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The map label for this gene is xapR [H]

Identifier: 154244638

GI number: 154244638

Start: 777841

End: 778827

Strand: Reverse

Name: xapR [H]

Synonym: Xaut_0687

Alternate gene names: 154244638

Gene position: 778827-777841 (Counterclockwise)

Preceding gene: 154244640

Following gene: 154244635

Centisome position: 14.67

GC content: 62.41

Gene sequence:

>987_bases
GTGGATGGGCCGGATGACATTGATCCGCGCCGGAGCAACAAGGCTCCAGATGAAATCCTGATACCTGAGCTGCCGCGCAG
TCGTATCAAGCTCCACCACCTCCGGTATTTCGTGGCGGCCGTGGAGCACGGCAGCTTTCGCAAGGCAGGCCGAGCACTCG
ATATCGAAGAATCGGCGATCAGCCGCCGCATTCGGGACATGGAAGACGAACTCGGCGCGTCGCTGTTCCAGCGACACGCG
GGAGGTGTCCGCTTGACGATCGCCGGCGAGAGATTTCTTGGGCCGGCGCGCAAGGCGCTCCGGCATATCGACACGGGCGC
CAGTGACGTCGCTGCGGTCGGTCGATCGGAAGAGGGACACGTCAGGGTAGGCGTCTTCTCGTCACTCGCATCTGGGTTCC
TGTTCGATCTGCTGCGGCAGTTCGGCAGGCTCCATCCAAATGTTCGAGTGGATCCCGTCGAAGGCAATCCGGCGGAGCAT
GTCGCTGCTGTCCGGACGCTGACTCTCGACGTCGCCTTCATTACCGGCACGAAGACCTGGGACGGCTGTGAGACCGAGCA
TCTGTGGTGCGAGAGGGTCTTCGTTGTACTGCCTGACGATCATCCGTTGGCTGACAAGGCCGAAATCGGTTGGCCCGACC
TGGCGGCGGAACGGTTCATCGTAAGCGATGTGGCGCCGGGCCAAGAGGTCCACAACTTCCTGGTCGCGCACCTGTCCGAT
CTCGGCTCTCACCCTGACATTCAGTCCCAACACGTCGGGCGCGATAACATGCTGTCGCTCGTCGCTGTCGGCCGCGGCAT
CACGCTAACGAGCGAAGCCACGATCGTCGCGAAATTTCCCGGGATCATCTATCGGGAGCTCACGGGTGAGGTCTTGCCGT
TCAGCATGGTATGGTCCACCCGGAACGATAATCCGGCATGCCGACGGTTGCTGAGTCTGGCGCGCACCCTGGGCCACACG
CCAAGGGCATCTCACCAGCCGGCCTGA

Upstream 100 bases:

>100_bases
GGGATAACGACGCGGCTGGAGCCTCGATCTGCATCAAAGGCGGCGCTCGGCGTCCTCAGGCGTCGGGTGGGGCGCGACGG
GCAGACGGGAACAGTTGATC

Downstream 100 bases:

>100_bases
CATCAGTGATGGACCGCCCAAGCCGCGGTCCACCTTGCTATTCGACCGACTTCTCGACAAACCCAAGCGTGTTGGCGTTT
TCGACCAGCGTTCGCACCTT

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Xanthosine operon regulatory protein [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MDGPDDIDPRRSNKAPDEILIPELPRSRIKLHHLRYFVAAVEHGSFRKAGRALDIEESAISRRIRDMEDELGASLFQRHA
GGVRLTIAGERFLGPARKALRHIDTGASDVAAVGRSEEGHVRVGVFSSLASGFLFDLLRQFGRLHPNVRVDPVEGNPAEH
VAAVRTLTLDVAFITGTKTWDGCETEHLWCERVFVVLPDDHPLADKAEIGWPDLAAERFIVSDVAPGQEVHNFLVAHLSD
LGSHPDIQSQHVGRDNMLSLVAVGRGITLTSEATIVAKFPGIIYRELTGEVLPFSMVWSTRNDNPACRRLLSLARTLGHT
PRASHQPA

Sequences:

>Translated_328_residues
MDGPDDIDPRRSNKAPDEILIPELPRSRIKLHHLRYFVAAVEHGSFRKAGRALDIEESAISRRIRDMEDELGASLFQRHA
GGVRLTIAGERFLGPARKALRHIDTGASDVAAVGRSEEGHVRVGVFSSLASGFLFDLLRQFGRLHPNVRVDPVEGNPAEH
VAAVRTLTLDVAFITGTKTWDGCETEHLWCERVFVVLPDDHPLADKAEIGWPDLAAERFIVSDVAPGQEVHNFLVAHLSD
LGSHPDIQSQHVGRDNMLSLVAVGRGITLTSEATIVAKFPGIIYRELTGEVLPFSMVWSTRNDNPACRRLLSLARTLGHT
PRASHQPA
>Mature_328_residues
MDGPDDIDPRRSNKAPDEILIPELPRSRIKLHHLRYFVAAVEHGSFRKAGRALDIEESAISRRIRDMEDELGASLFQRHA
GGVRLTIAGERFLGPARKALRHIDTGASDVAAVGRSEEGHVRVGVFSSLASGFLFDLLRQFGRLHPNVRVDPVEGNPAEH
VAAVRTLTLDVAFITGTKTWDGCETEHLWCERVFVVLPDDHPLADKAEIGWPDLAAERFIVSDVAPGQEVHNFLVAHLSD
LGSHPDIQSQHVGRDNMLSLVAVGRGITLTSEATIVAKFPGIIYRELTGEVLPFSMVWSTRNDNPACRRLLSLARTLGHT
PRASHQPA

Specific function: Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI2367136, Length=287, Percent_Identity=27.8745644599303, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1787879, Length=245, Percent_Identity=31.0204081632653, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1788887, Length=289, Percent_Identity=25.9515570934256, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI145693105, Length=239, Percent_Identity=26.3598326359833, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI157672245, Length=217, Percent_Identity=27.1889400921659, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1790399, Length=258, Percent_Identity=23.2558139534884, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1787601, Length=148, Percent_Identity=30.4054054054054, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI87081904, Length=178, Percent_Identity=28.0898876404494, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1790262, Length=196, Percent_Identity=27.5510204081633, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790208, Length=251, Percent_Identity=26.2948207171315, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789639, Length=134, Percent_Identity=29.8507462686567, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1787806, Length=254, Percent_Identity=25.1968503937008, Blast_Score=68, Evalue=8e-13,
Organism=Escherichia coli, GI1788748, Length=241, Percent_Identity=22.8215767634855, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1789173, Length=175, Percent_Identity=29.7142857142857, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1786401, Length=169, Percent_Identity=27.810650887574, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1787530, Length=199, Percent_Identity=28.643216080402, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789506, Length=143, Percent_Identity=26.5734265734266, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36126; Mature: 36126

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGPDDIDPRRSNKAPDEILIPELPRSRIKLHHLRYFVAAVEHGSFRKAGRALDIEESAI
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHH
SRRIRDMEDELGASLFQRHAGGVRLTIAGERFLGPARKALRHIDTGASDVAAVGRSEEGH
HHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHCCHHHHHHHHHCCCHHHHHHHCCCCCCC
VRVGVFSSLASGFLFDLLRQFGRLHPNVRVDPVEGNPAEHVAAVRTLTLDVAFITGTKTW
EEEHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHEEEEEEEEECCCCC
DGCETEHLWCERVFVVLPDDHPLADKAEIGWPDLAAERFIVSDVAPGQEVHNFLVAHLSD
CCCCCHHEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LGSHPDIQSQHVGRDNMLSLVAVGRGITLTSEATIVAKFPGIIYRELTGEVLPFSMVWST
CCCCCCCCHHHCCCHHHHHHHHHCCCEEEECCCEEEECCCCHHHHHHCCCCCCEEEEEEC
RNDNPACRRLLSLARTLGHTPRASHQPA
CCCCHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MDGPDDIDPRRSNKAPDEILIPELPRSRIKLHHLRYFVAAVEHGSFRKAGRALDIEESAI
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHH
SRRIRDMEDELGASLFQRHAGGVRLTIAGERFLGPARKALRHIDTGASDVAAVGRSEEGH
HHHHHHHHHHHHHHHHHHCCCCEEEEEECHHHCCHHHHHHHHHCCCHHHHHHHCCCCCCC
VRVGVFSSLASGFLFDLLRQFGRLHPNVRVDPVEGNPAEHVAAVRTLTLDVAFITGTKTW
EEEHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHEEEEEEEEECCCCC
DGCETEHLWCERVFVVLPDDHPLADKAEIGWPDLAAERFIVSDVAPGQEVHNFLVAHLSD
CCCCCHHEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
LGSHPDIQSQHVGRDNMLSLVAVGRGITLTSEATIVAKFPGIIYRELTGEVLPFSMVWST
CCCCCCCCHHHCCCHHHHHHHHHCCCEEEECCCEEEECCCCHHHHHHCCCCCCEEEEEEC
RNDNPACRRLLSLARTLGHTPRASHQPA
CCCCHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2201776; 9205837; 9278503; 7559336 [H]