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The map label for this gene is frmA [H]

Identifier: 154246551

GI number: 154246551

Start: 2895673

End: 2896800

Strand: Reverse

Name: frmA [H]

Synonym: Xaut_2610

Alternate gene names: 154246551

Gene position: 2896800-2895673 (Counterclockwise)

Preceding gene: 154246552

Following gene: 154246548

Centisome position: 54.56

GC content: 70.21

Gene sequence:

>1128_bases
ATGCGTATTCGCGCCGCCGTGCTCCGTGCGTCCCCTGTGAGCAAGCCGTATGGGCAGACGCGTCCGCTCTCCATTGAAAC
GGTTGAGCTCGCCCCGCCCCAGGCCGGCGAGGTGCTGATCAAGATCGCGGCGGCCGGCCTGTGCCATTCCGACCTGTCGG
TGATCAACGGCGACCGTCCCCGCCAGCTGCCCATGGTGTTGGGCCACGAGGCCTCCGGCGTGGTGGTGGAGCCCGGCCCC
GGCGTCACCGACCTTGCCCCCGGCGACCATGTGGTGATGAGCTTCGTGCCCACCTGCGGCACCTGCCCCTCCTGCCTCGA
CGGGCGCGCCCAGATGTGCGGCCCCGGCCAGGCCGCCAACGGCGCGGGCACCCTGCTCGGCGGCGGCCGGCGGCTGACCT
GCGACGACGGCACCGATGCCTATCATCTGTGCGGCATTTCCGGCTTCGGCGAATATGCGGTGATCTCGCGCCGCTCCATC
ATCAAGATCGACCCCGAGATGTCGCTGGTGGACGCCGCGCTGTTCGGCTGCGCGGTGATGACCGGCGTCGGTGCCATCGT
GAACACCTGCGGGGTACGGCCCGGCCAGTCCGTCGCGGTGGTGGGCCTCGGCGGCGTCGGCCTCTCGGCGGTAATGGGCG
CGGTGGCGGCGGGTGCGGAGCAGATTGTCGCCCTCGACCTGTCGCCGGCCAAGCTCGACATCGCCCGCTCGCTGGGCGCC
ACCGACACCTTCCTCGCCAACGATCCCGATGTGGTGGATGCGGTGAAGGCGGCAACCAAGGGCGGAGTAGACCACGCGGT
GGAGATGGCAGGCTCGGCTCCCGCCTTCGAGCTGGCCTACAAGATCACCAGGCGCGGCGGCACCACCGCCACCGGCGGCC
TCGCCAATCCCAACGCCCGGGTCTCGCTGCCCCCGGTGCATCTCGTGGCGGAGGAACGCACCATCAAGGGCAGCTACATG
GGCAGCTGCGTGCCCCCGCGCGACATTCCCCGCTTCATGGCGCTCTACCAGCGCGGCAAGCTGCCGGTGAACCGCCTGCT
CTCCTCCACCGGTCCGCTGGACGAGATCAACGAGGGCTTCGACCGCCTCGACCGCGGCGAGGTGGTGCGACACGTCATCG
TCTATTGA

Upstream 100 bases:

>100_bases
AGACTGAAATTCACCCCTCCCAAATGCGCAGTCCGACACGCTTGACGCTACGCCCCGGCGCCCTCAATACGGTCGGCAAA
GAGGCTCGGGAGGAAATATC

Downstream 100 bases:

>100_bases
GCGGGACGCGGCGGGAGAGGGTTCCCTTCCCCGCCGCATCGCAAGAGCCATTTGGCTGACGCGTTTTCTTCACGCGAACC
GGTATCCACATCGCGTGAAA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MRIRAAVLRASPVSKPYGQTRPLSIETVELAPPQAGEVLIKIAAAGLCHSDLSVINGDRPRQLPMVLGHEASGVVVEPGP
GVTDLAPGDHVVMSFVPTCGTCPSCLDGRAQMCGPGQAANGAGTLLGGGRRLTCDDGTDAYHLCGISGFGEYAVISRRSI
IKIDPEMSLVDAALFGCAVMTGVGAIVNTCGVRPGQSVAVVGLGGVGLSAVMGAVAAGAEQIVALDLSPAKLDIARSLGA
TDTFLANDPDVVDAVKAATKGGVDHAVEMAGSAPAFELAYKITRRGGTTATGGLANPNARVSLPPVHLVAEERTIKGSYM
GSCVPPRDIPRFMALYQRGKLPVNRLLSSTGPLDEINEGFDRLDRGEVVRHVIVY

Sequences:

>Translated_375_residues
MRIRAAVLRASPVSKPYGQTRPLSIETVELAPPQAGEVLIKIAAAGLCHSDLSVINGDRPRQLPMVLGHEASGVVVEPGP
GVTDLAPGDHVVMSFVPTCGTCPSCLDGRAQMCGPGQAANGAGTLLGGGRRLTCDDGTDAYHLCGISGFGEYAVISRRSI
IKIDPEMSLVDAALFGCAVMTGVGAIVNTCGVRPGQSVAVVGLGGVGLSAVMGAVAAGAEQIVALDLSPAKLDIARSLGA
TDTFLANDPDVVDAVKAATKGGVDHAVEMAGSAPAFELAYKITRRGGTTATGGLANPNARVSLPPVHLVAEERTIKGSYM
GSCVPPRDIPRFMALYQRGKLPVNRLLSSTGPLDEINEGFDRLDRGEVVRHVIVY
>Mature_375_residues
MRIRAAVLRASPVSKPYGQTRPLSIETVELAPPQAGEVLIKIAAAGLCHSDLSVINGDRPRQLPMVLGHEASGVVVEPGP
GVTDLAPGDHVVMSFVPTCGTCPSCLDGRAQMCGPGQAANGAGTLLGGGRRLTCDDGTDAYHLCGISGFGEYAVISRRSI
IKIDPEMSLVDAALFGCAVMTGVGAIVNTCGVRPGQSVAVVGLGGVGLSAVMGAVAAGAEQIVALDLSPAKLDIARSLGA
TDTFLANDPDVVDAVKAATKGGVDHAVEMAGSAPAFELAYKITRRGGTTATGGLANPNARVSLPPVHLVAEERTIKGSYM
GSCVPPRDIPRFMALYQRGKLPVNRLLSSTGPLDEINEGFDRLDRGEVVRHVIVY

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI34577061, Length=378, Percent_Identity=37.8306878306878, Blast_Score=243, Evalue=2e-64,
Organism=Homo sapiens, GI4501933, Length=378, Percent_Identity=37.3015873015873, Blast_Score=242, Evalue=4e-64,
Organism=Homo sapiens, GI71565152, Length=363, Percent_Identity=37.7410468319559, Blast_Score=238, Evalue=8e-63,
Organism=Homo sapiens, GI4501929, Length=378, Percent_Identity=36.2433862433862, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI71565154, Length=357, Percent_Identity=35.2941176470588, Blast_Score=224, Evalue=7e-59,
Organism=Homo sapiens, GI71743840, Length=378, Percent_Identity=33.8624338624339, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI262073058, Length=378, Percent_Identity=33.8624338624339, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI156523966, Length=379, Percent_Identity=35.6200527704486, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4501939, Length=372, Percent_Identity=36.0215053763441, Blast_Score=204, Evalue=9e-53,
Organism=Escherichia coli, GI1786552, Length=379, Percent_Identity=38.7862796833773, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1788407, Length=336, Percent_Identity=29.7619047619048, Blast_Score=117, Evalue=9e-28,
Organism=Escherichia coli, GI87082125, Length=313, Percent_Identity=30.0319488817891, Blast_Score=106, Evalue=3e-24,
Organism=Escherichia coli, GI87081918, Length=362, Percent_Identity=29.2817679558011, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790045, Length=353, Percent_Identity=28.0453257790368, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI226510992, Length=366, Percent_Identity=27.5956284153005, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786825, Length=372, Percent_Identity=27.4193548387097, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788075, Length=358, Percent_Identity=24.5810055865922, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786518, Length=366, Percent_Identity=25.4098360655738, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790718, Length=286, Percent_Identity=25.1748251748252, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI87082401, Length=360, Percent_Identity=24.7222222222222, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787863, Length=220, Percent_Identity=29.0909090909091, Blast_Score=62, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=370, Percent_Identity=37.027027027027, Blast_Score=248, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI71997431, Length=372, Percent_Identity=36.8279569892473, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17565904, Length=345, Percent_Identity=35.6521739130435, Blast_Score=214, Evalue=4e-56,
Organism=Caenorhabditis elegans, GI17562584, Length=357, Percent_Identity=28.8515406162465, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17562876, Length=361, Percent_Identity=27.1468144044321, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17562878, Length=362, Percent_Identity=26.5193370165746, Blast_Score=95, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17562582, Length=363, Percent_Identity=28.6501377410468, Blast_Score=92, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320033, Length=381, Percent_Identity=35.1706036745407, Blast_Score=227, Evalue=3e-60,
Organism=Saccharomyces cerevisiae, GI6319621, Length=366, Percent_Identity=28.9617486338798, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6324486, Length=365, Percent_Identity=28.7671232876712, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6323961, Length=365, Percent_Identity=28.7671232876712, Blast_Score=102, Evalue=7e-23,
Organism=Saccharomyces cerevisiae, GI6323729, Length=365, Percent_Identity=27.6712328767123, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6319258, Length=313, Percent_Identity=25.8785942492013, Blast_Score=83, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322619, Length=350, Percent_Identity=27.7142857142857, Blast_Score=80, Evalue=7e-16,
Organism=Drosophila melanogaster, GI17737895, Length=367, Percent_Identity=37.3297002724796, Blast_Score=245, Evalue=3e-65,
Organism=Drosophila melanogaster, GI17737897, Length=338, Percent_Identity=28.9940828402367, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI17137530, Length=338, Percent_Identity=26.9230769230769, Blast_Score=93, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 38595; Mature: 38595

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIRAAVLRASPVSKPYGQTRPLSIETVELAPPQAGEVLIKIAAAGLCHSDLSVINGDRP
CCCHHEEHHCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHCCCCCHHHHCCCCC
RQLPMVLGHEASGVVVEPGPGVTDLAPGDHVVMSFVPTCGTCPSCLDGRAQMCGPGQAAN
CCCCEEECCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCCCC
GAGTLLGGGRRLTCDDGTDAYHLCGISGFGEYAVISRRSIIKIDPEMSLVDAALFGCAVM
CCEEEECCCEEEEECCCCCEEEEECCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHH
TGVGAIVNTCGVRPGQSVAVVGLGGVGLSAVMGAVAAGAEQIVALDLSPAKLDIARSLGA
HHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCC
TDTFLANDPDVVDAVKAATKGGVDHAVEMAGSAPAFELAYKITRRGGTTATGGLANPNAR
CCCEECCCCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCE
VSLPPVHLVAEERTIKGSYMGSCVPPRDIPRFMALYQRGKLPVNRLLSSTGPLDEINEGF
EECCCEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHH
DRLDRGEVVRHVIVY
HHCCHHHHHHHHHCC
>Mature Secondary Structure
MRIRAAVLRASPVSKPYGQTRPLSIETVELAPPQAGEVLIKIAAAGLCHSDLSVINGDRP
CCCHHEEHHCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEHHHHCCCCCHHHHCCCCC
RQLPMVLGHEASGVVVEPGPGVTDLAPGDHVVMSFVPTCGTCPSCLDGRAQMCGPGQAAN
CCCCEEECCCCCCEEECCCCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCCCCCCCCCCC
GAGTLLGGGRRLTCDDGTDAYHLCGISGFGEYAVISRRSIIKIDPEMSLVDAALFGCAVM
CCEEEECCCEEEEECCCCCEEEEECCCCCCCEEEEECCEEEEECCCHHHHHHHHHHHHHH
TGVGAIVNTCGVRPGQSVAVVGLGGVGLSAVMGAVAAGAEQIVALDLSPAKLDIARSLGA
HHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHCCCCEEEEEECCCHHHHHHHHCCC
TDTFLANDPDVVDAVKAATKGGVDHAVEMAGSAPAFELAYKITRRGGTTATGGLANPNAR
CCCEECCCCHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCE
VSLPPVHLVAEERTIKGSYMGSCVPPRDIPRFMALYQRGKLPVNRLLSSTGPLDEINEGF
EECCCEEEEECCCEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHH
DRLDRGEVVRHVIVY
HHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]