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The map label for this gene is gor [H]

Identifier: 154244746

GI number: 154244746

Start: 887428

End: 888774

Strand: Reverse

Name: gor [H]

Synonym: Xaut_0796

Alternate gene names: 154244746

Gene position: 888774-887428 (Counterclockwise)

Preceding gene: 154244747

Following gene: 154244745

Centisome position: 16.74

GC content: 62.81

Gene sequence:

>1347_bases
GTGGCGAAGAGATATGACCTTGCGATCATCGGCACGGGAACGGCTGCGATCGTAACAGCACACAGGGTTCGTGCGGCTGG
CTGGAGCGTCGCCGTCGCGGACTTCCGGCCCTTCGGGGGCACCTGCGCCTTGCGCGGTTGCGATCCGAAGAAGATGATGG
TCGGCGGCGCCGAGGCGGCTGATCACGCCTGGCGCATGAGCGGACGTGGAATCGAAGGGGACGCGACGCTCGATTGGACG
GGACTGATGGCCTTCAAGCGCAGCTTCACCGATCCGGTACCGCAGAAGCGTGAGAAAGCCTTTGCCGACAAAGGGATTCA
CGCCTTCCACGGTCACGTTCGCTTTATCGGCCCGAATGCGCTCGAGTTCGGAGGAGAGAGGATCGAGGCGGACCGTATCG
TGATCGCCGCCGGCGCCGAGGCCGTGCCGCTCGGCATTCCGGGCGAGCAGCACCTGATCACCAATGAAGGCTTCCTGGAA
CTGGAGAGCCTGCCTGAACGCATCGTCCTTGTCGGCGGCGGTTATATCGCGGCCGAGTTTTCGCACATCGCGGCGCGCGC
CGGAGCACAGGTCACAATTCTTCAGCACGGGAAGCGAATGCTCAAGCAATTCGACCCCGATCTCGTCGGCTGGCTGATGG
ACAAGTTCAGCGAGCGCGGCATCAATGTCCGCACACAGGCAGGGGTGACCGCCATTGAGAAGGTATCAGACGGCTATCGC
GTCCGGGCGGACTGTCCTGACGGCGAACTCGATATGGACGCAGATCTGGTCGTCCATGCCGCGGGTCGGGCGCCGGCGCT
CGCGACGCTCGATCTCGATGCCGGGAGCGTAAAGCACCATAACGGGCGGCTGGCGTTGAACGGATTTTTGCAAAGCGTCT
CCAACCCCGCGGTCTACGCAGCAGGTGATGCCGCCGGCCTAGGACCGCCGCTCACTCCGGTATCAAGCCATGACGCGAAG
GTAGTCTCGGCGAACCTGCTCAACGGCAACACGGTCAGGCCTGAATACACAGGCGTTCCGAGTGTCGCCTTCACCATCCC
GCCGATCGCAGCCGTCGGCATGAGCGAAGCCAAGGCGCGTGAGAAAGGCCTGAACGTTCGCGTAAAGACCGAGCGCGTGG
ACGGCTGGTTCACCGCACGCCAGCAGGCCGAGACGGTGTATGGCTTCAAAACGTTGGTCGACGCGGACACTGACCGCATC
CTCGGCGCCCATCTTGTCGGTCCGCACGCTGACGAAGTGATCAACATCTTTGCACTGGCGATCAGGCAAGGGCTGACGGC
AGAGCAGTTGAAGACCACCATGTTCGCATATCCCAGCGGCGCGTCAGATATCGGCGAGATGCTTTGA

Upstream 100 bases:

>100_bases
CGGCTCTTGCCTTCGACAAGGACGTGGCGAAGCTCTCATGCTGCGCCGGCTGAGCCGTGAAGGCTCGGATGTCGAACGTG
ACAATGTTGGAGGAGATCTA

Downstream 100 bases:

>100_bases
GCGTAAGTGAGGTGGTCGACCGGTACGGCCGCGGAGCAGTCTGCACGAAAGAAATCCCTTCACCAGTCGCATTCGGTTCG
CTGAGCAGTCGTAAAAACCA

Product: pyridine nucleotide-disulfide oxidoreductase dimerisation region

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MAKRYDLAIIGTGTAAIVTAHRVRAAGWSVAVADFRPFGGTCALRGCDPKKMMVGGAEAADHAWRMSGRGIEGDATLDWT
GLMAFKRSFTDPVPQKREKAFADKGIHAFHGHVRFIGPNALEFGGERIEADRIVIAAGAEAVPLGIPGEQHLITNEGFLE
LESLPERIVLVGGGYIAAEFSHIAARAGAQVTILQHGKRMLKQFDPDLVGWLMDKFSERGINVRTQAGVTAIEKVSDGYR
VRADCPDGELDMDADLVVHAAGRAPALATLDLDAGSVKHHNGRLALNGFLQSVSNPAVYAAGDAAGLGPPLTPVSSHDAK
VVSANLLNGNTVRPEYTGVPSVAFTIPPIAAVGMSEAKAREKGLNVRVKTERVDGWFTARQQAETVYGFKTLVDADTDRI
LGAHLVGPHADEVINIFALAIRQGLTAEQLKTTMFAYPSGASDIGEML

Sequences:

>Translated_448_residues
MAKRYDLAIIGTGTAAIVTAHRVRAAGWSVAVADFRPFGGTCALRGCDPKKMMVGGAEAADHAWRMSGRGIEGDATLDWT
GLMAFKRSFTDPVPQKREKAFADKGIHAFHGHVRFIGPNALEFGGERIEADRIVIAAGAEAVPLGIPGEQHLITNEGFLE
LESLPERIVLVGGGYIAAEFSHIAARAGAQVTILQHGKRMLKQFDPDLVGWLMDKFSERGINVRTQAGVTAIEKVSDGYR
VRADCPDGELDMDADLVVHAAGRAPALATLDLDAGSVKHHNGRLALNGFLQSVSNPAVYAAGDAAGLGPPLTPVSSHDAK
VVSANLLNGNTVRPEYTGVPSVAFTIPPIAAVGMSEAKAREKGLNVRVKTERVDGWFTARQQAETVYGFKTLVDADTDRI
LGAHLVGPHADEVINIFALAIRQGLTAEQLKTTMFAYPSGASDIGEML
>Mature_447_residues
AKRYDLAIIGTGTAAIVTAHRVRAAGWSVAVADFRPFGGTCALRGCDPKKMMVGGAEAADHAWRMSGRGIEGDATLDWTG
LMAFKRSFTDPVPQKREKAFADKGIHAFHGHVRFIGPNALEFGGERIEADRIVIAAGAEAVPLGIPGEQHLITNEGFLEL
ESLPERIVLVGGGYIAAEFSHIAARAGAQVTILQHGKRMLKQFDPDLVGWLMDKFSERGINVRTQAGVTAIEKVSDGYRV
RADCPDGELDMDADLVVHAAGRAPALATLDLDAGSVKHHNGRLALNGFLQSVSNPAVYAAGDAAGLGPPLTPVSSHDAKV
VSANLLNGNTVRPEYTGVPSVAFTIPPIAAVGMSEAKAREKGLNVRVKTERVDGWFTARQQAETVYGFKTLVDADTDRIL
GAHLVGPHADEVINIFALAIRQGLTAEQLKTTMFAYPSGASDIGEML

Specific function: Maintains high levels of reduced glutathione in the cytosol [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=456, Percent_Identity=26.0964912280702, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI91199540, Length=452, Percent_Identity=26.9911504424779, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI33519430, Length=430, Percent_Identity=27.6744186046512, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI33519428, Length=430, Percent_Identity=27.6744186046512, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI33519426, Length=430, Percent_Identity=27.6744186046512, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI148277065, Length=430, Percent_Identity=27.6744186046512, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI148277071, Length=429, Percent_Identity=27.7389277389277, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI291045266, Length=486, Percent_Identity=26.9547325102881, Blast_Score=128, Evalue=9e-30,
Organism=Homo sapiens, GI22035672, Length=473, Percent_Identity=25.369978858351, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI291045268, Length=482, Percent_Identity=25.3112033195021, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1789915, Length=459, Percent_Identity=30.718954248366, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87081717, Length=458, Percent_Identity=29.2576419213974, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1786307, Length=456, Percent_Identity=27.6315789473684, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI87082354, Length=455, Percent_Identity=23.956043956044, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1789065, Length=214, Percent_Identity=28.0373831775701, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17557007, Length=476, Percent_Identity=26.4705882352941, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI32565766, Length=462, Percent_Identity=26.8398268398268, Blast_Score=140, Evalue=9e-34,
Organism=Caenorhabditis elegans, GI71983429, Length=454, Percent_Identity=27.7533039647577, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71983419, Length=455, Percent_Identity=27.6923076923077, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71982272, Length=459, Percent_Identity=24.400871459695, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=24.3534482758621, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6321091, Length=466, Percent_Identity=25.5364806866953, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6325240, Length=486, Percent_Identity=24.2798353909465, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI21358499, Length=460, Percent_Identity=28.4782608695652, Blast_Score=162, Evalue=5e-40,
Organism=Drosophila melanogaster, GI17737741, Length=475, Percent_Identity=27.7894736842105, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24640553, Length=474, Percent_Identity=28.0590717299578, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24640549, Length=474, Percent_Identity=28.0590717299578, Blast_Score=133, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24640551, Length=474, Percent_Identity=28.0590717299578, Blast_Score=132, Evalue=5e-31,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 47616; Mature: 47485

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRYDLAIIGTGTAAIVTAHRVRAAGWSVAVADFRPFGGTCALRGCDPKKMMVGGAEAA
CCCEEEEEEEECCCEEEEEHHHHHHCCCEEEEECCCCCCCEEEECCCCCHHEEECCCCHH
DHAWRMSGRGIEGDATLDWTGLMAFKRSFTDPVPQKREKAFADKGIHAFHGHVRFIGPNA
HHHHCCCCCCCCCCCEECHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECEEEEECCCH
LEFGGERIEADRIVIAAGAEAVPLGIPGEQHLITNEGFLELESLPERIVLVGGGYIAAEF
HHCCCCEEECCEEEEEECCCEEEECCCCCCEEECCCCCEECCCCCCEEEEEECCEEEHHH
SHIAARAGAQVTILQHGKRMLKQFDPDLVGWLMDKFSERGINVRTQAGVTAIEKVSDGYR
HHHHHHCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCCCE
VRADCPDGELDMDADLVVHAAGRAPALATLDLDAGSVKHHNGRLALNGFLQSVSNPAVYA
EEECCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCEECCCEEEEHHHHHHCCCCEEEE
AGDAAGLGPPLTPVSSHDAKVVSANLLNGNTVRPEYTGVPSVAFTIPPIAAVGMSEAKAR
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHCCCHHHHHH
EKGLNVRVKTERVDGWFTARQQAETVYGFKTLVDADTDRILGAHLVGPHADEVINIFALA
HCCCCEEEEEEECCCCHHHHHHHHHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHH
IRQGLTAEQLKTTMFAYPSGASDIGEML
HHCCCCHHHHHHEEEECCCCCHHHHHCC
>Mature Secondary Structure 
AKRYDLAIIGTGTAAIVTAHRVRAAGWSVAVADFRPFGGTCALRGCDPKKMMVGGAEAA
CCEEEEEEEECCCEEEEEHHHHHHCCCEEEEECCCCCCCEEEECCCCCHHEEECCCCHH
DHAWRMSGRGIEGDATLDWTGLMAFKRSFTDPVPQKREKAFADKGIHAFHGHVRFIGPNA
HHHHCCCCCCCCCCCEECHHHHHHHHHHCCCCCCHHHHHHHHHCCCEEEECEEEEECCCH
LEFGGERIEADRIVIAAGAEAVPLGIPGEQHLITNEGFLELESLPERIVLVGGGYIAAEF
HHCCCCEEECCEEEEEECCCEEEECCCCCCEEECCCCCEECCCCCCEEEEEECCEEEHHH
SHIAARAGAQVTILQHGKRMLKQFDPDLVGWLMDKFSERGINVRTQAGVTAIEKVSDGYR
HHHHHHCCCEEEHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEECCCCHHHHHCCCCCE
VRADCPDGELDMDADLVVHAAGRAPALATLDLDAGSVKHHNGRLALNGFLQSVSNPAVYA
EEECCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCEECCCEEEEHHHHHHCCCCEEEE
AGDAAGLGPPLTPVSSHDAKVVSANLLNGNTVRPEYTGVPSVAFTIPPIAAVGMSEAKAR
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEECCCHHHCCCHHHHHH
EKGLNVRVKTERVDGWFTARQQAETVYGFKTLVDADTDRILGAHLVGPHADEVINIFALA
HCCCCEEEEEEECCCCHHHHHHHHHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHH
IRQGLTAEQLKTTMFAYPSGASDIGEML
HHCCCCHHHHHHEEEECCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1849605; 10984043 [H]