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The map label for this gene is 154246397

Identifier: 154246397

GI number: 154246397

Start: 2744448

End: 2745158

Strand: Direct

Name: 154246397

Synonym: Xaut_2456

Alternate gene names: NA

Gene position: 2744448-2745158 (Clockwise)

Preceding gene: 154246396

Following gene: 154246398

Centisome position: 51.69

GC content: 73.84

Gene sequence:

>711_bases
ATGCGGCTCGTCTGCCTGCCCCATGCCGGAGCCTCGGCGGCGCTGTTCCGGCCCTGGAAGGTCACGCTCTCCGGCATCGC
CACCGTGGACAGCCCGGAGCTGCCGGGCCGCGGCACCCGCTACGGCGCCCCCTTCGCCACCGACATGGCGGCACTGGCGG
ATGATCTTGCCGACACGCTGGCGCAGCGCACCGTGCCGCTGGTGCTCTATGGCCATTCCATGGGCGCGCTTTTGGCCTTC
GAGGTGGCGCGATCGCTGGCCCGGCAGGGGGTGAGCGTGGCCGGGCTGGTGCTGTCGGGCCGCGCCGCGCCGCATCTCGA
CGGCCCGCCCCGCGCCCGCCACACCATGACCGACGCCGAGCTCGTGGCCGAGCTGACCGCCATCGGCGGCACCTCGAAGG
AGGTGCTGGCCCAGCCGGACCTGCTCGCCATGACCCTGCCCGCCGTGCGTGCCGACTTCCGCATGGTGGACACCTACGCC
TTCAAGCCCGGCCCGGCGCTGGCGGTGCCCGCCATCATCCTCGGCGGCTCCCAGGATGCCGCGACCCCGCCGGAAACCCT
CCACGCCTGGAGCGCGCTGATCAGTGGCCCGCTCACGGTGGAGCTGTGGCCCGGCGGCCATTTCTTCGTGCGCGACCAGG
AAGCGCGGCTGCTCGCCCTGCTGGCCAAGGTCATCCCCGCCTGGCGCGCCGCCCGCGCCGCTGTCGTCTGA

Upstream 100 bases:

>100_bases
TTTTCACGCTTACTCTCGGCGTGAGGGGCACGCCATGCAGATGATCCGACACGTCCGTTCCGTGATGCGCCGCAGCACCC
GCGCTGGGAGGGCCTGAGCC

Downstream 100 bases:

>100_bases
GCGAGACGGGTCAGGCCCTTGAATATCCAGCTCCACACCCTCACGTACCCATCTGTGAAAACGTTTCCAGACCCCGCCGG
CCTGCCGCTCCCCGGCCCCG

Product: thioesterase

Products: NA

Alternate protein names: ORF-1; Protein X [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MRLVCLPHAGASAALFRPWKVTLSGIATVDSPELPGRGTRYGAPFATDMAALADDLADTLAQRTVPLVLYGHSMGALLAF
EVARSLARQGVSVAGLVLSGRAAPHLDGPPRARHTMTDAELVAELTAIGGTSKEVLAQPDLLAMTLPAVRADFRMVDTYA
FKPGPALAVPAIILGGSQDAATPPETLHAWSALISGPLTVELWPGGHFFVRDQEARLLALLAKVIPAWRAARAAVV

Sequences:

>Translated_236_residues
MRLVCLPHAGASAALFRPWKVTLSGIATVDSPELPGRGTRYGAPFATDMAALADDLADTLAQRTVPLVLYGHSMGALLAF
EVARSLARQGVSVAGLVLSGRAAPHLDGPPRARHTMTDAELVAELTAIGGTSKEVLAQPDLLAMTLPAVRADFRMVDTYA
FKPGPALAVPAIILGGSQDAATPPETLHAWSALISGPLTVELWPGGHFFVRDQEARLLALLAKVIPAWRAARAAVV
>Mature_236_residues
MRLVCLPHAGASAALFRPWKVTLSGIATVDSPELPGRGTRYGAPFATDMAALADDLADTLAQRTVPLVLYGHSMGALLAF
EVARSLARQGVSVAGLVLSGRAAPHLDGPPRARHTMTDAELVAELTAIGGTSKEVLAQPDLLAMTLPAVRADFRMVDTYA
FKPGPALAVPAIILGGSQDAATPPETLHAWSALISGPLTVELWPGGHFFVRDQEARLLALLAKVIPAWRAARAAVV

Specific function: Probable thioesterase involved in the biosynthesis of candicidin. Could release the macrolide ring from the polyketide synthase [H]

COG id: COG3208

COG function: function code Q; Predicted thioesterase involved in non-ribosomal peptide biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI89257335, Length=223, Percent_Identity=29.1479820627803, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI8922871, Length=198, Percent_Identity=29.7979797979798, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR010693
- InterPro:   IPR012223
- InterPro:   IPR001031 [H]

Pfam domain/function: PF06902 DUF1271; PF00975 Thioesterase [H]

EC number: NA

Molecular weight: Translated: 24706; Mature: 24706

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVCLPHAGASAALFRPWKVTLSGIATVDSPELPGRGTRYGAPFATDMAALADDLADTL
CEEEEECCCCCCCEEECCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AQRTVPLVLYGHSMGALLAFEVARSLARQGVSVAGLVLSGRAAPHLDGPPRARHTMTDAE
HHCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHCCHHHH
LVAELTAIGGTSKEVLAQPDLLAMTLPAVRADFRMVDTYAFKPGPALAVPAIILGGSQDA
HHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCEECEEEECCCCCC
ATPPETLHAWSALISGPLTVELWPGGHFFVRDQEARLLALLAKVIPAWRAARAAVV
CCCHHHHHHHHHHHCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLVCLPHAGASAALFRPWKVTLSGIATVDSPELPGRGTRYGAPFATDMAALADDLADTL
CEEEEECCCCCCCEEECCCEEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
AQRTVPLVLYGHSMGALLAFEVARSLARQGVSVAGLVLSGRAAPHLDGPPRARHTMTDAE
HHCCCEEEEECCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCCCCCHHCCHHHH
LVAELTAIGGTSKEVLAQPDLLAMTLPAVRADFRMVDTYAFKPGPALAVPAIILGGSQDA
HHHHHHHCCCCCHHHHCCCCHHHHHHHHHHHCCEEEEEEEECCCCCCEECEEEECCCCCC
ATPPETLHAWSALISGPLTVELWPGGHFFVRDQEARLLALLAKVIPAWRAARAAVV
CCCHHHHHHHHHHHCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8472954 [H]