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The map label for this gene is gyaR [H]

Identifier: 154248047

GI number: 154248047

Start: 4565653

End: 4566654

Strand: Direct

Name: gyaR [H]

Synonym: Xaut_4126

Alternate gene names: 154248047

Gene position: 4565653-4566654 (Clockwise)

Preceding gene: 154248045

Following gene: 154248048

Centisome position: 86.0

GC content: 67.56

Gene sequence:

>1002_bases
ATGGTGCGTCGCAAACCCCTCGTCGTCGTCACGCGCAAGCTGCCGGACTCGGTTGAAACCCGGATGCGCGAGTTGTTCGA
CGCGCAATTGAATCTCGACGACGTGCCCATGGATCAGGCCGCGCTCGTGGAGGCCGTCCGGACCGCCGACGTGCTGGTTC
CCACCCTGACCGACCGCATCGATTCGGCGGTCCTGTCGCAGGCTGGGGAAAACCTGCGGCTGATTGCCTCCTTCTCCAAC
GGCGTCGATCACATCGACGTGGCGAGCGCGCTCAATCGCGGCATCACCGTCACCAACACGCCGGGCGTCCTCACCGAGGA
CACGGCCGACATGACCATGGCGCTGATCCTCGCCGTGCCTCGCCGGTTGGCCGAGGGTGCGCAGGCGGTGATCGCGGACA
AGGACGAATGGCTCGGCTGGTCGCCCACATGGATGCTGGGCCGGCGCATCTGGGGCAAGCGCCTCGGCATCATCGGCATG
GGCCGCATCGGCCAGGCGGTCGCGCGCCGCGCCAAGGCCTTCGGCCTGCAGATCCACTACCACAACCGCCGCCGCCTCCC
CACCGGCATCGAGGAGATGCTGGACGCCACCTATTGGGACAGCCTCGACCAGATGCTGGCGCGCATGGACATCGTGTCCA
TCAACTGCCCGCACACGCCGGCCACCTACCATCTGCTCTCGGCGCGGCGGCTCAAGCTGCTCAAGCCCGAGGCCTATGTG
GTGAACACCGCCCGCGGCGAGGTGATCGACGAGAACGCCCTGACCCGCCAGCTTGAGGCAGGCGAGCTGGCCGGTGCCGG
CCTCGACGTGTTCGAGCATGAGCCGGCGGTGAACCCGAAGCTCATCCGCCTCGCCAAGCAGGGCAAGGTGGTGCTGCTGC
CGCACCTGGGCTCGGCCACGCTGGAAGGCCGCGTGGACATGGGTGAGAAGGTCATCGTCAACATCAAGACCTTCATGGAC
GGCCACCGCCCGCCGGACCGCGTGCTTCCCGCCATGCTGTGA

Upstream 100 bases:

>100_bases
CGGGCGCGTCAAGGGCACGCGGTGCAGGGCGCCTTGTGTTTCCCTGTCTGTCTGATAGACGGGACCAGAAGCGTTAAGAA
ATGGGGAATGGGGAGTAACG

Downstream 100 bases:

>100_bases
GGGCGGGGGCGCCTGATTGGGGTGCGGTTAAGCCCATACCCGCGATTAGTGTGCCCCCTCTGGGGTCCTTGAACGAAGTT
CTTGGATCTAGGAGACAAGG

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MVRRKPLVVVTRKLPDSVETRMRELFDAQLNLDDVPMDQAALVEAVRTADVLVPTLTDRIDSAVLSQAGENLRLIASFSN
GVDHIDVASALNRGITVTNTPGVLTEDTADMTMALILAVPRRLAEGAQAVIADKDEWLGWSPTWMLGRRIWGKRLGIIGM
GRIGQAVARRAKAFGLQIHYHNRRRLPTGIEEMLDATYWDSLDQMLARMDIVSINCPHTPATYHLLSARRLKLLKPEAYV
VNTARGEVIDENALTRQLEAGELAGAGLDVFEHEPAVNPKLIRLAKQGKVVLLPHLGSATLEGRVDMGEKVIVNIKTFMD
GHRPPDRVLPAML

Sequences:

>Translated_333_residues
MVRRKPLVVVTRKLPDSVETRMRELFDAQLNLDDVPMDQAALVEAVRTADVLVPTLTDRIDSAVLSQAGENLRLIASFSN
GVDHIDVASALNRGITVTNTPGVLTEDTADMTMALILAVPRRLAEGAQAVIADKDEWLGWSPTWMLGRRIWGKRLGIIGM
GRIGQAVARRAKAFGLQIHYHNRRRLPTGIEEMLDATYWDSLDQMLARMDIVSINCPHTPATYHLLSARRLKLLKPEAYV
VNTARGEVIDENALTRQLEAGELAGAGLDVFEHEPAVNPKLIRLAKQGKVVLLPHLGSATLEGRVDMGEKVIVNIKTFMD
GHRPPDRVLPAML
>Mature_333_residues
MVRRKPLVVVTRKLPDSVETRMRELFDAQLNLDDVPMDQAALVEAVRTADVLVPTLTDRIDSAVLSQAGENLRLIASFSN
GVDHIDVASALNRGITVTNTPGVLTEDTADMTMALILAVPRRLAEGAQAVIADKDEWLGWSPTWMLGRRIWGKRLGIIGM
GRIGQAVARRAKAFGLQIHYHNRRRLPTGIEEMLDATYWDSLDQMLARMDIVSINCPHTPATYHLLSARRLKLLKPEAYV
VNTARGEVIDENALTRQLEAGELAGAGLDVFEHEPAVNPKLIRLAKQGKVVLLPHLGSATLEGRVDMGEKVIVNIKTFMD
GHRPPDRVLPAML

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=325, Percent_Identity=34.1538461538462, Blast_Score=171, Evalue=7e-43,
Organism=Homo sapiens, GI23308577, Length=315, Percent_Identity=29.2063492063492, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI61743967, Length=264, Percent_Identity=35.2272727272727, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI4557497, Length=266, Percent_Identity=34.9624060150376, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI145580578, Length=265, Percent_Identity=34.3396226415094, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI4557499, Length=265, Percent_Identity=34.3396226415094, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI145580575, Length=265, Percent_Identity=34.3396226415094, Blast_Score=127, Evalue=2e-29,
Organism=Escherichia coli, GI87082289, Length=331, Percent_Identity=38.368580060423, Blast_Score=177, Evalue=6e-46,
Organism=Escherichia coli, GI1789279, Length=287, Percent_Identity=30.6620209059233, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787645, Length=273, Percent_Identity=25.2747252747253, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788660, Length=292, Percent_Identity=26.027397260274, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=274, Percent_Identity=29.5620437956204, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI25147481, Length=268, Percent_Identity=30.2238805970149, Blast_Score=109, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=309, Percent_Identity=34.3042071197411, Blast_Score=155, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6320925, Length=306, Percent_Identity=29.4117647058824, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322116, Length=309, Percent_Identity=28.1553398058252, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324964, Length=283, Percent_Identity=28.2685512367491, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321253, Length=264, Percent_Identity=28.7878787878788, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325144, Length=156, Percent_Identity=33.974358974359, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=149, Percent_Identity=30.2013422818792, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI28571528, Length=290, Percent_Identity=38.2758620689655, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI45552429, Length=279, Percent_Identity=35.4838709677419, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI45551003, Length=279, Percent_Identity=35.4838709677419, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI24585514, Length=279, Percent_Identity=35.4838709677419, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI28574282, Length=279, Percent_Identity=35.4838709677419, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI28574284, Length=279, Percent_Identity=35.4838709677419, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI28574286, Length=304, Percent_Identity=32.8947368421053, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24646446, Length=207, Percent_Identity=39.6135265700483, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24646448, Length=207, Percent_Identity=39.6135265700483, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24646452, Length=207, Percent_Identity=39.6135265700483, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24646450, Length=207, Percent_Identity=39.6135265700483, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI62472511, Length=207, Percent_Identity=39.6135265700483, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI19921140, Length=275, Percent_Identity=31.6363636363636, Blast_Score=133, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24585516, Length=292, Percent_Identity=27.7397260273973, Blast_Score=130, Evalue=9e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36772; Mature: 36772

Theoretical pI: Translated: 7.84; Mature: 7.84

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRRKPLVVVTRKLPDSVETRMRELFDAQLNLDDVPMDQAALVEAVRTADVLVPTLTDRI
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DSAVLSQAGENLRLIASFSNGVDHIDVASALNRGITVTNTPGVLTEDTADMTMALILAVP
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCEECCHHHHHHHHHHHHH
RRLAEGAQAVIADKDEWLGWSPTWMLGRRIWGKRLGIIGMGRIGQAVARRAKAFGLQIHY
HHHHCCCCEEECCCHHCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHEEEEEE
HNRRRLPTGIEEMLDATYWDSLDQMLARMDIVSINCPHTPATYHLLSARRLKLLKPEAYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
VNTARGEVIDENALTRQLEAGELAGAGLDVFEHEPAVNPKLIRLAKQGKVVLLPHLGSAT
EECCCCCEECCHHHHHHHHCCHHCCCCCHHHCCCCCCCHHHHHEECCCCEEEEECCCCCC
LEGRVDMGEKVIVNIKTFMDGHRPPDRVLPAML
CCCCCCCCCEEEEEEHHHHCCCCCHHHHCCCCC
>Mature Secondary Structure
MVRRKPLVVVTRKLPDSVETRMRELFDAQLNLDDVPMDQAALVEAVRTADVLVPTLTDRI
CCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
DSAVLSQAGENLRLIASFSNGVDHIDVASALNRGITVTNTPGVLTEDTADMTMALILAVP
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCEEEECCCCCEECCHHHHHHHHHHHHH
RRLAEGAQAVIADKDEWLGWSPTWMLGRRIWGKRLGIIGMGRIGQAVARRAKAFGLQIHY
HHHHCCCCEEECCCHHCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHHHEEEEEE
HNRRRLPTGIEEMLDATYWDSLDQMLARMDIVSINCPHTPATYHLLSARRLKLLKPEAYV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHHHCCCCEEE
VNTARGEVIDENALTRQLEAGELAGAGLDVFEHEPAVNPKLIRLAKQGKVVLLPHLGSAT
EECCCCCEECCHHHHHHHHCCHHCCCCCHHHCCCCCCCHHHHHEECCCCEEEEECCCCCC
LEGRVDMGEKVIVNIKTFMDGHRPPDRVLPAML
CCCCCCCCCEEEEEEHHHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA