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The map label for this gene is czcC [H]

Identifier: 154247904

GI number: 154247904

Start: 4406991

End: 4408262

Strand: Direct

Name: czcC [H]

Synonym: Xaut_3981

Alternate gene names: 154247904

Gene position: 4406991-4408262 (Clockwise)

Preceding gene: 154247903

Following gene: 154247905

Centisome position: 83.01

GC content: 71.31

Gene sequence:

>1272_bases
ATGTCGCCTCGTGCCCTCGCGCTTGCGCTTGGGGCAGCGCTCGCGCTGCTTCACGCGTCGCAGACGCGCGCCGAAACCGC
CCGTCCGCTGACCCTGCCCAGCGCCCTCGCCAGCGCCCTTGCCGCCAATCCGCGCCTCACGGCGGCGGAGCGCGACATCG
GCATGGCGGCGGGGCGCAATACCCAGGCCGGGGCCCTGCCCAACCCCAACCTCTCCCTTGAGGTGGACAATGCGGCGGGC
TCCGGCTCCTACCAGGGGCTGGACCTTGCCGAGCAGACCCTCCAGATCAGCCAACTGGTGGAGCTGGGCGGCAAGCGCGA
GGCGCGGTTGGCGGCCGCCGGTGCCGGGGTCGGCGTAGCGCGTTGGGAGCGGGAGGCGATCCGCCTCCAGGTGCTGGCGG
AGACCGCCGCGGCCTTCGCCACCGTGCTCGGGGCGCAGCAGCGCGCCCATATCCTCGAAACGCAGGTGGCGGCCATCCAG
CGGCTGGCGCCGCTGCTGCAGAACCGTGTCCAGGCCGGCGCTTCCTCTCCGGCCGAGATTTCCCGCGCCCGGGTCGCTGC
CGATTTCGCCCGGGTGGAGCTGGACCGCTCCCGTGCCGCGCTCGGCACCGCAAGGCGGGAGCTCGCGCTGCTCATGGGTC
TTCAGGAAGCAAGGTTCGGACGGGCGACCGGCAACCTGCTGAAGGTCAGCGCCCCGCCGCCCCTGCCGGGTCTCATCAAG
CAGGCGCTGGGCAATCCGCAGCTCACCCGCTTCACCGCCTTGCGCGCCCAGCGCCACGCGGATCTGCGCGCCGCCCAGGC
CAAGTCGGTGCCGGACGTGACCCTCGGCGTCGGCTACCGGCACTACAACGAGACCGCCGACAGCGGCATGCGCTTCTCCC
TGTCCATGCCGATCCCGCTGTTCGACCGCAACGACGGCGGCATCAGCGAGGCGAACGAGCAGCTGCTGCGGGCCGAGGCG
GAGGAAGCCATTGCCCGCAACGTCCTCATCTCCCAGTTGGGCCGCGCCCATGACGGGATGAAGGCCGCCTTCGACGAAAT
CACGCTTCTACGCACCAGCACCATTCCCGGCGCGCGCACCGCCTTCGAGGGGGTGGAGGCCGGCTATTCCGAAGGCCGCT
ACACCCTGCTGGAACTGCTCGACGCCCAGTCCACCCTCACCGACGCCGCCTTGCGCGAGCTGGATGCGCTGGTCGCGTTC
CACACCGCCCTCGCCACCCTCGAAGGGCTGACGGGCCGGCCGGTGACCCTCACCAAAGGAAAAGCCAAATGA

Upstream 100 bases:

>100_bases
CCGTTCCCGCAGACATCCGCCCCCCGCGCGCCTGATCCGACTTCTGCTCGCGCGCTGACGCTCCGCGTCGGCGATCCGCT
ATCAGACTTTGGATCAGATC

Downstream 100 bases:

>100_bases
GCCGCACGGCGCGACGCGACGTGGCGATGCTCCTCGTCGGCCTCCTGGCCGGCGCGGGGGCGCTTTACACGTTCCAGGAC
CGCAACGCCCCCGTTTCGGG

Product: outer membrane efflux protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSPRALALALGAALALLHASQTRAETARPLTLPSALASALAANPRLTAAERDIGMAAGRNTQAGALPNPNLSLEVDNAAG
SGSYQGLDLAEQTLQISQLVELGGKREARLAAAGAGVGVARWEREAIRLQVLAETAAAFATVLGAQQRAHILETQVAAIQ
RLAPLLQNRVQAGASSPAEISRARVAADFARVELDRSRAALGTARRELALLMGLQEARFGRATGNLLKVSAPPPLPGLIK
QALGNPQLTRFTALRAQRHADLRAAQAKSVPDVTLGVGYRHYNETADSGMRFSLSMPIPLFDRNDGGISEANEQLLRAEA
EEAIARNVLISQLGRAHDGMKAAFDEITLLRTSTIPGARTAFEGVEAGYSEGRYTLLELLDAQSTLTDAALRELDALVAF
HTALATLEGLTGRPVTLTKGKAK

