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The map label for this gene is uvrB [H]

Identifier: 153952519

GI number: 153952519

Start: 1173322

End: 1175295

Strand: Direct

Name: uvrB [H]

Synonym: JJD26997_1327

Alternate gene names: 153952519

Gene position: 1173322-1175295 (Clockwise)

Preceding gene: 153951340

Following gene: 153951560

Centisome position: 63.59

GC content: 33.38

Gene sequence:

>1974_bases
ATGTTAGAACTTACAAGTGAATTTAAACCCAGTCCTGATCAACAAGAAGCCATAAAAGGCATAGTAAAAAGCATAAAAAA
AGGCAACAAATATCAAACCTTACTAGGCGTTACAGGAAGTGGAAAAACCTTTACCATGGCAAATGTCATTAAAGAACTTA
ATATACCCACTCTTATCATGAGTCACAACAAAAGCCTTTGTGCACAACTTTATAGCGAATTTAAAGGCTTTTTTTCTAAA
AATCATGTGGAATATTTTATATCTTATTATGATTATTATCAACCTGAAGCCTATATCCCACGCACTGATGTTTTCATAGA
AAAAGATAGCTCTACTAATGAAGACTTAGAGCGTTTAAGACTGAGTGCTACTGCTTCACTTTTAAGTTATGAAGATGTAG
TTTGTATAGCTAGTGTTTCAGCAAATTATGGACTTGGTAATCCAAATGAATACATAGGCATGGTTTTAATCTTTGAACTA
GGTATGCAAATTTCACAAAAAGAACTTCTAAAAAAACTTGTAGATATGGGTTATAAAAGAAATGATAATTTTTTTGATCG
TGCAGATTTTAGAGTTCAAGGAGATATTATAGACATTTATCCAGCTTATTATGAAGATGAAGTAGTAAGGCTTGAATTTT
TTGGCGATGAGCTTGATGCTATGTATCATTACAATGTTTTAGAAAATAAAAAAGGTAAAGATTTAAAACGCTTCATACTC
TATCCTACAAGCCAGTTTAGCGTGGGCGAAGCAAGGCTAAAACAAGCAATAAGAGATATAAAAATAGAACTTAACGAACG
CCTTGCTTATTTTGAGCATGAAAATAAACTCGTAGAATATCAACGCCTTAAACAAAGGGTTGAATTTGATCTTGAGATGC
TTACAAGCACAGGAATGTGTAAAGGCGTTGAAAATTATGCAAGACATCTAACAGGACTTAAAGAAGGCGATACTCCTTAT
ACGCTTTTTGATTATTTTGCGATTAAAAATAGAAAATTTCTTGTCATAGTCGATGAAAGCCATGTATCTTTACCGCAATT
TAGAGGTATGTTTGCAGGAGATAGAAGTAGAAAACAAACCTTGGTGGATTATGGTTTTCGTTTACCTTCAGCCTTGGATA
ATCGTCCTTTAATGTTTGATGAATTTATCCATAAAAATTGTCAATTTCTTTTTGTTTCAGCTACACCTGCACCTTTAGAA
CTTGAACTTAGCAAAGAAAATATCTTTCATCAAATCATGCGTCCTACAGGACTGCTTGATCCTTTGATAGAATTAAAAGA
TAGCGATAATCAGGTTGAAATTTTATTTGATGAGGCTAAAAAAGTCATACAAAGAAACGAACGGGTTTTAGTAACTGTAC
TGACTAAAAAACTCGCTGAAGAACTTACAAGGTATTATTTAGAACTTGGTATAAAAGTCAAATACATGCACTCAGACATC
GATGCTATAGAACGCAATGAAATCATAAGAGGTTTAAGAAGCGGTGCTTTTGATATGCTAATTGGCATTAACTTACTTAG
AGAAGGACTTGACTTGCCTGAAGTTTCACTCATTGCCATTATGGATGCAGATAAGGAAGGCTTTTTAAGAAGTACTACAA
GTTTAATCCAAACCATGGGAAGAGCAGCTAGAAATGTCAATGGTAAGGTTTTGCTTTTTTGCAAAAAGATTACAAAATCC
ATGCAAGAAGCTATGGATACTACCAATGAACGTCGCAAACTTCAAATGGCTTATAATAAAAAATACAATATCACACCAAC
TTCAGTTAAACGCCACATCGAAGAGAGCTTAAAAAATGAAGAGGATTTAGGCGAAATTTATCGCAAAGGTAAAAAACTAG
AAAAAATGCCTGCTAGCGAAAGAGCAAAACTTGTCAAAGAGTTAAGAAAACAAATGCTTGAAGCAGCTAAAGCGCTTGAG
TTTGAAAAAGCTGCTGCAATTAGAGATGAGATTAATAAATTAAGGGATTTATAA

Upstream 100 bases:

