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The map label for this gene is gntR [H]

Identifier: 154246096

GI number: 154246096

Start: 2414265

End: 2415278

Strand: Reverse

Name: gntR [H]

Synonym: Xaut_2153

Alternate gene names: 154246096

Gene position: 2415278-2414265 (Counterclockwise)

Preceding gene: 154246097

Following gene: 154246095

Centisome position: 45.49

GC content: 71.99

Gene sequence:

>1014_bases
ATGGCACGCATCGTCACCATTCGCACCGTCGCCGAACGCGCCGGCTGCTCCATCGCCACCGTCAGCCGGGTCATCAACCG
CTCGGCCCCCACCAGCACAGCTGTTGAGGCGCGCGTGCGGGCCGCCGTCGCTGAACTCGGCTTCCGCCCGAGCGAGATCG
GCCGCGCGCTGAAGACCCTGCGCACCCGGACGCTGGGCGTGGTCATCCCCAGCCTGACCAACCCGGTGTTCGCAGCCTCG
GTGGCCGGCATGCAGTCGGCGGCGCGGGAGCGGCAGCACACGTTGCTGCTCACCGCCACCGATTATGAGCCCGGTGCCGA
GGCCGAGTTGGTGGAGACGCTGGTCGCCCAGAACGTGGCCGGCCTCATCCTCACTGTCGCCGATGCCTGCGAGAATGCCA
CCCTCGACCTGCTGGAGGCGGAGGGCATCCCCTACGTGCTGGTCCACAACGAACCGGCCCGCCCCGGCCGGGCCGCCGTG
TGCGTGGACAACGCCGGCGCCACCTGCGCCCTCACCGAGACCATGATCGCGGCCGGCCACCGGCGCATCGCCTACCTCGC
CGGCCGCTTCGCCACCTCCGATCGCGCCCGCCGCCGCTTTGAGGGCTACCGCGCCGCCATGGAAGCGGCGGGCCTTGAGC
CCGAGGGTCCCCTCGAGCTCGATTATCTCGGCGATGCGCCGAGCCATGCCGAGGCCCTCGCCGGCCTCTTTCGCGCCGGA
GCGCCGCCCACGGCCGCGCTCTGCTCCAACGACCTGCTCGCCCTGTCCGTGGTCGGGGCCCTGCGCACGCTGGGGCTCCG
CGTGCCGGACGACATCTCCGTCGCCGGCTTCGACGGCATTGCCTTGGGCGGGGCGGTTCACCCCACCCTCGCCACGGTGG
ATACGCCCACCCGCCTCATGGGGGAGCACGCGGTGGCGATGCTCTTCACCATGATCGAGACGGGCGCCACGCCCCGTGTC
GAGCACCTGCCGTTTACGCTCCGCCCCGGCGGAACGCTTGCGTCCAGAGTTTAG

Upstream 100 bases:

>100_bases
CGCGCCAACGGTCATATGCCTGTCGTGCTTTGTAGAATAAGTTCGTGAAAACGATTTCACGGACTGGACGGCCTCCAGTC
GCCGGCTTCAGGATCGCTGG

Downstream 100 bases:

>100_bases
AACGCCCCTCTCCTTCTCCCGAGGCCAGCCATGCGCCCCACCCTTCCCCGCCTCCTCAAAGCCGGCGCCTTCGCCGCGCT
CGCCCTCGCGACGCTTCCCC

Product: alanine racemase

Products: NA

Alternate protein names: Gluconate utilization system GNT-I transcriptional repressor [H]

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MARIVTIRTVAERAGCSIATVSRVINRSAPTSTAVEARVRAAVAELGFRPSEIGRALKTLRTRTLGVVIPSLTNPVFAAS
VAGMQSAARERQHTLLLTATDYEPGAEAELVETLVAQNVAGLILTVADACENATLDLLEAEGIPYVLVHNEPARPGRAAV
CVDNAGATCALTETMIAAGHRRIAYLAGRFATSDRARRRFEGYRAAMEAAGLEPEGPLELDYLGDAPSHAEALAGLFRAG
APPTAALCSNDLLALSVVGALRTLGLRVPDDISVAGFDGIALGGAVHPTLATVDTPTRLMGEHAVAMLFTMIETGATPRV
EHLPFTLRPGGTLASRV

Sequences:

>Translated_337_residues
MARIVTIRTVAERAGCSIATVSRVINRSAPTSTAVEARVRAAVAELGFRPSEIGRALKTLRTRTLGVVIPSLTNPVFAAS
VAGMQSAARERQHTLLLTATDYEPGAEAELVETLVAQNVAGLILTVADACENATLDLLEAEGIPYVLVHNEPARPGRAAV
CVDNAGATCALTETMIAAGHRRIAYLAGRFATSDRARRRFEGYRAAMEAAGLEPEGPLELDYLGDAPSHAEALAGLFRAG
APPTAALCSNDLLALSVVGALRTLGLRVPDDISVAGFDGIALGGAVHPTLATVDTPTRLMGEHAVAMLFTMIETGATPRV
EHLPFTLRPGGTLASRV
>Mature_336_residues
ARIVTIRTVAERAGCSIATVSRVINRSAPTSTAVEARVRAAVAELGFRPSEIGRALKTLRTRTLGVVIPSLTNPVFAASV
AGMQSAARERQHTLLLTATDYEPGAEAELVETLVAQNVAGLILTVADACENATLDLLEAEGIPYVLVHNEPARPGRAAVC
VDNAGATCALTETMIAAGHRRIAYLAGRFATSDRARRRFEGYRAAMEAAGLEPEGPLELDYLGDAPSHAEALAGLFRAGA
PPTAALCSNDLLALSVVGALRTLGLRVPDDISVAGFDGIALGGAVHPTLATVDTPTRLMGEHAVAMLFTMIETGATPRVE
HLPFTLRPGGTLASRV

Specific function: Negative regulator for the gluconate utilization system GNT-I, the gntUKR operon [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI48994940, Length=328, Percent_Identity=34.4512195121951, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1790194, Length=328, Percent_Identity=34.1463414634146, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1790369, Length=311, Percent_Identity=27.6527331189711, Blast_Score=131, Evalue=6e-32,
Organism=Escherichia coli, GI1788474, Length=325, Percent_Identity=29.8461538461538, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1789202, Length=300, Percent_Identity=32.6666666666667, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1790715, Length=340, Percent_Identity=28.5294117647059, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786540, Length=325, Percent_Identity=29.8461538461538, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1787948, Length=312, Percent_Identity=28.2051282051282, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1789068, Length=316, Percent_Identity=28.4810126582279, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1787580, Length=323, Percent_Identity=24.1486068111455, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790689, Length=328, Percent_Identity=26.5243902439024, Blast_Score=98, Evalue=6e-22,
Organism=Escherichia coli, GI1787906, Length=254, Percent_Identity=29.5275590551181, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786268, Length=324, Percent_Identity=24.6913580246914, Blast_Score=67, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 35189; Mature: 35058

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIVTIRTVAERAGCSIATVSRVINRSAPTSTAVEARVRAAVAELGFRPSEIGRALKTL
CCEEEEEHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RTRTLGVVIPSLTNPVFAASVAGMQSAARERQHTLLLTATDYEPGAEAELVETLVAQNVA
HHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHH
GLILTVADACENATLDLLEAEGIPYVLVHNEPARPGRAAVCVDNAGATCALTETMIAAGH
HHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCCEEEEECCCCCEEHHHHHHHHHCC
RRIAYLAGRFATSDRARRRFEGYRAAMEAAGLEPEGPLELDYLGDAPSHAEALAGLFRAG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHCC
APPTAALCSNDLLALSVVGALRTLGLRVPDDISVAGFDGIALGGAVHPTLATVDTPTRLM
CCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCEEECCCCCCCEEECCCCHHHH
GEHAVAMLFTMIETGATPRVEHLPFTLRPGGTLASRV
HHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHCCC
>Mature Secondary Structure 
ARIVTIRTVAERAGCSIATVSRVINRSAPTSTAVEARVRAAVAELGFRPSEIGRALKTL
CEEEEEHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RTRTLGVVIPSLTNPVFAASVAGMQSAARERQHTLLLTATDYEPGAEAELVETLVAQNVA
HHHHHEEEECCCCCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCHHHHHHHHHHHHHH
GLILTVADACENATLDLLEAEGIPYVLVHNEPARPGRAAVCVDNAGATCALTETMIAAGH
HHHHHHHHHHCCCCEEEEECCCCCEEEEECCCCCCCCEEEEECCCCCEEHHHHHHHHHCC
RRIAYLAGRFATSDRARRRFEGYRAAMEAAGLEPEGPLELDYLGDAPSHAEALAGLFRAG
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHCC
APPTAALCSNDLLALSVVGALRTLGLRVPDDISVAGFDGIALGGAVHPTLATVDTPTRLM
CCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEECCCCCEEECCCCCCCEEECCCCHHHH
GEHAVAMLFTMIETGATPRVEHLPFTLRPGGTLASRV
HHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]