Click here to switch to the map view.

The map label for this gene is acsA [H]

Identifier: 154246039

GI number: 154246039

Start: 2358370

End: 2359968

Strand: Direct

Name: acsA [H]

Synonym: Xaut_2096

Alternate gene names: 154246039

Gene position: 2358370-2359968 (Clockwise)

Preceding gene: 154246038

Following gene: 154246040

Centisome position: 44.42

GC content: 70.86

Gene sequence:

>1599_bases
ATGCTGGCGCACACGAGTGAATACGAGCGCCGGTGCCGGGCGTTTTCCTGGGATATCCCGCGCCGCTACAACATGGCGGT
CCATGCCTGCGACGGCATTGCCGCCCGCGCGCCCGACCGTCCGGCCCTGTTCCTGCCCCATGGCGCAGGCTTTCGCCCGG
TCTCCTACGGCGCGCTGGCTGCGGCCTCCAACCGGCTGGCCCACGCCCTTCTGGCCCACGGCATCGGGCGCGGCGACCGG
GTGGCGATCCTGCTGCCCCAGTCGCTGGACGTGCTGGTCACCCACCTCGCCGTCTACAAGATGGGCGCCATCGCGGTGCC
GCTGGCCGGCGCCTTCGGGGTGGACGCCATCGCCTATCGCCTCGCCGATTCCGGCGCCAGGGCCCTCGTCACCGACGATG
CCGGCCTTGCCAAGGTGGTGGAGCGGCCGCAGGCGCTGGGGCTCCTCATCAATGTGGACGGGGCGCGGGCGGGGGTGCTC
GATTTCACCACCCTGCTGGATGCCGCCTCCGACCGGCCGCTCGCCATCACCTCCGGCCCGGACGATCCGGCGCTGATGAT
CTACACCTCCGGCACCACCGGCCAGCCCAAGGGCGCGCTGCACGGCCACCGGGTGCTCCTGCCCCATGTGAGCGGCGTCA
CCTTCACCCATGAGGGCATCGGCCAGGCGGGCGACCGCATGTGGACCCCCTCCGACTGGGCCTGGGCCGGCGGGCTGCTC
AACACCATCCTCCCCGCGCTGGCACTGGGGGTGCCGGTGGTGGCGCAGCCGCGCGGCAAGTTCGACCCCGAGGCGGCCTT
CGACCTGATCAAGCGGGCGCAGGTGCGCAACGTCTTCATCCCGCCCACCGCGCTCAAGATGATGCGCGCCGTGCCGGACC
CCAAGACCCGCTTCAACTTCGACCTGCGCACCGTGGGCTCGGCGGGCGAGGCGCTGGGGGCGGAGACCTTCGAATGGGGC
CGGCAGGCCCTCGGCGTGCCGGTGAACGAGTTCTACGGCCAGACCGAATGCAATTACGTCATCGGCTCCTCGGCGGCGCT
GGGCGTGGCGAAAGCCGGGGCCACCGGCAAGGCGGTGCCGGGCCACGAGGTTGCGGTGCTGGGCGAAGACGGCGCCGTGC
TGCCCCCCGGCCAGATGGGGCAGATCGCGGTGCGCGCGCCCGATCCGGTCATGTTCCTTGAGTACTGGAACAGGCCGGAC
GCCACGCAGGAGAAGGTGCGCGACGGCTGGCTCATCACCGGGGACCTCGCGACCCAGGACGAGGAGGGCTATTTCCACTT
CCTCGGCCGCGACGACGATGTGATCACCTCCGCCGGCTATCGCATCGGCCCAGCGGAGATCGAGGATGTGCTGCTGCGCC
ATCCGGCGGTGTCCATCGCCGCCGCGGTGGGCAAGAAGGACCCGCTGCGCACCGAGATCGTCAAGGCGGTGATCGTGCTG
ATGCCCGGCATCACACCCTCGCCGGCGCTGGAGGACGACATCCGCGCCTTCGTGCGCACCCGCCTTGCAGCTTACGAATA
TCCCCGCGAGATCGAGTTCGTGGCCGAGCTGCCCCTGACCACCACGGGCAAGGTCATCCGCCGGCTGCTCAGGGACTGA

Upstream 100 bases:

>100_bases
GGCCGGTGTGTCCGGAGTCGGCAAAAGACACTTGCATCTCGCAGCCGCAACCCTGTAGCGTGCGCCGCAACATTGCGGGG
GCAGAAGGGTCGGCCGGGTC

Downstream 100 bases:

>100_bases
CGGCGCGCGCGGCCGGGAGGCTGGAGCCGCCGCTCCCGCGTTCAGAGGGTGTCCGTTGCGGGCGGCCCCGACTGCGGCCT
GTCACGCCGCCCCCGGCTGC

Product: AMP-dependent synthetase and ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acetyl-CoA synthase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MLAHTSEYERRCRAFSWDIPRRYNMAVHACDGIAARAPDRPALFLPHGAGFRPVSYGALAAASNRLAHALLAHGIGRGDR
VAILLPQSLDVLVTHLAVYKMGAIAVPLAGAFGVDAIAYRLADSGARALVTDDAGLAKVVERPQALGLLINVDGARAGVL
DFTTLLDAASDRPLAITSGPDDPALMIYTSGTTGQPKGALHGHRVLLPHVSGVTFTHEGIGQAGDRMWTPSDWAWAGGLL
NTILPALALGVPVVAQPRGKFDPEAAFDLIKRAQVRNVFIPPTALKMMRAVPDPKTRFNFDLRTVGSAGEALGAETFEWG
RQALGVPVNEFYGQTECNYVIGSSAALGVAKAGATGKAVPGHEVAVLGEDGAVLPPGQMGQIAVRAPDPVMFLEYWNRPD
ATQEKVRDGWLITGDLATQDEEGYFHFLGRDDDVITSAGYRIGPAEIEDVLLRHPAVSIAAAVGKKDPLRTEIVKAVIVL
MPGITPSPALEDDIRAFVRTRLAAYEYPREIEFVAELPLTTTGKVIRRLLRD

Sequences:

>Translated_532_residues
MLAHTSEYERRCRAFSWDIPRRYNMAVHACDGIAARAPDRPALFLPHGAGFRPVSYGALAAASNRLAHALLAHGIGRGDR
VAILLPQSLDVLVTHLAVYKMGAIAVPLAGAFGVDAIAYRLADSGARALVTDDAGLAKVVERPQALGLLINVDGARAGVL
DFTTLLDAASDRPLAITSGPDDPALMIYTSGTTGQPKGALHGHRVLLPHVSGVTFTHEGIGQAGDRMWTPSDWAWAGGLL
NTILPALALGVPVVAQPRGKFDPEAAFDLIKRAQVRNVFIPPTALKMMRAVPDPKTRFNFDLRTVGSAGEALGAETFEWG
RQALGVPVNEFYGQTECNYVIGSSAALGVAKAGATGKAVPGHEVAVLGEDGAVLPPGQMGQIAVRAPDPVMFLEYWNRPD
ATQEKVRDGWLITGDLATQDEEGYFHFLGRDDDVITSAGYRIGPAEIEDVLLRHPAVSIAAAVGKKDPLRTEIVKAVIVL
MPGITPSPALEDDIRAFVRTRLAAYEYPREIEFVAELPLTTTGKVIRRLLRD
>Mature_532_residues
MLAHTSEYERRCRAFSWDIPRRYNMAVHACDGIAARAPDRPALFLPHGAGFRPVSYGALAAASNRLAHALLAHGIGRGDR
VAILLPQSLDVLVTHLAVYKMGAIAVPLAGAFGVDAIAYRLADSGARALVTDDAGLAKVVERPQALGLLINVDGARAGVL
DFTTLLDAASDRPLAITSGPDDPALMIYTSGTTGQPKGALHGHRVLLPHVSGVTFTHEGIGQAGDRMWTPSDWAWAGGLL
NTILPALALGVPVVAQPRGKFDPEAAFDLIKRAQVRNVFIPPTALKMMRAVPDPKTRFNFDLRTVGSAGEALGAETFEWG
RQALGVPVNEFYGQTECNYVIGSSAALGVAKAGATGKAVPGHEVAVLGEDGAVLPPGQMGQIAVRAPDPVMFLEYWNRPD
ATQEKVRDGWLITGDLATQDEEGYFHFLGRDDDVITSAGYRIGPAEIEDVLLRHPAVSIAAAVGKKDPLRTEIVKAVIVL
MPGITPSPALEDDIRAFVRTRLAAYEYPREIEFVAELPLTTTGKVIRRLLRD

Specific function: Has a role in growth and sporulation on acetate [H]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157311624, Length=550, Percent_Identity=33.8181818181818, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI157311622, Length=550, Percent_Identity=33.8181818181818, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI58082049, Length=550, Percent_Identity=33.6363636363636, Blast_Score=260, Evalue=3e-69,
Organism=Homo sapiens, GI122937307, Length=535, Percent_Identity=32.8971962616822, Blast_Score=254, Evalue=2e-67,
Organism=Homo sapiens, GI42544132, Length=547, Percent_Identity=31.2614259597806, Blast_Score=252, Evalue=7e-67,
Organism=Homo sapiens, GI115511026, Length=556, Percent_Identity=31.4748201438849, Blast_Score=250, Evalue=2e-66,
Organism=Homo sapiens, GI38505220, Length=535, Percent_Identity=31.7757009345794, Blast_Score=248, Evalue=1e-65,
Organism=Homo sapiens, GI28416953, Length=559, Percent_Identity=28.4436493738819, Blast_Score=182, Evalue=1e-45,
Organism=Homo sapiens, GI13375727, Length=523, Percent_Identity=30.9751434034417, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI8923896, Length=540, Percent_Identity=26.2962962962963, Blast_Score=164, Evalue=2e-40,
Organism=Homo sapiens, GI253970489, Length=553, Percent_Identity=25.497287522604, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI187761345, Length=540, Percent_Identity=26.4814814814815, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI187761343, Length=540, Percent_Identity=26.4814814814815, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI156151445, Length=542, Percent_Identity=27.1217712177122, Blast_Score=141, Evalue=1e-33,
Organism=Homo sapiens, GI42544134, Length=379, Percent_Identity=26.1213720316623, Blast_Score=118, Evalue=1e-26,
Organism=Homo sapiens, GI195947378, Length=390, Percent_Identity=27.1794871794872, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI38524616, Length=474, Percent_Identity=27.2151898734177, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI13325057, Length=542, Percent_Identity=26.0147601476015, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI1790505, Length=552, Percent_Identity=28.6231884057971, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1788107, Length=555, Percent_Identity=29.7297297297297, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI145693145, Length=522, Percent_Identity=28.735632183908, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1786529, Length=568, Percent_Identity=27.4647887323944, Blast_Score=151, Evalue=1e-37,
Organism=Escherichia coli, GI221142682, Length=506, Percent_Identity=26.4822134387352, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1786810, Length=507, Percent_Identity=27.6134122287968, Blast_Score=119, Evalue=6e-28,
Organism=Escherichia coli, GI1786801, Length=443, Percent_Identity=27.313769751693, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1789201, Length=500, Percent_Identity=23.2, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=501, Percent_Identity=27.7445109780439, Blast_Score=149, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI32563687, Length=501, Percent_Identity=26.9461077844311, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71994694, Length=536, Percent_Identity=25.7462686567164, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71994703, Length=536, Percent_Identity=25.7462686567164, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71994690, Length=536, Percent_Identity=25.7462686567164, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17557194, Length=506, Percent_Identity=28.0632411067194, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71982997, Length=529, Percent_Identity=26.2759924385633, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71983001, Length=529, Percent_Identity=26.2759924385633, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17538037, Length=529, Percent_Identity=26.8431001890359, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI17559526, Length=501, Percent_Identity=26.7465069860279, Blast_Score=127, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17560140, Length=494, Percent_Identity=25.9109311740891, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI17531443, Length=498, Percent_Identity=23.8955823293173, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71985884, Length=596, Percent_Identity=24.1610738255034, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71996755, Length=498, Percent_Identity=23.8955823293173, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17560308, Length=587, Percent_Identity=23.3390119250426, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319264, Length=568, Percent_Identity=27.112676056338, Blast_Score=174, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6323182, Length=569, Percent_Identity=26.5377855887522, Blast_Score=165, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6319699, Length=492, Percent_Identity=26.4227642276423, Blast_Score=142, Evalue=1e-34,
Organism=Drosophila melanogaster, GI62472339, Length=528, Percent_Identity=26.8939393939394, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24667955, Length=528, Percent_Identity=26.8939393939394, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI21355225, Length=538, Percent_Identity=28.6245353159851, Blast_Score=162, Evalue=6e-40,
Organism=Drosophila melanogaster, GI24667959, Length=495, Percent_Identity=25.8585858585859, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI24581924, Length=511, Percent_Identity=25.2446183953033, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI18859661, Length=488, Percent_Identity=27.0491803278689, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI24656500, Length=489, Percent_Identity=28.2208588957055, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24648260, Length=365, Percent_Identity=27.3972602739726, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI19922652, Length=495, Percent_Identity=27.0707070707071, Blast_Score=115, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24653035, Length=411, Percent_Identity=24.8175182481752, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI21355181, Length=489, Percent_Identity=24.1308793456033, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI21356947, Length=489, Percent_Identity=23.1083844580777, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161076582, Length=418, Percent_Identity=23.6842105263158, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI281365686, Length=449, Percent_Identity=23.8307349665924, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24648253, Length=461, Percent_Identity=22.9934924078091, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356441, Length=340, Percent_Identity=26.7647058823529, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24648255, Length=461, Percent_Identity=22.7765726681128, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21358303, Length=464, Percent_Identity=24.7844827586207, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24648257, Length=415, Percent_Identity=24.3373493975904, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI20130357, Length=365, Percent_Identity=23.5616438356164, Blast_Score=85, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 56863; Mature: 56863

Theoretical pI: Translated: 6.58; Mature: 6.58

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAHTSEYERRCRAFSWDIPRRYNMAVHACDGIAARAPDRPALFLPHGAGFRPVSYGALA
CCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCHHHH
AASNRLAHALLAHGIGRGDRVAILLPQSLDVLVTHLAVYKMGAIAVPLAGAFGVDAIAYR
HHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHH
LADSGARALVTDDAGLAKVVERPQALGLLINVDGARAGVLDFTTLLDAASDRPLAITSGP
HHCCCCEEEEECCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEECCC
DDPALMIYTSGTTGQPKGALHGHRVLLPHVSGVTFTHEGIGQAGDRMWTPSDWAWAGGLL
CCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHH
NTILPALALGVPVVAQPRGKFDPEAAFDLIKRAQVRNVFIPPTALKMMRAVPDPKTRFNF
HHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCEEECCHHHHHHHHHCCCCCCEEEE
DLRTVGSAGEALGAETFEWGRQALGVPVNEFYGQTECNYVIGSSAALGVAKAGATGKAVP
EEEECCCCCHHCCCHHHHHHHHHCCCCHHHHCCCCCCCEEECCCCHHHHEECCCCCCCCC
GHEVAVLGEDGAVLPPGQMGQIAVRAPDPVMFLEYWNRPDATQEKVRDGWLITGDLATQD
CCEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHCCCEEECCCCCCC
EEGYFHFLGRDDDVITSAGYRIGPAEIEDVLLRHPAVSIAAAVGKKDPLRTEIVKAVIVL
CCCEEEEECCCCCEEECCCCEECHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHH
MPGITPSPALEDDIRAFVRTRLAAYEYPREIEFVAELPLTTTGKVIRRLLRD
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCC
>Mature Secondary Structure
MLAHTSEYERRCRAFSWDIPRRYNMAVHACDGIAARAPDRPALFLPHGAGFRPVSYGALA
CCCCCHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCHHHH
AASNRLAHALLAHGIGRGDRVAILLPQSLDVLVTHLAVYKMGAIAVPLAGAFGVDAIAYR
HHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHH
LADSGARALVTDDAGLAKVVERPQALGLLINVDGARAGVLDFTTLLDAASDRPLAITSGP
HHCCCCEEEEECCCHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEECCC
DDPALMIYTSGTTGQPKGALHGHRVLLPHVSGVTFTHEGIGQAGDRMWTPSDWAWAGGLL
CCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHH
NTILPALALGVPVVAQPRGKFDPEAAFDLIKRAQVRNVFIPPTALKMMRAVPDPKTRFNF
HHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHHHHCEEECCHHHHHHHHHCCCCCCEEEE
DLRTVGSAGEALGAETFEWGRQALGVPVNEFYGQTECNYVIGSSAALGVAKAGATGKAVP
EEEECCCCCHHCCCHHHHHHHHHCCCCHHHHCCCCCCCEEECCCCHHHHEECCCCCCCCC
GHEVAVLGEDGAVLPPGQMGQIAVRAPDPVMFLEYWNRPDATQEKVRDGWLITGDLATQD
CCEEEEECCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCHHHHHHHCCCEEECCCCCCC
EEGYFHFLGRDDDVITSAGYRIGPAEIEDVLLRHPAVSIAAAVGKKDPLRTEIVKAVIVL
CCCEEEEECCCCCEEECCCCEECHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHH
MPGITPSPALEDDIRAFVRTRLAAYEYPREIEFVAELPLTTTGKVIRRLLRD
CCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7934817; 9387221; 9384377 [H]