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The map label for this gene is alsR [H]

Identifier: 154247911

GI number: 154247911

Start: 4418696

End: 4419706

Strand: Direct

Name: alsR [H]

Synonym: Xaut_3989

Alternate gene names: 154247911

Gene position: 4418696-4419706 (Clockwise)

Preceding gene: 154247910

Following gene: 154247923

Centisome position: 83.23

GC content: 53.71

Gene sequence:

>1011_bases
ATGCCGTTATTGAAATGGAGAACGTTTCCAATGTCGAATAACAGTACGGAAATTGAAATCCGCTACCTCAGGTATTTAAT
CGCTGCTTCCGAATATGGAAGCTTTCGGAAGGCAGCAGCGGCACTCGGTGTGCAGGAGTCCTCCGTTAGTCGGCGGATCC
GGGACATCGAGGATCAGGTCGGGGCCTCCCTGTTCTTGCGACACCCCGGGGGGATCAACCTGACCATAGCCGGACAACGC
TTCCTGCATCGGGTCCGCCATGCGTTGGACCACATTCGCGACGCGGCGGCGGAGGTGGCCGCCATTGGTCGTGCCGAGGA
CGGATACGTCAAAGTGGGACTATTTTCTTCACTTTCATCGGGTTTTTTGTCGGACTTATTTCGAGAATATGACGCAAAAT
ATGGATCTGTTCATATCGATTTCGTCGACGGCGAAGCACACGATCACATCAACTCCATTCGGAAATTTCAGCTTGATATT
GCTTTTGTCATCGGATTGGGCGATTGGCCGGAATGCGATACAACTTATCTTTGGTCGGAACAGGTTCTTGTGGCATTGCC
CGAAGGCCATCCGCTTTCCACCGAGGACGCGTTGACATGGCGAGATCTCAGTTCTGAAAAAATTCTTATCCGAGACACTG
CGGCTGGGATGAGAATCCAAGACTATGTCATTCGCAAAATCCGGGAAGTCGAATGCGAGCCCCGTGTCGAGGCTCAGCGG
GTTGGGCGATATAAGCTTCTCAATCTCGTCGCGTCCGGCCGCGGAATAACGTTGGTCATAGAATCCGAAAATTTGGTCAA
GGTCCCCGGCGTTATCTATCGTTCTCTGCGCGGCGAGGTGCTCCAGTTCTATGCTGCATGGTCGCCGAAAAACGACAATC
CCGCGTTTCGGACATTGCTCAGCCTTGCTCGATCGATGGCTCGCTCTTCAGCACCCCAGACGTCATCCCCCGTGCAGGAT
CTGGATGGGGTGCTTGCCGAGCCTTCGCGAAAACGCGATCTGTCGCGATGA

Upstream 100 bases:

>100_bases
TAATCCGACGATATAATTTTAATATTTCGCATACTTGCACATAAAATACAAACATTTGATGCGTAATATTTGTGATATCA
TGTAATTCATACTGAATTGT

Downstream 100 bases:

>100_bases
AGCGCTCCAGCATGGGCGCGATCAGCCTGACGGGATCGGTGATCGGATTCCCCGTCTCGCCACCCAGCACCTGCGCATAG
GCGACAAGATCGCGGTGCAG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MPLLKWRTFPMSNNSTEIEIRYLRYLIAASEYGSFRKAAAALGVQESSVSRRIRDIEDQVGASLFLRHPGGINLTIAGQR
FLHRVRHALDHIRDAAAEVAAIGRAEDGYVKVGLFSSLSSGFLSDLFREYDAKYGSVHIDFVDGEAHDHINSIRKFQLDI
AFVIGLGDWPECDTTYLWSEQVLVALPEGHPLSTEDALTWRDLSSEKILIRDTAAGMRIQDYVIRKIREVECEPRVEAQR
VGRYKLLNLVASGRGITLVIESENLVKVPGVIYRSLRGEVLQFYAAWSPKNDNPAFRTLLSLARSMARSSAPQTSSPVQD
LDGVLAEPSRKRDLSR

Sequences:

>Translated_336_residues
MPLLKWRTFPMSNNSTEIEIRYLRYLIAASEYGSFRKAAAALGVQESSVSRRIRDIEDQVGASLFLRHPGGINLTIAGQR
FLHRVRHALDHIRDAAAEVAAIGRAEDGYVKVGLFSSLSSGFLSDLFREYDAKYGSVHIDFVDGEAHDHINSIRKFQLDI
AFVIGLGDWPECDTTYLWSEQVLVALPEGHPLSTEDALTWRDLSSEKILIRDTAAGMRIQDYVIRKIREVECEPRVEAQR
VGRYKLLNLVASGRGITLVIESENLVKVPGVIYRSLRGEVLQFYAAWSPKNDNPAFRTLLSLARSMARSSAPQTSSPVQD
LDGVLAEPSRKRDLSR
>Mature_335_residues
PLLKWRTFPMSNNSTEIEIRYLRYLIAASEYGSFRKAAAALGVQESSVSRRIRDIEDQVGASLFLRHPGGINLTIAGQRF
LHRVRHALDHIRDAAAEVAAIGRAEDGYVKVGLFSSLSSGFLSDLFREYDAKYGSVHIDFVDGEAHDHINSIRKFQLDIA
FVIGLGDWPECDTTYLWSEQVLVALPEGHPLSTEDALTWRDLSSEKILIRDTAAGMRIQDYVIRKIREVECEPRVEAQRV
GRYKLLNLVASGRGITLVIESENLVKVPGVIYRSLRGEVLQFYAAWSPKNDNPAFRTLLSLARSMARSSAPQTSSPVQDL
DGVLAEPSRKRDLSR

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788887, Length=289, Percent_Identity=25.6055363321799, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1787879, Length=290, Percent_Identity=26.8965517241379, Blast_Score=101, Evalue=6e-23,
Organism=Escherichia coli, GI2367136, Length=285, Percent_Identity=26.3157894736842, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1790399, Length=242, Percent_Identity=23.5537190082645, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI157672245, Length=207, Percent_Identity=24.1545893719807, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790262, Length=193, Percent_Identity=23.8341968911917, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788748, Length=243, Percent_Identity=23.4567901234568, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1787601, Length=177, Percent_Identity=22.5988700564972, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI145693105, Length=201, Percent_Identity=20.3980099502488, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1789204, Length=193, Percent_Identity=25.9067357512953, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787806, Length=173, Percent_Identity=23.121387283237, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786401, Length=143, Percent_Identity=28.6713286713287, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 37673; Mature: 37542

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLLKWRTFPMSNNSTEIEIRYLRYLIAASEYGSFRKAAAALGVQESSVSRRIRDIEDQV
CCCCEEEECCCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GASLFLRHPGGINLTIAGQRFLHRVRHALDHIRDAAAEVAAIGRAEDGYVKVGLFSSLSS
CCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHH
GFLSDLFREYDAKYGSVHIDFVDGEAHDHINSIRKFQLDIAFVIGLGDWPECDTTYLWSE
HHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHEEEEEEEEECCCCCCCCCEEEECC
QVLVALPEGHPLSTEDALTWRDLSSEKILIRDTAAGMRIQDYVIRKIREVECEPRVEAQR
CEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHH
VGRYKLLNLVASGRGITLVIESENLVKVPGVIYRSLRGEVLQFYAAWSPKNDNPAFRTLL
CCHHHHHHHHHCCCCEEEEEECCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
SLARSMARSSAPQTSSPVQDLDGVLAEPSRKRDLSR
HHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHCCCCC
>Mature Secondary Structure 
PLLKWRTFPMSNNSTEIEIRYLRYLIAASEYGSFRKAAAALGVQESSVSRRIRDIEDQV
CCCEEEECCCCCCCCEEEHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHC
GASLFLRHPGGINLTIAGQRFLHRVRHALDHIRDAAAEVAAIGRAEDGYVKVGLFSSLSS
CCEEEEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEHHHHHHH
GFLSDLFREYDAKYGSVHIDFVDGEAHDHINSIRKFQLDIAFVIGLGDWPECDTTYLWSE
HHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHEEEEEEEEECCCCCCCCCEEEECC
QVLVALPEGHPLSTEDALTWRDLSSEKILIRDTAAGMRIQDYVIRKIREVECEPRVEAQR
CEEEECCCCCCCCCCCCEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHH
VGRYKLLNLVASGRGITLVIESENLVKVPGVIYRSLRGEVLQFYAAWSPKNDNPAFRTLL
CCHHHHHHHHHCCCCEEEEEECCCEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
SLARSMARSSAPQTSSPVQDLDGVLAEPSRKRDLSR
HHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]