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The map label for this gene is acdA [H]

Identifier: 154246133

GI number: 154246133

Start: 2449367

End: 2450509

Strand: Reverse

Name: acdA [H]

Synonym: Xaut_2190

Alternate gene names: 154246133

Gene position: 2450509-2449367 (Counterclockwise)

Preceding gene: 154246134

Following gene: 154246132

Centisome position: 46.16

GC content: 69.29

Gene sequence:

>1143_bases
ATGTTCACGCTCACCGAGGACCAGATCGCCATCCGCGAGATGGCGCGGGATTTCGCGAACGCCGAGATCGCGCCCCACGC
CGTGGAGTGGGACGAGAAGAAGCACTTCCCGGTGGACACCCTGCGCGCCGCCGCGGCGCTGGGCATGGGCGGCATCTATG
TGCAGGACGACGTGGGCGGGTCCGGCCTGTCGCGGCTCGACGCGGCGCTGATCTTCGAGGCGCTCGCCACCGGCTGCCCC
GGCACCGCGGCCTTTCTCTCCATCCATAACATGGCCACCTGGATGATCGACCGCTTCGGCGACGAGGACCAGCGCGCCAC
ATGGGTGCCGCGCCTCACCGCCATGGAGCACATCGCCTCCTACTGCCTCACCGAGCCGGGCGCGGGGTCGGACGCCGCCG
CCCTGAAGACGAAGGCGGTGCGCGACGGCGACCATTACATCGTGGACGGGCAGAAGCAGTTCATCTCCGGGGCGGGGGCC
TCCGACATTTATGTGGTGATGGTGCGCACCGGCGGGGACGGCCCCAAGGGCATCTCCACCCTGGTGATCGAGGCCGGCAC
CCCCGGCCTCTCCTTCGGCGCCAACGAGAAGAAGATGGGCTGGAACGTGCAGCCCACCCGCGCCGTCATCCTCGAGGGCG
TGCGCGTGCCGGTGCAAAACCGCCTCGGCGCCGAGGGCGACGGCTTCAAGATCGCCATGGCCGGGCTCGACGGCGGGCGG
CTGAACATCGGCGCCTGCTCGCTGGGCGGGGCGCAGGCGGCACTCGACAAAACGCTCGCCTACATGCGCGAGCGCAAGGC
GTTCGGGCAACGGCTCGACGCCTTCCAGGCACTGCAATTCCGCCTCGCCGACATGGCCACCGAGCTGGAGGTGGCGCGCA
CCTTCCTGTGGCGCGCGGCGGCAGCGCTGGACGCCAAGACGCCGGACGCCACCAGGCTCTGCGCCATGGCCAAGCGCTTT
GCCACCGACGCCGGATTCAATGTCGCCAACGAGGCGCTCCAGCTCCACGGCGGCTACGGCTATCTCGCCGACTACGGGGT
GGAGAAGATCGTGCGCGACCTCAGGGTCCACCAGATCCTGGAAGGCACCAACGAGATCATGCGGCTCATCATCTCCCGCG
CGCTGATCGCGCAGGGGAACTGA

Upstream 100 bases:

>100_bases
GATTGCCCTTTCCTGACTGCCGACCGCCGGCTCGCTCGCAAGGCTGCGGGCGAGAGGGACCTTCCCCCAATCCTCTCACT
CGATCACTGGCGCCCCTGAC

Downstream 100 bases:

>100_bases
GCGGGCCGGCTGGCGCTGCCGCCGGCCGTGGGCAAGTCATTCAGGCCGGAAGAACCGGTCCGCCCCCCTCTGCCGCTTGG
GGGGTGGAGAAGGGGGGAAG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MFTLTEDQIAIREMARDFANAEIAPHAVEWDEKKHFPVDTLRAAAALGMGGIYVQDDVGGSGLSRLDAALIFEALATGCP
GTAAFLSIHNMATWMIDRFGDEDQRATWVPRLTAMEHIASYCLTEPGAGSDAAALKTKAVRDGDHYIVDGQKQFISGAGA
SDIYVVMVRTGGDGPKGISTLVIEAGTPGLSFGANEKKMGWNVQPTRAVILEGVRVPVQNRLGAEGDGFKIAMAGLDGGR
LNIGACSLGGAQAALDKTLAYMRERKAFGQRLDAFQALQFRLADMATELEVARTFLWRAAAALDAKTPDATRLCAMAKRF
ATDAGFNVANEALQLHGGYGYLADYGVEKIVRDLRVHQILEGTNEIMRLIISRALIAQGN

Sequences:

>Translated_380_residues
MFTLTEDQIAIREMARDFANAEIAPHAVEWDEKKHFPVDTLRAAAALGMGGIYVQDDVGGSGLSRLDAALIFEALATGCP
GTAAFLSIHNMATWMIDRFGDEDQRATWVPRLTAMEHIASYCLTEPGAGSDAAALKTKAVRDGDHYIVDGQKQFISGAGA
SDIYVVMVRTGGDGPKGISTLVIEAGTPGLSFGANEKKMGWNVQPTRAVILEGVRVPVQNRLGAEGDGFKIAMAGLDGGR
LNIGACSLGGAQAALDKTLAYMRERKAFGQRLDAFQALQFRLADMATELEVARTFLWRAAAALDAKTPDATRLCAMAKRF
ATDAGFNVANEALQLHGGYGYLADYGVEKIVRDLRVHQILEGTNEIMRLIISRALIAQGN
>Mature_380_residues
MFTLTEDQIAIREMARDFANAEIAPHAVEWDEKKHFPVDTLRAAAALGMGGIYVQDDVGGSGLSRLDAALIFEALATGCP
GTAAFLSIHNMATWMIDRFGDEDQRATWVPRLTAMEHIASYCLTEPGAGSDAAALKTKAVRDGDHYIVDGQKQFISGAGA
SDIYVVMVRTGGDGPKGISTLVIEAGTPGLSFGANEKKMGWNVQPTRAVILEGVRVPVQNRLGAEGDGFKIAMAGLDGGR
LNIGACSLGGAQAALDKTLAYMRERKAFGQRLDAFQALQFRLADMATELEVARTFLWRAAAALDAKTPDATRLCAMAKRF
ATDAGFNVANEALQLHGGYGYLADYGVEKIVRDLRVHQILEGTNEIMRLIISRALIAQGN

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI7656849, Length=375, Percent_Identity=61.6, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI4557231, Length=379, Percent_Identity=39.3139841688654, Blast_Score=274, Evalue=8e-74,
Organism=Homo sapiens, GI187960098, Length=379, Percent_Identity=39.3139841688654, Blast_Score=274, Evalue=9e-74,
Organism=Homo sapiens, GI4501859, Length=378, Percent_Identity=37.037037037037, Blast_Score=249, Evalue=2e-66,
Organism=Homo sapiens, GI4557233, Length=375, Percent_Identity=38.4, Blast_Score=248, Evalue=6e-66,
Organism=Homo sapiens, GI4501857, Length=371, Percent_Identity=33.9622641509434, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI226958412, Length=380, Percent_Identity=32.6315789473684, Blast_Score=214, Evalue=2e-55,
Organism=Homo sapiens, GI21361497, Length=350, Percent_Identity=34.8571428571429, Blast_Score=211, Evalue=6e-55,
Organism=Homo sapiens, GI4557235, Length=335, Percent_Identity=34.6268656716418, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI76496475, Length=335, Percent_Identity=34.6268656716418, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI226958414, Length=335, Percent_Identity=33.7313432835821, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI4503943, Length=376, Percent_Identity=27.3936170212766, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI7669494, Length=348, Percent_Identity=27.0114942528736, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI38505218, Length=358, Percent_Identity=27.0949720670391, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI211971008, Length=328, Percent_Identity=27.4390243902439, Blast_Score=93, Evalue=4e-19,
Organism=Homo sapiens, GI48976061, Length=328, Percent_Identity=27.4390243902439, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI87081958, Length=380, Percent_Identity=28.9473684210526, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786223, Length=384, Percent_Identity=27.0833333333333, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI87082384, Length=271, Percent_Identity=27.6752767527675, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17533517, Length=377, Percent_Identity=50.9283819628647, Blast_Score=403, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17534899, Length=380, Percent_Identity=39.4736842105263, Blast_Score=274, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=38.7862796833773, Blast_Score=274, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=36.2204724409449, Blast_Score=249, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17506239, Length=374, Percent_Identity=34.7593582887701, Blast_Score=231, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=34.1397849462366, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=383, Percent_Identity=33.1592689295039, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI71985184, Length=353, Percent_Identity=31.1614730878187, Blast_Score=194, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71990804, Length=277, Percent_Identity=36.8231046931408, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI32563615, Length=230, Percent_Identity=39.1304347826087, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=30.6569343065693, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71985192, Length=286, Percent_Identity=30.4195804195804, Blast_Score=144, Evalue=8e-35,
Organism=Caenorhabditis elegans, GI17551932, Length=374, Percent_Identity=29.4117647058824, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17505929, Length=359, Percent_Identity=30.08356545961, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI17534353, Length=375, Percent_Identity=26.6666666666667, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17562446, Length=325, Percent_Identity=27.6923076923077, Blast_Score=107, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=26.8595041322314, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI86563381, Length=332, Percent_Identity=25, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI86563383, Length=332, Percent_Identity=25.3012048192771, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=38.0952380952381, Blast_Score=264, Evalue=6e-71,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=38.2352941176471, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI21356377, Length=377, Percent_Identity=35.0132625994695, Blast_Score=242, Evalue=4e-64,
Organism=Drosophila melanogaster, GI24666513, Length=374, Percent_Identity=34.4919786096257, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI21355753, Length=383, Percent_Identity=33.6814621409922, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI281363737, Length=335, Percent_Identity=32.8358208955224, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI19920834, Length=377, Percent_Identity=27.8514588859416, Blast_Score=129, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: NA

Molecular weight: Translated: 40753; Mature: 40753

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFTLTEDQIAIREMARDFANAEIAPHAVEWDEKKHFPVDTLRAAAALGMGGIYVQDDVGG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCC
SGLSRLDAALIFEALATGCPGTAAFLSIHNMATWMIDRFGDEDQRATWVPRLTAMEHIAS
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
YCLTEPGAGSDAAALKTKAVRDGDHYIVDGQKQFISGAGASDIYVVMVRTGGDGPKGIST
HHCCCCCCCCCHHHHHHHHEECCCEEEECCHHHHHCCCCCCCEEEEEEEECCCCCCCCEE
LVIEAGTPGLSFGANEKKMGWNVQPTRAVILEGVRVPVQNRLGAEGDGFKIAMAGLDGGR
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCCCCCCEEEEEEECCCCE
LNIGACSLGGAQAALDKTLAYMRERKAFGQRLDAFQALQFRLADMATELEVARTFLWRAA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALDAKTPDATRLCAMAKRFATDAGFNVANEALQLHGGYGYLADYGVEKIVRDLRVHQIL
HHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHH
EGTNEIMRLIISRALIAQGN
HHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MFTLTEDQIAIREMARDFANAEIAPHAVEWDEKKHFPVDTLRAAAALGMGGIYVQDDVGG
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCC
SGLSRLDAALIFEALATGCPGTAAFLSIHNMATWMIDRFGDEDQRATWVPRLTAMEHIAS
CCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
YCLTEPGAGSDAAALKTKAVRDGDHYIVDGQKQFISGAGASDIYVVMVRTGGDGPKGIST
HHCCCCCCCCCHHHHHHHHEECCCEEEECCHHHHHCCCCCCCEEEEEEEECCCCCCCCEE
LVIEAGTPGLSFGANEKKMGWNVQPTRAVILEGVRVPVQNRLGAEGDGFKIAMAGLDGGR
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHCCCCCCCCEEEEEEECCCCE
LNIGACSLGGAQAALDKTLAYMRERKAFGQRLDAFQALQFRLADMATELEVARTFLWRAA
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AALDAKTPDATRLCAMAKRFATDAGFNVANEALQLHGGYGYLADYGVEKIVRDLRVHQIL
HHHCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHH
EGTNEIMRLIISRALIAQGN
HHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]