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The map label for this gene is ldc [H]

Identifier: 154246083

GI number: 154246083

Start: 2402902

End: 2404032

Strand: Reverse

Name: ldc [H]

Synonym: Xaut_2140

Alternate gene names: 154246083

Gene position: 2404032-2402902 (Counterclockwise)

Preceding gene: 154246090

Following gene: 154246082

Centisome position: 45.28

GC content: 67.55

Gene sequence:

>1131_bases
ATGACCGATCGCATCCGCGAATTCTTGCGTACCCGACGAGAGGATGGCCCCTGCGTGGTGGTGGACCTCGACGTGGTCCG
TACCAATTACCAGGCCTTCGCCCGCGCCCTGCCGGACACCCGCGTCTATTACGCGGTGAAGGCCAACCCCGACGCCGCGA
TCCTGCAGGCGCTGGAAGAGCTGGGCTCGTCGTTCGATTGCGCCTCCGTGGGCGAAATCGAGATGGTGCTTGCCACCGGC
GCCGGCGCCGAGCGCATCTCGTTTGGCAACACCATCAAGAAGGAGCGCGATATCGAGCGCGCCTTCCGCCTGGGTGTGCG
CCTGTTCGCGGTGGACTCTTACGAGGAGGCGGAGAAGATCGCCCGCGTGGCGCCCCACGCCAAGGTGTTCTGCCGCATCC
TGTGCGACGGCGCCGGCGCCGAATGGCCCCTGTCGCGCAAGTTCGGCTGCGAGCCGGAGATGGCCGCGGACGTGCTGGAG
CACGCCCATCGCCTGGGCCTTGCCGCCTATGGCGTGTCCTTCCATGTGGGCTCGCAGCAGAAGAACGTGCACGCCTGGGA
CGGCGCGCTCGCCTCGGCCGCGCAGATCTTCCGGGCCTGCGCGGAGCGGGGCATCTCGCTCTCCATGGTCAACCTGGGCG
GCGGCTTTCCCACCCGCTACCTGCAGGAGGTGCCGGGCGCGCAGTCCTATGGCGAGGCGATCTTCTCCTCCCTGCGCAAG
CACTTCGGCAACCAGGTCCCGGAAACCATCATGGAGCCGGGCCGCGGCATGGTGGGCAACGCCGGCCTCATCGAGGCCGA
GGTGGTGCTGATCTCGAAGAAGTCCGAGGCCGACGCCATGCGCTGGGTATACTTGGACATCGGCAAGTTCGGCGGTCTCG
CCGAGACCATGGACGAGGCGATCCGTTACCCGCTGCGCACCCCGCGCGACGGCGACGACACCGCCCCGTGCGTGCTCGCC
GGCCCGACCTGCGATTCGGCCGACGTGATGTATGAGAAGACCCCGGTCGAGCTGCCGCTGTCGCTCTCCATCGGCGACAA
GGTGATCATCGAGGCCTGCGGCGCCTACACCACCACCTATTCGGCGGTGGCGTTCAACGGCTTCCCGCCGCTGAAGTCCT
ACGTGATCTGA

Upstream 100 bases:

>100_bases
TTGCGCGTGCCCCGGCCGAGCCCAGTGCGGGTTCGTCCGTCCCTGTCGTCGCGCGGAATTCTCCGTGCTTCACGAGGCTT
CAGGTCACGGGGAGGACACC

Downstream 100 bases:

>100_bases
GCACCTGATTAAGGCCGCGTCTCAGGCCCTGCGATCGAAAGGGGACAGCGCGTCGAGGAACCGGACCCGAGAGGTCCGGT
CTTTGGCGCCTCCTGCCCCC

Product: Orn/DAP/Arg decarboxylase 2

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MTDRIREFLRTRREDGPCVVVDLDVVRTNYQAFARALPDTRVYYAVKANPDAAILQALEELGSSFDCASVGEIEMVLATG
AGAERISFGNTIKKERDIERAFRLGVRLFAVDSYEEAEKIARVAPHAKVFCRILCDGAGAEWPLSRKFGCEPEMAADVLE
HAHRLGLAAYGVSFHVGSQQKNVHAWDGALASAAQIFRACAERGISLSMVNLGGGFPTRYLQEVPGAQSYGEAIFSSLRK
HFGNQVPETIMEPGRGMVGNAGLIEAEVVLISKKSEADAMRWVYLDIGKFGGLAETMDEAIRYPLRTPRDGDDTAPCVLA
GPTCDSADVMYEKTPVELPLSLSIGDKVIIEACGAYTTTYSAVAFNGFPPLKSYVI

Sequences:

>Translated_376_residues
MTDRIREFLRTRREDGPCVVVDLDVVRTNYQAFARALPDTRVYYAVKANPDAAILQALEELGSSFDCASVGEIEMVLATG
AGAERISFGNTIKKERDIERAFRLGVRLFAVDSYEEAEKIARVAPHAKVFCRILCDGAGAEWPLSRKFGCEPEMAADVLE
HAHRLGLAAYGVSFHVGSQQKNVHAWDGALASAAQIFRACAERGISLSMVNLGGGFPTRYLQEVPGAQSYGEAIFSSLRK
HFGNQVPETIMEPGRGMVGNAGLIEAEVVLISKKSEADAMRWVYLDIGKFGGLAETMDEAIRYPLRTPRDGDDTAPCVLA
GPTCDSADVMYEKTPVELPLSLSIGDKVIIEACGAYTTTYSAVAFNGFPPLKSYVI
>Mature_375_residues
TDRIREFLRTRREDGPCVVVDLDVVRTNYQAFARALPDTRVYYAVKANPDAAILQALEELGSSFDCASVGEIEMVLATGA
GAERISFGNTIKKERDIERAFRLGVRLFAVDSYEEAEKIARVAPHAKVFCRILCDGAGAEWPLSRKFGCEPEMAADVLEH
AHRLGLAAYGVSFHVGSQQKNVHAWDGALASAAQIFRACAERGISLSMVNLGGGFPTRYLQEVPGAQSYGEAIFSSLRKH
FGNQVPETIMEPGRGMVGNAGLIEAEVVLISKKSEADAMRWVYLDIGKFGGLAETMDEAIRYPLRTPRDGDDTAPCVLAG
PTCDSADVMYEKTPVELPLSLSIGDKVIIEACGAYTTTYSAVAFNGFPPLKSYVI

Specific function: Decarboxylates both L-lysine and L-ornithine with similar catalytic efficiency [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=378, Percent_Identity=32.8042328042328, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI16506287, Length=358, Percent_Identity=29.3296089385475, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI22538418, Length=367, Percent_Identity=27.7929155313352, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI21361583, Length=367, Percent_Identity=27.7929155313352, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1789203, Length=394, Percent_Identity=25.8883248730964, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17562780, Length=387, Percent_Identity=32.8165374677003, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI25141365, Length=379, Percent_Identity=22.1635883905013, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322664, Length=385, Percent_Identity=30.3896103896104, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24586472, Length=373, Percent_Identity=30.0268096514745, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24586474, Length=360, Percent_Identity=30, Blast_Score=124, Evalue=8e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183
- InterPro:   IPR002433 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.17; =4.1.1.18 [H]

Molecular weight: Translated: 40876; Mature: 40745

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRIREFLRTRREDGPCVVVDLDVVRTNYQAFARALPDTRVYYAVKANPDAAILQALEE
CCHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
LGSSFDCASVGEIEMVLATGAGAERISFGNTIKKERDIERAFRLGVRLFAVDSYEEAEKI
HCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCHHHHHHH
ARVAPHAKVFCRILCDGAGAEWPLSRKFGCEPEMAADVLEHAHRLGLAAYGVSFHVGSQQ
HHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCC
KNVHAWDGALASAAQIFRACAERGISLSMVNLGGGFPTRYLQEVPGAQSYGEAIFSSLRK
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHH
HFGNQVPETIMEPGRGMVGNAGLIEAEVVLISKKSEADAMRWVYLDIGKFGGLAETMDEA
HHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHH
IRYPLRTPRDGDDTAPCVLAGPTCDSADVMYEKTPVELPLSLSIGDKVIIEACGAYTTTY
HHCCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHCCHHHCC
SAVAFNGFPPLKSYVI
CEEEECCCCCHHHHCC
>Mature Secondary Structure 
TDRIREFLRTRREDGPCVVVDLDVVRTNYQAFARALPDTRVYYAVKANPDAAILQALEE
CHHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
LGSSFDCASVGEIEMVLATGAGAERISFGNTIKKERDIERAFRLGVRLFAVDSYEEAEKI
HCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCEEEEEECCHHHHHHH
ARVAPHAKVFCRILCDGAGAEWPLSRKFGCEPEMAADVLEHAHRLGLAAYGVSFHVGSQQ
HHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCC
KNVHAWDGALASAAQIFRACAERGISLSMVNLGGGFPTRYLQEVPGAQSYGEAIFSSLRK
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHH
HFGNQVPETIMEPGRGMVGNAGLIEAEVVLISKKSEADAMRWVYLDIGKFGGLAETMDEA
HHCCCCCHHHHCCCCCCCCCCCEEEEEEEEEECCCCCCCEEEEEEECCCCCCHHHHHHHH
IRYPLRTPRDGDDTAPCVLAGPTCDSADVMYEKTPVELPLSLSIGDKVIIEACGAYTTTY
HHCCCCCCCCCCCCCCEEEECCCCCCCCEEEECCCCCEEEEECCCCHHHHHHHCCHHHCC
SAVAFNGFPPLKSYVI
CEEEECCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11073919 [H]