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The map label for this gene is serA [H]

Identifier: 154247745

GI number: 154247745

Start: 4238963

End: 4240252

Strand: Direct

Name: serA [H]

Synonym: Xaut_3822

Alternate gene names: 154247745

Gene position: 4238963-4240252 (Clockwise)

Preceding gene: 154247744

Following gene: 154247746

Centisome position: 79.85

GC content: 67.98

Gene sequence:

>1290_bases
TTGCTGAAGGACGCCGCGATCGTGCACGACAGCCATTCCCCCACGCCGCACCTCTCCCTGTCCAAGGACAAGATCAAGGT
GCTGCTCCTCGAAGGCGTGAACGACAGCGCCGTGGAGCTGCTGACCAATGCCGGCTACACCAACCTCACCCGCCTGCCCA
AGGCGCTGGACGGCGACGCGCTGAAGGAGGCCATCAAGGGCGTCCATATCCTCGGCATCCGCTCGCGCACCCAGATCACG
CCCGACGTGCTGGAGGCCGCGGACCGGCTGATCGCCATCGGCTGCTTCAGCGTCGGCACCAACCAGGTGGACCTCGACGC
CTCCCGCATCAGCGGCGTGCCGGTGTTCAACGCACCCTTCTCCAACACCCGCAGCGTCGCCGAGCTGGTGATCGGCGAGA
TCGTGATGCTGCTGCGCCGCATCCCCACCCGCTCCCACGCGGCGCATGAGGGCCGCTGGGACAAGTCCGCCACCAACAGC
GTGGAAGTGCGCGGCAAGACGCTCGGCATCGTCGGCTACGGCAATATCGGCTCGCAGCTCTCGATCCTGGCCGAGGCCAT
GGGCCTCAAGGTGATCTTCTACGATCACACCGACAAGCTGCGCCACGGCCAGGCCGAGCCGGTGTCGACCCTCAACGCCC
TGCTGGCCCAGAGCGACATCGTCAGCCTGCACGTGCCGGAGACGGCGGCGACCCACGGCATGATCGGCCGCGCCGAGATC
GCCACCATGAAGCCGGGGGCCTACCTTATCAACAACAGCCGCGGCACGGTGGTGGACCTCGACGCCCTCGCCGAGGCGCT
GAAGGCGGGCCACCTGCGCGGCGCGGCGGTGGACGTGTTCCCGGTGGAGCCCGGCTCCAACGCCGAGCGCTTCGTCTCTC
CGCTCCAGGGCCTCGACAACGTGATTCTGACGCCGCACATCGGCGGCTCCACCGAGGAGGCGCAGGAGCGCATCGGCGCC
GAGGTCGCCCGCAAGCTGGTGGATTATTCAGACACCGGCTCCACCATGGGCGCAGTGAACTTTCCCGAGGTGCAGCTGCC
GGCCCGCCCGACGGGGACCCGCTTCATCCAGATTCACCGCAACCTGCCGGGCATGCTGGGGCGGCTCAACGAGGTGCTGG
CCCGCCACTCCGTCAACATCGCCGCGCAATATCTGGAGACCTACGCGGACGTGGGCTACGTGGTTCTGGACGCCGATGCC
TCCACCGCGGACAGCCAGAGCGTGCTCGCCGACATCCGGGAGATCGAGGGCACCATCCGCGCCCGGCTGCTCTACGAACG
CAAGATCTGA

Upstream 100 bases:

>100_bases
CTAAATATGCGCCAGCCCAGAGGAGAGCCGCCGAAATTTCCGGCAGCATTGAGCCGGGCCGCGCCTCCTGTTACGCGGTT
CCCGGCCCACGCCTCATCCA

Downstream 100 bases:

>100_bases
AGCCGGATCCGATCCGGCGGGCGCATCCTGATCGCAGGGTGTGCCCGCCGATGGCCTCTTGTGCGTCGCCCGGGTCGAGG
GCGAATCGAACGCGCCGCCC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MLKDAAIVHDSHSPTPHLSLSKDKIKVLLLEGVNDSAVELLTNAGYTNLTRLPKALDGDALKEAIKGVHILGIRSRTQIT
PDVLEAADRLIAIGCFSVGTNQVDLDASRISGVPVFNAPFSNTRSVAELVIGEIVMLLRRIPTRSHAAHEGRWDKSATNS
VEVRGKTLGIVGYGNIGSQLSILAEAMGLKVIFYDHTDKLRHGQAEPVSTLNALLAQSDIVSLHVPETAATHGMIGRAEI
ATMKPGAYLINNSRGTVVDLDALAEALKAGHLRGAAVDVFPVEPGSNAERFVSPLQGLDNVILTPHIGGSTEEAQERIGA
EVARKLVDYSDTGSTMGAVNFPEVQLPARPTGTRFIQIHRNLPGMLGRLNEVLARHSVNIAAQYLETYADVGYVVLDADA
STADSQSVLADIREIEGTIRARLLYERKI

Sequences:

>Translated_429_residues
MLKDAAIVHDSHSPTPHLSLSKDKIKVLLLEGVNDSAVELLTNAGYTNLTRLPKALDGDALKEAIKGVHILGIRSRTQIT
PDVLEAADRLIAIGCFSVGTNQVDLDASRISGVPVFNAPFSNTRSVAELVIGEIVMLLRRIPTRSHAAHEGRWDKSATNS
VEVRGKTLGIVGYGNIGSQLSILAEAMGLKVIFYDHTDKLRHGQAEPVSTLNALLAQSDIVSLHVPETAATHGMIGRAEI
ATMKPGAYLINNSRGTVVDLDALAEALKAGHLRGAAVDVFPVEPGSNAERFVSPLQGLDNVILTPHIGGSTEEAQERIGA
EVARKLVDYSDTGSTMGAVNFPEVQLPARPTGTRFIQIHRNLPGMLGRLNEVLARHSVNIAAQYLETYADVGYVVLDADA
STADSQSVLADIREIEGTIRARLLYERKI
>Mature_429_residues
MLKDAAIVHDSHSPTPHLSLSKDKIKVLLLEGVNDSAVELLTNAGYTNLTRLPKALDGDALKEAIKGVHILGIRSRTQIT
PDVLEAADRLIAIGCFSVGTNQVDLDASRISGVPVFNAPFSNTRSVAELVIGEIVMLLRRIPTRSHAAHEGRWDKSATNS
VEVRGKTLGIVGYGNIGSQLSILAEAMGLKVIFYDHTDKLRHGQAEPVSTLNALLAQSDIVSLHVPETAATHGMIGRAEI
ATMKPGAYLINNSRGTVVDLDALAEALKAGHLRGAAVDVFPVEPGSNAERFVSPLQGLDNVILTPHIGGSTEEAQERIGA
EVARKLVDYSDTGSTMGAVNFPEVQLPARPTGTRFIQIHRNLPGMLGRLNEVLARHSVNIAAQYLETYADVGYVVLDADA
STADSQSVLADIREIEGTIRARLLYERKI

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=317, Percent_Identity=33.4384858044164, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI145580578, Length=246, Percent_Identity=37.3983739837398, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4557499, Length=246, Percent_Identity=37.3983739837398, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI61743967, Length=238, Percent_Identity=34.8739495798319, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI4557497, Length=238, Percent_Identity=34.8739495798319, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI145580575, Length=246, Percent_Identity=37.3983739837398, Blast_Score=129, Evalue=6e-30,
Organism=Homo sapiens, GI6912396, Length=275, Percent_Identity=29.8181818181818, Blast_Score=97, Evalue=4e-20,
Organism=Escherichia coli, GI1789279, Length=408, Percent_Identity=58.8235294117647, Blast_Score=474, Evalue=1e-135,
Organism=Escherichia coli, GI87082289, Length=263, Percent_Identity=33.4600760456274, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1787645, Length=250, Percent_Identity=29.6, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1788660, Length=251, Percent_Identity=30.6772908366534, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87081824, Length=204, Percent_Identity=27.9411764705882, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=32.9192546583851, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI25147481, Length=242, Percent_Identity=31.8181818181818, Blast_Score=115, Evalue=7e-26,
Organism=Saccharomyces cerevisiae, GI6320925, Length=422, Percent_Identity=48.3412322274881, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6322116, Length=422, Percent_Identity=47.8672985781991, Blast_Score=372, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6324964, Length=256, Percent_Identity=30.859375, Blast_Score=106, Evalue=6e-24,
Organism=Saccharomyces cerevisiae, GI6324055, Length=274, Percent_Identity=27.3722627737226, Blast_Score=96, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6324980, Length=193, Percent_Identity=29.5336787564767, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321253, Length=166, Percent_Identity=28.3132530120482, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6325144, Length=158, Percent_Identity=29.1139240506329, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19921140, Length=310, Percent_Identity=32.5806451612903, Blast_Score=155, Evalue=6e-38,
Organism=Drosophila melanogaster, GI24646446, Length=265, Percent_Identity=35.4716981132075, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646448, Length=265, Percent_Identity=35.4716981132075, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646452, Length=265, Percent_Identity=35.4716981132075, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24646450, Length=265, Percent_Identity=35.4716981132075, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI62472511, Length=265, Percent_Identity=35.4716981132075, Blast_Score=125, Evalue=4e-29,
Organism=Drosophila melanogaster, GI28574286, Length=261, Percent_Identity=29.1187739463602, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24585514, Length=264, Percent_Identity=28.4090909090909, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574282, Length=264, Percent_Identity=28.4090909090909, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45552429, Length=264, Percent_Identity=28.4090909090909, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45551003, Length=264, Percent_Identity=28.4090909090909, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI28574284, Length=264, Percent_Identity=28.4090909090909, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28571528, Length=303, Percent_Identity=27.7227722772277, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24585516, Length=320, Percent_Identity=25, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 46007; Mature: 46007

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKDAAIVHDSHSPTPHLSLSKDKIKVLLLEGVNDSAVELLTNAGYTNLTRLPKALDGDA
CCCCCEEEECCCCCCCCCEECCCCEEEEEEECCCHHHHHHHHCCCCCHHHHCCCCCCCHH
LKEAIKGVHILGIRSRTQITPDVLEAADRLIAIGCFSVGTNQVDLDASRISGVPVFNAPF
HHHHHCCEEEEEECCCCCCCHHHHHHHHHEEEEEEEECCCCEEECCHHHHCCCEEECCCC
SNTRSVAELVIGEIVMLLRRIPTRSHAAHEGRWDKSATNSVEVRGKTLGIVGYGNIGSQL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCEEEEEEEECCCCHHH
SILAEAMGLKVIFYDHTDKLRHGQAEPVSTLNALLAQSDIVSLHVPETAATHGMIGRAEI
HHHHHHHCCEEEEECCCHHHHCCCCCHHHHHHHHHHHCCEEEEECCCHHHHCCCCCCCEE
ATMKPGAYLINNSRGTVVDLDALAEALKAGHLRGAAVDVFPVEPGSNAERFVSPLQGLDN
EEECCCEEEEECCCCCEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCC
VILTPHIGGSTEEAQERIGAEVARKLVDYSDTGSTMGAVNFPEVQLPARPTGTRFIQIHR
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEEC
NLPGMLGRLNEVLARHSVNIAAQYLETYADVGYVVLDADASTADSQSVLADIREIEGTIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
ARLLYERKI
HHHEEECCC
>Mature Secondary Structure
MLKDAAIVHDSHSPTPHLSLSKDKIKVLLLEGVNDSAVELLTNAGYTNLTRLPKALDGDA
CCCCCEEEECCCCCCCCCEECCCCEEEEEEECCCHHHHHHHHCCCCCHHHHCCCCCCCHH
LKEAIKGVHILGIRSRTQITPDVLEAADRLIAIGCFSVGTNQVDLDASRISGVPVFNAPF
HHHHHCCEEEEEECCCCCCCHHHHHHHHHEEEEEEEECCCCEEECCHHHHCCCEEECCCC
SNTRSVAELVIGEIVMLLRRIPTRSHAAHEGRWDKSATNSVEVRGKTLGIVGYGNIGSQL
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCEEEEEEEECCCCHHH
SILAEAMGLKVIFYDHTDKLRHGQAEPVSTLNALLAQSDIVSLHVPETAATHGMIGRAEI
HHHHHHHCCEEEEECCCHHHHCCCCCHHHHHHHHHHHCCEEEEECCCHHHHCCCCCCCEE
ATMKPGAYLINNSRGTVVDLDALAEALKAGHLRGAAVDVFPVEPGSNAERFVSPLQGLDN
EEECCCEEEEECCCCCEEEHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHCCCC
VILTPHIGGSTEEAQERIGAEVARKLVDYSDTGSTMGAVNFPEVQLPARPTGTRFIQIHR
EEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCEEEEEEC
NLPGMLGRLNEVLARHSVNIAAQYLETYADVGYVVLDADASTADSQSVLADIREIEGTIR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHH
ARLLYERKI
HHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]