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The map label for this gene is hbd [H]

Identifier: 154244384

GI number: 154244384

Start: 462874

End: 463821

Strand: Reverse

Name: hbd [H]

Synonym: Xaut_0427

Alternate gene names: 154244384

Gene position: 463821-462874 (Counterclockwise)

Preceding gene: 154244385

Following gene: 154244383

Centisome position: 8.74

GC content: 69.41

Gene sequence:

>948_bases
ATGACCAAGATCGCCATCATCGGCTCCGGCTTCATCGGCCGTGCCTGGGCCATCACCTTTGCCCGCGCCGGCTTCGACGT
GGCACTAGCCGACCACGCGCAGGGCGCCCCCGAGGCGGCGCTGGCCTATATCGAGGGCGTGCTGCCGGACCTCGCCGACA
ACGATCTGCTGAACGGCGCCTCCCCTGACGCGGTGCGCGCGCGGCTGTCGGCCACCACCTCCTATGCGCAGGCGCTCGAC
GGGGCCGTCCATGCGCAGGAGAACGCGCCGGAAGACCTCGCCATCAAGAAATACCTCTATGAGGAACTCGACTCCCTCGC
CGGCCCCGACACGGTGCTTGCCTCCTCAACCTCGGCGCTCCTGCCGTCCCTGTTCTCCAAGCACCTGAAGGGGCGGGAGC
GGGTGTGCGTGTGCCATCCCATCAACCCGCCCTATCTGATCCCCGCGGTGGAGGTGGTGCCCGCCCCCTGGACCAGCGCC
GATACCATGACCCGCGCCGCGGACCTCATGCGTGCCGCCGGCCAATCCCCCATCGTGATGAAGAAGGAGCTGGACGGCTT
CGTCATGAACCGCATGCAGGGCGCGCTGCTGGAGGAGGCCTTCCGCCTGGTCGCCGACGGCTATGCGAGCGTGGAGGACG
TGGACATCGGCATCCGCGAGGGCCTCGCGCTGCGCTGGTCGTTCATGGGGCCGTTCGAGACCATCGACCTCAATGCGCCC
GGCGGCGTCGCCGACTATGTGGCGCGCTACCAGCAGATCTACGAGCGCATCTCGCCCGACCAATGGCGCCGCGTGGACTG
GGCCGGGCCGGTGCTCGAAACCGTGCTTGCCGAGCGCCGCGCCCGCCTGCCTGAAGACGGGCTGGCCGAGCGTCAGGTAT
GGCGCGACCGGCGCCTGATGGCGCTTGCCGCCCACAAGCGCAAGGCCGCCAAGGACATCGGCGCCTGA

Upstream 100 bases:

>100_bases
CGGGCATGACGCGAGTGATCGCGGGTACGCCCTTCGGCGTTTCCAAAGCGGCTGCAGAGGTCGCCCTCCTCTCGCAAAGG
TTCATTCTGAAGAGGCTTCC

Downstream 100 bases:

>100_bases
CGATGCCAAGCCCGCGCGGCGCTTGAGCGAAGTCCCTCGGCACCGGTCAAGGACCGGAGCCGCTGGCAGGATACATTCAT
TTCACTATTTCCACAGAGGC

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MTKIAIIGSGFIGRAWAITFARAGFDVALADHAQGAPEAALAYIEGVLPDLADNDLLNGASPDAVRARLSATTSYAQALD
GAVHAQENAPEDLAIKKYLYEELDSLAGPDTVLASSTSALLPSLFSKHLKGRERVCVCHPINPPYLIPAVEVVPAPWTSA
DTMTRAADLMRAAGQSPIVMKKELDGFVMNRMQGALLEEAFRLVADGYASVEDVDIGIREGLALRWSFMGPFETIDLNAP
GGVADYVARYQQIYERISPDQWRRVDWAGPVLETVLAERRARLPEDGLAERQVWRDRRLMALAAHKRKAAKDIGA

Sequences:

