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The map label for this gene is ilvA [H]

Identifier: 153951864

GI number: 153951864

Start: 1038599

End: 1039810

Strand: Direct

Name: ilvA [H]

Synonym: JJD26997_1187

Alternate gene names: 153951864

Gene position: 1038599-1039810 (Clockwise)

Preceding gene: 153951666

Following gene: 153951658

Centisome position: 56.29

GC content: 34.9

Gene sequence:

>1212_bases
GTGTTAGAGCTTAATAAAATTTACAAAGCAAAACAACAAATTTCAGGGTTTGTAAACAAAACTCCTTTCATACACTCTTC
TTTTTTAAGCGACATTTGTCAAAGTGAAATTTATCTTAAAAATGAAAATTTACAAATCACAGGTGCTTATAAAATTCGTG
GAGCTTACAACAAAATAGCCAATCTTAGCGCTGAACAAAAACAACATGGAGTTATTGCAGCAAGTGCAGGAAACCATGCT
CAAGGCGTGGCCATTAGTGCAAAAAAATTTGGCATTAAAGCAGTTATCGTAATGCCAGAATCCACTCCACTCTTAAAAGT
TTCTGCTACAAAAGCCTTAGGAGCAGAGGTGATACTCAAAGGGGATAATTTCGATGAAGCCTATGCCTTTGCAACCTCTT
ATGCTAAAGAAAATAATCTTAGCTTTATCCATCCTTTTGACGATGAATTTGTAATGGCAGGACAAGGAACTTTAATGCTT
GAAATGCTTGATGAAATAAGCGATCTTGATATGATTATCGCACCTGTTGGAGGCGGAGGACTTATAAGCGGTATCGCAAG
CGCAGCTAAACAAATCAATCCAAACATTAAAATCATCGGAGTTGGAGCCAAAGGAGCTCCTGCAATGTATGAAAGTTTTC
ACGCTAAAAAAATCAAAAATGCAAAAAGCGTGCGCACTATAGCCGATGGTATTGCTGTGCGTGATGCAAATCCTATTAAT
TTTAACATTATTTTGGAATGCGTGGATGATTTTATCCAAGTTGATGATGAAGAAATCGCTAATGCGGTATTGTTTTTGCT
CGAAAAACATAAGATCATAGTTGAAGGTGCAGGAGCTGCAAGTGTAGCCGCCCTGCTTCATCAAAAAATAAATACACAAA
ATCATAAAAAAATTGGCGTAGTTTTAAGCGGAGGCAACATCGATGCACAAATGCTAAATATCATCATAGAAAAAGGTTTA
TTTAAATCTTACAGAAAAATGCAAATTCATGTTACTTTAGTAGATAAACCAGGAGCGTTATTACATCTTACAGATAGTTT
AAAAATAGCCAATGCAAATATAGTAAAAATCGATTATGATAGATTTTCTACCAAGCTTGATTATGGCGATGCGATGATTT
CAATCACTCTAGAGACCAAAGGCAAAGAACATCAAGAAGAAATAAGAAAAATTTTAACTCAAAAGGCTTTTAATTTCTAT
GAAAGTTTTTAA

Upstream 100 bases:

>100_bases
ATGAAAAAGCCAAAGAAGAATGTAAAAAATTAGATATAAATTTTATACAAAATCGTTGCATTATGCTAGAATATCCGGAT
TTTAAAACAAAGGAAAAATA

Downstream 100 bases:

>100_bases
TAACATATACGGCTTAAATAAAGCCCATTTGGTGGTGCTAAAAAGTGATTGCATTGCTTTTTAGCCTCAATCTGTTCTTT
TAGTTCTTTTTCACTCATTT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MLELNKIYKAKQQISGFVNKTPFIHSSFLSDICQSEIYLKNENLQITGAYKIRGAYNKIANLSAEQKQHGVIAASAGNHA
QGVAISAKKFGIKAVIVMPESTPLLKVSATKALGAEVILKGDNFDEAYAFATSYAKENNLSFIHPFDDEFVMAGQGTLML
EMLDEISDLDMIIAPVGGGGLISGIASAAKQINPNIKIIGVGAKGAPAMYESFHAKKIKNAKSVRTIADGIAVRDANPIN
FNIILECVDDFIQVDDEEIANAVLFLLEKHKIIVEGAGAASVAALLHQKINTQNHKKIGVVLSGGNIDAQMLNIIIEKGL
FKSYRKMQIHVTLVDKPGALLHLTDSLKIANANIVKIDYDRFSTKLDYGDAMISITLETKGKEHQEEIRKILTQKAFNFY
ESF

Sequences:

