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The map label for this gene is kdsA [H]

Identifier: 154248123

GI number: 154248123

Start: 4653155

End: 4654033

Strand: Direct

Name: kdsA [H]

Synonym: Xaut_4203

Alternate gene names: 154248123

Gene position: 4653155-4654033 (Clockwise)

Preceding gene: 154248122

Following gene: 154248124

Centisome position: 87.65

GC content: 70.31

Gene sequence:

>879_bases
ATGACCGCCGCACCGCCCGCCACCACGCCGCAGCCCATCGTCGAGGTGGGGCAAGATGTGGACCTCGTGCGCATCGGCAA
TGGCCTGCCGCTGGCGCTCATCGCCGGCCCCTGCCAGATGGAAAGCCGCGCCCACGCGCTGGAGGTGGCCTCCGCCCTGA
AGGAGATCACCCGGCGGCGCGGCATCGGCCTCATCTTCAAGACCTCATTCGACAAGGCCAACCGCACCTCGCTCTCGGCC
CAGCGGGGCCTCGGGCTGGAAGCCGCCCTGCCGGTGTTCGCCGAGATCCGCGAGAGCCTCGGCCTGCCGGTGCTCACCGA
CGTGCACGAGATCGACCAGTGCGCCGCCGCCGCGCAGGCGGTGGACGTGCTCCAGATCCCCGCCTTCCTGTGCCGCCAGA
CCGATCTGCTCATCGCCGCCGCCCGCACCGGCAAGACGGTGAACGTGAAGAAGGGCCAGTTCCTCGCCCCCTGGGACATG
GCCAATGTGGTGAACAAGCTCACCGGCGCCGGCAACGGCCGGGTGCTGGTGACCGAGCGGGGCGTGTCGTTCGGCTACAA
CACCCTCGTCTCCGACATGCGGGCGCTGCCCATCCTCGCCAAGACCACGGGCGCGCCGGTGGTGTTCGATGCCACCCATT
CGGTGCAGCAGCCGGGCGGGCAGGGCTCCTCCTCCGGCGGCCAGCGCGAGTTCGTGCCGGTGCTGGCCCGCGCGGCGGTG
GCCGTGGGAGTCGCCGCGGTGTTCATCGAGACCCACCCCGACCCGGACAAGGCCCCTTCCGACGGGCCGAACATGGTGCC
GCTCTCCCAGCTGGAAGCGCTGATCACCACGCTTCAGGCGTTCGACGCCGTTGCAAAAGCCAATCCCGTCACCATCTGA

Upstream 100 bases:

>100_bases
GCTGAAGCTGGTCACGCCCTGACGAACCGACTAGTTTGGCGCGCCGCCGGGGCCTCACTGTAAAGCGTTGCCCGGCGGCG
CTGCTTCCAAGGATGATCCC

Downstream 100 bases:

>100_bases
CCACAGCTTGGGCTTGGCTGTCCGGCCCCTTCGGACCAGCCGCTTCGGGCGCGTTCCTGTGCGCCGGGCGGCATGGTCCG
GCTGAAGGGTGCGTCCGCGC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MTAAPPATTPQPIVEVGQDVDLVRIGNGLPLALIAGPCQMESRAHALEVASALKEITRRRGIGLIFKTSFDKANRTSLSA
QRGLGLEAALPVFAEIRESLGLPVLTDVHEIDQCAAAAQAVDVLQIPAFLCRQTDLLIAAARTGKTVNVKKGQFLAPWDM
ANVVNKLTGAGNGRVLVTERGVSFGYNTLVSDMRALPILAKTTGAPVVFDATHSVQQPGGQGSSSGGQREFVPVLARAAV
AVGVAAVFIETHPDPDKAPSDGPNMVPLSQLEALITTLQAFDAVAKANPVTI

Sequences:

>Translated_292_residues
MTAAPPATTPQPIVEVGQDVDLVRIGNGLPLALIAGPCQMESRAHALEVASALKEITRRRGIGLIFKTSFDKANRTSLSA
QRGLGLEAALPVFAEIRESLGLPVLTDVHEIDQCAAAAQAVDVLQIPAFLCRQTDLLIAAARTGKTVNVKKGQFLAPWDM
ANVVNKLTGAGNGRVLVTERGVSFGYNTLVSDMRALPILAKTTGAPVVFDATHSVQQPGGQGSSSGGQREFVPVLARAAV
AVGVAAVFIETHPDPDKAPSDGPNMVPLSQLEALITTLQAFDAVAKANPVTI
>Mature_291_residues
TAAPPATTPQPIVEVGQDVDLVRIGNGLPLALIAGPCQMESRAHALEVASALKEITRRRGIGLIFKTSFDKANRTSLSAQ
RGLGLEAALPVFAEIRESLGLPVLTDVHEIDQCAAAAQAVDVLQIPAFLCRQTDLLIAAARTGKTVNVKKGQFLAPWDMA
NVVNKLTGAGNGRVLVTERGVSFGYNTLVSDMRALPILAKTTGAPVVFDATHSVQQPGGQGSSSGGQREFVPVLARAAVA
VGVAAVFIETHPDPDKAPSDGPNMVPLSQLEALITTLQAFDAVAKANPVTI

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=278, Percent_Identity=43.8848920863309, Blast_Score=252, Evalue=2e-68,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 30465; Mature: 30334

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAAPPATTPQPIVEVGQDVDLVRIGNGLPLALIAGPCQMESRAHALEVASALKEITRRR
CCCCCCCCCCHHHHHCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHC
GIGLIFKTSFDKANRTSLSAQRGLGLEAALPVFAEIRESLGLPVLTDVHEIDQCAAAAQA
CCEEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
VDVLQIPAFLCRQTDLLIAAARTGKTVNVKKGQFLAPWDMANVVNKLTGAGNGRVLVTER
HHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCEECCHHHHHHHHHHCCCCCCEEEEEEC
GVSFGYNTLVSDMRALPILAKTTGAPVVFDATHSVQQPGGQGSSSGGQREFVPVLARAAV
CCCCCHHHHHHHHHHCCEEEECCCCCEEEECCHHHCCCCCCCCCCCCCHHHHHHHHHHHH
AVGVAAVFIETHPDPDKAPSDGPNMVPLSQLEALITTLQAFDAVAKANPVTI
HHHHHHEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TAAPPATTPQPIVEVGQDVDLVRIGNGLPLALIAGPCQMESRAHALEVASALKEITRRR
CCCCCCCCCHHHHHCCCCCCEEEECCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHC
GIGLIFKTSFDKANRTSLSAQRGLGLEAALPVFAEIRESLGLPVLTDVHEIDQCAAAAQA
CCEEEEEECCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
VDVLQIPAFLCRQTDLLIAAARTGKTVNVKKGQFLAPWDMANVVNKLTGAGNGRVLVTER
HHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCEECCHHHHHHHHHHCCCCCCEEEEEEC
GVSFGYNTLVSDMRALPILAKTTGAPVVFDATHSVQQPGGQGSSSGGQREFVPVLARAAV
CCCCCHHHHHHHHHHCCEEEECCCCCEEEECCHHHCCCCCCCCCCCCCHHHHHHHHHHHH
AVGVAAVFIETHPDPDKAPSDGPNMVPLSQLEALITTLQAFDAVAKANPVTI
HHHHHHEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]