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The map label for this gene is pntAA [H]

Identifier: 154245891

GI number: 154245891

Start: 2203447

End: 2204610

Strand: Direct

Name: pntAA [H]

Synonym: Xaut_1948

Alternate gene names: 154245891

Gene position: 2203447-2204610 (Clockwise)

Preceding gene: 154245890

Following gene: 154245892

Centisome position: 41.5

GC content: 68.9

Gene sequence:

>1164_bases
ATGAAAATCGCTGTCCCCGCCGAGGTTGATCTCGGCGAGCCGCGGGTCGCTGCGACCCCGGATACGGTGAAGCGTCTGGT
CGCGCTCGGCGCCAGCGTGGCGGTCGAGACGGGCGCGGGCCTCAAGTCGGGCATTCTGGATGCCGACTTCGAAGCCGCCG
GCGCCACCATCGCGCCCACCGCCGCCGATGCCCTGTACGGCGCTGAAGTGGTACTGAAGGTTCGCCGTCCGACGGAAGCT
GAACTTTCGTCGTACAAGCCCGGCGCGCTGCTGCTGGCCATCGTCGATCCCTATGGCAACGACGAGGCCCTGGCCACGCT
GGCGCGCTACAACGTCAACGCCTTCGCCATGGAGCTGATGCCCCGCATCACCCGCGCGCAGGTGATGGACGTGCTGTCCT
CGCAGGCGAACCTCGCCGGCTATCGCGCCGTCATCGACGCCGCGGCCGAATTCAATCGCGCCCTGCCGCAGATGATGACA
GCCGCCGGCACTGTGCCCGCCGCGCGCGTCTTCGTCATGGGCGCCGGCGTGGCGGGCCTTCAGGCCATCGCCACCGCGCG
CCGCCTCGGCGCCATCGTGACTGCCACCGACGTGCGCCCCGCCGCCAAGGAACAGGTCGCCTCGCTGGGCGCCAAGTTCG
TCGCGGTGGAGGACGAGGAGTTCAAGCAGGCCGAGACCGCCGCCGGCTACGCCAAGCCCATGTCGGCCGAGTACCAGGCC
AAGCAGGCGGCCCTCGTCGCCGAGCACATCAAGAAGCAGGACATTGTCATCACCACCGCCCTGATCCCCGGCCGGCCCGC
GCCGCGCCTGATCACGGCGCAGATGGTGGCCTCCATGCGGCCCGGCTCCATCATCGTCGACCTGGCGGTGGAGCGTGGCG
GCAACGTGGAAGGCTCGGTGCCCGGCGAAGTGGCCTGGGTCGGCAACGTCAAGATCGTCGGCCACCTCAACGTGCCCGGC
CGCATCGCGGCGTCGTCCTCGCCGCTCTACGCCAAGAACCTGTTCAACTTCTTCGAGACGATGGTGGACAAGGCGACCAA
GTCCCTTGCCGTGAAGTGGGACGACGAGCTGGTCAAGGCCACCCTCCTCACCCGCGACGGCGCCGTCGTGCATCCCAACT
TCGCACCCAAGAATCTCGCCACCACCAGCGAGGGAGCGGCCTGA

Upstream 100 bases:

>100_bases
TGACCAAATGGGGCGCGATCGCTGTCGCCGTCCTCCTCACCCTCATGTGGATCTTCCTCCTCTGACCCCCTGACGGGTTG
GAGCACCGGAGACATCTCTG

Downstream 100 bases:

>100_bases
TGAATCCCGCCTCAGCCCAGACCGCGACGGACGCCGCCTCCCAGGCCCGCGCCGCTGCAGAGATCGCGCGTCAGGCGGCC
GAAGCCGCCCAGCTCTATGC

Product: NAD(P)(+) transhydrogenase

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit alpha 1; Proton-translocating transhydrogenase component 1; Pyridine nucleotide transhydrogenase subunit alpha 1; dI [H]

Number of amino acids: Translated: 387; Mature: 387

Protein sequence:

>387_residues
MKIAVPAEVDLGEPRVAATPDTVKRLVALGASVAVETGAGLKSGILDADFEAAGATIAPTAADALYGAEVVLKVRRPTEA
ELSSYKPGALLLAIVDPYGNDEALATLARYNVNAFAMELMPRITRAQVMDVLSSQANLAGYRAVIDAAAEFNRALPQMMT
AAGTVPAARVFVMGAGVAGLQAIATARRLGAIVTATDVRPAAKEQVASLGAKFVAVEDEEFKQAETAAGYAKPMSAEYQA
KQAALVAEHIKKQDIVITTALIPGRPAPRLITAQMVASMRPGSIIVDLAVERGGNVEGSVPGEVAWVGNVKIVGHLNVPG
RIAASSSPLYAKNLFNFFETMVDKATKSLAVKWDDELVKATLLTRDGAVVHPNFAPKNLATTSEGAA

Sequences:

>Translated_387_residues
MKIAVPAEVDLGEPRVAATPDTVKRLVALGASVAVETGAGLKSGILDADFEAAGATIAPTAADALYGAEVVLKVRRPTEA
ELSSYKPGALLLAIVDPYGNDEALATLARYNVNAFAMELMPRITRAQVMDVLSSQANLAGYRAVIDAAAEFNRALPQMMT
AAGTVPAARVFVMGAGVAGLQAIATARRLGAIVTATDVRPAAKEQVASLGAKFVAVEDEEFKQAETAAGYAKPMSAEYQA
KQAALVAEHIKKQDIVITTALIPGRPAPRLITAQMVASMRPGSIIVDLAVERGGNVEGSVPGEVAWVGNVKIVGHLNVPG
RIAASSSPLYAKNLFNFFETMVDKATKSLAVKWDDELVKATLLTRDGAVVHPNFAPKNLATTSEGAA
>Mature_387_residues
MKIAVPAEVDLGEPRVAATPDTVKRLVALGASVAVETGAGLKSGILDADFEAAGATIAPTAADALYGAEVVLKVRRPTEA
ELSSYKPGALLLAIVDPYGNDEALATLARYNVNAFAMELMPRITRAQVMDVLSSQANLAGYRAVIDAAAEFNRALPQMMT
AAGTVPAARVFVMGAGVAGLQAIATARRLGAIVTATDVRPAAKEQVASLGAKFVAVEDEEFKQAETAAGYAKPMSAEYQA
KQAALVAEHIKKQDIVITTALIPGRPAPRLITAQMVASMRPGSIIVDLAVERGGNVEGSVPGEVAWVGNVKIVGHLNVPG
RIAASSSPLYAKNLFNFFETMVDKATKSLAVKWDDELVKATLLTRDGAVVHPNFAPKNLATTSEGAA

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG3288

COG function: function code C; NAD/NADP transhydrogenase alpha subunit

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AlaDH/PNT family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=394, Percent_Identity=38.8324873096447, Blast_Score=249, Evalue=3e-66,
Organism=Homo sapiens, GI122939153, Length=394, Percent_Identity=38.8324873096447, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1787887, Length=373, Percent_Identity=45.5764075067024, Blast_Score=316, Evalue=2e-87,
Organism=Caenorhabditis elegans, GI17550456, Length=367, Percent_Identity=43.8692098092643, Blast_Score=296, Evalue=1e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007698
- InterPro:   IPR008142
- InterPro:   IPR008143
- InterPro:   IPR007886 [H]

Pfam domain/function: PF01262 AlaDh_PNT_C; PF05222 AlaDh_PNT_N [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 40298; Mature: 40298

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS00837 ALADH_PNT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAVPAEVDLGEPRVAATPDTVKRLVALGASVAVETGAGLKSGILDADFEAAGATIAPT
CEEECCCCCCCCCCCCCCCHHHHHHHHHHCCHHEEECCCCCCCCCCCCCHHHCCCEECCC
AADALYGAEVVLKVRRPTEAELSSYKPGALLLAIVDPYGNDEALATLARYNVNAFAMELM
HHHHHHCCEEEEEECCCCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHH
PRITRAQVMDVLSSQANLAGYRAVIDAAAEFNRALPQMMTAAGTVPAARVFVMGAGVAGL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCHHHH
QAIATARRLGAIVTATDVRPAAKEQVASLGAKFVAVEDEEFKQAETAAGYAKPMSAEYQA
HHHHHHHHHCEEEEECCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCHHHH
KQAALVAEHIKKQDIVITTALIPGRPAPRLITAQMVASMRPGSIIVDLAVERGGNVEGSV
HHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
PGEVAWVGNVKIVGHLNVPGRIAASSSPLYAKNLFNFFETMVDKATKSLAVKWDDELVKA
CCCEEEEECEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHH
TLLTRDGAVVHPNFAPKNLATTSEGAA
HHEECCCCEECCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIAVPAEVDLGEPRVAATPDTVKRLVALGASVAVETGAGLKSGILDADFEAAGATIAPT
CEEECCCCCCCCCCCCCCCHHHHHHHHHHCCHHEEECCCCCCCCCCCCCHHHCCCEECCC
AADALYGAEVVLKVRRPTEAELSSYKPGALLLAIVDPYGNDEALATLARYNVNAFAMELM
HHHHHHCCEEEEEECCCCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHCCHHHHHHHH
PRITRAQVMDVLSSQANLAGYRAVIDAAAEFNRALPQMMTAAGTVPAARVFVMGAGVAGL
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHEEEEEECCHHHH
QAIATARRLGAIVTATDVRPAAKEQVASLGAKFVAVEDEEFKQAETAAGYAKPMSAEYQA
HHHHHHHHHCEEEEECCCCHHHHHHHHHCCCEEEEECCHHHHHHHHHCCCCCCCCCHHHH
KQAALVAEHIKKQDIVITTALIPGRPAPRLITAQMVASMRPGSIIVDLAVERGGNVEGSV
HHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
PGEVAWVGNVKIVGHLNVPGRIAASSSPLYAKNLFNFFETMVDKATKSLAVKWDDELVKA
CCCEEEEECEEEEEEECCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHEEEEECHHHHHH
TLLTRDGAVVHPNFAPKNLATTSEGAA
HHEECCCCEECCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]