>100_bases
AGCAGAAAAAAATTTAAATTTAGGTTTTTATTGTCAATTAATTTTTAATTAAAGCATTTTCTTTTAAAATTTTTTCAAAA
ATAAAAATCAAAGTAGAAAA

Downstream 100 bases:

>100_bases
TAAAAATATATCCCTTGTTCTAACTCCTGCCTCATTAAGCAAAGCACTTAAAATTTCATACGAAAGTCTTGCAAGGGACG
TTTTTATTTTAAAAACAGGA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 657; Mature: 657

Protein sequence:

>657_residues
MLELTSEFKPSPDQQEAIKGIVKSIKKGNKYQTLLGVTGSGKTFTMANVIKELNIPTLIMSHNKSLCAQLYSEFKGFFSK
NHVEYFISYYDYYQPEAYIPRTDVFIEKDSSTNEDLERLRLSATASLLSYEDVVCIASVSANYGLGNPNEYIGMVLIFEL
GMQISQKELLKKLVDMGYKRNDNFFDRADFRVQGDIIDIYPAYYEDEVVRLEFFGDELDAMYHYNVLENKKGKDLKRFIL
YPTSQFSVGEARLKQAIRDIKIELNERLAYFEHENKLVEYQRLKQRVEFDLEMLTSTGMCKGVENYARHLTGLKEGDTPY
TLFDYFAIKNRKFLVIVDESHVSLPQFRGMFAGDRSRKQTLVDYGFRLPSALDNRPLMFDEFIHKNCQFLFVSATPAPLE
LELSKENIFHQIMRPTGLLDPLIELKDSDNQVEILFDEAKKVIQRNERVLVTVLTKKLAEELTRYYLELGIKVKYMHSDI
DAIERNEIIRGLRSGAFDMLIGINLLREGLDLPEVSLIAIMDADKEGFLRSTTSLIQTMGRAARNVNGKVLLFCKKITKS
MQEAMDTTNERRKLQMAYNKKYNITPTSVKRHIEESLKNEEDLGEIYRKGKKLEKMPASERAKLVKELRKQMLEAAKALE
FEKAAAIRDEINKLRDL

Sequences:

>Translated_657_residues
MLELTSEFKPSPDQQEAIKGIVKSIKKGNKYQTLLGVTGSGKTFTMANVIKELNIPTLIMSHNKSLCAQLYSEFKGFFSK
NHVEYFISYYDYYQPEAYIPRTDVFIEKDSSTNEDLERLRLSATASLLSYEDVVCIASVSANYGLGNPNEYIGMVLIFEL
GMQISQKELLKKLVDMGYKRNDNFFDRADFRVQGDIIDIYPAYYEDEVVRLEFFGDELDAMYHYNVLENKKGKDLKRFIL
YPTSQFSVGEARLKQAIRDIKIELNERLAYFEHENKLVEYQRLKQRVEFDLEMLTSTGMCKGVENYARHLTGLKEGDTPY
TLFDYFAIKNRKFLVIVDESHVSLPQFRGMFAGDRSRKQTLVDYGFRLPSALDNRPLMFDEFIHKNCQFLFVSATPAPLE
LELSKENIFHQIMRPTGLLDPLIELKDSDNQVEILFDEAKKVIQRNERVLVTVLTKKLAEELTRYYLELGIKVKYMHSDI
DAIERNEIIRGLRSGAFDMLIGINLLREGLDLPEVSLIAIMDADKEGFLRSTTSLIQTMGRAARNVNGKVLLFCKKITKS
MQEAMDTTNERRKLQMAYNKKYNITPTSVKRHIEESLKNEEDLGEIYRKGKKLEKMPASERAKLVKELRKQMLEAAKALE
FEKAAAIRDEINKLRDL
>Mature_657_residues
MLELTSEFKPSPDQQEAIKGIVKSIKKGNKYQTLLGVTGSGKTFTMANVIKELNIPTLIMSHNKSLCAQLYSEFKGFFSK
NHVEYFISYYDYYQPEAYIPRTDVFIEKDSSTNEDLERLRLSATASLLSYEDVVCIASVSANYGLGNPNEYIGMVLIFEL
GMQISQKELLKKLVDMGYKRNDNFFDRADFRVQGDIIDIYPAYYEDEVVRLEFFGDELDAMYHYNVLENKKGKDLKRFIL
YPTSQFSVGEARLKQAIRDIKIELNERLAYFEHENKLVEYQRLKQRVEFDLEMLTSTGMCKGVENYARHLTGLKEGDTPY
TLFDYFAIKNRKFLVIVDESHVSLPQFRGMFAGDRSRKQTLVDYGFRLPSALDNRPLMFDEFIHKNCQFLFVSATPAPLE
LELSKENIFHQIMRPTGLLDPLIELKDSDNQVEILFDEAKKVIQRNERVLVTVLTKKLAEELTRYYLELGIKVKYMHSDI
DAIERNEIIRGLRSGAFDMLIGINLLREGLDLPEVSLIAIMDADKEGFLRSTTSLIQTMGRAARNVNGKVLLFCKKITKS
MQEAMDTTNERRKLQMAYNKKYNITPTSVKRHIEESLKNEEDLGEIYRKGKKLEKMPASERAKLVKELRKQMLEAAKALE
FEKAAAIRDEINKLRDL

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=665, Percent_Identity=50.9774436090226, Blast_Score=660, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 75976; Mature: 75976

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELTSEFKPSPDQQEAIKGIVKSIKKGNKYQTLLGVTGSGKTFTMANVIKELNIPTLIM
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHHHHHCCCCEEEE
SHNKSLCAQLYSEFKGFFSKNHVEYFISYYDYYQPEAYIPRTDVFIEKDSSTNEDLERLR
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHH
LSATASLLSYEDVVCIASVSANYGLGNPNEYIGMVLIFELGMQISQKELLKKLVDMGYKR
HHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
NDNFFDRADFRVQGDIIDIYPAYYEDEVVRLEFFGDELDAMYHYNVLENKKGKDLKRFIL
CCCCCCCCCCEEECCEEEECCCCCCCCEEEEEECCCHHHHHHEHHHHCCCCCCCCCCEEE
YPTSQFSVGEARLKQAIRDIKIELNERLAYFEHENKLVEYQRLKQRVEFDLEMLTSTGMC
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
KGVENYARHLTGLKEGDTPYTLFDYFAIKNRKFLVIVDESHVSLPQFRGMFAGDRSRKQT
CCHHHHHHHHCCCCCCCCCEEHHHHHEECCCEEEEEECCCCCCCHHHCCCCCCCCHHHHH
LVDYGFRLPSALDNRPLMFDEFIHKNCQFLFVSATPAPLELELSKENIFHQIMRPTGLLD
HHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCEEEEECHHHHHHHHHCCCCHHH
PLIELKDSDNQVEILFDEAKKVIQRNERVLVTVLTKKLAEELTRYYLELGIKVKYMHSDI
HHHHHCCCCCEEEEEHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEECCCH
DAIERNEIIRGLRSGAFDMLIGINLLREGLDLPEVSLIAIMDADKEGFLRSTTSLIQTMG
HHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHH
RAARNVNGKVLLFCKKITKSMQEAMDTTNERRKLQMAYNKKYNITPTSVKRHIEESLKNE
HHHHCCCCCEEEEEHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCH
EDLGEIYRKGKKLEKMPASERAKLVKELRKQMLEAAKALEFEKAAAIRDEINKLRDL
HHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLELTSEFKPSPDQQEAIKGIVKSIKKGNKYQTLLGVTGSGKTFTMANVIKELNIPTLIM
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEHHHHHHHHCCCCEEEE
SHNKSLCAQLYSEFKGFFSKNHVEYFISYYDYYQPEAYIPRTDVFIEKDSSTNEDLERLR
CCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHH
LSATASLLSYEDVVCIASVSANYGLGNPNEYIGMVLIFELGMQISQKELLKKLVDMGYKR
HHHHHHHHHHCCEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCC
NDNFFDRADFRVQGDIIDIYPAYYEDEVVRLEFFGDELDAMYHYNVLENKKGKDLKRFIL
CCCCCCCCCCEEECCEEEECCCCCCCCEEEEEECCCHHHHHHEHHHHCCCCCCCCCCEEE
YPTSQFSVGEARLKQAIRDIKIELNERLAYFEHENKLVEYQRLKQRVEFDLEMLTSTGMC
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCC
KGVENYARHLTGLKEGDTPYTLFDYFAIKNRKFLVIVDESHVSLPQFRGMFAGDRSRKQT
CCHHHHHHHHCCCCCCCCCEEHHHHHEECCCEEEEEECCCCCCCHHHCCCCCCCCHHHHH
LVDYGFRLPSALDNRPLMFDEFIHKNCQFLFVSATPAPLELELSKENIFHQIMRPTGLLD
HHHHCCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCEEEEECHHHHHHHHHCCCCHHH
PLIELKDSDNQVEILFDEAKKVIQRNERVLVTVLTKKLAEELTRYYLELGIKVKYMHSDI
HHHHHCCCCCEEEEEHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCCEEEEECCCH
DAIERNEIIRGLRSGAFDMLIGINLLREGLDLPEVSLIAIMDADKEGFLRSTTSLIQTMG
HHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHH
RAARNVNGKVLLFCKKITKSMQEAMDTTNERRKLQMAYNKKYNITPTSVKRHIEESLKNE
HHHHCCCCCEEEEEHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCH
EDLGEIYRKGKKLEKMPASERAKLVKELRKQMLEAAKALEFEKAAAIRDEINKLRDL
HHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10688204 [H]