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The map label for this gene is envZ [H]

Identifier: 154246365

GI number: 154246365

Start: 2706854

End: 2708335

Strand: Direct

Name: envZ [H]

Synonym: Xaut_2424

Alternate gene names: 154246365

Gene position: 2706854-2708335 (Clockwise)

Preceding gene: 154246364

Following gene: 154246366

Centisome position: 50.99

GC content: 71.05

Gene sequence:

>1482_bases
ATGATCCGCCTGTTCCGGCGCAGCCTCGCGGCGCGCTTCATCTGTTTCACCCTGGTCATTCTCGCCCTGTCGCAGGTGGT
GGCATTCTGCATCTCGTGGGACCAGCACGGCCAGTCCCTGCGCAAGGTGGCCAAGGGCGAGATGCTGAGCCGCTGCGCCG
CGCTGGTGCGGGTGCTGGAGGCGACGCCGCCGTCGCTTCAGGGCGACATCCTGCGCGCCAGCGACACCAGCCTCACCCGC
TACTGGATCTCGCCGGATGCGCCCAAGCCGCCCAAGGAGTGGCGCGCCGCCGCCTGGAGGGAGCTTCGCCGGCCGCTGCC
GCGGGTCCAATTGCCCATGCACAGCAGCACGGGGGAGCCGGAGCAGCCGGTGTACCAGCTGCCGAAGGAGCCCACCACGG
GCGGCTCGACCGAATGGTTCCCGCTTTCGGGGGAGGCGTGGCCGCTGCCGACCCCGGCCAAGTTCATCTATCTCGATGAC
GAGAACGGCATGGGCATCGCGGCGCAGCTGTCCAACGGGTCATGGCTCAACGCGGCGTTTGTGAAGCCCGGCCACGAGTG
GTTCTGGACCGCCCGCTCGCTCACCTTCCTGGCCGCCGCCGGCCTGTTCTTCTGTGTCCTTGCTGTGGTCGCGGCGCAGG
GCATCACCCGGCCGCTGCGGCGCCTTGCCAACGCGGCGGAAGCCCTCGGCCGGGGCGAGAAGATCGAGCCTTTGCCCGAA
AGCGGCCCGGATGATGTGACCGCCATCGCCTTCAACCGCATGCAGGAGCGCCTGACGCGCTTCGTCGACGACCGCACCCG
CATGTTCGCGGCCCTGAGCCACGACCTGCGCACGCCGCTCACCTCCCTGCGCCTGCGCGCCGAGTTCGTCGCCGACGACG
AGCTGCGGGAGAAGATGCTCGGCACCATCGCCGAGATCCAGGGCATGGCGGAGGCAAGCCTTGCCTTCGTGCGCGCCGAC
GCCACCGCCGAGACCACCCGCACCGTGGACCTGTCGGCGCTGGTGGAGAGCCTGTGCGACGACCTCGCCGAGATCGGCTG
GGACGTGACCTTCGAGGAGTCCCCCAAGGTCGGTTGCCGCTGCCGGCCGGATGCGGTGCGCCGCGCCTGCCGCAACCTGG
TGGAGAATGCCGTGCGCTACGGCAAGCGGGCGCGGGTGCGGGTGGAGCGCAGCGGCGATGCCGCGCTGATCGTGGTGGAG
GACGACGGGCCGGGCATCGCCGAGGAACTGAAGGAGCAGGTGTTTGCCCCCTTCTTCCGGCTGGAAAGCTCGCGGTGCAT
GGAGACCGGCGGCCATGGCCTCGGCCTTGCCATCGTGCGCACGGTGGCGCGCCGCCACGGCGGCGATGTCACCCTCGCCA
ACCGGCCAAGCGGGCTCACCGCCATCTTCAGCCTGCCGCTCGACGGCAGCGCGCCGGTGCTGGAGGCGGAGCCTGTCGGC
CGGCCGGAGCCCGAGCCGCGGGGCCTCGCCGCGACCTCGTGA

Upstream 100 bases:

>100_bases
GCCGCCTGCGCAAGAAGGTGGAGGCCGATCCCAAGGTGCCGGCCCTCATCAAGACCCACTGGGGCGGGGGCTACAGCCTT
GCAGCGGAGGTGGAACGCGC

Downstream 100 bases:

>100_bases
CCTGAGGCGGGCCGAGGCCGTTCCAAGGGGCGGCGCGCCCGCCGCTTCTCCTGAAATCCCAGGCGGTTGCCGTCGGGTGT
CACCGGCCTGACGGGGTGGC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MIRLFRRSLAARFICFTLVILALSQVVAFCISWDQHGQSLRKVAKGEMLSRCAALVRVLEATPPSLQGDILRASDTSLTR
YWISPDAPKPPKEWRAAAWRELRRPLPRVQLPMHSSTGEPEQPVYQLPKEPTTGGSTEWFPLSGEAWPLPTPAKFIYLDD
ENGMGIAAQLSNGSWLNAAFVKPGHEWFWTARSLTFLAAAGLFFCVLAVVAAQGITRPLRRLANAAEALGRGEKIEPLPE
SGPDDVTAIAFNRMQERLTRFVDDRTRMFAALSHDLRTPLTSLRLRAEFVADDELREKMLGTIAEIQGMAEASLAFVRAD
ATAETTRTVDLSALVESLCDDLAEIGWDVTFEESPKVGCRCRPDAVRRACRNLVENAVRYGKRARVRVERSGDAALIVVE
DDGPGIAEELKEQVFAPFFRLESSRCMETGGHGLGLAIVRTVARRHGGDVTLANRPSGLTAIFSLPLDGSAPVLEAEPVG
RPEPEPRGLAATS

Sequences:

>Translated_493_residues
MIRLFRRSLAARFICFTLVILALSQVVAFCISWDQHGQSLRKVAKGEMLSRCAALVRVLEATPPSLQGDILRASDTSLTR
YWISPDAPKPPKEWRAAAWRELRRPLPRVQLPMHSSTGEPEQPVYQLPKEPTTGGSTEWFPLSGEAWPLPTPAKFIYLDD
ENGMGIAAQLSNGSWLNAAFVKPGHEWFWTARSLTFLAAAGLFFCVLAVVAAQGITRPLRRLANAAEALGRGEKIEPLPE
SGPDDVTAIAFNRMQERLTRFVDDRTRMFAALSHDLRTPLTSLRLRAEFVADDELREKMLGTIAEIQGMAEASLAFVRAD
ATAETTRTVDLSALVESLCDDLAEIGWDVTFEESPKVGCRCRPDAVRRACRNLVENAVRYGKRARVRVERSGDAALIVVE
DDGPGIAEELKEQVFAPFFRLESSRCMETGGHGLGLAIVRTVARRHGGDVTLANRPSGLTAIFSLPLDGSAPVLEAEPVG
RPEPEPRGLAATS
>Mature_493_residues
MIRLFRRSLAARFICFTLVILALSQVVAFCISWDQHGQSLRKVAKGEMLSRCAALVRVLEATPPSLQGDILRASDTSLTR
YWISPDAPKPPKEWRAAAWRELRRPLPRVQLPMHSSTGEPEQPVYQLPKEPTTGGSTEWFPLSGEAWPLPTPAKFIYLDD
ENGMGIAAQLSNGSWLNAAFVKPGHEWFWTARSLTFLAAAGLFFCVLAVVAAQGITRPLRRLANAAEALGRGEKIEPLPE
SGPDDVTAIAFNRMQERLTRFVDDRTRMFAALSHDLRTPLTSLRLRAEFVADDELREKMLGTIAEIQGMAEASLAFVRAD
ATAETTRTVDLSALVESLCDDLAEIGWDVTFEESPKVGCRCRPDAVRRACRNLVENAVRYGKRARVRVERSGDAALIVVE
DDGPGIAEELKEQVFAPFFRLESSRCMETGGHGLGLAIVRTVARRHGGDVTLANRPSGLTAIFSLPLDGSAPVLEAEPVG
RPEPEPRGLAATS

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=255, Percent_Identity=35.2941176470588, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1790346, Length=266, Percent_Identity=32.3308270676692, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787894, Length=265, Percent_Identity=31.6981132075472, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1786600, Length=247, Percent_Identity=31.5789473684211, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790551, Length=279, Percent_Identity=28.673835125448, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=26.1818181818182, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1786783, Length=304, Percent_Identity=25.3289473684211, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1788279, Length=287, Percent_Identity=26.4808362369338, Blast_Score=82, Evalue=7e-17,
Organism=Escherichia coli, GI87082128, Length=324, Percent_Identity=26.2345679012346, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=31.1688311688312, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1788713, Length=255, Percent_Identity=23.5294117647059, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1790861, Length=264, Percent_Identity=26.5151515151515, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1788549, Length=221, Percent_Identity=27.1493212669683, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1787374, Length=281, Percent_Identity=24.1992882562278, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54150; Mature: 54150

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRLFRRSLAARFICFTLVILALSQVVAFCISWDQHGQSLRKVAKGEMLSRCAALVRVLE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATPPSLQGDILRASDTSLTRYWISPDAPKPPKEWRAAAWRELRRPLPRVQLPMHSSTGEP
CCCCCCCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
EQPVYQLPKEPTTGGSTEWFPLSGEAWPLPTPAKFIYLDDENGMGIAAQLSNGSWLNAAF
CCHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEEEE
VKPGHEWFWTARSLTFLAAAGLFFCVLAVVAAQGITRPLRRLANAAEALGRGEKIEPLPE
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SGPDDVTAIAFNRMQERLTRFVDDRTRMFAALSHDLRTPLTSLRLRAEFVADDELREKML
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH
GTIAEIQGMAEASLAFVRADATAETTRTVDLSALVESLCDDLAEIGWDVTFEESPKVGCR
HHHHHHHHHHHHHHHHEECCCCCHHHHEEEHHHHHHHHHHHHHHCCCCEEECCCCCCCCE
CRPDAVRRACRNLVENAVRYGKRARVRVERSGDAALIVVEDDGPGIAEELKEQVFAPFFR
ECHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHH
LESSRCMETGGHGLGLAIVRTVARRHGGDVTLANRPSGLTAIFSLPLDGSAPVLEAEPVG
HCCHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCCEEECCCCC
RPEPEPRGLAATS
CCCCCCCCCCCCC
>Mature Secondary Structure
MIRLFRRSLAARFICFTLVILALSQVVAFCISWDQHGQSLRKVAKGEMLSRCAALVRVLE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ATPPSLQGDILRASDTSLTRYWISPDAPKPPKEWRAAAWRELRRPLPRVQLPMHSSTGEP
CCCCCCCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
EQPVYQLPKEPTTGGSTEWFPLSGEAWPLPTPAKFIYLDDENGMGIAAQLSNGSWLNAAF
CCHHHHCCCCCCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCEEEEEE
VKPGHEWFWTARSLTFLAAAGLFFCVLAVVAAQGITRPLRRLANAAEALGRGEKIEPLPE
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
SGPDDVTAIAFNRMQERLTRFVDDRTRMFAALSHDLRTPLTSLRLRAEFVADDELREKML
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCHHHHHHHH
GTIAEIQGMAEASLAFVRADATAETTRTVDLSALVESLCDDLAEIGWDVTFEESPKVGCR
HHHHHHHHHHHHHHHHEECCCCCHHHHEEEHHHHHHHHHHHHHHCCCCEEECCCCCCCCE
CRPDAVRRACRNLVENAVRYGKRARVRVERSGDAALIVVEDDGPGIAEELKEQVFAPFFR
ECHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCEEEEEEECCCCCHHHHHHHHHHHHHHH
LESSRCMETGGHGLGLAIVRTVARRHGGDVTLANRPSGLTAIFSLPLDGSAPVLEAEPVG
HCCHHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCCEEECCCCC
RPEPEPRGLAATS
CCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]