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The map label for this gene is lysC [H]

Identifier: 154246566

GI number: 154246566

Start: 2912506

End: 2913765

Strand: Reverse

Name: lysC [H]

Synonym: Xaut_2625

Alternate gene names: 154246566

Gene position: 2913765-2912506 (Counterclockwise)

Preceding gene: 154246570

Following gene: 154246565

Centisome position: 54.88

GC content: 66.11

Gene sequence:

>1260_bases
ATGGCTCGGCTGGTGATGAAGTTCGGCGGCACCTCGGTCGCCAATATCGAGCGCATCCGCAATGTGGCGCGCCATGTGAA
GCGCGAAGTCGAGGCCGGCTACCAGGTCGCGGTGGTGGTCTCCGCCATGTCGGGCAAGACCAACGAACTGGTCGGCTGGT
GCAAGGATGCCTCCGCCCTCTACGACCCGCGCGAATATGACGCGGTGGTGGCTTCGGGCGAGCAGGTGACGAGCGGGCTC
CTCGCCATCGTGCTCCAGGAAATGGGCCTCTCCGCCCGGTCCTGGCAGGGCTGGCAGCTGCCCATTTCCACCGACGATGC
CCACGGCTCCGCCCGCATCCTCGACATCGACAGCGAGAAGCTCGGCGCCGCCATCGACGGCGGCCAGGTGGCGGTGATCG
CCGGTTTCCAGGGCATTCACCTGCCCACCGGCCGCCTGACCACCCTCGGCCGGGGCGGCTCGGACACCTCGGCGGTGGCG
GTGGCGGCGGCGCTGAAGGCCGAGCGCTGCGACATCTACACCGATGTGGACGGGGTCTACACCACCGACCCGCGCGTGGT
GCCCAAGGCTCGCCGCCTCGACCGCATCGCCTTCGAGGAGATGCTGGAAATGGCGTCTCTCGGGGCCAAGGTGCTGCAGG
TGCGCTCGGTGGAGCTTGCCATGGTGCATAATGTGCGCACCTTCGTGCGCTCGAGCCTTGTGGATCCCGACGCCCCCGAG
ACGGCGAACGTGGAAAAGGCCGGTACGCTCATCTGCGACGAGGAGGAGATCGTGGCAAACCAGATGGAATCGCAGGTGGT
CACCGGCATCGCCTTCTCCAAGGACGAAGCCCAGGTCTCCATCCGCCGGGTCGCCGACAAGCCGGGCATCGCCGCCGCCG
TGTTCGGGCCTTTGGCCGATGCCCACATCAATGTGGACATGATCGTTCAGAACGTGTCGGCGGATGGCTTCACCGACATC
ACCTTCACCGTTCCCACCGCCGATTTCGAGCGCGCCAAGGCGGTGATCGAGAAGGCGCGGGACACCATCGCCCACCAGGT
GGTGGAAGGCGCCACCGACGTGACGAAGGTGTCGGTCATCGGCATCGGCATGCGCTCCCACGCCGGCGTTGCGGCGCAGG
CGTTCCAGGCGCTGGCAGGCAAGGGAATCAACATCCGGGCCATCACCACGTCGGAGATCAAGATCTCGTTCCTGATCGAT
GCGGCATATACCGAACTTGCGGTTCGGACTCTCCATTCGCTATACGGGCTGGACAGCTGA

Upstream 100 bases:

>100_bases
GGCGCGCCGGCGAAAATGACGCGTCCCTGACCCCGGCCCACCTCAGCGGGCCACCAGAGACGTTTCCCATCCGTTTTCCA
GGCGAAGAAAGGCACGAGCG

Downstream 100 bases:

>100_bases
TGGGCGAACCTGCGGGCGCGCGCCGTTCGACGAAGAGCCCCGCGGGCACCTGAAACCCGCCCACATTTAAGGATGCGGCC
GATGCGTGGCGCGCTCGGCG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MARLVMKFGGTSVANIERIRNVARHVKREVEAGYQVAVVVSAMSGKTNELVGWCKDASALYDPREYDAVVASGEQVTSGL
LAIVLQEMGLSARSWQGWQLPISTDDAHGSARILDIDSEKLGAAIDGGQVAVIAGFQGIHLPTGRLTTLGRGGSDTSAVA
VAAALKAERCDIYTDVDGVYTTDPRVVPKARRLDRIAFEEMLEMASLGAKVLQVRSVELAMVHNVRTFVRSSLVDPDAPE
TANVEKAGTLICDEEEIVANQMESQVVTGIAFSKDEAQVSIRRVADKPGIAAAVFGPLADAHINVDMIVQNVSADGFTDI
TFTVPTADFERAKAVIEKARDTIAHQVVEGATDVTKVSVIGIGMRSHAGVAAQAFQALAGKGINIRAITTSEIKISFLID
AAYTELAVRTLHSLYGLDS

Sequences:

>Translated_419_residues
MARLVMKFGGTSVANIERIRNVARHVKREVEAGYQVAVVVSAMSGKTNELVGWCKDASALYDPREYDAVVASGEQVTSGL
LAIVLQEMGLSARSWQGWQLPISTDDAHGSARILDIDSEKLGAAIDGGQVAVIAGFQGIHLPTGRLTTLGRGGSDTSAVA
VAAALKAERCDIYTDVDGVYTTDPRVVPKARRLDRIAFEEMLEMASLGAKVLQVRSVELAMVHNVRTFVRSSLVDPDAPE
TANVEKAGTLICDEEEIVANQMESQVVTGIAFSKDEAQVSIRRVADKPGIAAAVFGPLADAHINVDMIVQNVSADGFTDI
TFTVPTADFERAKAVIEKARDTIAHQVVEGATDVTKVSVIGIGMRSHAGVAAQAFQALAGKGINIRAITTSEIKISFLID
AAYTELAVRTLHSLYGLDS
>Mature_418_residues
ARLVMKFGGTSVANIERIRNVARHVKREVEAGYQVAVVVSAMSGKTNELVGWCKDASALYDPREYDAVVASGEQVTSGLL
AIVLQEMGLSARSWQGWQLPISTDDAHGSARILDIDSEKLGAAIDGGQVAVIAGFQGIHLPTGRLTTLGRGGSDTSAVAV
AAALKAERCDIYTDVDGVYTTDPRVVPKARRLDRIAFEEMLEMASLGAKVLQVRSVELAMVHNVRTFVRSSLVDPDAPET
ANVEKAGTLICDEEEIVANQMESQVVTGIAFSKDEAQVSIRRVADKPGIAAAVFGPLADAHINVDMIVQNVSADGFTDIT
FTVPTADFERAKAVIEKARDTIAHQVVEGATDVTKVSVIGIGMRSHAGVAAQAFQALAGKGINIRAITTSEIKISFLIDA
AYTELAVRTLHSLYGLDS

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=387, Percent_Identity=31.5245478036176, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1790455, Length=468, Percent_Identity=30.982905982906, Blast_Score=115, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6320893, Length=379, Percent_Identity=26.6490765171504, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 44576; Mature: 44445

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLVMKFGGTSVANIERIRNVARHVKREVEAGYQVAVVVSAMSGKTNELVGWCKDASAL
CCEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHEEECCCHHH
YDPREYDAVVASGEQVTSGLLAIVLQEMGLSARSWQGWQLPISTDDAHGSARILDIDSEK
CCCHHHHHHEECCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCEEEEEECCHH
LGAAIDGGQVAVIAGFQGIHLPTGRLTTLGRGGSDTSAVAVAAALKAERCDIYTDVDGVY
HCCEECCCCEEEEECCCCEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCEE
TTDPRVVPKARRLDRIAFEEMLEMASLGAKVLQVRSVELAMVHNVRTFVRSSLVDPDAPE
ECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TANVEKAGTLICDEEEIVANQMESQVVTGIAFSKDEAQVSIRRVADKPGIAAAVFGPLAD
CCCCHHCCCEEECCHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCCCEEEHHHCCCC
AHINVDMIVQNVSADGFTDITFTVPTADFERAKAVIEKARDTIAHQVVEGATDVTKVSVI
CCCCHHHEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GIGMRSHAGVAAQAFQALAGKGINIRAITTSEIKISFLIDAAYTELAVRTLHSLYGLDS
EECCCCCCCHHHHHHHHHHCCCCEEEEEEECCEEEEEEEEHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ARLVMKFGGTSVANIERIRNVARHVKREVEAGYQVAVVVSAMSGKTNELVGWCKDASAL
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHEEECCCHHH
YDPREYDAVVASGEQVTSGLLAIVLQEMGLSARSWQGWQLPISTDDAHGSARILDIDSEK
CCCHHHHHHEECCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCEEEEEECCHH
LGAAIDGGQVAVIAGFQGIHLPTGRLTTLGRGGSDTSAVAVAAALKAERCDIYTDVDGVY
HCCEECCCCEEEEECCCCEECCCCCEEECCCCCCCHHHHHHHHHHHHHCCCEEECCCCEE
TTDPRVVPKARRLDRIAFEEMLEMASLGAKVLQVRSVELAMVHNVRTFVRSSLVDPDAPE
ECCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
TANVEKAGTLICDEEEIVANQMESQVVTGIAFSKDEAQVSIRRVADKPGIAAAVFGPLAD
CCCCHHCCCEEECCHHHHHHHHHHHHHHEEEECCCHHHHHHHHHCCCCCCEEEHHHCCCC
AHINVDMIVQNVSADGFTDITFTVPTADFERAKAVIEKARDTIAHQVVEGATDVTKVSVI
CCCCHHHEEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEE
GIGMRSHAGVAAQAFQALAGKGINIRAITTSEIKISFLIDAAYTELAVRTLHSLYGLDS
EECCCCCCCHHHHHHHHHHCCCCEEEEEEECCEEEEEEEEHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]