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The map label for this gene is ccdA [H]

Identifier: 154247709

GI number: 154247709

Start: 4192763

End: 4193494

Strand: Direct

Name: ccdA [H]

Synonym: Xaut_3785

Alternate gene names: 154247709

Gene position: 4192763-4193494 (Clockwise)

Preceding gene: 154247707

Following gene: 154247710

Centisome position: 78.98

GC content: 68.44

Gene sequence:

>732_bases
ATGGCCGACGTGACCCTGCCCGCCGCCTTTCTCGCCGGCCTCGTGAGCTTCGTTTCCCCCTGCGTGCTGCCTTTGGTGCC
GCCCTATTTGTGCTTTCTCGGCGGCAGCACGCTGGATGACCTCGCCGGCGACGAGCCGGTGAAGGAGGTGGGGCGCCGGG
CCATGGTGGGGGCCGTGCTGTTCGTGGCCGGCTTCAGCGTGGTGTTCGTGATGCTGGGGGCGGGGGCGTCGGCCATCGGC
GATCTGCTGCGGGCGCATCTCGACGTGCTCTCCATCATCGCCGGCCTCGCCATCATCGTGATGGGGCTGAACTTCCTCGG
CGTGTTCCGCATTCACCTGCTGCATCGTACCGCGCGCGCCCATGTGCACGAGCCCACCGGCATCTGGGGCGCCTTCGTGA
TGGGACTGGCCTTCGCCTTCGGCTGGACGCCCTGCCTCGGCCCGGTGCTGGGCGCGATTCTCGCGGTGGCGGGGTCGGAG
GCGACGGTGTCCAAGGGGGCGGGGCTGCTCGCCATCTATTCGCTGGGGCTCGGGGTGCCGTTCCTGCTGGCGGCGTTTGC
GGTGCGGCCGTTCCTGAAAAGCCTCGTCCATATGCGCAAGATCCTGCCGGTGGTGGAGAAGGCCATGGGCGCGCTGCTGG
TGCTCACAGGCATCGCCTTCATGTCCGGCTGGATCGCCCATGCGAGCTATTGGCTCATCGAGACCTTCCCGGCGCTCTCG
ACGCTGGGGTGA

Upstream 100 bases:

>100_bases
GTCTCCGGCGGCTCATGAGGCAAAGCAACGCGAGACGGTGCGTCGACGGGACGCCCGCCTGCTCACCGGATGCGCGACAG
AGGAGCTGCGACGAAGACCC

Downstream 100 bases:

>100_bases
CGGGTCCATGCCATTTCCGCCGGCAAGCGTGGCGAAAGGCCACCTCGCCGTTGCGCCATGCCGGACCTTCCGGGATACTC
CGCGCCCGATCGAGTCTGGC

Product: cytochrome c biogenesis protein transmembrane subunit

Products: DsbDoxidized; DsbGreduced [C]

Alternate protein names: NA

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MADVTLPAAFLAGLVSFVSPCVLPLVPPYLCFLGGSTLDDLAGDEPVKEVGRRAMVGAVLFVAGFSVVFVMLGAGASAIG
DLLRAHLDVLSIIAGLAIIVMGLNFLGVFRIHLLHRTARAHVHEPTGIWGAFVMGLAFAFGWTPCLGPVLGAILAVAGSE
ATVSKGAGLLAIYSLGLGVPFLLAAFAVRPFLKSLVHMRKILPVVEKAMGALLVLTGIAFMSGWIAHASYWLIETFPALS
TLG

Sequences:

>Translated_243_residues
MADVTLPAAFLAGLVSFVSPCVLPLVPPYLCFLGGSTLDDLAGDEPVKEVGRRAMVGAVLFVAGFSVVFVMLGAGASAIG
DLLRAHLDVLSIIAGLAIIVMGLNFLGVFRIHLLHRTARAHVHEPTGIWGAFVMGLAFAFGWTPCLGPVLGAILAVAGSE
ATVSKGAGLLAIYSLGLGVPFLLAAFAVRPFLKSLVHMRKILPVVEKAMGALLVLTGIAFMSGWIAHASYWLIETFPALS
TLG
>Mature_242_residues
ADVTLPAAFLAGLVSFVSPCVLPLVPPYLCFLGGSTLDDLAGDEPVKEVGRRAMVGAVLFVAGFSVVFVMLGAGASAIGD
LLRAHLDVLSIIAGLAIIVMGLNFLGVFRIHLLHRTARAHVHEPTGIWGAFVMGLAFAFGWTPCLGPVLGAILAVAGSEA
TVSKGAGLLAIYSLGLGVPFLLAAFAVRPFLKSLVHMRKILPVVEKAMGALLVLTGIAFMSGWIAHASYWLIETFPALST
LG

Specific function: Cytochrome c oxidase activity is partially restored by mutations in bdbC or bdbD that are defective in the synthesis of disulfide bond containing proteins. The same mutations abrogate the need for CcdA in sporulation [H]

COG id: COG0785

COG function: function code O; Cytochrome c biogenesis protein

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DsbD family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834 [H]

Pfam domain/function: PF02683 DsbD [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 25276; Mature: 25144

Theoretical pI: Translated: 8.12; Mature: 8.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCC
>Mature Secondary Structure 
ADVTLPAAFLAGLVSFVSPCVLPLVPPYLCFLGGSTLDDLAGDEPVKEVGRRAMVGAVL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHH
FVAGFSVVFVMLGAGASAIGDLLRAHLDVLSIIAGLAIIVMGLNFLGVFRIHLLHRTARA
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HVHEPTGIWGAFVMGLAFAFGWTPCLGPVLGAILAVAGSEATVSKGAGLLAIYSLGLGVP
HCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHCCHH
FLLAAFAVRPFLKSLVHMRKILPVVEKAMGALLVLTGIAFMSGWIAHASYWLIETFPALS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLG
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DsbGoxidized; DsbDreduced/thiol:disulfide reductase [C]

Specific reaction: DsbDreduced/thiol:disulfide reductase + DsbCoxidized = DsbDoxidized + DsbCreduced DsbGoxidized + DsbDreduced/thiol:disulfide reductase = DsbGreduced + DsbDoxidized [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969507; 9068642; 9384377; 10781554; 11844773 [H]