Sequences:

>Translated_423_residues
MSPRALALALGAALALLHASQTRAETARPLTLPSALASALAANPRLTAAERDIGMAAGRNTQAGALPNPNLSLEVDNAAG
SGSYQGLDLAEQTLQISQLVELGGKREARLAAAGAGVGVARWEREAIRLQVLAETAAAFATVLGAQQRAHILETQVAAIQ
RLAPLLQNRVQAGASSPAEISRARVAADFARVELDRSRAALGTARRELALLMGLQEARFGRATGNLLKVSAPPPLPGLIK
QALGNPQLTRFTALRAQRHADLRAAQAKSVPDVTLGVGYRHYNETADSGMRFSLSMPIPLFDRNDGGISEANEQLLRAEA
EEAIARNVLISQLGRAHDGMKAAFDEITLLRTSTIPGARTAFEGVEAGYSEGRYTLLELLDAQSTLTDAALRELDALVAF
HTALATLEGLTGRPVTLTKGKAK
>Mature_422_residues
SPRALALALGAALALLHASQTRAETARPLTLPSALASALAANPRLTAAERDIGMAAGRNTQAGALPNPNLSLEVDNAAGS
GSYQGLDLAEQTLQISQLVELGGKREARLAAAGAGVGVARWEREAIRLQVLAETAAAFATVLGAQQRAHILETQVAAIQR
LAPLLQNRVQAGASSPAEISRARVAADFARVELDRSRAALGTARRELALLMGLQEARFGRATGNLLKVSAPPPLPGLIKQ
ALGNPQLTRFTALRAQRHADLRAAQAKSVPDVTLGVGYRHYNETADSGMRFSLSMPIPLFDRNDGGISEANEQLLRAEAE
EAIARNVLISQLGRAHDGMKAAFDEITLLRTSTIPGARTAFEGVEAGYSEGRYTLLELLDAQSTLTDAALRELDALVAFH
TALATLEGLTGRPVTLTKGKAK

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 44550; Mature: 44419

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRALALALGAALALLHASQTRAETARPLTLPSALASALAANPRLTAAERDIGMAAGRN
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHCHHHHCCCC
TQAGALPNPNLSLEVDNAAGSGSYQGLDLAEQTLQISQLVELGGKREARLAAAGAGVGVA
CCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHH
RWEREAIRLQVLAETAAAFATVLGAQQRAHILETQVAAIQRLAPLLQNRVQAGASSPAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
SRARVAADFARVELDRSRAALGTARRELALLMGLQEARFGRATGNLLKVSAPPPLPGLIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHH
QALGNPQLTRFTALRAQRHADLRAAQAKSVPDVTLGVGYRHYNETADSGMRFSLSMPIPL
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCCEEEEECCCCE
FDRNDGGISEANEQLLRAEAEEAIARNVLISQLGRAHDGMKAAFDEITLLRTSTIPGART
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCHHH
AFEGVEAGYSEGRYTLLELLDAQSTLTDAALRELDALVAFHTALATLEGLTGRPVTLTKG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
KAK
CCC
>Mature Secondary Structure 
SPRALALALGAALALLHASQTRAETARPLTLPSALASALAANPRLTAAERDIGMAAGRN
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHCHHHHCCCC
TQAGALPNPNLSLEVDNAAGSGSYQGLDLAEQTLQISQLVELGGKREARLAAAGAGVGVA
CCCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCHH
RWEREAIRLQVLAETAAAFATVLGAQQRAHILETQVAAIQRLAPLLQNRVQAGASSPAEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
SRARVAADFARVELDRSRAALGTARRELALLMGLQEARFGRATGNLLKVSAPPPLPGLIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHH
QALGNPQLTRFTALRAQRHADLRAAQAKSVPDVTLGVGYRHYNETADSGMRFSLSMPIPL
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCCEEEEECCCCE
FDRNDGGISEANEQLLRAEAEEAIARNVLISQLGRAHDGMKAAFDEITLLRTSTIPGART
EECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEEECCCCCHHH
AFEGVEAGYSEGRYTLLELLDAQSTLTDAALRELDALVAFHTALATLEGLTGRPVTLTKG
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
KAK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]