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The map label for this gene is hisC

Identifier: 154244351

GI number: 154244351

Start: 422723

End: 423901

Strand: Reverse

Name: hisC

Synonym: Xaut_0394

Alternate gene names: 154244351

Gene position: 423901-422723 (Counterclockwise)

Preceding gene: 154244352

Following gene: 154244350

Centisome position: 7.98

GC content: 69.38

Gene sequence:

>1179_bases
ATGTCCGCCGTGCTGAAAGACCCGATCCCCGCTCCCGGCCGCCCCGAGTCCACGCGACCCGAGCCGCGGCCCGGTGTGCT
CGCCATCGAGGCCTATGTGCCCGGCAAGAGCCACGCCCCCGGGGTGGAGAAGGTCTTCAAGCTCTCCTCCAACGAGACCC
CGCTCGGCCCGAGCGAGAAGGCGGTGGCTGCCTTCGCCGAGGCCGGCCGCAAGCTGGAGGACTATCCCGACGGCTCCGCC
ACCGTGCTGCGGCAAGCCATCGCCACGGCCTATGGTCTCGATCCCGCGCGCATCATCTGCGGCGCCGGCTCGGACGAGAT
CCTGAACCTCGTGGCCCACACCTATGTGGGACCGGGCGACGAGGTGATCTTCAGCGAGCACGGCTTCCTCGTCTACAAGA
TCGCGACGCTGGCCTCCGGCGGCACCCCGGTGGTGGCCAGGGAACGGGACCTGACCGCCGACGTGGACGCCATCCTCGCG
CTGGTGACGCCGCGGACACGGCTCGTCTTCCTTGCGAATCCGAACAATCCCACCGGCACCTACCTTCCGTTCGACGAGGT
GCGCCGCCTGCATGCCGGCCTGCCCGCCAATGTGCTGCTGGTGCTGGACGCGGCCTATGCGGAATATGTCCGCCGCAACG
ATTACGAGACCGGGCTGGAACTGGCGCTCACCGCCGACAACGTGCTGATGAGCCGGACCTTCTCCAAGATCCATGGCCTT
GCCGCCCTGCGTATCGGCTGGGCGGTGGGCCCGGCCCATGTGATCGACGCCATGAACCGGGTGCGCGGCCCGTTCAACAT
GAACACCCCGGCCCTGCTCGCCGGCGCCGCCGCCATCGCGGATGCCGCCCATGTGGAAAAGGCGGTGGCGCACAACGCGC
GCTGGCTGCCGTGGCTGACGGAGCAGATCGAGGGGCTCGGCCTCAAGGTCACGCCCTCGGTCGCCAACTTCCTGCTCATC
CACTTCCCCGACACCCCCGGCCGCACGGCGAAGGAGGCGGATGCCTTCCTGATGAAGCGGGGCCTGGTGCTGCGGCAGGT
GGCATCCTACGGCCTGCCGCACGCCCTGCGCATGACGGTGGGCACGGAGGAGGCCAACCACCTGGTGGTGGCCGCCCTCG
CGGACTTCATGTCGGGCAACAGCTCGGCGGGGCAGGAAGCCGGGGGCAAGGACAAGTGA

Upstream 100 bases:

>100_bases
TTAGTGGGCTCGCTCAGGTGCCGCGCGGGCTTAAGACCTAAGGGCTGAATGCCAAGGGCCGCCGGGCGGCCCGATCCGTC
AGGTTCTGGAGTATGTTGAG

Downstream 100 bases:

>100_bases
TCCGCCCGCTCGTTCCACGCCTCGCCATCATCGGGGCGGGGCTCATCGGCTCGTCGCTGGCCCGCGCGGCACGGGAGAAG
CATCTCGCCGGCACCATCGT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSAVLKDPIPAPGRPESTRPEPRPGVLAIEAYVPGKSHAPGVEKVFKLSSNETPLGPSEKAVAAFAEAGRKLEDYPDGSA
TVLRQAIATAYGLDPARIICGAGSDEILNLVAHTYVGPGDEVIFSEHGFLVYKIATLASGGTPVVARERDLTADVDAILA
LVTPRTRLVFLANPNNPTGTYLPFDEVRRLHAGLPANVLLVLDAAYAEYVRRNDYETGLELALTADNVLMSRTFSKIHGL
AALRIGWAVGPAHVIDAMNRVRGPFNMNTPALLAGAAAIADAAHVEKAVAHNARWLPWLTEQIEGLGLKVTPSVANFLLI
HFPDTPGRTAKEADAFLMKRGLVLRQVASYGLPHALRMTVGTEEANHLVVAALADFMSGNSSAGQEAGGKDK

Sequences:

>Translated_392_residues
MSAVLKDPIPAPGRPESTRPEPRPGVLAIEAYVPGKSHAPGVEKVFKLSSNETPLGPSEKAVAAFAEAGRKLEDYPDGSA
TVLRQAIATAYGLDPARIICGAGSDEILNLVAHTYVGPGDEVIFSEHGFLVYKIATLASGGTPVVARERDLTADVDAILA
LVTPRTRLVFLANPNNPTGTYLPFDEVRRLHAGLPANVLLVLDAAYAEYVRRNDYETGLELALTADNVLMSRTFSKIHGL
AALRIGWAVGPAHVIDAMNRVRGPFNMNTPALLAGAAAIADAAHVEKAVAHNARWLPWLTEQIEGLGLKVTPSVANFLLI
HFPDTPGRTAKEADAFLMKRGLVLRQVASYGLPHALRMTVGTEEANHLVVAALADFMSGNSSAGQEAGGKDK
>Mature_391_residues
SAVLKDPIPAPGRPESTRPEPRPGVLAIEAYVPGKSHAPGVEKVFKLSSNETPLGPSEKAVAAFAEAGRKLEDYPDGSAT
VLRQAIATAYGLDPARIICGAGSDEILNLVAHTYVGPGDEVIFSEHGFLVYKIATLASGGTPVVARERDLTADVDAILAL
VTPRTRLVFLANPNNPTGTYLPFDEVRRLHAGLPANVLLVLDAAYAEYVRRNDYETGLELALTADNVLMSRTFSKIHGLA
ALRIGWAVGPAHVIDAMNRVRGPFNMNTPALLAGAAAIADAAHVEKAVAHNARWLPWLTEQIEGLGLKVTPSVANFLLIH
FPDTPGRTAKEADAFLMKRGLVLRQVASYGLPHALRMTVGTEEANHLVVAALADFMSGNSSAGQEAGGKDK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=341, Percent_Identity=24.3401759530792, Blast_Score=79, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6322075, Length=384, Percent_Identity=25.5208333333333, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_XANP2 (A7ICA9)

Other databases:

- EMBL:   CP000781
- RefSeq:   YP_001415309.1
- ProteinModelPortal:   A7ICA9
- SMR:   A7ICA9
- STRING:   A7ICA9
- GeneID:   5423457
- GenomeReviews:   CP000781_GR
- KEGG:   xau:Xaut_0394
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   NPANILC
- ProtClustDB:   PRK02731
- BioCyc:   XAUT78245:XAUT_0394-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 41607; Mature: 41476

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVLKDPIPAPGRPESTRPEPRPGVLAIEAYVPGKSHAPGVEKVFKLSSNETPLGPSEK
CCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCHH
AVAAFAEAGRKLEDYPDGSATVLRQAIATAYGLDPARIICGAGSDEILNLVAHTYVGPGD
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEECCCHHHHHHHHHHHCCCCCC
EVIFSEHGFLVYKIATLASGGTPVVARERDLTADVDAILALVTPRTRLVFLANPNNPTGT
CEEEECCCEEEEEEEHHCCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCC
YLPFDEVRRLHAGLPANVLLVLDAAYAEYVRRNDYETGLELALTADNVLMSRTFSKIHGL
CCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHH
AALRIGWAVGPAHVIDAMNRVRGPFNMNTPALLAGAAAIADAAHVEKAVAHNARWLPWLT
HHEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
EQIEGLGLKVTPSVANFLLIHFPDTPGRTAKEADAFLMKRGLVLRQVASYGLPHALRMTV
HHHCCCCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
GTEEANHLVVAALADFMSGNSSAGQEAGGKDK
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SAVLKDPIPAPGRPESTRPEPRPGVLAIEAYVPGKSHAPGVEKVFKLSSNETPLGPSEK
CCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHCCCCCCCCCCCHH
AVAAFAEAGRKLEDYPDGSATVLRQAIATAYGLDPARIICGAGSDEILNLVAHTYVGPGD
HHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEECCCHHHHHHHHHHHCCCCCC
EVIFSEHGFLVYKIATLASGGTPVVARERDLTADVDAILALVTPRTRLVFLANPNNPTGT
CEEEECCCEEEEEEEHHCCCCCCEEEECCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCC
YLPFDEVRRLHAGLPANVLLVLDAAYAEYVRRNDYETGLELALTADNVLMSRTFSKIHGL
CCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHH
AALRIGWAVGPAHVIDAMNRVRGPFNMNTPALLAGAAAIADAAHVEKAVAHNARWLPWLT
HHEEECCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
EQIEGLGLKVTPSVANFLLIHFPDTPGRTAKEADAFLMKRGLVLRQVASYGLPHALRMTV
HHHCCCCEEECCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEE
GTEEANHLVVAALADFMSGNSSAGQEAGGKDK
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA