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The map label for this gene is arsC [H]

Identifier: 154247889

GI number: 154247889

Start: 4389033

End: 4389467

Strand: Direct

Name: arsC [H]

Synonym: Xaut_3966

Alternate gene names: 154247889

Gene position: 4389033-4389467 (Clockwise)

Preceding gene: 154247888

Following gene: 154247890

Centisome position: 82.67

GC content: 66.9

Gene sequence:

>435_bases
ATGACTGAGCATTCCCTTGTCACCATCTGGCACAATCCGGCCTGCGGCACATCGCGCAACACGCTCGCCCTGATCCGCAA
CGCCGGTATCGAGCCGACGATCGTCGAATATCTCAAGACCCCGCCCGCGCGGGAAGAGGTCGCCGCCGCCATCGCCGCGG
CGGGCCTCACGGTGCGCGCCGCGACCCGCCAGAAGGGCACACCCTATGCCGAACTCGGCCTCGACGATCCCGCCCTCACC
GACGACACTCTGCTCGATGCCATGATGGCCCACCCCATCCTCATTAACCGGCCGTTCGTCTTCACCCCGCTCGGGGCGCG
GCTGTGCCGGCCGTCGGAAAGGGTCCTGGACATCCTGCCCGCGCCGCAGAAAGGGCCGTTTACGAAGGAGGATGGAGAGG
TGGTGATCGATGCCGAGGGACGGCGCGTTTGCTGA

Upstream 100 bases:

>100_bases
TGACGCTGATCCTCATGGTGATCCTCGCCACCGTGGTGGTGAGCGAATGGGTGTCCGCCAAGGTCCGCCACGCCATCATC
TGATCTTCGGAGCCTGAACG

Downstream 100 bases:

>100_bases
CGCGGGGAGCGCTTTCAAGTATGCCTTGATGATTGACACATTGATGATCGATGTATAGCCTTCCTGCATGTCTCGAACCT
CTCCATCGGCCACCCCATCC

Product: arsenate reductase

Products: NA

Alternate protein names: Arsenical pump modifier [H]

Number of amino acids: Translated: 144; Mature: 143

Protein sequence:

>144_residues
MTEHSLVTIWHNPACGTSRNTLALIRNAGIEPTIVEYLKTPPAREEVAAAIAAAGLTVRAATRQKGTPYAELGLDDPALT
DDTLLDAMMAHPILINRPFVFTPLGARLCRPSERVLDILPAPQKGPFTKEDGEVVIDAEGRRVC

Sequences:

>Translated_144_residues
MTEHSLVTIWHNPACGTSRNTLALIRNAGIEPTIVEYLKTPPAREEVAAAIAAAGLTVRAATRQKGTPYAELGLDDPALT
DDTLLDAMMAHPILINRPFVFTPLGARLCRPSERVLDILPAPQKGPFTKEDGEVVIDAEGRRVC
>Mature_143_residues
TEHSLVTIWHNPACGTSRNTLALIRNAGIEPTIVEYLKTPPAREEVAAAIAAAGLTVRAATRQKGTPYAELGLDDPALTD
DTLLDAMMAHPILINRPFVFTPLGARLCRPSERVLDILPAPQKGPFTKEDGEVVIDAEGRRVC

Specific function: Reduction of arsenate [As(V)] to arsenite [As(III)]. This protein expands the substrate specificity of ArsAB pump which can extrude arsenite and antimonite to allow for arsenate pumping and resistance [H]

COG id: COG1393

COG function: function code P; Arsenate reductase and related proteins, glutaredoxin family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ArsC family [H]

Homologues:

Organism=Escherichia coli, GI1789918, Length=139, Percent_Identity=62.589928057554, Blast_Score=187, Evalue=2e-49,
Organism=Escherichia coli, GI1788841, Length=114, Percent_Identity=40.3508771929825, Blast_Score=89, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006659
- InterPro:   IPR006660
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF03960 ArsC [H]

EC number: =1.20.4.1 [H]

Molecular weight: Translated: 15552; Mature: 15421

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEHSLVTIWHNPACGTSRNTLALIRNAGIEPTIVEYLKTPPAREEVAAAIAAAGLTVRA
CCCCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHCEEEEE
ATRQKGTPYAELGLDDPALTDDTLLDAMMAHPILINRPFVFTPLGARLCRPSERVLDILP
CCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCEEECCCEEECCCCHHHCCCHHHHHHHCC
APQKGPFTKEDGEVVIDAEGRRVC
CCCCCCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
TEHSLVTIWHNPACGTSRNTLALIRNAGIEPTIVEYLKTPPAREEVAAAIAAAGLTVRA
CCCCEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHCCCCCHHHHHHHHHHHCEEEEE
ATRQKGTPYAELGLDDPALTDDTLLDAMMAHPILINRPFVFTPLGARLCRPSERVLDILP
CCCCCCCCEEECCCCCCCCCHHHHHHHHHHCCEEECCCEEECCCCHHHCCCHHHHHHHCC
APQKGPFTKEDGEVVIDAEGRRVC
CCCCCCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3021763; 1703401; 1704144 [H]