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The map label for this gene is gabT [H]

Identifier: 154244990

GI number: 154244990

Start: 1192497

End: 1193906

Strand: Reverse

Name: gabT [H]

Synonym: Xaut_1040

Alternate gene names: 154244990

Gene position: 1193906-1192497 (Counterclockwise)

Preceding gene: 154244991

Following gene: 154244989

Centisome position: 22.49

GC content: 65.32

Gene sequence:

>1410_bases
ATGCTTGATCGCCAGACCGAAATCTCCACCGCCGCTGCCGAGCGTACCCGCCTGCGCGAGCTGGAGGAGACCTATTGCTC
CCATGGAGACACGGTCCATTACACTGAAGAGCCGAAGATCTTCGAGCGCTGCGAGGGGTCTTTCATCTATGACGACGAGG
ACCGCGCCTTCCTGGATCTGCAGATGTGGTATTCGGCGGTCAATTTCGGCTATGCCAATCCGCGCCTGAACGAGGCCATG
CGCCGCCAGCTCGATCGCCTGCCCCAGGTGGCGAGCCAGTATCTGCACCGCGAGAAGATCGAGCTGGCCGCCGAGATCGC
GGAAGGCGCCATGGCGCGCTTCGGCCACAAGGGGCGGGTGCATTTCAACGTGGGCGGCGCCCAGGCCATCGAGGATTCCC
TCAAGCTGGTGCGCAACGCCTGCGGCGGCAAGAGCCTGATGTTCGCCTTCGAGGGCGGCTACCACGGCCGCACGCTCGGC
GCCTCGGCCATCACCTCGTCCTACCGCTATCGCCGCCGCTTCGGCCATTTCGGCGAGCGCGCCCACTTCATCCCCTTCCC
CTATCATTTCCGCGGCCCGCGCGGCATGACGAAGGAGGAATACGGCCACCGCTGCGTCGAGCAGTTCGCCCGCCTGTTCG
AGAGCGAATACAACGGCGTGTGGGACCCCAAGGCCGGCCAGTGCGAATACGCCGCCTTCTATGTGGAGCCGATCCAAGGC
ACCGGCGGATACGTCATCCCGCCCGCCAACTTCTTCCCGGAGCTGAAGGAAGTGCTCGACCGCCACGGCATCCTGCTGGT
GGTGGACGAGATTCAGATGGGCTTCTACCGCACCGGCAAATTGTGGGCGATCGAGCACTTTGGCGTGGCGCCTGACATCA
TCGTGTTCGGCAAGGCGCTGACCAACGGGCTGAACCCCCTGTCCGGGCTCTGGGCGCGGGAGGCGCTCATCAATCCGCAG
GCGTTCCCGCCCGGCTCCACCCATTCCACCTTCAATGCCAATCCGCTCGGCACCGCCGTGGCGCTGGAAGCCATGCGCAT
GATGCGCGAGGAGGATTTCGCCACCTCCGTGGCCGAAAAGGGCGCCCGTTTCCTCGATGGGCTCAAGGAGCTGAAGGCGA
AGCACGCCATCGTCGGCGACGTGGACGGGCTGGGCCTTGCCCTGCGGGTGGAGATCTGCGAGCCGCATGACAGCTACACC
CCCTCAAAAGCCATCGTCGACCGCATGGTGGACGAGGCGCTGAAGGGCGATCTCGTCCATGGCGGCGAGCGCTACGGGCT
GGTGCTGGACATCGGCGGCTACCACAAGAATGTCATCACCCTGGCGCCGGCGCTGACCATCAGCCATGCCGAGATCGACC
TCGCCCTGGCGCTCATGGACCAGCTGTTTGCCCGCGTGACGCCCCGGTGA

Upstream 100 bases:

>100_bases
GGCTTCGCCGACGCCCTCGCCTTCCTGGACTTCGCCTTTCTGGAACCGCTGCGCGCCCGCCGCGCCGCCTCCCCCTCCCG
CCTCACCCTCGAGGAAGTTC

Downstream 100 bases:

>100_bases
GCGCCATGCGCATCAAGGTCATCGATCTGGACGGCGCGCTCACCGTGCAGGACGAGGTCATGGCCGGCCTGCCCGGCTGT
GACGCCGACCTGTTCATTGC

Product: class III aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MLDRQTEISTAAAERTRLRELEETYCSHGDTVHYTEEPKIFERCEGSFIYDDEDRAFLDLQMWYSAVNFGYANPRLNEAM
RRQLDRLPQVASQYLHREKIELAAEIAEGAMARFGHKGRVHFNVGGAQAIEDSLKLVRNACGGKSLMFAFEGGYHGRTLG
ASAITSSYRYRRRFGHFGERAHFIPFPYHFRGPRGMTKEEYGHRCVEQFARLFESEYNGVWDPKAGQCEYAAFYVEPIQG
TGGYVIPPANFFPELKEVLDRHGILLVVDEIQMGFYRTGKLWAIEHFGVAPDIIVFGKALTNGLNPLSGLWAREALINPQ
AFPPGSTHSTFNANPLGTAVALEAMRMMREEDFATSVAEKGARFLDGLKELKAKHAIVGDVDGLGLALRVEICEPHDSYT
PSKAIVDRMVDEALKGDLVHGGERYGLVLDIGGYHKNVITLAPALTISHAEIDLALALMDQLFARVTPR

Sequences:

>Translated_469_residues
MLDRQTEISTAAAERTRLRELEETYCSHGDTVHYTEEPKIFERCEGSFIYDDEDRAFLDLQMWYSAVNFGYANPRLNEAM
RRQLDRLPQVASQYLHREKIELAAEIAEGAMARFGHKGRVHFNVGGAQAIEDSLKLVRNACGGKSLMFAFEGGYHGRTLG
ASAITSSYRYRRRFGHFGERAHFIPFPYHFRGPRGMTKEEYGHRCVEQFARLFESEYNGVWDPKAGQCEYAAFYVEPIQG
TGGYVIPPANFFPELKEVLDRHGILLVVDEIQMGFYRTGKLWAIEHFGVAPDIIVFGKALTNGLNPLSGLWAREALINPQ
AFPPGSTHSTFNANPLGTAVALEAMRMMREEDFATSVAEKGARFLDGLKELKAKHAIVGDVDGLGLALRVEICEPHDSYT
PSKAIVDRMVDEALKGDLVHGGERYGLVLDIGGYHKNVITLAPALTISHAEIDLALALMDQLFARVTPR
>Mature_469_residues
MLDRQTEISTAAAERTRLRELEETYCSHGDTVHYTEEPKIFERCEGSFIYDDEDRAFLDLQMWYSAVNFGYANPRLNEAM
RRQLDRLPQVASQYLHREKIELAAEIAEGAMARFGHKGRVHFNVGGAQAIEDSLKLVRNACGGKSLMFAFEGGYHGRTLG
ASAITSSYRYRRRFGHFGERAHFIPFPYHFRGPRGMTKEEYGHRCVEQFARLFESEYNGVWDPKAGQCEYAAFYVEPIQG
TGGYVIPPANFFPELKEVLDRHGILLVVDEIQMGFYRTGKLWAIEHFGVAPDIIVFGKALTNGLNPLSGLWAREALINPQ
AFPPGSTHSTFNANPLGTAVALEAMRMMREEDFATSVAEKGARFLDGLKELKAKHAIVGDVDGLGLALRVEICEPHDSYT
PSKAIVDRMVDEALKGDLVHGGERYGLVLDIGGYHKNVITLAPALTISHAEIDLALALMDQLFARVTPR

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=449, Percent_Identity=27.3942093541203, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI37574042, Length=436, Percent_Identity=23.1651376146789, Blast_Score=145, Evalue=9e-35,
Organism=Homo sapiens, GI24119277, Length=446, Percent_Identity=25.3363228699552, Blast_Score=139, Evalue=7e-33,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=23.8095238095238, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI226442705, Length=436, Percent_Identity=23.1651376146789, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI13994255, Length=436, Percent_Identity=24.5412844036697, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI284507298, Length=231, Percent_Identity=31.6017316017316, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI188536080, Length=462, Percent_Identity=24.025974025974, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI38679950, Length=462, Percent_Identity=24.025974025974, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI38679946, Length=462, Percent_Identity=24.025974025974, Blast_Score=100, Evalue=3e-21,
Organism=Escherichia coli, GI1789016, Length=430, Percent_Identity=29.7674418604651, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=30, Blast_Score=174, Evalue=2e-44,
Organism=Escherichia coli, GI1789759, Length=432, Percent_Identity=27.3148148148148, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI1788044, Length=433, Percent_Identity=28.6374133949192, Blast_Score=148, Evalue=9e-37,
Organism=Escherichia coli, GI145693181, Length=355, Percent_Identity=27.0422535211268, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1786991, Length=381, Percent_Identity=29.9212598425197, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786349, Length=347, Percent_Identity=23.342939481268, Blast_Score=79, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI71992977, Length=478, Percent_Identity=25.7322175732218, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25144271, Length=434, Percent_Identity=24.6543778801843, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI32564660, Length=448, Percent_Identity=26.5625, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25144274, Length=229, Percent_Identity=30.1310043668122, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17541228, Length=474, Percent_Identity=24.0506329113924, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=455, Percent_Identity=32.0879120879121, Blast_Score=208, Evalue=1e-54,
Organism=Saccharomyces cerevisiae, GI6324432, Length=434, Percent_Identity=26.4976958525346, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI161085790, Length=469, Percent_Identity=26.226012793177, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21357415, Length=455, Percent_Identity=26.1538461538462, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28574759, Length=474, Percent_Identity=25.9493670886076, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21356575, Length=471, Percent_Identity=22.9299363057325, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI281366494, Length=382, Percent_Identity=25.130890052356, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24667139, Length=382, Percent_Identity=25.130890052356, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24667143, Length=382, Percent_Identity=25.130890052356, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 52498; Mature: 52498

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS01159 WW_DOMAIN_1 ; PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDRQTEISTAAAERTRLRELEETYCSHGDTVHYTEEPKIFERCEGSFIYDDEDRAFLDL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCCCEEEECCCCEEEHH
QMWYSAVNFGYANPRLNEAMRRQLDRLPQVASQYLHREKIELAAEIAEGAMARFGHKGRV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
HFNVGGAQAIEDSLKLVRNACGGKSLMFAFEGGYHGRTLGASAITSSYRYRRRFGHFGER
EEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
AHFIPFPYHFRGPRGMTKEEYGHRCVEQFARLFESEYNGVWDPKAGQCEYAAFYVEPIQG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCC
TGGYVIPPANFFPELKEVLDRHGILLVVDEIQMGFYRTGKLWAIEHFGVAPDIIVFGKAL
CCCEEECCHHHHHHHHHHHHHCCEEEEEECHHCCEEECCCEEEEECCCCCCHHHHEHHHH
TNGLNPLSGLWAREALINPQAFPPGSTHSTFNANPLGTAVALEAMRMMREEDFATSVAEK
HCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GARFLDGLKELKAKHAIVGDVDGLGLALRVEICEPHDSYTPSKAIVDRMVDEALKGDLVH
HHHHHHHHHHHHHHHCEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCC
GGERYGLVLDIGGYHKNVITLAPALTISHAEIDLALALMDQLFARVTPR
CCCEEEEEEEECCCCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLDRQTEISTAAAERTRLRELEETYCSHGDTVHYTEEPKIFERCEGSFIYDDEDRAFLDL
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHCCCCEEEECCCCEEEHH
QMWYSAVNFGYANPRLNEAMRRQLDRLPQVASQYLHREKIELAAEIAEGAMARFGHKGRV
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
HFNVGGAQAIEDSLKLVRNACGGKSLMFAFEGGYHGRTLGASAITSSYRYRRRFGHFGER
EEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCC
AHFIPFPYHFRGPRGMTKEEYGHRCVEQFARLFESEYNGVWDPKAGQCEYAAFYVEPIQG
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEEEECCC
TGGYVIPPANFFPELKEVLDRHGILLVVDEIQMGFYRTGKLWAIEHFGVAPDIIVFGKAL
CCCEEECCHHHHHHHHHHHHHCCEEEEEECHHCCEEECCCEEEEECCCCCCHHHHEHHHH
TNGLNPLSGLWAREALINPQAFPPGSTHSTFNANPLGTAVALEAMRMMREEDFATSVAEK
HCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GARFLDGLKELKAKHAIVGDVDGLGLALRVEICEPHDSYTPSKAIVDRMVDEALKGDLVH
HHHHHHHHHHHHHHHCEECCCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCC
GGERYGLVLDIGGYHKNVITLAPALTISHAEIDLALALMDQLFARVTPR
CCCEEEEEEEECCCCCCEEEEECCEEEEHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]