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The map label for this gene is idnD [H]

Identifier: 154246377

GI number: 154246377

Start: 2722996

End: 2724033

Strand: Reverse

Name: idnD [H]

Synonym: Xaut_2436

Alternate gene names: 154246377

Gene position: 2724033-2722996 (Counterclockwise)

Preceding gene: 154246384

Following gene: 154246376

Centisome position: 51.31

GC content: 69.85

Gene sequence:

>1038_bases
ATGAAGGCCGCCGTCATCCACGCCGCCAAGGACCTGCGCCTCGACGAGTGCCCCGAGCCGGAAATGGCCGCCAACGAGGT
GCTGGTGTCGTTCCGCGCCGGCGGCATCTGCGGCTCGGACCTGTCCTATTACGGCAAGGGCCGGGTGGGCGATTTCGCCC
TCAGGCAGCCCATGGTGCTGGGCCACGAGATTTCCGGCGAGGTGATCAAGCTCGGCGCGTCCGTGAGCACGCTGGCGCTG
GGCGACCATGTGGCGGTGAACCCGAGCCGGCCGTGCCTGGAATGCGACTATTGCCGCGCCGGGCGCAGCAATCTGTGCCG
CAACATGCGCTTCTTCGGCAGCGCCGCCATCTATCCCCACGTGCAGGGCGCCTTTTCCGAAACCTTCGTGTGCCGCGCCG
ACCAGTGCGTGAGCGTGCCCCGCGACATCCCGTTCCGCCGGGTGGCCATGGCCGAACCGCTGTCGGTGGCCATCCATGGC
GTGCGCCGTGCAGGCGAGCTGGCGGGCAAGCGCGTGCTGATCGCCGGCGCCGGCCCCATCGGCATGCTGCTCGCCATCGC
CGCGCGGCGGGTTGGCGCGAGCTACATCGCCATCACCGACATCGTGGATGCGCCGCTGGAGCTGGCCCGCGCCGCCGGCG
TGGACGAGACCATCAACGTCGCCACCGCGCCCGAGCAGCTCGCCCGCTACGAGAAGGACAAGGGCTTCTTCGACGCCGCG
CTGGAGGCCACCGGCGTGCCGCAGGCCCTCGCCTCCCTGTTCAAGGTGGTGCGGCCGGGCGGACGGGTGGTGCAACTCGG
CATGATGCCCCCCGGCGACGTGCCGGTGCCGGCCAACATGCTGATGGCGCGGGAGATCGATTTCGTCGGCGCCTTCCGCT
TCTCCGGCGAGTTCGCGACCGCCGTGGACTGGCTGGTGCGCGGCCTCATCGATGTGGAGCCGGTCATGTCCGCGGACCTG
CCCATGAGCCGTCTGGACGAAGCCTTCCAACTCGCCGCCGACCGCAGCCGCGCCATCAAGGTGCATCTGCATTTTTGA

Upstream 100 bases:

>100_bases
CTCTTGCGCGAACTGTATTTCATGATATCGGTAACATGACAAGAGGCAAAGCGGACCGCGATCCGCACTTTCGCCGCCTG
CATCAGCAAGGAGAGGAAAC

Downstream 100 bases:

>100_bases
ACCGGCACGTGTGAACGCACCCGCCCCATCCCCATTCCGCGCCGGTCGGACGCCCGCGCGCCGCTTCATCTGGAGACAAT
CATGTTCACGCGCAGCGCCG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKAAVIHAAKDLRLDECPEPEMAANEVLVSFRAGGICGSDLSYYGKGRVGDFALRQPMVLGHEISGEVIKLGASVSTLAL
GDHVAVNPSRPCLECDYCRAGRSNLCRNMRFFGSAAIYPHVQGAFSETFVCRADQCVSVPRDIPFRRVAMAEPLSVAIHG
VRRAGELAGKRVLIAGAGPIGMLLAIAARRVGASYIAITDIVDAPLELARAAGVDETINVATAPEQLARYEKDKGFFDAA
LEATGVPQALASLFKVVRPGGRVVQLGMMPPGDVPVPANMLMAREIDFVGAFRFSGEFATAVDWLVRGLIDVEPVMSADL
PMSRLDEAFQLAADRSRAIKVHLHF

Sequences:

>Translated_345_residues
MKAAVIHAAKDLRLDECPEPEMAANEVLVSFRAGGICGSDLSYYGKGRVGDFALRQPMVLGHEISGEVIKLGASVSTLAL
GDHVAVNPSRPCLECDYCRAGRSNLCRNMRFFGSAAIYPHVQGAFSETFVCRADQCVSVPRDIPFRRVAMAEPLSVAIHG
VRRAGELAGKRVLIAGAGPIGMLLAIAARRVGASYIAITDIVDAPLELARAAGVDETINVATAPEQLARYEKDKGFFDAA
LEATGVPQALASLFKVVRPGGRVVQLGMMPPGDVPVPANMLMAREIDFVGAFRFSGEFATAVDWLVRGLIDVEPVMSADL
PMSRLDEAFQLAADRSRAIKVHLHF
>Mature_345_residues
MKAAVIHAAKDLRLDECPEPEMAANEVLVSFRAGGICGSDLSYYGKGRVGDFALRQPMVLGHEISGEVIKLGASVSTLAL
GDHVAVNPSRPCLECDYCRAGRSNLCRNMRFFGSAAIYPHVQGAFSETFVCRADQCVSVPRDIPFRRVAMAEPLSVAIHG
VRRAGELAGKRVLIAGAGPIGMLLAIAARRVGASYIAITDIVDAPLELARAAGVDETINVATAPEQLARYEKDKGFFDAA
LEATGVPQALASLFKVVRPGGRVVQLGMMPPGDVPVPANMLMAREIDFVGAFRFSGEFATAVDWLVRGLIDVEPVMSADL
PMSRLDEAFQLAADRSRAIKVHLHF

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=331, Percent_Identity=35.0453172205438, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=24.7978436657682, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI71565152, Length=374, Percent_Identity=22.7272727272727, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1790718, Length=321, Percent_Identity=42.6791277258567, Blast_Score=271, Evalue=4e-74,
Organism=Escherichia coli, GI1790045, Length=337, Percent_Identity=30.8605341246291, Blast_Score=164, Evalue=8e-42,
Organism=Escherichia coli, GI1788073, Length=333, Percent_Identity=29.4294294294294, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787863, Length=349, Percent_Identity=28.3667621776504, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1788407, Length=328, Percent_Identity=29.5731707317073, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI226510992, Length=354, Percent_Identity=28.8135593220339, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788075, Length=350, Percent_Identity=24.2857142857143, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87082125, Length=305, Percent_Identity=28.1967213114754, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081918, Length=336, Percent_Identity=29.1666666666667, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786825, Length=223, Percent_Identity=26.9058295964126, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786552, Length=332, Percent_Identity=25.3012048192771, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786518, Length=283, Percent_Identity=27.208480565371, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=346, Percent_Identity=36.7052023121387, Blast_Score=227, Evalue=8e-60,
Organism=Caenorhabditis elegans, GI17562878, Length=346, Percent_Identity=37.8612716763006, Blast_Score=215, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI17562584, Length=323, Percent_Identity=26.3157894736842, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI71988145, Length=267, Percent_Identity=26.9662921348315, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=288, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=272, Percent_Identity=29.0441176470588, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=213, Percent_Identity=28.6384976525822, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562582, Length=167, Percent_Identity=27.5449101796407, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322619, Length=336, Percent_Identity=30.6547619047619, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319955, Length=336, Percent_Identity=30.3571428571429, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6323099, Length=337, Percent_Identity=30.5637982195846, Blast_Score=168, Evalue=9e-43,
Organism=Saccharomyces cerevisiae, GI6319258, Length=361, Percent_Identity=28.2548476454294, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6319257, Length=343, Percent_Identity=25.9475218658892, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6324486, Length=336, Percent_Identity=26.1904761904762, Blast_Score=85, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323729, Length=339, Percent_Identity=25.6637168141593, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6319621, Length=330, Percent_Identity=26.6666666666667, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323961, Length=343, Percent_Identity=23.9067055393586, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=361, Percent_Identity=22.9916897506925, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17737897, Length=347, Percent_Identity=37.463976945245, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI17137530, Length=347, Percent_Identity=36.0230547550432, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI17737895, Length=364, Percent_Identity=26.6483516483516, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221457811, Length=322, Percent_Identity=24.8447204968944, Blast_Score=85, Evalue=8e-17,
Organism=Drosophila melanogaster, GI45550770, Length=322, Percent_Identity=24.8447204968944, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI45551930, Length=322, Percent_Identity=24.8447204968944, Blast_Score=85, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 36933; Mature: 36933

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAAVIHAAKDLRLDECPEPEMAANEVLVSFRAGGICGSDLSYYGKGRVGDFALRQPMVL
CCCCEEEHHHHCCCCCCCCCCHHHHHEEEEEECCCCCCCCCCCCCCCCCCCHHHCCCCCC
GHEISGEVIKLGASVSTLALGDHVAVNPSRPCLECDYCRAGRSNLCRNMRFFGSAAIYPH
CCCCCCCEEEECCCEEEEEECCEEEECCCCCCCCCHHHHCCHHHHHHHHHHHCCEECCCC
VQGAFSETFVCRADQCVSVPRDIPFRRVAMAEPLSVAIHGVRRAGELAGKRVLIAGAGPI
CCCCHHHHEEECCHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCHH
GMLLAIAARRVGASYIAITDIVDAPLELARAAGVDETINVATAPEQLARYEKDKGFFDAA
HHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHCCCHHHHH
LEATGVPQALASLFKVVRPGGRVVQLGMMPPGDVPVPANMLMAREIDFVGAFRFSGEFAT
HHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCHHH
AVDWLVRGLIDVEPVMSADLPMSRLDEAFQLAADRSRAIKVHLHF
HHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEC
>Mature Secondary Structure
MKAAVIHAAKDLRLDECPEPEMAANEVLVSFRAGGICGSDLSYYGKGRVGDFALRQPMVL
CCCCEEEHHHHCCCCCCCCCCHHHHHEEEEEECCCCCCCCCCCCCCCCCCCHHHCCCCCC
GHEISGEVIKLGASVSTLALGDHVAVNPSRPCLECDYCRAGRSNLCRNMRFFGSAAIYPH
CCCCCCCEEEECCCEEEEEECCEEEECCCCCCCCCHHHHCCHHHHHHHHHHHCCEECCCC
VQGAFSETFVCRADQCVSVPRDIPFRRVAMAEPLSVAIHGVRRAGELAGKRVLIAGAGPI
CCCCHHHHEEECCHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCCEEEEECCCHH
GMLLAIAARRVGASYIAITDIVDAPLELARAAGVDETINVATAPEQLARYEKDKGFFDAA
HHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHCCCHHHHH
LEATGVPQALASLFKVVRPGGRVVQLGMMPPGDVPVPANMLMAREIDFVGAFRFSGEFAT
HHHCCCHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEEECCCHHH
AVDWLVRGLIDVEPVMSADLPMSRLDEAFQLAADRSRAIKVHLHF
HHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]