>Translated_315_residues
MTKIAIIGSGFIGRAWAITFARAGFDVALADHAQGAPEAALAYIEGVLPDLADNDLLNGASPDAVRARLSATTSYAQALD
GAVHAQENAPEDLAIKKYLYEELDSLAGPDTVLASSTSALLPSLFSKHLKGRERVCVCHPINPPYLIPAVEVVPAPWTSA
DTMTRAADLMRAAGQSPIVMKKELDGFVMNRMQGALLEEAFRLVADGYASVEDVDIGIREGLALRWSFMGPFETIDLNAP
GGVADYVARYQQIYERISPDQWRRVDWAGPVLETVLAERRARLPEDGLAERQVWRDRRLMALAAHKRKAAKDIGA
>Mature_314_residues
TKIAIIGSGFIGRAWAITFARAGFDVALADHAQGAPEAALAYIEGVLPDLADNDLLNGASPDAVRARLSATTSYAQALDG
AVHAQENAPEDLAIKKYLYEELDSLAGPDTVLASSTSALLPSLFSKHLKGRERVCVCHPINPPYLIPAVEVVPAPWTSAD
TMTRAADLMRAAGQSPIVMKKELDGFVMNRMQGALLEEAFRLVADGYASVEDVDIGIREGLALRWSFMGPFETIDLNAPG
GVADYVARYQQIYERISPDQWRRVDWAGPVLETVLAERRARLPEDGLAERQVWRDRRLMALAAHKRKAAKDIGA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI115430219, Length=309, Percent_Identity=38.8349514563107, Blast_Score=213, Evalue=1e-55,
Organism=Homo sapiens, GI296179429, Length=238, Percent_Identity=29.8319327731092, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI296179427, Length=255, Percent_Identity=27.843137254902, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI68989263, Length=238, Percent_Identity=27.3109243697479, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI261878539, Length=238, Percent_Identity=27.3109243697479, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1787661, Length=234, Percent_Identity=30.3418803418803, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1788682, Length=223, Percent_Identity=27.8026905829596, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI115533614, Length=281, Percent_Identity=38.7900355871886, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI193203623, Length=281, Percent_Identity=39.1459074733096, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17549919, Length=241, Percent_Identity=29.4605809128631, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71985923, Length=240, Percent_Identity=27.9166666666667, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17553560, Length=296, Percent_Identity=26.6891891891892, Blast_Score=81, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17558304, Length=250, Percent_Identity=25.6, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17508953, Length=250, Percent_Identity=25.2, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25144276, Length=250, Percent_Identity=25.2, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508951, Length=250, Percent_Identity=25.2, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI45549573, Length=307, Percent_Identity=41.042345276873, Blast_Score=238, Evalue=5e-63,
Organism=Drosophila melanogaster, GI20129993, Length=249, Percent_Identity=47.3895582329317, Blast_Score=230, Evalue=9e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 34251; Mature: 34120

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00067 3HCDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKIAIIGSGFIGRAWAITFARAGFDVALADHAQGAPEAALAYIEGVLPDLADNDLLNGA
CCEEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
SPDAVRARLSATTSYAQALDGAVHAQENAPEDLAIKKYLYEELDSLAGPDTVLASSTSAL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHH
LPSLFSKHLKGRERVCVCHPINPPYLIPAVEVVPAPWTSADTMTRAADLMRAAGQSPIVM
HHHHHHHHHCCCCCEEEECCCCCCEECCHHHEECCCCCCHHHHHHHHHHHHHCCCCCEEE
KKELDGFVMNRMQGALLEEAFRLVADGYASVEDVDIGIREGLALRWSFMGPFETIDLNAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHCCCEEEEEECCCCEEEECCCC
GGVADYVARYQQIYERISPDQWRRVDWAGPVLETVLAERRARLPEDGLAERQVWRDRRLM
CCHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ALAAHKRKAAKDIGA
HHHHHHHHHHHHCCC
>Mature Secondary Structure 
TKIAIIGSGFIGRAWAITFARAGFDVALADHAQGAPEAALAYIEGVLPDLADNDLLNGA
CEEEEEECCCCHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCC
SPDAVRARLSATTSYAQALDGAVHAQENAPEDLAIKKYLYEELDSLAGPDTVLASSTSAL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCCHHHH
LPSLFSKHLKGRERVCVCHPINPPYLIPAVEVVPAPWTSADTMTRAADLMRAAGQSPIVM
HHHHHHHHHCCCCCEEEECCCCCCEECCHHHEECCCCCCHHHHHHHHHHHHHCCCCCEEE
KKELDGFVMNRMQGALLEEAFRLVADGYASVEDVDIGIREGLALRWSFMGPFETIDLNAP
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHCCCEEEEEECCCCEEEECCCC
GGVADYVARYQQIYERISPDQWRRVDWAGPVLETVLAERRARLPEDGLAERQVWRDRRLM
CCHHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ALAAHKRKAAKDIGA
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA