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The map label for this gene is lpd [H]

Identifier: 154247817

GI number: 154247817

Start: 4313200

End: 4314615

Strand: Direct

Name: lpd [H]

Synonym: Xaut_3894

Alternate gene names: 154247817

Gene position: 4313200-4314615 (Clockwise)

Preceding gene: 154247816

Following gene: 154247818

Centisome position: 81.24

GC content: 65.75

Gene sequence:

>1416_bases
ATGGCTGACAGTTACGACATCATCGTCATCGGCGGCGGGCCCGGCGGCTACGTGGCCGCCATCCGCGCCGCCCAGCTCGG
CTTCAAGGTGGCCGTGGTGGAGAAGAGCCATCTCGGCGGCATCTGCCTGAACTGGGGCTGCATTCCCACCAAGGCTCTGC
TGCGCTCGGCCGAGATCTATCACTACATGGAGCACGCCAAGGATTACGGCCTCTCCGCCGAGAAGATCGGCTTCGATGCG
GCGGCCGTGGTGAAGCGCTCGCGCGGGGTCTCGGCCCAGCTGGCCGGCGGCGTGGCCTTCCTGCTCAACAAGAACAAGGT
GGACGTGATCTGGGGCAAGGCGACCTTCACCGCCCCCGGCAAGATCAAGGTGGAAGCCAGCCAGAACCCGCCCAAGGGCG
CCAAGGGCGGCGGCGACTACACCGCCAAGCACATCATCGTCGCCACCGGTGCCCGCCCGCGCGCGCTGCCGGGCCTTGAG
CCCGACAAGAAGCTGATCTGGACCTATTTCGACGCCATGGTGCCGGAAAAGATGCCCAAGAGCCTGCTGGTGATGGGTTC
GGGCGCCATCGGCATCGAGTTCGCCTCCTTCTATCGCACCATGGGCACCGAGGTGACCGTGGTGGAGGTGCTGCCTCAGA
TCCTCCCCGTGGAGGACGAGGAGATCGCTGCCGTCGCCCGCAAGCGCTTCGAGAAGCTCGGCATGAAGATCCTGTCCGGC
GCCAAGGTGACCGGCGTCACCAAGCATGCCGACAGCATCACCGCGCATGTGGAGGATGCCAAGGGCGCCAAGCACGACAT
CACGGTGGAGCGCATGATCTCCGCCGTGGGCGTGGTGGGCAACGTGGAGGGCCTCGGCCTCGAGGCCATCGGCGTGAAAA
TCGAGCGCGGCTGCGTGGTCATCGACGGCTATGGCCGCACCAATGTGCCCGGCGTCTATGCCATCGGCGACATTGCCGGT
CCGCCCATGCTGGCCCACAAGGCGGAGCACGAGGGCGTGATCTGCGTGGAGACCATCAAGGGCCTGCACACCCACCCCAT
GGACAAGAACAAGATCCCCGGCTGCACCTATTGCACGCCGCAGATCGCCTCCGTGGGCCTCACCGAGAAGAAGGCCAAGG
AAGCCGGCCGCGAGATCAAGGTGGGCCGCTTCTCCTTCATCGGCAACGGCAAGGCCATCGCGCTGGGCGAGCCGGACGGC
CTGGTGAAGACCATCTTCGACGCCAAGACCGGCGAGCTGCTGGGCGCCCACATGGTGGGCGCGGAAGTGACCGAGCTGAT
CCAGGGCTTCGTGGTGGCCATGAACCTTGAGACCACCGAGGAAGACCTAATCCACACGGTGTTCCCGCACCCGACCCTGT
CGGAGATGATGCACGAGAGCGTCATGTCCGCCTACGGCCGCGCCATCCATTCGTGA

Upstream 100 bases:

>100_bases
TCCGTTTTGGCCGAGGCCCGGTCCGCCGGCCGCCTTGGCACGACCCCATCCCTTTCCCATCCAGAACCCGCCGGACAGGC
GCACGGCGAGGAGACCTTCC

Downstream 100 bases:

>100_bases
GCGAGGCGGCGGGGCGTGGGACTTTGTCCCGCGCCTCTCGCCAAAGCGCCGTGGCGGCGGCATGATCCGCCACCACCCGC
CGGCGGTCCTCGCCGGATGA

Product: dihydrolipoamide dehydrogenase

Products: NA

Alternate protein names: Dihydrolipoamide dehydrogenase; E3 component of pyruvate and 2-oxoglutarate dehydrogenases complexes [H]

Number of amino acids: Translated: 471; Mature: 470

Protein sequence:

>471_residues
MADSYDIIVIGGGPGGYVAAIRAAQLGFKVAVVEKSHLGGICLNWGCIPTKALLRSAEIYHYMEHAKDYGLSAEKIGFDA
AAVVKRSRGVSAQLAGGVAFLLNKNKVDVIWGKATFTAPGKIKVEASQNPPKGAKGGGDYTAKHIIVATGARPRALPGLE
PDKKLIWTYFDAMVPEKMPKSLLVMGSGAIGIEFASFYRTMGTEVTVVEVLPQILPVEDEEIAAVARKRFEKLGMKILSG
AKVTGVTKHADSITAHVEDAKGAKHDITVERMISAVGVVGNVEGLGLEAIGVKIERGCVVIDGYGRTNVPGVYAIGDIAG
PPMLAHKAEHEGVICVETIKGLHTHPMDKNKIPGCTYCTPQIASVGLTEKKAKEAGREIKVGRFSFIGNGKAIALGEPDG
LVKTIFDAKTGELLGAHMVGAEVTELIQGFVVAMNLETTEEDLIHTVFPHPTLSEMMHESVMSAYGRAIHS

Sequences:

>Translated_471_residues
MADSYDIIVIGGGPGGYVAAIRAAQLGFKVAVVEKSHLGGICLNWGCIPTKALLRSAEIYHYMEHAKDYGLSAEKIGFDA
AAVVKRSRGVSAQLAGGVAFLLNKNKVDVIWGKATFTAPGKIKVEASQNPPKGAKGGGDYTAKHIIVATGARPRALPGLE
PDKKLIWTYFDAMVPEKMPKSLLVMGSGAIGIEFASFYRTMGTEVTVVEVLPQILPVEDEEIAAVARKRFEKLGMKILSG
AKVTGVTKHADSITAHVEDAKGAKHDITVERMISAVGVVGNVEGLGLEAIGVKIERGCVVIDGYGRTNVPGVYAIGDIAG
PPMLAHKAEHEGVICVETIKGLHTHPMDKNKIPGCTYCTPQIASVGLTEKKAKEAGREIKVGRFSFIGNGKAIALGEPDG
LVKTIFDAKTGELLGAHMVGAEVTELIQGFVVAMNLETTEEDLIHTVFPHPTLSEMMHESVMSAYGRAIHS
>Mature_470_residues
ADSYDIIVIGGGPGGYVAAIRAAQLGFKVAVVEKSHLGGICLNWGCIPTKALLRSAEIYHYMEHAKDYGLSAEKIGFDAA
AVVKRSRGVSAQLAGGVAFLLNKNKVDVIWGKATFTAPGKIKVEASQNPPKGAKGGGDYTAKHIIVATGARPRALPGLEP
DKKLIWTYFDAMVPEKMPKSLLVMGSGAIGIEFASFYRTMGTEVTVVEVLPQILPVEDEEIAAVARKRFEKLGMKILSGA
KVTGVTKHADSITAHVEDAKGAKHDITVERMISAVGVVGNVEGLGLEAIGVKIERGCVVIDGYGRTNVPGVYAIGDIAGP
PMLAHKAEHEGVICVETIKGLHTHPMDKNKIPGCTYCTPQIASVGLTEKKAKEAGREIKVGRFSFIGNGKAIALGEPDGL
VKTIFDAKTGELLGAHMVGAEVTELIQGFVVAMNLETTEEDLIHTVFPHPTLSEMMHESVMSAYGRAIHS

Specific function: Lipoamide dehydrogenase is a component of the alpha- ketoacid dehydrogenase complexes [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=475, Percent_Identity=38.1052631578947, Blast_Score=295, Evalue=8e-80,
Organism=Homo sapiens, GI50301238, Length=462, Percent_Identity=29.6536796536797, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI22035672, Length=486, Percent_Identity=28.6008230452675, Blast_Score=130, Evalue=4e-30,
Organism=Homo sapiens, GI291045266, Length=479, Percent_Identity=28.39248434238, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI33519430, Length=476, Percent_Identity=28.3613445378151, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI33519428, Length=476, Percent_Identity=28.3613445378151, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI33519426, Length=476, Percent_Identity=28.3613445378151, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI148277065, Length=476, Percent_Identity=28.3613445378151, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI148277071, Length=476, Percent_Identity=28.3613445378151, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI291045268, Length=475, Percent_Identity=28.2105263157895, Blast_Score=98, Evalue=2e-20,
Organism=Escherichia coli, GI1786307, Length=457, Percent_Identity=36.5426695842451, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI87082354, Length=470, Percent_Identity=27.6595744680851, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1789915, Length=444, Percent_Identity=29.7297297297297, Blast_Score=160, Evalue=1e-40,
Organism=Escherichia coli, GI87081717, Length=471, Percent_Identity=26.963906581741, Blast_Score=157, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI32565766, Length=477, Percent_Identity=37.1069182389937, Blast_Score=296, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17557007, Length=485, Percent_Identity=25.979381443299, Blast_Score=131, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI71983419, Length=444, Percent_Identity=25.6756756756757, Blast_Score=121, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI71983429, Length=444, Percent_Identity=25.6756756756757, Blast_Score=121, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI71982272, Length=486, Percent_Identity=26.5432098765432, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6321091, Length=474, Percent_Identity=39.4514767932489, Blast_Score=301, Evalue=1e-82,
Organism=Saccharomyces cerevisiae, GI6325166, Length=471, Percent_Identity=30.5732484076433, Blast_Score=183, Evalue=6e-47,
Organism=Saccharomyces cerevisiae, GI6325240, Length=479, Percent_Identity=27.7661795407098, Blast_Score=168, Evalue=1e-42,
Organism=Drosophila melanogaster, GI21358499, Length=473, Percent_Identity=40.3805496828753, Blast_Score=323, Evalue=2e-88,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=28.9029535864979, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24640551, Length=473, Percent_Identity=28.9640591966173, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=28.9029535864979, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI17737741, Length=473, Percent_Identity=27.061310782241, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1880 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 6,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006258
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.4 [H]

Molecular weight: Translated: 49942; Mature: 49810

Theoretical pI: Translated: 7.69; Mature: 7.69

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADSYDIIVIGGGPGGYVAAIRAAQLGFKVAVVEKSHLGGICLNWGCIPTKALLRSAEIY
CCCCEEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
HYMEHAKDYGLSAEKIGFDAAAVVKRSRGVSAQLAGGVAFLLNKNKVDVIWGKATFTAPG
HHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCEECCCCEEEEEECCCEEEEECCEEECCCC
KIKVEASQNPPKGAKGGGDYTAKHIIVATGARPRALPGLEPDKKLIWTYFDAMVPEKMPK
EEEEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
SLLVMGSGAIGIEFASFYRTMGTEVTVVEVLPQILPVEDEEIAAVARKRFEKLGMKILSG
EEEEEECCCCHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
AKVTGVTKHADSITAHVEDAKGAKHDITVERMISAVGVVGNVEGLGLEAIGVKIERGCVV
CEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEECCEEE
IDGYGRTNVPGVYAIGDIAGPPMLAHKAEHEGVICVETIKGLHTHPMDKNKIPGCTYCTP
EECCCCCCCCCEEEECCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCH
QIASVGLTEKKAKEAGREIKVGRFSFIGNGKAIALGEPDGLVKTIFDAKTGELLGAHMVG
HHHHCCCCHHHHHHCCCEEEEEEEEEECCCCEEEECCCCCHHHHHHCCCCCHHHHHHHHH
AEVTELIQGFVVAMNLETTEEDLIHTVFPHPTLSEMMHESVMSAYGRAIHS
HHHHHHHHHEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ADSYDIIVIGGGPGGYVAAIRAAQLGFKVAVVEKSHLGGICLNWGCIPTKALLRSAEIY
CCCEEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCCCCEEEECCCCCHHHHHHHHHHH
HYMEHAKDYGLSAEKIGFDAAAVVKRSRGVSAQLAGGVAFLLNKNKVDVIWGKATFTAPG
HHHHHHHHCCCCHHHCCCCHHHHHHHHCCCCEECCCCEEEEEECCCEEEEECCEEECCCC
KIKVEASQNPPKGAKGGGDYTAKHIIVATGARPRALPGLEPDKKLIWTYFDAMVPEKMPK
EEEEEECCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCC
SLLVMGSGAIGIEFASFYRTMGTEVTVVEVLPQILPVEDEEIAAVARKRFEKLGMKILSG
EEEEEECCCCHHHHHHHHHHHCCCEEHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
AKVTGVTKHADSITAHVEDAKGAKHDITVERMISAVGVVGNVEGLGLEAIGVKIERGCVV
CEEEEEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEECCEEE
IDGYGRTNVPGVYAIGDIAGPPMLAHKAEHEGVICVETIKGLHTHPMDKNKIPGCTYCTP
EECCCCCCCCCEEEECCCCCCCHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCH
QIASVGLTEKKAKEAGREIKVGRFSFIGNGKAIALGEPDGLVKTIFDAKTGELLGAHMVG
HHHHCCCCHHHHHHCCCEEEEEEEEEECCCCEEEECCCCCHHHHHHCCCCCHHHHHHHHH
AEVTELIQGFVVAMNLETTEEDLIHTVFPHPTLSEMMHESVMSAYGRAIHS
HHHHHHHHHEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9515924 [H]