>Translated_403_residues
MLELNKIYKAKQQISGFVNKTPFIHSSFLSDICQSEIYLKNENLQITGAYKIRGAYNKIANLSAEQKQHGVIAASAGNHA
QGVAISAKKFGIKAVIVMPESTPLLKVSATKALGAEVILKGDNFDEAYAFATSYAKENNLSFIHPFDDEFVMAGQGTLML
EMLDEISDLDMIIAPVGGGGLISGIASAAKQINPNIKIIGVGAKGAPAMYESFHAKKIKNAKSVRTIADGIAVRDANPIN
FNIILECVDDFIQVDDEEIANAVLFLLEKHKIIVEGAGAASVAALLHQKINTQNHKKIGVVLSGGNIDAQMLNIIIEKGL
FKSYRKMQIHVTLVDKPGALLHLTDSLKIANANIVKIDYDRFSTKLDYGDAMISITLETKGKEHQEEIRKILTQKAFNFY
ESF
>Mature_403_residues
MLELNKIYKAKQQISGFVNKTPFIHSSFLSDICQSEIYLKNENLQITGAYKIRGAYNKIANLSAEQKQHGVIAASAGNHA
QGVAISAKKFGIKAVIVMPESTPLLKVSATKALGAEVILKGDNFDEAYAFATSYAKENNLSFIHPFDDEFVMAGQGTLML
EMLDEISDLDMIIAPVGGGGLISGIASAAKQINPNIKIIGVGAKGAPAMYESFHAKKIKNAKSVRTIADGIAVRDANPIN
FNIILECVDDFIQVDDEEIANAVLFLLEKHKIIVEGAGAASVAALLHQKINTQNHKKIGVVLSGGNIDAQMLNIIIEKGL
FKSYRKMQIHVTLVDKPGALLHLTDSLKIANANIVKIDYDRFSTKLDYGDAMISITLETKGKEHQEEIRKILTQKAFNFY
ESF

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=309, Percent_Identity=34.6278317152104, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI19923959, Length=296, Percent_Identity=28.0405405405405, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI33469958, Length=311, Percent_Identity=26.6881028938907, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1789505, Length=307, Percent_Identity=43.9739413680782, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1790207, Length=380, Percent_Identity=35, Blast_Score=201, Evalue=5e-53,
Organism=Escherichia coli, GI1789235, Length=194, Percent_Identity=26.8041237113402, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71991565, Length=391, Percent_Identity=39.386189258312, Blast_Score=257, Evalue=9e-69,
Organism=Caenorhabditis elegans, GI17537387, Length=390, Percent_Identity=34.8717948717949, Blast_Score=201, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=28.0254777070064, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322631, Length=310, Percent_Identity=40, Blast_Score=204, Evalue=3e-53,
Organism=Saccharomyces cerevisiae, GI6320930, Length=339, Percent_Identity=37.4631268436578, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6319788, Length=295, Percent_Identity=23.728813559322, Blast_Score=83, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21355833, Length=389, Percent_Identity=34.4473007712082, Blast_Score=183, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24645328, Length=305, Percent_Identity=31.8032786885246, Blast_Score=118, Evalue=6e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 43938; Mature: 43938

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLELNKIYKAKQQISGFVNKTPFIHSSFLSDICQSEIYLKNENLQITGAYKIRGAYNKIA
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCEEEEEEEEECCHHHHHH
NLSAEQKQHGVIAASAGNHAQGVAISAKKFGIKAVIVMPESTPLLKVSATKALGAEVILK
CCCCHHHHCCEEEECCCCCCCCEEEEEEECCEEEEEEECCCCCEEEEECCCCCCEEEEEE
GDNFDEAYAFATSYAKENNLSFIHPFDDEFVMAGQGTLMLEMLDEISDLDMIIAPVGGGG
CCCCCHHHHHHHHHCCCCCCEEECCCCCCEEEECCCEEHHHHHHHHCCCEEEEEECCCCH
LISGIASAAKQINPNIKIIGVGAKGAPAMYESFHAKKIKNAKSVRTIADGIAVRDANPIN
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHCCEEEECCCCCC
FNIILECVDDFIQVDDEEIANAVLFLLEKHKIIVEGAGAASVAALLHQKINTQNHKKIGV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEE
VLSGGNIDAQMLNIIIEKGLFKSYRKMQIHVTLVDKPGALLHLTDSLKIANANIVKIDYD
EEECCCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCEEEEEECCEEEECCEEEEEEHH
RFSTKLDYGDAMISITLETKGKEHQEEIRKILTQKAFNFYESF
HHCCEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLELNKIYKAKQQISGFVNKTPFIHSSFLSDICQSEIYLKNENLQITGAYKIRGAYNKIA
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEECCCEEEEEEEEECCHHHHHH
NLSAEQKQHGVIAASAGNHAQGVAISAKKFGIKAVIVMPESTPLLKVSATKALGAEVILK
CCCCHHHHCCEEEECCCCCCCCEEEEEEECCEEEEEEECCCCCEEEEECCCCCCEEEEEE
GDNFDEAYAFATSYAKENNLSFIHPFDDEFVMAGQGTLMLEMLDEISDLDMIIAPVGGGG
CCCCCHHHHHHHHHCCCCCCEEECCCCCCEEEECCCEEHHHHHHHHCCCEEEEEECCCCH
LISGIASAAKQINPNIKIIGVGAKGAPAMYESFHAKKIKNAKSVRTIADGIAVRDANPIN
HHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHCCEEEECCCCCC
FNIILECVDDFIQVDDEEIANAVLFLLEKHKIIVEGAGAASVAALLHQKINTQNHKKIGV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEE
VLSGGNIDAQMLNIIIEKGLFKSYRKMQIHVTLVDKPGALLHLTDSLKIANANIVKIDYD
EEECCCCCHHHHHHHHHHHHHHCCEEEEEEEEEECCCCEEEEEECCEEEECCEEEEEEHH
RFSTKLDYGDAMISITLETKGKEHQEEIRKILTQKAFNFYESF
HHCCEECCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA