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The map label for this gene is rnc [H]

Identifier: 154247804

GI number: 154247804

Start: 4300011

End: 4300721

Strand: Direct

Name: rnc [H]

Synonym: Xaut_3881

Alternate gene names: 154247804

Gene position: 4300011-4300721 (Clockwise)

Preceding gene: 154247803

Following gene: 154247805

Centisome position: 81.0

GC content: 69.76

Gene sequence:

>711_bases
TTGAACGCGGTGGGCTCTGACCTCGCGTCCGTAGAAGAGCGGATCGGATATCGCTTCCGTGACCGGTCGATCCTTGAGCT
CGCGCTCTCCCACATCAGCGCCGTGAAAGGCGAGGCTCCGCGCCTGCGCTCCTACCAGCGCATGGAGTTCCTGGGCGACC
ACGTGCTCGGCTCGGTGGTGTCGCACATGCTCTATCTTGCCTTCCCGGAAGGGGAGGAGGGCGAGCTTTCGCGCCGGCTC
GCCGAACTGGTGCGCGAGGAGGCCTGCGCCGAGGTGGCGCAGGACATGGATCTCGGCCCCTTCATCCGCCTTGGCCCCGG
CGAGAGCCAGTCCGGCGCCCACAAGCGGCGGGCCATCCTTGCCGATGTGGCGGAAGGCGTGGTGGCGGCGGTGTTCCTCG
ACGGTGGCTACGAGGCGGCCCACCAGGTGGTGGAGCGCTTCTGGCGACCCCGCCTGGAGACCCCGCGCCGGCCGCTGCGG
GACGCCAAGACGGTGTTGCAGGAATGGGCGCAGGCCCGCGGCCTGCCGCCGCCTTCCTATCGCGAGGTGACCCGTTCCGG
TCCGGACCACGCCCCCCGCTTCACGGTGGCGGTGGATCTTCCGGGCCTGGCCTCCGAGCAGGCGGACGGGGCCTCCAAGC
AGAATGCGCAGAAGGCGGCAGCCGCCGCTTTCCTCGTCCGTGAGGGCGTGTGGAAAAAGGACGAGTCGTGA

Upstream 100 bases:

>100_bases
CGCAGGTGATCTTCTTCTCGGTCGACGAGGGCGCGTCCGCGTGGCAGGTTTGGACTTGGCCTTGGACGGTGCGATGGGAT
CGGCTGTTCTCTCGGGTACA

Downstream 100 bases:

>100_bases
TGGCACCGGCAGGGAGGGGTCCCAAGGGCCCCAAGAACAGCCCGGATAAGAACAGCCCGGATGAGAGCGGCCCCGGCAAC
GGCGCTCCGGCCAGTGATGT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MNAVGSDLASVEERIGYRFRDRSILELALSHISAVKGEAPRLRSYQRMEFLGDHVLGSVVSHMLYLAFPEGEEGELSRRL
AELVREEACAEVAQDMDLGPFIRLGPGESQSGAHKRRAILADVAEGVVAAVFLDGGYEAAHQVVERFWRPRLETPRRPLR
DAKTVLQEWAQARGLPPPSYREVTRSGPDHAPRFTVAVDLPGLASEQADGASKQNAQKAAAAAFLVREGVWKKDES

Sequences:

>Translated_236_residues
MNAVGSDLASVEERIGYRFRDRSILELALSHISAVKGEAPRLRSYQRMEFLGDHVLGSVVSHMLYLAFPEGEEGELSRRL
AELVREEACAEVAQDMDLGPFIRLGPGESQSGAHKRRAILADVAEGVVAAVFLDGGYEAAHQVVERFWRPRLETPRRPLR
DAKTVLQEWAQARGLPPPSYREVTRSGPDHAPRFTVAVDLPGLASEQADGASKQNAQKAAAAAFLVREGVWKKDES
>Mature_236_residues
MNAVGSDLASVEERIGYRFRDRSILELALSHISAVKGEAPRLRSYQRMEFLGDHVLGSVVSHMLYLAFPEGEEGELSRRL
AELVREEACAEVAQDMDLGPFIRLGPGESQSGAHKRRAILADVAEGVVAAVFLDGGYEAAHQVVERFWRPRLETPRRPLR
DAKTVLQEWAQARGLPPPSYREVTRSGPDHAPRFTVAVDLPGLASEQADGASKQNAQKAAAAAFLVREGVWKKDES

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=221, Percent_Identity=29.8642533936652, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI155030234, Length=221, Percent_Identity=29.8642533936652, Blast_Score=79, Evalue=4e-15,
Organism=Escherichia coli, GI1788920, Length=196, Percent_Identity=37.7551020408163, Blast_Score=140, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI193202651, Length=222, Percent_Identity=28.8288288288288, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17506883, Length=222, Percent_Identity=28.8288288288288, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17137682, Length=230, Percent_Identity=29.5652173913043, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 25969; Mature: 25969

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAVGSDLASVEERIGYRFRDRSILELALSHISAVKGEAPRLRSYQRMEFLGDHVLGSVV
CCCCHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
SHMLYLAFPEGEEGELSRRLAELVREEACAEVAQDMDLGPFIRLGPGESQSGAHKRRAIL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHH
ADVAEGVVAAVFLDGGYEAAHQVVERFWRPRLETPRRPLRDAKTVLQEWAQARGLPPPSY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
REVTRSGPDHAPRFTVAVDLPGLASEQADGASKQNAQKAAAAAFLVREGVWKKDES
HHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MNAVGSDLASVEERIGYRFRDRSILELALSHISAVKGEAPRLRSYQRMEFLGDHVLGSVV
CCCCHHHHHHHHHHHCCHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
SHMLYLAFPEGEEGELSRRLAELVREEACAEVAQDMDLGPFIRLGPGESQSGAHKRRAIL
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCHHHHHHHH
ADVAEGVVAAVFLDGGYEAAHQVVERFWRPRLETPRRPLRDAKTVLQEWAQARGLPPPSY
HHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCH
REVTRSGPDHAPRFTVAVDLPGLASEQADGASKQNAQKAAAAAFLVREGVWKKDES
HHHHHCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA