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The map label for this gene is hisA

Identifier: 154246232

GI number: 154246232

Start: 2555476

End: 2556213

Strand: Reverse

Name: hisA

Synonym: Xaut_2290

Alternate gene names: 154246232

Gene position: 2556213-2555476 (Counterclockwise)

Preceding gene: 154246233

Following gene: 154246231

Centisome position: 48.15

GC content: 69.38

Gene sequence:

>738_bases
GTGGCATCCGTGATCCTTTTTCCGGCCATCGACCTCAAGGACGGCCTCGCCGTGCGCCTCGAACAGGGCGACATGGCGCG
GGCCACCGTGTTCAACCGCGATCCCGCCGCCCAGGCCGCGGAGTTCGAGACCCTCGGCTTTCGCTACCTCCATCTCGTGG
ACCTTGACGGCGCCTTCGCTGGCAAGCCGGTCAACGCGGCGGCGGTGGAGCGGATTTTGGAGACGGTCTCCATTCCCGTG
CAGCTCGGCGGCGGCATCCGCGACCTGAAGACCGTCGAGGCCTGGCTGGAGAAGGGGGTGACCCGCGTCATCCTTGGCAC
CGCCGCGGTGCGCGACCCGGACTTCGTGAAGCAGGCGGCGAAGGCCCATCCCGGCCGCATCGTGGTGGGCCTTGATGCCC
GCGATGGCCGCGTCGCCGTGGAGGGCTGGGCCGAGACCTCGGACATTGCCGCCGTGGACATCGCCAAAAGGTTCGAGGAT
GCCGGCGTCACCGCCATCATCTACACCGACATCGCCCGCGACGGCCTGCTCAAGGGGCTGAACCTCGACGCCACCGTGGC
GCTGGCGGAAGCGGTCAACCTGCCGGTGATCGCCTCGGGCGGCCTTGCCTCGCTCGCCGATATCGAGGCGCTGCTCACGC
CGCGCGCGAAAAAGCTGGAAGGCGCCATTACCGGCCGCGCCCTCTATGATGGCCGGCTCGATGCCCGCGAGGCGCTGGCG
CTGGTGGCGGGACGATAG

Upstream 100 bases:

>100_bases
CCATCACCGCCATGGTCGCGCGCGACAACGTGGCCGGCACCCAGTTCCATCCCGAGAAGAGCCAGAGGCTCGGCCTCGCG
CTCCTCGCGAATTTCCTGAA

Downstream 100 bases:

>100_bases
GTGTGCCATGCTGAAAGTCCGCGTCATCCCCTGCCTCGACGTGAAGGACGGCCGCGTGGTGAAGGGTGTCCAGTTCGTGG
ACCTGCGCGACGCCGGCGAT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MASVILFPAIDLKDGLAVRLEQGDMARATVFNRDPAAQAAEFETLGFRYLHLVDLDGAFAGKPVNAAAVERILETVSIPV
QLGGGIRDLKTVEAWLEKGVTRVILGTAAVRDPDFVKQAAKAHPGRIVVGLDARDGRVAVEGWAETSDIAAVDIAKRFED
AGVTAIIYTDIARDGLLKGLNLDATVALAEAVNLPVIASGGLASLADIEALLTPRAKKLEGAITGRALYDGRLDAREALA
LVAGR

Sequences:

>Translated_245_residues
MASVILFPAIDLKDGLAVRLEQGDMARATVFNRDPAAQAAEFETLGFRYLHLVDLDGAFAGKPVNAAAVERILETVSIPV
QLGGGIRDLKTVEAWLEKGVTRVILGTAAVRDPDFVKQAAKAHPGRIVVGLDARDGRVAVEGWAETSDIAAVDIAKRFED
AGVTAIIYTDIARDGLLKGLNLDATVALAEAVNLPVIASGGLASLADIEALLTPRAKKLEGAITGRALYDGRLDAREALA
LVAGR
>Mature_244_residues
ASVILFPAIDLKDGLAVRLEQGDMARATVFNRDPAAQAAEFETLGFRYLHLVDLDGAFAGKPVNAAAVERILETVSIPVQ
LGGGIRDLKTVEAWLEKGVTRVILGTAAVRDPDFVKQAAKAHPGRIVVGLDARDGRVAVEGWAETSDIAAVDIAKRFEDA
GVTAIIYTDIARDGLLKGLNLDATVALAEAVNLPVIASGGLASLADIEALLTPRAKKLEGAITGRALYDGRLDAREALAL
VAGR

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=248, Percent_Identity=35.8870967741936, Blast_Score=134, Evalue=4e-33,
Organism=Escherichia coli, GI1788336, Length=250, Percent_Identity=24, Blast_Score=63, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_XANP2 (A7IHP0)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001417190.1
- ProteinModelPortal:   A7IHP0
- SMR:   A7IHP0
- STRING:   A7IHP0
- GeneID:   5420798
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_2290
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- ProtClustDB:   PRK00748
- BioCyc:   XAUT78245:XAUT_2290-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25743; Mature: 25612

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: ACT_SITE 11-11 ACT_SITE 132-132

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.4 %Met     (Mature Protein)
0.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASVILFPAIDLKDGLAVRLEQGDMARATVFNRDPAAQAAEFETLGFRYLHLVDLDGAFA
CCCEEEEECEECCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHCCEEEEEEEECCCCCC
GKPVNAAAVERILETVSIPVQLGGGIRDLKTVEAWLEKGVTRVILGTAAVRDPDFVKQAA
CCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCEEEEEHHCCCCHHHHHHHH
KAHPGRIVVGLDARDGRVAVEGWAETSDIAAVDIAKRFEDAGVTAIIYTDIARDGLLKGL
HCCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEECHHHHHHHCCC
NLDATVALAEAVNLPVIASGGLASLADIEALLTPRAKKLEGAITGRALYDGRLDAREALA
CCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHEECCEEECCCCCHHHHHH
LVAGR
HHCCC
>Mature Secondary Structure 
ASVILFPAIDLKDGLAVRLEQGDMARATVFNRDPAAQAAEFETLGFRYLHLVDLDGAFA
CCEEEEECEECCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHCCEEEEEEEECCCCCC
GKPVNAAAVERILETVSIPVQLGGGIRDLKTVEAWLEKGVTRVILGTAAVRDPDFVKQAA
CCCCCHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHCCCCEEEEEHHCCCCHHHHHHHH
KAHPGRIVVGLDARDGRVAVEGWAETSDIAAVDIAKRFEDAGVTAIIYTDIARDGLLKGL
HCCCCEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEEEEECHHHHHHHCCC
NLDATVALAEAVNLPVIASGGLASLADIEALLTPRAKKLEGAITGRALYDGRLDAREALA
CCCHHHHHHHHCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHEECCEEECCCCCHHHHHH
LVAGR
HHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA