGAATTAAATATACCTATTTTATCTTATCCTGAGGCTCT
TGGAGAGCTTTCTAGAAAGTACTATAGCATTGGAATTGCAGGTTCTCATGGTAAAACTACCACTACGGCGTTTTTAGGTG
TTCTTTTTAATAAATTAGGATTAAATCCCAATGTTATTGTGGGGTCAAGTGTTAAAGATTTTAAAGATAATTCTGCAATA
GCAGGTATTAGCAATATTTTTATTGTTGAAACTTGTGAATATAAGAAACATTTTTTGAATTTTAGCCCTAATATGCTTAT
TTTAACCAATGTTGACTACGAGCATGTTGATTTTTTTAAAAATTATGAGGCTCTTGAAGAGGCTTTTTTACAGTATATTA
ATAATTTAAAGAAAAATGGAATATTGATAATTAATTCCGATGATAATAATTTGCTTAAAATTAAAAGGCAAATCAACAGA
AAAGATATAAGTATTTTTAGCTATGGGTCTGGAGATTTATCTGATTTTCAAATAAGTAATATTGCAGTTAGGAGTGAATA
TTTTTGTTTTTCTTTTTTAGGCTTGTTAAATGTTGAGCTTAAGACTGTTTTATTTCATAATGTATTAAATTTTTCAGCAG
CGCTTTTGGCTTTAAATCTTTTCTTAGAAAGTAATGGGAAATCAATTTTTGATTTTGAAGAAGCAATAAAGAGAATTGCA
AAAAATTATAGCGGTATAAAAAGAAGGGTTGAAGTTGTTAAAGAGGAAAATGGAGTGATTTACATGGACGATTATGCTCA
TCATCCTAGGGAAATTAAAAATACTCTTTTTGGTATTAAAAATTTTTATAAGAATAAACGTATAATTTTGGATTTTATGC
CTCATACCTTTACAAGAACAAAAGAATTTTTTGCCGATTTTGTTGAAGTTCTAAGTGCTGCCGATATATTAATTTTGCAC
AATATATATCTTTCAAATAGGGAAAATTTTAATCCAGATGAACTTTCTGTTAAATTGTTTTTAAATATTAAAAAAATAAA
TAAGAATACTTATTTTTTTAAGGATGTTAAAGACTCTATTAATTTTATAAAAAGTTTATTAATATCTGGAGACTTGTTTA
TTACAATGGGCGCTGGAAATAATTTTATTTTACACGATTTTCTGTAA

Upstream 100 bases:

>100_bases
ATTATTACGAACGTACTTAAGTATACAATAATTAATATATTATCTATCGATATAGTTATACATAAATTTTATGACAAAAA
AGATTATTTAGAAGAGAGCT

Downstream 100 bases:

>100_bases
GGGTGTTATATTGAAAAGCATGACGGGATTTTTTTATTTGGAAAAGATAATTGGTAACTATATGTTTAGTGTTAATTTGA
AATCTTATAATGGAAAGTTT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 468; Mature: 468

Protein sequence:

>468_residues
MKVDFDDLNNIFFVGIKGSGACSLACFLNSKGYCVEGVDVSDKFYTDEILSNNKISYYDNIYEFSLKQLDRSFDLIVYSS
AYNKDGLQVLLEAKELNIPILSYPEALGELSRKYYSIGIAGSHGKTTTTAFLGVLFNKLGLNPNVIVGSSVKDFKDNSAI
AGISNIFIVETCEYKKHFLNFSPNMLILTNVDYEHVDFFKNYEALEEAFLQYINNLKKNGILIINSDDNNLLKIKRQINR
KDISIFSYGSGDLSDFQISNIAVRSEYFCFSFLGLLNVELKTVLFHNVLNFSAALLALNLFLESNGKSIFDFEEAIKRIA
KNYSGIKRRVEVVKEENGVIYMDDYAHHPREIKNTLFGIKNFYKNKRIILDFMPHTFTRTKEFFADFVEVLSAADILILH
NIYLSNRENFNPDELSVKLFLNIKKINKNTYFFKDVKDSINFIKSLLISGDLFITMGAGNNFILHDFL

Sequences:

>Translated_468_residues
MKVDFDDLNNIFFVGIKGSGACSLACFLNSKGYCVEGVDVSDKFYTDEILSNNKISYYDNIYEFSLKQLDRSFDLIVYSS
AYNKDGLQVLLEAKELNIPILSYPEALGELSRKYYSIGIAGSHGKTTTTAFLGVLFNKLGLNPNVIVGSSVKDFKDNSAI
AGISNIFIVETCEYKKHFLNFSPNMLILTNVDYEHVDFFKNYEALEEAFLQYINNLKKNGILIINSDDNNLLKIKRQINR
KDISIFSYGSGDLSDFQISNIAVRSEYFCFSFLGLLNVELKTVLFHNVLNFSAALLALNLFLESNGKSIFDFEEAIKRIA
KNYSGIKRRVEVVKEENGVIYMDDYAHHPREIKNTLFGIKNFYKNKRIILDFMPHTFTRTKEFFADFVEVLSAADILILH
NIYLSNRENFNPDELSVKLFLNIKKINKNTYFFKDVKDSINFIKSLLISGDLFITMGAGNNFILHDFL
>Mature_468_residues
MKVDFDDLNNIFFVGIKGSGACSLACFLNSKGYCVEGVDVSDKFYTDEILSNNKISYYDNIYEFSLKQLDRSFDLIVYSS
AYNKDGLQVLLEAKELNIPILSYPEALGELSRKYYSIGIAGSHGKTTTTAFLGVLFNKLGLNPNVIVGSSVKDFKDNSAI
AGISNIFIVETCEYKKHFLNFSPNMLILTNVDYEHVDFFKNYEALEEAFLQYINNLKKNGILIINSDDNNLLKIKRQINR
KDISIFSYGSGDLSDFQISNIAVRSEYFCFSFLGLLNVELKTVLFHNVLNFSAALLALNLFLESNGKSIFDFEEAIKRIA
KNYSGIKRRVEVVKEENGVIYMDDYAHHPREIKNTLFGIKNFYKNKRIILDFMPHTFTRTKEFFADFVEVLSAADILILH
NIYLSNRENFNPDELSVKLFLNIKKINKNTYFFKDVKDSINFIKSLLISGDLFITMGAGNNFILHDFL

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=464, Percent_Identity=27.801724137931, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1790680, Length=475, Percent_Identity=23.5789473684211, Blast_Score=115, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53481; Mature: 53481

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00936 RIBOSOMAL_L35

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVDFDDLNNIFFVGIKGSGACSLACFLNSKGYCVEGVDVSDKFYTDEILSNNKISYYDN
CCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHCCCCEEEHHH
IYEFSLKQLDRSFDLIVYSSAYNKDGLQVLLEAKELNIPILSYPEALGELSRKYYSIGIA
HHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEHHHCCCCEEECHHHHHHHHHHEEEEEEE
GSHGKTTTTAFLGVLFNKLGLNPNVIVGSSVKDFKDNSAIAGISNIFIVETCEYKKHFLN
CCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCEECCCEEEEEEECHHHHHHHC
FSPNMLILTNVDYEHVDFFKNYEALEEAFLQYINNLKKNGILIINSDDNNLLKIKRQINR
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHCCC
KDISIFSYGSGDLSDFQISNIAVRSEYFCFSFLGLLNVELKTVLFHNVLNFSAALLALNL
CCEEEEECCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLESNGKSIFDFEEAIKRIAKNYSGIKRRVEVVKEENGVIYMDDYAHHPREIKNTLFGIK
HEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHH
NFYKNKRIILDFMPHTFTRTKEFFADFVEVLSAADILILHNIYLSNRENFNPDELSVKLF
HHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCEEEEEE
LNIKKINKNTYFFKDVKDSINFIKSLLISGDLFITMGAGNNFILHDFL
EEEEEECCCEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCC
>Mature Secondary Structure
MKVDFDDLNNIFFVGIKGSGACSLACFLNSKGYCVEGVDVSDKFYTDEILSNNKISYYDN
CCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEECCCCCCCHHHHHHHCCCCEEEHHH
IYEFSLKQLDRSFDLIVYSSAYNKDGLQVLLEAKELNIPILSYPEALGELSRKYYSIGIA
HHHHHHHHCCCCEEEEEEECCCCCCCCEEEEEHHHCCCCEEECHHHHHHHHHHEEEEEEE
GSHGKTTTTAFLGVLFNKLGLNPNVIVGSSVKDFKDNSAIAGISNIFIVETCEYKKHFLN
CCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCEECCCEEEEEEECHHHHHHHC
FSPNMLILTNVDYEHVDFFKNYEALEEAFLQYINNLKKNGILIINSDDNNLLKIKRQINR
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCEEHHHHHCCC
KDISIFSYGSGDLSDFQISNIAVRSEYFCFSFLGLLNVELKTVLFHNVLNFSAALLALNL
CCEEEEECCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FLESNGKSIFDFEEAIKRIAKNYSGIKRRVEVVKEENGVIYMDDYAHHPREIKNTLFGIK
HEECCCCEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHH
NFYKNKRIILDFMPHTFTRTKEFFADFVEVLSAADILILHNIYLSNRENFNPDELSVKLF
HHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCCCCCCEEEEEE
LNIKKINKNTYFFKDVKDSINFIKSLLISGDLFITMGAGNNFILHDFL
EEEEEECCCEEEEHHHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA