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The map label for this gene is apt [H]

Identifier: 15595122

GI number: 15595122

Start: 818018

End: 818548

Strand: Direct

Name: apt [H]

Synonym: BB0777

Alternate gene names: 15595122

Gene position: 818018-818548 (Clockwise)

Preceding gene: 15595121

Following gene: 15595123

Centisome position: 89.82

GC content: 32.96

Gene sequence:

>531_bases
ATGAAAAATAAGACAGAGTATTATGATCAGTTTATTTCAAAAATACCCAATTTTCCTAAAAAGGGTGTTCTTTTTTATGA
TATTACTAGCGTTTTGCTAAAACCCGAAGTTTATAGTTCATTAATAAATGAAGTATATTCTTTTTATAATTTTAAAAAGA
TCGATTGCATTGCAGTTGTTGAGTCTAGGGGATATTTAATAGGTGCTCCTTTGTCTTTAAAAATGCAGCTACCCCTTGTT
TTAATTCGAAAAGAGGGTAAATTGCCCAGAGAGGTTTTTAGTGAAGAGTATGAGCTTGAATATGGTTTTGGGAGAATAGA
GGTGCACAAAGACGATGTTAGGACGTATTCCAATATTCTTTTAATAGATGACATATTAGCTACCGGTGGAACTTTAAAGT
CGTCTGCAATTTTGCTAGAGAGAGCCGGGGGCAAGGTTAAGGATATTTTTTGTTTTATTGAGCTTTGCGCTATTAATGGT
AGACAAAGTCTTGAAAGTTATGAAGTCAATTCCCTTGTAAGGTATAATTAA

Upstream 100 bases:

>100_bases
TTGCATAATCTTGTTCCAGCGCCCCCTGTGAAAAAATAAATTTGGCTTTTGGTCTTGATATTTGAAAAATATATAAACAT
ATAGATGGGATAAGTAGGTT

Downstream 100 bases:

>100_bases
TTTAATGCTTGACTTTTCTTTTTTATTAAATTTACAATGTTTAGTTGAGGTAATATATGTATGCACTGGTAGAAATAAAT
GGCAAGCAATATAAGGCTAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MKNKTEYYDQFISKIPNFPKKGVLFYDITSVLLKPEVYSSLINEVYSFYNFKKIDCIAVVESRGYLIGAPLSLKMQLPLV
LIRKEGKLPREVFSEEYELEYGFGRIEVHKDDVRTYSNILLIDDILATGGTLKSSAILLERAGGKVKDIFCFIELCAING
RQSLESYEVNSLVRYN

Sequences:

>Translated_176_residues
MKNKTEYYDQFISKIPNFPKKGVLFYDITSVLLKPEVYSSLINEVYSFYNFKKIDCIAVVESRGYLIGAPLSLKMQLPLV
LIRKEGKLPREVFSEEYELEYGFGRIEVHKDDVRTYSNILLIDDILATGGTLKSSAILLERAGGKVKDIFCFIELCAING
RQSLESYEVNSLVRYN
>Mature_176_residues
MKNKTEYYDQFISKIPNFPKKGVLFYDITSVLLKPEVYSSLINEVYSFYNFKKIDCIAVVESRGYLIGAPLSLKMQLPLV
LIRKEGKLPREVFSEEYELEYGFGRIEVHKDDVRTYSNILLIDDILATGGTLKSSAILLERAGGKVKDIFCFIELCAING
RQSLESYEVNSLVRYN

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=177, Percent_Identity=35.0282485875706, Blast_Score=114, Evalue=3e-26,
Organism=Homo sapiens, GI71773201, Length=130, Percent_Identity=36.9230769230769, Blast_Score=91, Evalue=5e-19,
Organism=Escherichia coli, GI1786675, Length=169, Percent_Identity=39.6449704142012, Blast_Score=136, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=35.8823529411765, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=159, Percent_Identity=34.5911949685535, Blast_Score=88, Evalue=8e-19,
Organism=Drosophila melanogaster, GI17136334, Length=178, Percent_Identity=34.8314606741573, Blast_Score=105, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20174; Mature: 20174

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNKTEYYDQFISKIPNFPKKGVLFYDITSVLLKPEVYSSLINEVYSFYNFKKIDCIAVV
CCCHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEEEE
ESRGYLIGAPLSLKMQLPLVLIRKEGKLPREVFSEEYELEYGFGRIEVHKDDVRTYSNIL
ECCCEEEECCEEEEEECCEEEEECCCCCCHHHCCCCEEEEECCCEEEEEHHHHHHHHCEE
LIDDILATGGTLKSSAILLERAGGKVKDIFCFIELCAINGRQSLESYEVNSLVRYN
EEEHHHHCCCCCCHHEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHCCCEEEECC
>Mature Secondary Structure
MKNKTEYYDQFISKIPNFPKKGVLFYDITSVLLKPEVYSSLINEVYSFYNFKKIDCIAVV
CCCHHHHHHHHHHHCCCCCCCCEEEEEHHHHHHCHHHHHHHHHHHHHHHCCCCEEEEEEE
ESRGYLIGAPLSLKMQLPLVLIRKEGKLPREVFSEEYELEYGFGRIEVHKDDVRTYSNIL
ECCCEEEECCEEEEEECCEEEEECCCCCCHHHCCCCEEEEECCCEEEEEHHHHHHHHCEE
LIDDILATGGTLKSSAILLERAGGKVKDIFCFIELCAINGRQSLESYEVNSLVRYN
EEEHHHHCCCCCCHHEEEEECCCCCHHHHHHHHHHHHCCCHHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA