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The map label for this gene is mltA [H]

Identifier: 154245992

GI number: 154245992

Start: 2307613

End: 2308803

Strand: Direct

Name: mltA [H]

Synonym: Xaut_2049

Alternate gene names: 154245992

Gene position: 2307613-2308803 (Clockwise)

Preceding gene: 154245991

Following gene: 154245993

Centisome position: 43.47

GC content: 71.7

Gene sequence:

>1191_bases
ATGCTCCTCTCCCTTGTGGCCGTCGCCGCTGCGCCGGCCCACGCTGCCATGCTGAGTGTGGTTGCCCCGCCCGATATCGC
CGGCTCGAAGCTGGTGCCGGTGGCCTTCGGCGCTCTCGACGGCTGGGCGGCGGACGACCATGCCGCCGCCTTCCAGACCT
TTTTGAACAGCTGCGCCGCCCGTCGCGCCTCGCCGGCCGAGGTGGGACCCGCCTCCGCTCCGACGCTGGCCGCCGGCCTG
ACCCATGCCTGCGCGGCCGCCGCGCGGCTGGGCGCCACCACCCCGTCGCGGGAGGTGGCGCGGCTGTTCTTCGAGGCCAA
TTTCCGCCCCTATCGCGTGGTGCCGGACACAGGCGGCGAAGCCTTCTTCACCGGCTATTACGAGCCGGAGGTGGCAGGCG
CGCTGGCCCCCGGCAATGGATTCGACGTGCCGGTCTATGGCCGTCCGGCCGACCTGCTGATGAGCGGCGGCGGCCCCACT
CCCAATTCGGGCGGCGCCCTGCGGCGGGAGGGCGATGCCCTCGTGCCCTATTTCGACCGCGCCGCCATCGAGGATGGGGC
GCTCGCCGGCCGGGGACTGGAAGTCGCCTGGCTGAAGGACCCCATCGACCTGTTCTTCATGCAGATCCAGGGCTCGGCCC
GGGTCCGGCTGCCGGACGGGCGGGTGCTCCGGCTGAATTACGACGGCTATAACGGCCATCCCTACCTGCCTGTAGGCCGG
CTCCTCATCGCGCGGGGCCTGGTGCCGCGGGAGGAGATGTCCATGGACCGCATCCGCGCCTTCATGGAGGCGGATCCGGA
GGCTGGCCGGGCGCTGCGGCGCGAGAACCGGTCCTATGTGTTCTTCAAGGCCCTCGATCTTGGCGGGGAGGCCGGTGCCA
TGGGCGCTGAGGGCGTGCCGCTGACCGCAGGCCGCTCCATCGCCGTGGACCGCAGGCTGCACACCTATGGCACGCCGGTG
TTCGTGGCGGCGGACCTGCCGCTTTCCGCGCCCGGTAGCAGCGAGCCCTTCCGTCGCCTGATGATCGCGCAGGATACCGG
CTCGGCCATCGTCGGGCCGGCACGGGCGGATCTTTATTTCGGCACCGGGCTTGAGGCCGGCGCGGTGGCCGGGCGTATCC
GCCATTCCGGCAGCTTCACCTTGCTGGTACCGCGCTTCGCAGCCGCCGGGACGCCGGGGCACCCCCGATGA

Upstream 100 bases:

>100_bases
TGGCGGAGTAAGGGGGCTTGGAACGGGTCATGACCCTGACCGTCGCCCCGCGACGGGCGCGGCCGGAAGCACGAAGCGCC
GCGTGCACCGGGTGGTGGCA

Downstream 100 bases:

>100_bases
GCCGGCGCGGACGGCGGCGCCAGCTTTCGGCGGAAGAGCGCGCGCTCTGGGATCATGTGGTGCGCTCGGTGACGCCGCTG
AAGCTGCCCGCCGTGCCGCA

Product: MltA domain-containing protein

Products: Muramic Acid Residue [C]

Alternate protein names: Murein hydrolase A [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MLLSLVAVAAAPAHAAMLSVVAPPDIAGSKLVPVAFGALDGWAADDHAAAFQTFLNSCAARRASPAEVGPASAPTLAAGL
THACAAAARLGATTPSREVARLFFEANFRPYRVVPDTGGEAFFTGYYEPEVAGALAPGNGFDVPVYGRPADLLMSGGGPT
PNSGGALRREGDALVPYFDRAAIEDGALAGRGLEVAWLKDPIDLFFMQIQGSARVRLPDGRVLRLNYDGYNGHPYLPVGR
LLIARGLVPREEMSMDRIRAFMEADPEAGRALRRENRSYVFFKALDLGGEAGAMGAEGVPLTAGRSIAVDRRLHTYGTPV
FVAADLPLSAPGSSEPFRRLMIAQDTGSAIVGPARADLYFGTGLEAGAVAGRIRHSGSFTLLVPRFAAAGTPGHPR

Sequences:

>Translated_396_residues
MLLSLVAVAAAPAHAAMLSVVAPPDIAGSKLVPVAFGALDGWAADDHAAAFQTFLNSCAARRASPAEVGPASAPTLAAGL
THACAAAARLGATTPSREVARLFFEANFRPYRVVPDTGGEAFFTGYYEPEVAGALAPGNGFDVPVYGRPADLLMSGGGPT
PNSGGALRREGDALVPYFDRAAIEDGALAGRGLEVAWLKDPIDLFFMQIQGSARVRLPDGRVLRLNYDGYNGHPYLPVGR
LLIARGLVPREEMSMDRIRAFMEADPEAGRALRRENRSYVFFKALDLGGEAGAMGAEGVPLTAGRSIAVDRRLHTYGTPV
FVAADLPLSAPGSSEPFRRLMIAQDTGSAIVGPARADLYFGTGLEAGAVAGRIRHSGSFTLLVPRFAAAGTPGHPR
>Mature_396_residues
MLLSLVAVAAAPAHAAMLSVVAPPDIAGSKLVPVAFGALDGWAADDHAAAFQTFLNSCAARRASPAEVGPASAPTLAAGL
THACAAAARLGATTPSREVARLFFEANFRPYRVVPDTGGEAFFTGYYEPEVAGALAPGNGFDVPVYGRPADLLMSGGGPT
PNSGGALRREGDALVPYFDRAAIEDGALAGRGLEVAWLKDPIDLFFMQIQGSARVRLPDGRVLRLNYDGYNGHPYLPVGR
LLIARGLVPREEMSMDRIRAFMEADPEAGRALRRENRSYVFFKALDLGGEAGAMGAEGVPLTAGRSIAVDRRLHTYGTPV
FVAADLPLSAPGSSEPFRRLMIAQDTGSAIVGPARADLYFGTGLEAGAVAGRIRHSGSFTLLVPRFAAAGTPGHPR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=272, Percent_Identity=35.2941176470588, Blast_Score=112, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 41409; Mature: 41409

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLSLVAVAAAPAHAAMLSVVAPPDIAGSKLVPVAFGALDGWAADDHAAAFQTFLNSCAA
CHHEEEHHHHCCHHHHEEEEECCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
RRASPAEVGPASAPTLAAGLTHACAAAARLGATTPSREVARLFFEANFRPYRVVPDTGGE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
AFFTGYYEPEVAGALAPGNGFDVPVYGRPADLLMSGGGPTPNSGGALRREGDALVPYFDR
EEEEECCCCHHCCEECCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCCCCCEECCCHHH
AAIEDGALAGRGLEVAWLKDPIDLFFMQIQGSARVRLPDGRVLRLNYDGYNGHPYLPVGR
HHCCCCCCCCCCEEEEEECCCCEEEEEEECCCEEEECCCCEEEEEEECCCCCCCCCHHHH
LLIARGLVPREEMSMDRIRAFMEADPEAGRALRRENRSYVFFKALDLGGEAGAMGAEGVP
HHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCC
LTAGRSIAVDRRLHTYGTPVFVAADLPLSAPGSSEPFRRLMIAQDTGSAIVGPARADLYF
CCCCCCEEECCCHHHCCCCEEEEECCCCCCCCCCCCHHEEEEEECCCCEEECCCCCEEEE
GTGLEAGAVAGRIRHSGSFTLLVPRFAAAGTPGHPR
CCCCCCCHHHHHEECCCCEEEEEECHHCCCCCCCCC
>Mature Secondary Structure
MLLSLVAVAAAPAHAAMLSVVAPPDIAGSKLVPVAFGALDGWAADDHAAAFQTFLNSCAA
CHHEEEHHHHCCHHHHEEEEECCCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHH
RRASPAEVGPASAPTLAAGLTHACAAAARLGATTPSREVARLFFEANFRPYRVVPDTGGE
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCEEEEECCCCCC
AFFTGYYEPEVAGALAPGNGFDVPVYGRPADLLMSGGGPTPNSGGALRREGDALVPYFDR
EEEEECCCCHHCCEECCCCCCCCCCCCCCHHHEEECCCCCCCCCCCCCCCCCEECCCHHH
AAIEDGALAGRGLEVAWLKDPIDLFFMQIQGSARVRLPDGRVLRLNYDGYNGHPYLPVGR
HHCCCCCCCCCCEEEEEECCCCEEEEEEECCCEEEECCCCEEEEEEECCCCCCCCCHHHH
LLIARGLVPREEMSMDRIRAFMEADPEAGRALRRENRSYVFFKALDLGGEAGAMGAEGVP
HHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCC
LTAGRSIAVDRRLHTYGTPVFVAADLPLSAPGSSEPFRRLMIAQDTGSAIVGPARADLYF
CCCCCCEEECCCHHHCCCCEEEEECCCCCCCCCCCCHHEEEEEECCCCEEECCCCCEEEE
GTGLEAGAVAGRIRHSGSFTLLVPRFAAAGTPGHPR
CCCCCCCHHHHHEECCCCEEEEEECHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]