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The map label for this gene is acrB [C]

Identifier: 154245005

GI number: 154245005

Start: 1208433

End: 1210493

Strand: Reverse

Name: acrB [C]

Synonym: Xaut_1055

Alternate gene names: 154245005

Gene position: 1210493-1208433 (Counterclockwise)

Preceding gene: 154245006

Following gene: 154245003

Centisome position: 22.8

GC content: 64.0

Gene sequence:

>2061_bases
ATGGTGATCCACACGCTGGTGGAGGCGCTGGCCATCGTGACCCTGGTGGTATTCGCCTTCCTCGGCTCCTGGCGCTCGGT
GCTCATACCGGTGATCGCGATCCCACTGTCGCTGATCGGCACCTTCCTGATGATGCTGGCCTTCGGCTTCAGCATCAACC
TGCTGACGCTGCTGGCCTTGGTGCTCGCCATTGGCCTCGTGGTGGACGACGCCATCATCGTGGTGGAAAGCGTCAACCAT
CACATGGAAGAGGGCATGAGCGCGCTTCAGGCCGCCTTCGCCTCGGCGCGCCAGCTCGCCAATCCCATCATCGCCATGAC
CGTGGTGCTGATCGCGGTCTATGTGCCCATCGGCTTCCAGGGCGGGCTCACGGGTGCGCTGTTCACCGAGTTCGCCTTCA
CGCTGGTGGGCGCGGTGACCATCTCGGCCGTGGTGGCGCTGACGCTGACGCCGATGATGTCCGCCTACATGCTGAAGCCG
GTGGACCATGCGGGCGGGGACCTGGAATCGCGCATGGTGCTGGCGGTGGACCGGGTGATGGGCAGGATCACCGCCGCCTA
TTCCCGCTCGCTGACGGGCGCTCTCAACTACATGTCCGTCACCGCCGTGTTCGCCGCCCTCGTGCTGTGCAGCGTCTACT
GGCTGTATGGCGCCGCGCAGAGCGAGCTGGCGCCCGAGGAGGACCAGGGCATCATTCTCGCCCAGAGCATTTCCGCCCCC
AATGCGACACTGCAGCAGAAGCTGCTCTACAATCGACAGACCTACGAGACCTTCGCCCGGCACCCCGAGACCGAGACGGT
GTTCCAGGTGGAGAGCACCGGCACCAGCATCGCCGGCTGGGTGCTGAAGCCCTGGGACGAGCGCAAGGCGACCACCAAGA
CCCTTCAGCCGATGATCCAGCAGGAGCTGAACGCCATCGCCGGGCAGAAGATCGTCGCCTTCCAGACCTCGCCTCTGCCC
GGCTCGAACGGCCTGCCCATGCAGATCGTGATCGGCACCTCTGATGGCTTCGACAAGCTCAACGAGGTGGCCGCGAAGTT
CCTGCAGGAGGCGCTGGACACTGGCCTGTTCATCTTCCTCAACAACGATCTCAAGATTGACCAGCCGCAGGCCTCCATCG
TCATCGACCGGGAGAAGACCTCGCTCCTCGGCCTCTCCATGAGCGACGTGGGCGGTGCCCTCTCCTCGCTGCTGGGCGGC
GGCTATGTGAACTACTTCAGCTTGGACGGGCGGTCCTACAAGGTCATCCCGCAGGTGAAGCAGGAGGCGCGGCTCAATAC
CGACCAGGTGCTCGATTATTACATGCGCATGACCGACGGAACGATGATCCCGCTGTCGACCGTGGCGCGTATCGAAACGA
AGACCGTGCCGGAATCCCTCAACCACTTCCAGCAGGTAAACGCGGCTACGATTGCCGGCGTGGTTGCACCCGGGATTACC
ACGGGTGATGCCATCACGGCGTTGAAGGATCTCGCCAAGCGCACCCTGCCCGCGGGCTATACGCTCGATTTCGGTGGCGC
CTCGCGGCAGTACGTGCAGGAGAGCGGCGGCTTCGTCACCACCTTCGCCTTTGCGCTGATCGTGATTTTCCTGTCGCTCG
CCGCGCTGTTCAACAGCTTCCGCGATCCGGTGGTGATCCTCTTGTCGGTGCCCATGTCGCTCGCCGGCGCGCTGCTGTTC
ATCAGCGTCGGCATCGGCGGGGCCAGCATCAACATCTACACACAGGTCGGCCTCACCACGCTGATGGGACTCATCAGCAA
GCACGGCATCCTGATGCTGGAGGTGGCCAACGAACTGCAGCTTGAAGGCAAGTCCAAGCGCGAGGCCATCGTCGAGGCGG
CCACGCTCCGCCTGCGGCCGATCCTGATGACGACGGCGGCGATGGTGCTCGGCGTCTTACCGCTCATCTTCGCGTCCGGC
GCGGGCGCCGCCTCGCGCTTCAACCTTGGCCTCGTCATCGCCACCGGCCTCGCCATCGGCACGCTCTTCACGCTGTACGT
GGTGCCCACGGCTTATGTTTTGATGGGCCAGACGCACCACGCTTCGAAGAATGAAGACTGA

Upstream 100 bases:

>100_bases
GTGCGCGCGGTGCTGCCGGAGATCGAGAGCCAGCTGCCCACCGGGCTCTCGATGGGCGTGATCTACGATTCCTCAGCCTT
CGTGAATTCCTCCATCGAGG

Downstream 100 bases:

>100_bases
ATTTGCCGGGCGGATGCTCCGTCCGGCGTGCAATACCGGGACCGGCACGGCGCCGGTCCCGGGTCGCTTGCACCCAGACT
GCCGACGGAGGTTTCCACGC

Product: acriflavin resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MVIHTLVEALAIVTLVVFAFLGSWRSVLIPVIAIPLSLIGTFLMMLAFGFSINLLTLLALVLAIGLVVDDAIIVVESVNH
HMEEGMSALQAAFASARQLANPIIAMTVVLIAVYVPIGFQGGLTGALFTEFAFTLVGAVTISAVVALTLTPMMSAYMLKP
VDHAGGDLESRMVLAVDRVMGRITAAYSRSLTGALNYMSVTAVFAALVLCSVYWLYGAAQSELAPEEDQGIILAQSISAP
NATLQQKLLYNRQTYETFARHPETETVFQVESTGTSIAGWVLKPWDERKATTKTLQPMIQQELNAIAGQKIVAFQTSPLP
GSNGLPMQIVIGTSDGFDKLNEVAAKFLQEALDTGLFIFLNNDLKIDQPQASIVIDREKTSLLGLSMSDVGGALSSLLGG
GYVNYFSLDGRSYKVIPQVKQEARLNTDQVLDYYMRMTDGTMIPLSTVARIETKTVPESLNHFQQVNAATIAGVVAPGIT
TGDAITALKDLAKRTLPAGYTLDFGGASRQYVQESGGFVTTFAFALIVIFLSLAALFNSFRDPVVILLSVPMSLAGALLF
ISVGIGGASINIYTQVGLTTLMGLISKHGILMLEVANELQLEGKSKREAIVEAATLRLRPILMTTAAMVLGVLPLIFASG
AGAASRFNLGLVIATGLAIGTLFTLYVVPTAYVLMGQTHHASKNED

Sequences:

>Translated_686_residues
MVIHTLVEALAIVTLVVFAFLGSWRSVLIPVIAIPLSLIGTFLMMLAFGFSINLLTLLALVLAIGLVVDDAIIVVESVNH
HMEEGMSALQAAFASARQLANPIIAMTVVLIAVYVPIGFQGGLTGALFTEFAFTLVGAVTISAVVALTLTPMMSAYMLKP
VDHAGGDLESRMVLAVDRVMGRITAAYSRSLTGALNYMSVTAVFAALVLCSVYWLYGAAQSELAPEEDQGIILAQSISAP
NATLQQKLLYNRQTYETFARHPETETVFQVESTGTSIAGWVLKPWDERKATTKTLQPMIQQELNAIAGQKIVAFQTSPLP
GSNGLPMQIVIGTSDGFDKLNEVAAKFLQEALDTGLFIFLNNDLKIDQPQASIVIDREKTSLLGLSMSDVGGALSSLLGG
GYVNYFSLDGRSYKVIPQVKQEARLNTDQVLDYYMRMTDGTMIPLSTVARIETKTVPESLNHFQQVNAATIAGVVAPGIT
TGDAITALKDLAKRTLPAGYTLDFGGASRQYVQESGGFVTTFAFALIVIFLSLAALFNSFRDPVVILLSVPMSLAGALLF
ISVGIGGASINIYTQVGLTTLMGLISKHGILMLEVANELQLEGKSKREAIVEAATLRLRPILMTTAAMVLGVLPLIFASG
AGAASRFNLGLVIATGLAIGTLFTLYVVPTAYVLMGQTHHASKNED
>Mature_686_residues
MVIHTLVEALAIVTLVVFAFLGSWRSVLIPVIAIPLSLIGTFLMMLAFGFSINLLTLLALVLAIGLVVDDAIIVVESVNH
HMEEGMSALQAAFASARQLANPIIAMTVVLIAVYVPIGFQGGLTGALFTEFAFTLVGAVTISAVVALTLTPMMSAYMLKP
VDHAGGDLESRMVLAVDRVMGRITAAYSRSLTGALNYMSVTAVFAALVLCSVYWLYGAAQSELAPEEDQGIILAQSISAP
NATLQQKLLYNRQTYETFARHPETETVFQVESTGTSIAGWVLKPWDERKATTKTLQPMIQQELNAIAGQKIVAFQTSPLP
GSNGLPMQIVIGTSDGFDKLNEVAAKFLQEALDTGLFIFLNNDLKIDQPQASIVIDREKTSLLGLSMSDVGGALSSLLGG
GYVNYFSLDGRSYKVIPQVKQEARLNTDQVLDYYMRMTDGTMIPLSTVARIETKTVPESLNHFQQVNAATIAGVVAPGIT
TGDAITALKDLAKRTLPAGYTLDFGGASRQYVQESGGFVTTFAFALIVIFLSLAALFNSFRDPVVILLSVPMSLAGALLF
ISVGIGGASINIYTQVGLTTLMGLISKHGILMLEVANELQLEGKSKREAIVEAATLRLRPILMTTAAMVLGVLPLIFASG
AGAASRFNLGLVIATGLAIGTLFTLYVVPTAYVLMGQTHHASKNED

Specific function: Could be a drug efflux pump [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family [H]

Homologues:

Organism=Escherichia coli, GI1786667, Length=695, Percent_Identity=35.3956834532374, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1788814, Length=691, Percent_Identity=33.5745296671491, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1789930, Length=687, Percent_Identity=33.3333333333333, Blast_Score=332, Evalue=4e-92,
Organism=Escherichia coli, GI1789666, Length=686, Percent_Identity=33.8192419825073, Blast_Score=330, Evalue=3e-91,
Organism=Escherichia coli, GI1788390, Length=690, Percent_Identity=32.3188405797101, Blast_Score=289, Evalue=3e-79,
Organism=Escherichia coli, GI1788391, Length=684, Percent_Identity=30.4093567251462, Blast_Score=274, Evalue=2e-74,
Organism=Escherichia coli, GI1786788, Length=739, Percent_Identity=23.4100135317997, Blast_Score=142, Evalue=6e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001036 [H]

Pfam domain/function: PF00873 ACR_tran [H]

EC number: NA

Molecular weight: Translated: 73172; Mature: 73172

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIHTLVEALAIVTLVVFAFLGSWRSVLIPVIAIPLSLIGTFLMMLAFGFSINLLTLLAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VLAIGLVVDDAIIVVESVNHHMEEGMSALQAAFASARQLANPIIAMTVVLIAVYVPIGFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GGLTGALFTEFAFTLVGAVTISAVVALTLTPMMSAYMLKPVDHAGGDLESRMVLAVDRVM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
GRITAAYSRSLTGALNYMSVTAVFAALVLCSVYWLYGAAQSELAPEEDQGIILAQSISAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEECCCCC
NATLQQKLLYNRQTYETFARHPETETVFQVESTGTSIAGWVLKPWDERKATTKTLQPMIQ
CHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCCCEECCEECCCHHHHHHHHHHHHHHH
QELNAIAGQKIVAFQTSPLPGSNGLPMQIVIGTSDGFDKLNEVAAKFLQEALDTGLFIFL
HHHHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEE
NNDLKIDQPQASIVIDREKTSLLGLSMSDVGGALSSLLGGGYVNYFSLDGRSYKVIPQVK
CCCEEECCCCCCEEEECCCCHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEECHHHH
QEARLNTDQVLDYYMRMTDGTMIPLSTVARIETKTVPESLNHFQQVNAATIAGVVAPGIT
HHHCCCHHHHHHHHHHHCCCCEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
TGDAITALKDLAKRTLPAGYTLDFGGASRQYVQESGGFVTTFAFALIVIFLSLAALFNSF
CCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
RDPVVILLSVPMSLAGALLFISVGIGGASINIYTQVGLTTLMGLISKHGILMLEVANELQ
CCCEEEEECCCHHHHHHHHHHEECCCCCEEEEEEHHHHHHHHHHHHHCCEEEEEEHHHHH
LEGKSKREAIVEAATLRLRPILMTTAAMVLGVLPLIFASGAGAASRFNLGLVIATGLAIG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHH
TLFTLYVVPTAYVLMGQTHHASKNED
HHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MVIHTLVEALAIVTLVVFAFLGSWRSVLIPVIAIPLSLIGTFLMMLAFGFSINLLTLLAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
VLAIGLVVDDAIIVVESVNHHMEEGMSALQAAFASARQLANPIIAMTVVLIAVYVPIGFQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
GGLTGALFTEFAFTLVGAVTISAVVALTLTPMMSAYMLKPVDHAGGDLESRMVLAVDRVM
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
GRITAAYSRSLTGALNYMSVTAVFAALVLCSVYWLYGAAQSELAPEEDQGIILAQSISAP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCEEEEECCCCC
NATLQQKLLYNRQTYETFARHPETETVFQVESTGTSIAGWVLKPWDERKATTKTLQPMIQ
CHHHHHHHHHCHHHHHHHHHCCCCCEEEEEECCCCCEECCEECCCHHHHHHHHHHHHHHH
QELNAIAGQKIVAFQTSPLPGSNGLPMQIVIGTSDGFDKLNEVAAKFLQEALDTGLFIFL
HHHHHHCCCEEEEEECCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCEEEEE
NNDLKIDQPQASIVIDREKTSLLGLSMSDVGGALSSLLGGGYVNYFSLDGRSYKVIPQVK
CCCEEECCCCCCEEEECCCCHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCEEECHHHH
QEARLNTDQVLDYYMRMTDGTMIPLSTVARIETKTVPESLNHFQQVNAATIAGVVAPGIT
HHHCCCHHHHHHHHHHHCCCCEECHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCC
TGDAITALKDLAKRTLPAGYTLDFGGASRQYVQESGGFVTTFAFALIVIFLSLAALFNSF
CCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
RDPVVILLSVPMSLAGALLFISVGIGGASINIYTQVGLTTLMGLISKHGILMLEVANELQ
CCCEEEEECCCHHHHHHHHHHEECCCCCEEEEEEHHHHHHHHHHHHHCCEEEEEEHHHHH
LEGKSKREAIVEAATLRLRPILMTTAAMVLGVLPLIFASGAGAASRFNLGLVIATGLAIG
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCHHHHHHHHHHH
TLFTLYVVPTAYVLMGQTHHASKNED
HHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]